LOCUS       NM_001012074            3850 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus HECT and RLD domain containing E3 ubiquitin
            protein ligase 4 (Herc4), mRNA.
ACCESSION   NM_001012074 XM_228147
VERSION     NM_001012074.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3850)
  AUTHORS   Sun,X., Sun,B., Cui,M. and Zhou,Z.
  TITLE     HERC4 exerts an anti-tumor role through destabilizing the
            oncoprotein Smo
  JOURNAL   Biochem Biophys Res Commun 513 (4), 1013-1018 (2019)
   PUBMED   31010679
REFERENCE   2  (bases 1 to 3850)
  AUTHORS   Rodriguez,C.I. and Stewart,C.L.
  TITLE     Disruption of the ubiquitin ligase HERC4 causes defects in
            spermatozoon maturation and impaired fertility
  JOURNAL   Dev Biol 312 (2), 501-508 (2007)
   PUBMED   17967448
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC087104.1.
            
            On Feb 11, 2005 this sequence version replaced XM_228147.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087104.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3850
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p11"
     gene            1..3850
                     /gene="Herc4"
                     /note="HECT and RLD domain containing E3 ubiquitin protein
                     ligase 4"
                     /db_xref="GeneID:309758"
                     /db_xref="RGD:1310971"
     exon            1..317
                     /gene="Herc4"
                     /inference="alignment:Splign:2.1.0"
     exon            318..348
                     /gene="Herc4"
                     /inference="alignment:Splign:2.1.0"
     exon            349..652
                     /gene="Herc4"
                     /inference="alignment:Splign:2.1.0"
     CDS             427..3600
                     /gene="Herc4"
                     /EC_number="2.3.2.26"
                     /note="HECT domain and RCC1-like domain-containing protein
                     4; hect domain and RLD 4; HECT-type E3 ubiquitin
                     transferase HERC4"
                     /codon_start=1
                     /product="probable E3 ubiquitin-protein ligase HERC4"
                     /protein_id="NP_001012074.1"
                     /db_xref="GeneID:309758"
                     /db_xref="RGD:1310971"
                     /translation="MLCWGNASYGQLGLGGIDEEIVLEPRKSDFFVNKKVRDVGCGLR
                     HTVFVLDDGTVYTCGCNDLGQLGHEKSRKKPEQVVALDAQNIVAVSCGEAHTLALNDK
                     GQVYAWGLDSDGQLGLQGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFC
                     WGQNKYGQLGLGIECQKQTSPQLIKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNK
                     FGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGH
                     NSTSHEINPRKVFELMGSIVTQIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSN
                     RKSPFTVKGNWFSYNGQCPQDIGSEDYFCVKRIFSGGDQSFSHYSSPQSCGPPDDFRR
                     SDPSKQIWTVNEALIQKWLSYPSGRFPVEIANEIDGTFSSSGCLNGSFLAVSNDDHYR
                     TGTRFSGVDMNAARLLFHRLIQPDHPQISQQVAASLEKNLIPKLTSSLPDVEALRFYL
                     TLPECPLMSDCNNFTTIAIPFGTALVNLEKAPLKVLENWWSVLEPPLFLKIVELFKEV
                     VVHLLKLYKIGIPPSERRIFNSFLHTALKVLEILHRVNERTGQLIQYDKFYIHEVQEL
                     IDIRNDYINWVQQQAYGVDVSHGITELADIPVTICTYPFVFDAQAKTTLLQTDAVLQM
                     QMAIDQAHRQNVSSLFLPVIESVNPCLILVVRRENIVGDAMEVLRKTKNIDYKKPLKV
                     IFVGEDAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEDSRLIWFSDKTFEDSDLFHLI
                     GVICGLAIYNFTIVDLHFPLALYKKLLKRKPSLDDLKELMPDVGRSMQQLLDYPEDDI
                     EETFCLNFTITVENFGATEVKELVLNGADTAVNKQNRQEFVDAYVDYIFNKSVASLFD
                     AFHAGFHKVCGGKVLLLFQPNELQAMVIGNTNYDWKELEKNTEYKGEYWAEHPTIKIF
