LOCUS       NM_001012474            4251 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus HECT and RLD domain containing E3 ubiquitin
            protein ligase family member 6 (Herc6), mRNA.
ACCESSION   NM_001012474 XM_008762963
VERSION     NM_001012474.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4251)
  AUTHORS   Nagamachi,A., Matsui,H., Asou,H., Ozaki,Y., Aki,D., Kanai,A.,
            Takubo,K., Suda,T., Nakamura,T., Wolff,L., Honda,H. and Inaba,T.
  TITLE     Haploinsufficiency of SAMD9L, an endosome fusion facilitator,
            causes myeloid malignancies in mice mimicking human diseases with
            monosomy 7
  JOURNAL   Cancer Cell 24 (3), 305-317 (2013)
   PUBMED   24029230
REFERENCE   2  (bases 1 to 4251)
  AUTHORS   Archambaud,C., Nahori,M.A., Soubigou,G., Becavin,C., Laval,L.,
            Lechat,P., Smokvina,T., Langella,P., Lecuit,M. and Cossart,P.
  TITLE     Impact of lactobacilli on orally acquired listeriosis
  JOURNAL   Proc Natl Acad Sci U S A 109 (41), 16684-16689 (2012)
   PUBMED   23012479
REFERENCE   3  (bases 1 to 4251)
  AUTHORS   Ebstein,F., Lange,N., Urban,S., Seifert,U., Kruger,E. and
            Kloetzel,P.M.
  TITLE     Maturation of human dendritic cells is accompanied by functional
            remodelling of the ubiquitin-proteasome system
  JOURNAL   Int J Biochem Cell Biol 41 (5), 1205-1215 (2009)
   PUBMED   19028597
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1 and BC085921.1.
            
            On Jan 7, 2022 this sequence version replaced XM_008762963.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085921.1, SRR26643298.23230.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                JAXUCZ010000004.1  88896973-88896993   c
            22-4251             BC085921.1         1-4230
FEATURES             Location/Qualifiers
     source          1..4251
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q24"
     gene            1..4251
                     /gene="Herc6"
                     /note="HECT and RLD domain containing E3 ubiquitin protein
                     ligase family member 6"
                     /db_xref="GeneID:362376"
                     /db_xref="RGD:1561739"
     exon            1..235
                     /gene="Herc6"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..3126
                     /gene="Herc6"
                     /EC_number="2.3.2.26"
                     /note="potential ubiquitin ligase; hect domain and RLD 6"
                     /codon_start=1
                     /product="probable E3 ubiquitin-protein ligase HERC6"
                     /protein_id="NP_001012492.1"
                     /db_xref="GeneID:362376"
                     /db_xref="RGD:1561739"
                     /translation="MYFTWAPGRRQPRRLEAGTGLKLLKAASGERHSLLLFSNHRVYS
                     CGDNSRGQLGQKSPQSTKRPEPIQALSTVHIDLVSCGKEHSVAVCHQGRVFTWGAGSE
                     GQLGIGESKEISFMPTKINSLAGIKIIQVSCGHYHSLALSEDGQVFSWGSNRQGQLGL
                     GNNLCSQASPQKVKSLEGIPLAQVAAGGTHSFALSLMGTSFGWGNNRSGQLALSGNSA
                     KEQIYKPHSIGALKTLNVVYISCGYEHTSVLTEDGQVFTFGGSSSEQLQHSPRSGRGG
                     PQLIEGIGGHVSQIECGSYHTIAYVYTTGQVVSLGRGPSCTSNATHQEAACSDVTCLL
                     SAKDLVDIEVKDIFAGAHANFVTTCRHTRSTSVSMKILPEIIRITQPLVKKWRAAKKG
                     KVHEDAKREISLIFSSPACLTASFLKKRDAGENNFINVDLKLARDVFKMLTAEKWISS
                     LITTCLEETLLRGLPYSSPHQEALLVFLLLPECSIMQDPKNWKTLAFEFASAIHKMRS
                     KSLTFLRNWWASLEVSSLNSLVQMLKKTIVSQLHNEVPMMKDTSNLKVSLEMMKEVQK
                     ILEKTNSHLHNEVPKMEDTSNLKVLLEVMKEVHEANCQLPENAFIMNDIFNFNTEEGI
                     MAKQQMFFIKYYSMVFNDFPFILDLPSKIILMKHDSSVKLSDEVKVAASPEKMGCPFF
                     ILKVRRSHLVEDTLRQLRQAEDFDLRKTLSVGFINEIRPEGGGVSSEFFHCIFEEMTD
                     PKYEMFMYPENGSNMWFPVNPKFEKSRYFLFGILCGLSLNNLNVINLSFPLALYKKLL
                     EQKPSLEDLKDLSLLLGRNLQEVLNCEAGVIEELHMYFSIYWDQRDVDLIPDGISVPV
                     NETNKRDYVSKCVDYIFNISIKTIYDEFHRGFYKVCNRDSIRHFQPEELMAAIIGNPT
                     CDWKQFENNSKYENGYSKSHPTILLFWKAFHELTLDEKKKFLLFLTGCDRLHVKGLQN
