LOCUS       NM_053523               1857 bp    mRNA    linear   ROD 24-MAR-2023
DEFINITION  Rattus norvegicus homocysteine inducible ER protein with ubiquitin
            like domain 1 (Herpud1), mRNA.
ACCESSION   NM_053523
VERSION     NM_053523.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1857)
  AUTHORS   Fujioka R, Yamamoto T, Maruta A, Nakamura Y, Tominaga N, Inamitsu
            M, Oda T, Kobayashi S and Yano M.
  TITLE     Herpud1 modulates hypertrophic signals independently of calmodulin
            nuclear translocation in rat myocardium-derived H9C2 cells
  JOURNAL   Biochem Biophys Res Commun 652, 61-67 (2023)
   PUBMED   36812708
  REMARK    GeneRIF: Herpud1 modulates hypertrophic signals independently of
            calmodulin nuclear translocation in rat myocardium-derived H9C2
            cells.
REFERENCE   2  (bases 1 to 1857)
  AUTHORS   Ding W, Chen R, Wu C, Chen W, Zhang H, Fan X, Wang H, Ji Y, Xie L,
            Ning X and Shen L.
  TITLE     Increased expression of HERPUD1 involves in neuronal apoptosis
            after intracerebral hemorrhage
  JOURNAL   Brain Res Bull 128, 40-47 (2017)
   PUBMED   27871950
  REMARK    GeneRIF: Results showed that expression of HERPUD1 was increased
            around the hematoma, which indicated that HERPUD1 might involve in
            the physiological and pathological process during intracerebral
            hemorrhage; suggested that HERPUD1 was involved in neuronal
            apoptosis following intracerebral hemorrhage.
REFERENCE   3  (bases 1 to 1857)
  AUTHORS   Noda T, Maeda K, Hayano S, Asai N, Enomoto A, Takahashi M and
            Murohara T.
  TITLE     New endoplasmic reticulum stress regulator, Gipie, regulates the
            survival of vascular smooth muscle cells and the neointima
            formation after vascular injury
  JOURNAL   Arterioscler Thromb Vasc Biol 35 (5), 1246-1253 (2015)
   PUBMED   25792451
  REMARK    GeneRIF: Endoplasmic reticulum stress regulator regulates the
            survival of vascular smooth cells and neointima formation.
REFERENCE   4  (bases 1 to 1857)
  AUTHORS   Zhong Y, Shen H, Wang Y, Yang Y, Yang P and Fang S.
  TITLE     Identification of ERAD components essential for dislocation of the
            null Hong Kong variant of alpha-1-antitrypsin (NHK)
  JOURNAL   Biochem Biophys Res Commun 458 (2), 424-428 (2015)
   PUBMED   25660456
REFERENCE   5  (bases 1 to 1857)
  AUTHORS   Ho DV and Chan JY.
  TITLE     Induction of Herpud1 expression by ER stress is regulated by Nrf1
  JOURNAL   FEBS Lett 589 (5), 615-620 (2015)
   PUBMED   25637874
REFERENCE   6  (bases 1 to 1857)
  AUTHORS   Kim TY, Kim E, Yoon SK and Yoon JB.
  TITLE     Herp enhances ER-associated protein degradation by recruiting
            ubiquilins
  JOURNAL   Biochem Biophys Res Commun 369 (2), 741-746 (2008)
   PUBMED   18307982
REFERENCE   7  (bases 1 to 1857)
  AUTHORS   Chan SL, Fu W, Zhang P, Cheng A, Lee J, Kokame K and Mattson MP.
  TITLE     Herp stabilizes neuronal Ca2+ homeostasis and mitochondrial
            function during endoplasmic reticulum stress
  JOURNAL   J Biol Chem 279 (27), 28733-28743 (2004)
   PUBMED   15102845
  REMARK    GeneRIF: Herp stabilizes neuronal Ca2+ homeostasis and
            mitochondrial function during endoplasmic reticulum stress
REFERENCE   8  (bases 1 to 1857)
  AUTHORS   Hori O, Ichinoda F, Yamaguchi A, Tamatani T, Taniguchi M, Koyama Y,
            Katayama T, Tohyama M, Stern DM, Ozawa K, Kitao Y and Ogawa S.
  TITLE     Role of Herp in the endoplasmic reticulum stress response
  JOURNAL   Genes Cells 9 (5), 457-469 (2004)
   PUBMED   15147274
REFERENCE   9  (bases 1 to 1857)
  AUTHORS   Kokame K, Agarwala KL, Kato H and Miyata T.
  TITLE     Herp, a new ubiquitin-like membrane protein induced by endoplasmic
            reticulum stress
  JOURNAL   J Biol Chem 275 (42), 32846-32853 (2000)
   PUBMED   10922362
REFERENCE   10 (bases 1 to 1857)
  AUTHORS   van Laar T, Schouten T, Hoogervorst E, van Eck M, van der Eb AJ and
            Terleth C.