                     WEVFHELPLEKKKQFLLFLTGSDRIPILGMKSLKLVIQSTGGGESYLPVSHTCFNLLD
                     LPKYTEKETLRCKLIQAIDHNEGFSLI"
     exon            653..812
                     /gene="Herc4"
                     /inference="alignment:Splign:2.1.0"
     exon            813..889
                     /gene="Herc4"
                     /inference="alignment:Splign:2.1.0"
     exon            890..1111
                     /gene="Herc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1203
                     /gene="Herc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1334
                     /gene="Herc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1495
                     /gene="Herc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1496..1572
                     /gene="Herc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..1697
                     /gene="Herc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1698..1757
                     /gene="Herc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1758..1869
                     /gene="Herc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1870..2059
                     /gene="Herc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2060..2232
                     /gene="Herc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2233..2352
                     /gene="Herc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2353..2376
                     /gene="Herc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2377..2475
                     /gene="Herc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2476..2643
                     /gene="Herc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2644..2787
                     /gene="Herc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2788..2954
                     /gene="Herc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2955..3021
                     /gene="Herc4"
                     /inference="alignment:Splign:2.1.0"
     exon            3022..3104
                     /gene="Herc4"
                     /inference="alignment:Splign:2.1.0"
     exon            3105..3288
                     /gene="Herc4"
                     /inference="alignment:Splign:2.1.0"
     exon            3289..3391
                     /gene="Herc4"
                     /inference="alignment:Splign:2.1.0"
     exon            3392..3820
                     /gene="Herc4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccctcggctc tctccacccc tcgtgttctc cgccctgctc gccaccagcc cttcccctcc
       61 cgctccatcc gggtcgctga cggctgtctc tcggtcggga gagtgcaggc ggcagcttct
      121 ctctgaggaa cctgggaaag tttcaccgga gagccgggca gcagaggcag cagtgctgcg
      181 gccgggacgc gggaggaacc gtggtaatcg ccgcggtcgg ctgaaggagg aaggtctcgg
      241 gagccggaga gcggtcctga ggtccaggga gcggtcgtcc tccatcgcct agggctctcc
      301 ctgtcgtgag ggaccggata agaacttcag ttttctgttg atgtggagac atcggctacc
      361 tccaagttcc cggtgcttca gaagggactt ttgtattgaa gctggaagac caaagtcatt
      421 gcaagcatgt tgtgctgggg aaacgcatcc tatggacaac taggtttggg tggaattgat
      481 gaagaaattg tactagagcc caggaaaagt gactttttcg taaataaaaa ggtccgagat
      541 gtaggatgtg gactcagaca tactgtgttc gtcctggacg acggaactgt gtacacatgt
      601 ggatgtaatg atctaggaca gctaggtcat gaaaagtcca gaaagaaacc agagcaggtt
      661 gttgccctgg atgcccaaaa tatcgtagct gtttcatgtg gagaagctca tacattagca
      721 cttaatgaca agggccaggt gtatgcttgg ggtctcgact ctgatggaca gcttggcctg
      781 caaggatcag aggaatgtat cagagtaccc agaaatatta aaagtctttc ggacatccag
      841 atagtacagg ttgcatgtgg ttactatcat tcacttgcac tttctaaagc aagtgaagtt
      901 ttctgttggg gacagaataa atatggccag ctcggtctcg gcattgaatg tcaaaagcaa
