LOCUS       NM_019236                647 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus hes family bHLH transcription factor 2 (Hes2),
            mRNA.
ACCESSION   NM_019236
VERSION     NM_019236.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 647)
  AUTHORS   Kobayashi,T., Terada,Y., Kuwana,H., Tanaka,H., Okado,T.,
            Kuwahara,M., Tohda,S., Sakano,S. and Sasaki,S.
  TITLE     Expression and function of the Delta-1/Notch-2/Hes-1 pathway during
            experimental acute kidney injury
  JOURNAL   Kidney Int 73 (11), 1240-1250 (2008)
   PUBMED   18418349
  REMARK    GeneRIF: Delta-1/Notch-2/Hes-1 signaling pathway may regulate the
            regeneration and proliferation of renal tubules during acute kidney
            injury.
REFERENCE   2  (bases 1 to 647)
  AUTHORS   Ishibashi,M., Sasai,Y., Nakanishi,S. and Kageyama,R.
  TITLE     Molecular characterization of HES-2, a mammalian helix-loop-helix
            factor structurally related to Drosophila hairy and Enhancer of
            split
  JOURNAL   Eur J Biochem 215 (3), 645-652 (1993)
   PUBMED   8354270
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from D14029.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D14029.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760434
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..647
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..647
                     /gene="Hes2"
                     /note="hes family bHLH transcription factor 2"
                     /db_xref="GeneID:29567"
                     /db_xref="RGD:62082"
     exon            1..164
                     /gene="Hes2"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..593
                     /gene="Hes2"
                     /note="hairy and enhancer of split 2"
                     /codon_start=1
                     /product="transcription factor HES-2"
                     /protein_id="NP_062109.1"
                     /db_xref="GeneID:29567"
                     /db_xref="RGD:62082"
                     /translation="MRLPRGVGDAAELRKSLKPLLEKRRRARINESLSQLKGLVLPLL
                     GAETSRYSKLEKADILEMTVRFLREQPASVCSTEAPGSLDSYLEGYRACLARLARVLP
                     ACSVLEPAVSARLLEHLRQRTVSGGPPSLTPASASAPAPSPPVPPPSSLGLWRPW"
     exon            165..260
                     /gene="Hes2"
                     /inference="alignment:Splign:2.1.0"
     exon            261..360
                     /gene="Hes2"
                     /inference="alignment:Splign:2.1.0"
     exon            361..647
                     /gene="Hes2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcttgggtca agcttgaact tggttaccgc cttctgtttt cgctctgcct taaaacaggg
       61 gcaaggatcc tccaccccga ggtaacagac cctgtgggcc cgtcgctttc ccgcagaaca
      121 tgagactgcc tagaggagta ggggacgcgg cagagctgcg caagagcctg aagccactgc
      181 tggagaagcg ccggcgcgcg cggatcaatg agagcctgag ccagctaaag ggtctagtat
      241 tgccgctgct aggagcagag acttcccgct attcgaagtt ggagaaggcg gacatcctgg
      301 aaatgactgt gcgcttccta cgggagcagc ctgcgtcagt atgttccacg gaagcacctg
      361 ggtctttgga tagctacctc gagggttacc gagcctgtct ggcgcgcctg gcccgcgtgc
      421 tgcccgcctg cagcgtcctg gagccggccg tgagcgcgcg cctgctagag cacctgcgac
      481 agaggactgt cagtggcggc ccgccctcac tgaccccagc atccgcttca gctccagcac
      541 cctctcctcc ggtgcctcct ccaagcagcc ttggactttg gaggccatgg taggttcctg
      601 gatgttccac aggatcctgc tgctggctgt caagggacct agctgac
//