                     EGIRFRCPEVFSERDNPRSLTCHSILDLPKYSTMRRMKEALQVAINNNKGFISPE"
     exon            236..395
                     /gene="Herc6"
                     /inference="alignment:Splign:2.1.0"
     exon            396..472
                     /gene="Herc6"
                     /inference="alignment:Splign:2.1.0"
     exon            473..700
                     /gene="Herc6"
                     /inference="alignment:Splign:2.1.0"
     exon            701..795
                     /gene="Herc6"
                     /inference="alignment:Splign:2.1.0"
     exon            796..923
                     /gene="Herc6"
                     /inference="alignment:Splign:2.1.0"
     exon            924..1054
                     /gene="Herc6"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1122
                     /gene="Herc6"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1241
                     /gene="Herc6"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1301
                     /gene="Herc6"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1395
                     /gene="Herc6"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..1585
                     /gene="Herc6"
                     /inference="alignment:Splign:2.1.0"
     exon            1586..1740
                     /gene="Herc6"
                     /inference="alignment:Splign:2.1.0"
     exon            1741..1842
                     /gene="Herc6"
                     /inference="alignment:Splign:2.1.0"
     exon            1843..1932
                     /gene="Herc6"
                     /inference="alignment:Splign:2.1.0"
     exon            1933..2037
                     /gene="Herc6"
                     /inference="alignment:Splign:2.1.0"
     exon            2038..2178
                     /gene="Herc6"
                     /inference="alignment:Splign:2.1.0"
     exon            2179..2322
                     /gene="Herc6"
                     /inference="alignment:Splign:2.1.0"
     exon            2323..2489
                     /gene="Herc6"
                     /inference="alignment:Splign:2.1.0"
     exon            2490..2553
                     /gene="Herc6"
                     /inference="alignment:Splign:2.1.0"
     exon            2554..2624
                     /gene="Herc6"
                     /inference="alignment:Splign:2.1.0"
     exon            2625..2808
                     /gene="Herc6"
                     /inference="alignment:Splign:2.1.0"
     exon            2809..2911
                     /gene="Herc6"
                     /inference="alignment:Splign:2.1.0"
     exon            2912..4251
                     /gene="Herc6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ataccagagc cacagagcca cgggtggctg ggcatcgcag ggatgtactt cacctgggct
       61 ccaggaaggc ggcagcctcg gcgcctggag gcaggaactg gtcttaagct cttgaaggcg
      121 gccagcgggg aacgccactc gctgctactg ttcagcaacc acagggtgta ctcctgcggg
      181 gacaacagca ggggccagct gggccagaag agtccgcaga gcaccaaacg gccagaacca
      241 attcaggcac taagtactgt acacattgac ctggtgagct gtgggaagga gcactcagtg
      301 gctgtctgcc accaaggaag ggtcttcaca tggggagccg gttctgaagg gcagctgggg
      361 attggagaat ctaaggaaat aagcttcatg cctacgaaaa taaactctct ggctggcata
      421 aaaataatcc aagtttcctg tggacactac cactctttgg cattatcaga agatggccaa
      481 gtgttttcat ggggaagtaa cagacaagga caactgggcc tggggaataa tttatgttcc
      541 caagccagcc cacagaaggt gaagtccctg gaggggatcc cactggctca agtagctgca
      601 ggtggcacac acagttttgc tctgtctctc atggggactt catttggctg ggggaacaac
      661 agatctgggc agctggccct cagtgggaac agtgctaaag agcaaatcta caagcctcat
      721 tcaattggtg ccctgaagac tctcaatgtg gtttatatta gctgtggtta tgagcacact
      781 tcagtgctta ccgaggatgg acaagtgttt acatttggag gcagtagctc tgaacagcta
      841 cagcacagcc ccaggagtgg gagaggaggt ccacaactca tagaagggat tggcggccat
      901 gtttcacaga tagaatgtgg aagttatcac accattgcat atgtctacac cactggtcag
      961 gtggtatctt taggccgtgg accaagttgc acaagcaacg caactcatca ggaggctgct