      961 acctcaccac agctgattaa gtctttgctt ggaataccat tcatgcaagt cgcagcagga
     1021 ggagcccata gttttgtact caccctttct ggagctatct ttggatgggg acgtaacaaa
     1081 tttggtcagc taggtcttaa tgatgagaac gataggtatg ttcctaattt actaaagtca
     1141 ctaagatctc agaaaatagt ttatatttgt tgcggagaag atcatactgc tgcattaacc
     1201 aaggaaggtg gagtgtttac ctttggagct ggaggctatg gccagctggg tcataattct
     1261 accagtcatg aaataaaccc caggaaagtg tttgagctta tgggaagcat tgttactcaa
     1321 attgcttgtg gaaggcagca tacttctgca tttgttcctt cttcaggacg aatttactcc
     1381 ttcggtctcg gtggtaatgg gcagttggga actggttcaa caagcaacag aaaaagccct
     1441 ttcactgtaa aaggaaactg gttttcttat aatggacaat gtccacaaga tattggttct
     1501 gaagactatt tctgtgtcaa aagaattttc tcaggtggag atcaaagctt ttcacattac
     1561 tctagtcctc agagctgtgg acctccagat gactttagac gctctgaccc ttcaaagcag
     1621 atctggacag tgaatgaagc tctgattcag aaatggctca gctacccctc tggaaggttc
     1681 cctgtggaga tagccaatga gatagatgga acattttctt cgtctggttg cctaaatgga
     1741 agttttctgg ctgttagcaa tgatgatcac tatagaacag gcaccagatt ttcaggggtc
     1801 gacatgaatg ccgctagact cttattccac agactcatac agcctgacca cccgcagata
     1861 tctcagcagg tggcagctag tttggaaaag aaccttatcc ctaaactgac tagttcctta
     1921 cctgatgttg aagctttgag gttttatctt accctgccag agtgccccct gatgagtgac
     1981 tgcaacaatt tcacaaccat agcaatcccc tttggcacag cccttgtgaa cctagaaaaa
     2041 gcaccactga aagtacttga aaactggtgg tcagtacttg aacctccact attcctcaag
     2101 atagtagaac tttttaagga agttgtggta catcttttga aactctacaa gatcggcatt
     2161 cccccttctg aaagaagaat tttcaacagt tttcttcata ccgcattaaa ggttttagaa
     2221 atattacata gggtaaatga gagaacagga caacttatac agtacgacaa gttttacata
     2281 catgaagtcc aagagctgat agacataagg aatgactata tcaactgggt ccagcagcaa
     2341 gcctatggag tggatgtcag ccatggaata actgagttgg cagatatccc tgtgacaatt
     2401 tgtacatatc catttgtatt tgatgcccag gcaaaaacta ctctgctaca gacagacgca
     2461 gtcttgcaga tgcagatggc tattgaccag gcccataggc agaatgtctc ctctcttttt
     2521 ctgccagtga ttgagtctgt gaatccttgc ttaattctgg ttgttcgcag agaaaatatt
     2581 gtaggagatg caatggaagt cctcaggaaa accaagaata tagattataa aaagccactc
     2641 aaagttatat ttgttggaga agatgctgtt gatgctggag gtgtacgcaa agaatttttc
     2701 ttgctcatca tgagggaatt attggatcct aaatatggca tgtttcgata ttatgaagat
     2761 tccaggctta tttggttttc agataagaca tttgaagaca gtgatttgtt ccacttaatt
     2821 ggtgttatct gtggattagc aatttataat tttactattg tggacctcca cttccctttg
     2881 gctttatata agaagctact gaaaaggaag ccatccctgg atgatctgaa agagctgatg
     2941 ccagatgtag ggagaagcat gcaacaattg ctggactacc cggaggacga tatagaggaa
     3001 acattttgtc taaactttac gatcacagtt gaaaattttg gtgcaacaga agtgaaagag
     3061 ctggttctga atggtgcaga caccgctgtt aacaaacaga atcggcagga gtttgttgat
     3121 gcctatgtgg attacatatt caataaatca gtggcatctt tatttgatgc tttccatgcc
     3181 ggctttcata aggtctgtgg aggaaaagtt cttctgctct tccagcccaa tgaattacaa
     3241 gctatggtta ttgggaatac aaattatgat tggaaagaac tggagaagaa tacagaatac
     3301 aaaggagagt attgggcaga acatcccacg ataaaaattt tttgggaagt atttcatgaa
     3361 ttaccactag aaaagaagaa acaattccta ttatttttga caggtagtga tcgaattcct
     3421 attcttggta tgaagagtct gaaactagtc atccagtcaa caggaggtgg tgagagctat
     3481 ctcccggttt cccatacctg ttttaatctt ctagatctcc caaaatatac agagaaagaa
     3541 accctacgat gtaaactgat ccaagctatt gatcacaatg aaggcttcag tttaatataa
     3601 ccttggagtt ctgactttct gtttagtgca aaggcatcaa actactcgtt tttcttgtga
     3661 attcagcagt gagagttact tctgtaattc ttgcctaaaa attgttcact actgtactga
     3721 tgatgaaagc caaaaattaa aaactgtaca gaaccatgaa ttgtaccatc ctcataaaca
     3781 tacaagtatt gtgaatacat taaagtttta ctaacagtaa aaaaaaaaaa aaaaaaaaaa
     3841 aaaaaaaaaa
//
