LOCUS       NM_001108631            5230 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus HECT and RLD domain containing E3 ubiquitin
            protein ligase 3 (Herc3), mRNA.
ACCESSION   NM_001108631 XM_001060220 XM_001060283 XM_001060353 XM_001060411
            XM_001060473 XM_342701
VERSION     NM_001108631.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5230)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474011.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001060411.1, XM_001060473.1, XM_001060283.1, XM_001060353.1,
            XM_342701.2, XM_001060220.1.
FEATURES             Location/Qualifiers
     source          1..5230
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q24"
     gene            1..5230
                     /gene="Herc3"
                     /note="HECT and RLD domain containing E3 ubiquitin protein
                     ligase 3"
                     /db_xref="GeneID:362377"
                     /db_xref="RGD:1307803"
     exon            1..425
                     /gene="Herc3"
                     /inference="alignment:Splign:2.1.0"
     exon            426..566
                     /gene="Herc3"
                     /inference="alignment:Splign:2.1.0"
     exon            567..821
                     /gene="Herc3"
                     /inference="alignment:Splign:2.1.0"
     CDS             596..3748
                     /gene="Herc3"
                     /EC_number="2.3.2.26"
                     /note="hect domain and RLD 3"
                     /codon_start=1
                     /product="probable E3 ubiquitin-protein ligase HERC3"
                     /protein_id="NP_001102101.1"
                     /db_xref="GeneID:362377"
                     /db_xref="RGD:1307803"
                     /translation="MLCWGYWSLGQPGISSNLQGIVAEPQVCRFVSDRSIKEVACGGN
                     HSVFLLEDGEVYTCGVNTKGQLGHEREGNKPEQIGALADQHIIHVACGESHSLALSDR
                     GQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFT
                     WGKNSHGQLGLGKEFPSQTSPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNN
                     AGQLGLSDEKDRESPCHVKLLRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGH
                     DSVNDEVNPRRVLELMGSEVTQIACGRQHTLALVPSSGLIYAFGCGAKGQLGTGHTCN
                     VKCPSPVKGHWAAHSGQLSARADRFKYRVVKQIFSGGDQTFVLCSTYENSSPAVDFRT
                     VNQAHYTNLINDETIAVWRQKLTEHNNANTVNGVVQILSSAACWNGSFLEKKIDEHFK
                     TSPKIPGIDLNSTRVLFEKLMHSQHSMILEQILNSFESCLIPQLSSSPPDVEAMRIYL
                     ILPEFPLLQDSKYYITLTIPLAMAILRLETNPSKVLDNWWSQACPKYFMKLVTLYKSA
                     VLYLLRGRKTFLIPVLFNNYMTATLKLLEKLYKVNLKVKHVEYDKFYIPEISSLVDIQ
                     EDYLMWFLHQSGMKARPSIMQDAVTLCSYPFIFDAQAKTKMLQTDAELQMQVAVNGAN
                     LQNVFMLLTLEPLLARSPFLVLHVRRNHLVGDALRELSIHSDIDLKKPLKVIFDGEEG
                     VDAGGVTKEFFLLLLKELLNPIYGMFTYYQDSNLLWFSDTCFVEHNWFHLIGITCGLA
                     IYNSTVVDLHFPLALYKKLLNVKPSLEDLKELSPTEGRSLQELLDYPGEDIEETFCLN
                     FTVCRESYGVIEQKKLIPGGDRVAVCKDNRQEFVDAYVNYIFQISVHEWYTAFSSGFL
                     KVCGGKVLELFQPAELRAMMVGNSNYNWEELEETAVYKGDYSSTHPTVKLFWETFHEF
                     PLEKKKRFLLFLTGSDRIPIYGMASLQIVIQSTATGEDYLPVAHTCYNLLDLPKYSSK
                     EIMKARLTQALDNYEGFSLA"
     exon            822..981
                     /gene="Herc3"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1058
                     /gene="Herc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1280
                     /gene="Herc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1372
                     /gene="Herc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1503
                     /gene="Herc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1504..1664
                     /gene="Herc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1665..1741