     1021 tgctctgacg ttacctgctt gctatctgcc aaggaccttg tggatattga agtcaaagac
     1081 atttttgctg gagcacacgc caactttgtg acaacctgcc ggcatactag gtccacaagt
     1141 gtttccatga aaatcctgcc agaaattatc cgaatcaccc agccactggt aaagaaatgg
     1201 cgagcagcaa agaaaggaaa agtccatgaa gacgccaaaa gagaaatcag cttgatattt
     1261 tcatctcctg cttgtttgac tgcaagtttt ttgaagaaaa gagatgctgg agagaataat
     1321 ttcattaacg tggacttaaa actggcaagg gatgtcttca agatgttaac agcagagaaa
     1381 tggatttcct ccttgataac cacttgtctt gaggagactc tgcttagagg tcttccatac
     1441 agctctccac atcaagaagc tctattagtt tttcttttgc tcccggaatg ttccattatg
     1501 caggatccca agaactggaa gacactggca tttgaatttg caagcgctat tcataaaatg
     1561 aggtcaaagt cattaacatt cctgagaaac tggtgggcat ctttggaagt ttcttctctg
     1621 aactcactgg tccagatgct aaagaaaacc atcgtctctc aactgcataa tgaagttcca
     1681 atgatgaagg atacgtctaa ccttaaagtt tctttagaaa tgatgaaaga agtgcaaaag
     1741 atactagaga aaaccaactc tcatcttcat aatgaagttc caaagatgga ggatacgtct
     1801 aatcttaaag ttctcttaga agtgatgaaa gaagtgcatg aggctaactg tcaacttcca
     1861 gaaaatgctt tcatcatgaa tgacatcttt aacttcaata cagaagaagg aataatggcc
     1921 aaacagcaaa tgttctttat aaaatactat tctatggttt tcaatgattt tccatttatc
     1981 cttgatttgc catccaaaat tatattaatg aaacatgact catctgtaaa gctgtcggat
     2041 gaagtcaaag tcgctgcatc tccagaaaag atgggatgcc cgttctttat actgaaagtc
     2101 agacgaagtc atctggtgga agacaccttg cgtcaattaa gacaagctga agattttgac
     2161 cttaggaaga cactatcggt cggatttatt aatgaaattc gtcctgaggg tgggggagta
     2221 agttctgagt tcttccactg tatatttgaa gagatgacag accccaaata tgaaatgttc
     2281 atgtatcctg aaaatggttc caacatgtgg tttccagtca atcccaagtt tgagaagagc
     2341 agatatttcc tctttgggat cttatgtgga ctctccctaa ataatttaaa tgttatcaac
     2401 ctctctttcc cactggcttt atataaaaaa cttttggagc aaaagccatc tttggaagat
     2461 ttaaaagacc ttagtcttct cctggggagg aatttgcaag aagttctaaa ttgtgaggct
     2521 ggtgttattg aagaacttca catgtatttt tctatatact gggatcaaag agatgttgat
     2581 ttaattccag atgggatctc tgtgcctgtg aatgaaacaa acaagagaga ctatgtgtcc
     2641 aagtgtgttg attacatttt taacatttct ataaagacaa tttatgacga atttcataga
     2701 ggattttaca aggtgtgtaa ccgggacagt attaggcatt tccagcctga agaactaatg
     2761 gcagcaataa ttggaaaccc tacttgtgac tggaaacaat ttgaaaataa ttcaaagtat
     2821 gaaaatggat attccaaatc acacccaact attctactgt tttggaaggc tttccatgaa
     2881 ctaactttgg atgaaaagaa aaagttcctc ttgtttctta caggatgtga taggctacat
     2941 gtaaaaggcc tacagaatga aggaataaga ttccggtgtc ctgaagtttt cagtgaaaga
     3001 gataacccaa gatcattgac atgtcacagt attctagacc tgcctaagta ttccacaatg
     3061 agaaggatga aggaagcact tcaggttgca atcaacaata acaaggggtt tatctcaccg
     3121 gaatgatgca gaagcattca cctcccagca gtccacagcc tcagggatta ggtcttttac
     3181 tttggggttc ttctgtcttt ccttaatcta attagggaca agagattaaa ggattttact
     3241 ttagtttttg agataaataa gttataaaat aatattttag tgaaagaatt ctataaaaca
     3301 tttgccacat tcctaacatt gctcttttag aatgttttgg ctgcaatatt ttctgaacaa
     3361 actatgttcc tttaataata tactaaatat ttaaaatgtt caagactagg ggctaaagag
     3421 agaacttagt ggttaagatc actggctgct catccagagg ccagggctca attcccagca
     3481 cccacatagc tgcttacatc ctgtctgtaa tcccagtctt aggggatcca acactctcct
     3541 ctggcctcca aaacacacca tggatatggt gcatagacat acatgctaaa aacacctaaa
     3601 atatataaaa taaaataaaa taaaataaaa aataaaatag tatttactta tttaaagtgt
     3661 tattgtacca ataataaact attagtttaa aagtattaag aaaccaagtt tggaaaagat
     3721 aagcaaaata tgtactgctt tcaacagttt ttgaagcata tagatgtata ttttgtatta
     3781 aggaatatat ttagagttgt gattttagta aatgctaaat gatttatttt caacttctaa
     3841 gtgttgatat ttattactat ttaaagatac ttatacttag tgctccaaaa tacattctaa
     3901 atatagatcc tgttattaca cctacttctg tttggtaaaa tgtgaagaag ttgaaatatg
     3961 tcttattatg atgctataga gtaaattaac aaagcaacat aactgctatg ggaaaagacc
     4021 aatacatctt gtatactagt tctacttaat gttaaaactt aaattgcatt atacagtttt
     4081 gaaatgattt cataaactca tatagtttgt tgtaagaatg acatatatgc tgctgtgacg
     4141 acccctcttc attaaagctc catttctata aggctgtttt atctttatag acttatcaga
     4201 ctttatgtgt ttactggatt ccaaagtgac caaataaact tattaaaaat a
//