  TITLE     The novel MMS-inducible gene Mif1/KIAA0025 is a target of the
            unfolded protein response pathway
  JOURNAL   FEBS Lett 469 (1), 123-131 (2000)
   PUBMED   10708769
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB033771.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB033771.1, BC061849.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1857
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19p13"
     gene            1..1857
                     /gene="Herpud1"
                     /gene_synonym="Sup"
                     /note="homocysteine inducible ER protein with ubiquitin
                     like domain 1"
                     /db_xref="GeneID:85430"
                     /db_xref="RGD:620818"
     exon            1..238
                     /gene="Herpud1"
                     /gene_synonym="Sup"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..1267
                     /gene="Herpud1"
                     /gene_synonym="Sup"
                     /note="homocysteine-inducible, endoplasmic reticulum
                     stress-inducible, ubiquitin-like domain member 1"
                     /codon_start=1
                     /product="homocysteine-responsive endoplasmic
                     reticulum-resident ubiquitin-like domain member 1 protein"
                     /protein_id="NP_445975.1"
                     /db_xref="GeneID:85430"
                     /db_xref="RGD:620818"
                     /translation="MEPEPQPEPVTLLVKSPNQRHRDLELSGDRGWSVSRLKAHLSRV
                     YPERPRPEDQRLIYSGKLLLDHQCLQDLLPKQEKRHVLHLVCNVRSPSKKPEASTKGA
                     ESTEQPDNTSQAQYPGDSSSDGLREREVLRNLPPSGWENVSRPEAVQQTFQGLGPGFS
                     GYTTYGWLQLSWFQQIYARQYYMQYLAATAASGAFGPTPSAQEIPVVSTPAPAPIHNQ
                     FPAENQPANQNAAAQAVVNPGANQNLRMNAQGGPLVEEDDEINRDWLDWTYSAATFSV
                     FLSILYFYSSLSRFLMVMGATVVMYLHHVGWFPFRQRPVQNFPDDGPPQEAANQDPNN
                     NLQGGLDPEMEDPNRLPVGREVLDPEHTSPSFMSTAWLVFKTFFASLLPEGPPALAN"
     exon            239..316
                     /gene="Herpud1"
                     /gene_synonym="Sup"
                     /inference="alignment:Splign:2.1.0"
     exon            317..391
                     /gene="Herpud1"
                     /gene_synonym="Sup"
                     /inference="alignment:Splign:2.1.0"
     exon            392..522
                     /gene="Herpud1"
                     /gene_synonym="Sup"
                     /inference="alignment:Splign:2.1.0"
     exon            523..645
                     /gene="Herpud1"
                     /gene_synonym="Sup"
                     /inference="alignment:Splign:2.1.0"
     exon            646..996
                     /gene="Herpud1"
                     /gene_synonym="Sup"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1102
                     /gene="Herpud1"
                     /gene_synonym="Sup"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1844
                     /gene="Herpud1"
                     /gene_synonym="Sup"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagacaccaa gtgtcgttgt ggggtcgcag acggctgcgt cgccgcccgt tcggcatccc
       61 tgagcgcagt cgagcctcca gcgccgcaga catggagccc gagccacagc ccgagccggt
      121 cacgctgctg gtgaagagcc ccaatcagcg ccaccgcgac ttggagctga gtggcgaccg
      181 cggttggagt gtgagtcgcc tcaaggccca cctgagccga gtctaccccg aacgcccgcg
      241 cccagaggac cagaggttaa tttattctgg gaagctgctg ttggatcacc aatgtctcca
      301 agacttgctt ccaaagcagg aaaagcgaca tgttttgcac ctcgtgtgca atgtgaggag
      361 tccctcaaaa aagccagaag ccagcacaaa gggtgctgag tccacagagc agccggacaa
      421 cactagtcag gcacagtatc ctggggattc ctcaagcgat ggcttacggg aaagggaagt
      481 ccttcggaac cttcctccct ctggatggga gaacgtctct aggcctgaag ccgtccagca
      541 gactttccaa ggcctcgggc ccggcttctc tggctacacc acctacgggt ggctgcagct
      601 ctcctggttc cagcagatct atgcaagaca gtactacatg caatacttgg ctgccactgc
      661 tgcttcagga gcttttggcc ctacaccaag tgcacaagaa atacctgtgg tctctacacc
      721 ggctcccgcc cctatacaca accagtttcc ggcagaaaac cagccggcca atcagaatgc
      781 agccgctcaa gcggttgtta atcccggagc caatcagaac ttgcggatga atgcacaagg
      841 cggccctctg gtggaagaag atgatgagat aaaccgagac tggttggatt ggacctactc
      901 agcagcgaca ttttccgttt tcctcagcat tctttacttc tactcctccc tgagcagatt
      961 cctcatggtc atgggcgcca ccgtagtcat gtacctgcac cacgtcgggt ggtttccatt
     1021 cagacagagg ccagttcaga acttcccaga tgacggtccc cctcaggaag ctgccaacca
     1081 ggaccccaac aataacctcc agggaggttt ggaccctgaa atggaagacc ccaaccgcct
     1141 ccccgtaggc cgtgaagtgc tggaccctga gcataccagc ccctcgttca tgagcacagc
     1201 atggctagtc ttcaagactt tctttgcctc tcttcttccg gaaggcccac cagccctagc
     1261 aaactgatgg cccctgtgct ctgttgctgg aggctttcac agcttggact ggatcgtccc
     1321 ctggcgtgga ctcgagagag tcattgaaaa cccacaggat gacgatgtgc ttctgtgcca
     1381 agcaaaagca caaactaaga catgaagccg tggtacaaac tgaacagggc ccctcatgtc
     1441 gttattctga agagctttaa tgtatactgt atgtagtctc ataggcactg taaacagaag
     1501 gcccagggtc gcatgttctg cctgagcacc tccccagacg tgtgtgcatg tgtgccgtac
     1561 atggaagtca tagacgtgtg tgcatgtgtg ctctacatgg aagtcataga tgcagaaacg
     1621 gttctgctgg ttcgatttga ttcctgttgg aatgttgcaa ttacactaag tgtactactt
     1681 tatataatca gtgacttgct agacatgtta gcaggacttt tctaggagag acttattgta
     1741 tcattgcttt ttaaaacgca gtgcttactt actgagggcg gcgacttggc acaggtaaag
     1801 cctttgccgg gttttctgtt caataaagtt ttgctatgaa cgacaaaaaa aaaaaaa
//