                     /gene="Herc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1742..1866
                     /gene="Herc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1867..1926
                     /gene="Herc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1927..2038
                     /gene="Herc3"
                     /inference="alignment:Splign:2.1.0"
     exon            2039..2228
                     /gene="Herc3"
                     /inference="alignment:Splign:2.1.0"
     exon            2229..2392
                     /gene="Herc3"
                     /inference="alignment:Splign:2.1.0"
     exon            2393..2506
                     /gene="Herc3"
                     /inference="alignment:Splign:2.1.0"
     exon            2507..2530
                     /gene="Herc3"
                     /inference="alignment:Splign:2.1.0"
     exon            2531..2620
                     /gene="Herc3"
                     /inference="alignment:Splign:2.1.0"
     exon            2621..2791
                     /gene="Herc3"
                     /inference="alignment:Splign:2.1.0"
     exon            2792..2935
                     /gene="Herc3"
                     /inference="alignment:Splign:2.1.0"
     exon            2936..3102
                     /gene="Herc3"
                     /inference="alignment:Splign:2.1.0"
     exon            3103..3169
                     /gene="Herc3"
                     /inference="alignment:Splign:2.1.0"
     exon            3170..3252
                     /gene="Herc3"
                     /inference="alignment:Splign:2.1.0"
     exon            3253..3436
                     /gene="Herc3"
                     /inference="alignment:Splign:2.1.0"
     exon            3437..3539
                     /gene="Herc3"
                     /inference="alignment:Splign:2.1.0"
     exon            3540..5230
                     /gene="Herc3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggaagtcgt tctcctagct cgatctgcgg gagtgcgggg ggaaacttca ttattactgt
       61 gacgctgaag gccggggagg cccgagctgc ctgagggctg cagccgccgg gtcggcgctg
      121 cggacccggg tgcgggtgca ggcggggcga cgatctcagg gcaccgagcc cgccgcactc
      181 gcgggggagg gagggggctg ggctgtccgc agctccctgt cgcggaggcg cctaccggct
      241 ctgctcggcc gccggcagcg ggtgacctcc ctgcgtgaag agcatcgcgg cgcggcggca
      301 ggggaattcg cgttgcggct ggccgcgggc tcctcccacc cagctggcgg gcggggctcg
      361 gggatccggt gtctggtgca gacgctgctg cggccgagcg agccgacggc tggaccttgg
      421 agcagaaaaa caaaatcggt ggcttacaca ctccagtttt gaccccatct gagaagttag
      481 actgcaggaa tcaaattaga tgcaaaacac ctttgtcatg aaaaaaatag aagcctggtt
      541 cactggtagc cacttggact tgttcagcta tatgagaccc tgaaggataa gaacaatgct
      601 atgttggggg tattggtccc tgggccaacc aggcatcagc tccaacctgc aaggaatcgt
      661 ggctgagccc caggtgtgcc gcttcgtatc ggacagaagc atcaaggaag tggcgtgtgg
      721 aggaaaccat tcagtgttcc tgctggagga tggggaggtt tacacgtgtg gagtaaacac
      781 caaggggcag cttggccacg agagggaagg taacaagcca gagcaaattg gagcactggc
      841 tgatcagcac atcatccacg tggcgtgtgg cgagtcacac agtctggctc tcagtgaccg
      901 gggccagctg ttctcttggg gtgcagggag tgatggccaa ctgggcctca tgaccactga
      961 ggattctgtg gcggtgccca ggttaataca gaagctgaac cagcagacca tattacaagt
     1021 ttcctgtggc aactggcact gcttggctct ggcagctgat ggccagttct tcacatgggg
     1081 aaagaacagc catggacagc tgggcctggg gaaggagttc ccctcccaaa ccagcccaca
     1141 gagggtgaga tctttggaag ggatcccact ggctcaggtg gctgcaggag gggctcatag
     1201 ctttgccctg tctctctcag gagccgtttt tggctgggga atgaataatg cagggcagct
     1261 agggctcagt gatgaaaaag atcgagagtc tccatgccac gtgaagcttt tacgaacaca
     1321 gaaagtcgtc tatattagtt gtggagagga gcacacagca gttctcacaa agagtggggg
     1381 cgtgtttacc tttggtgctg gctcctgtgg acagcttgga cacgactctg tgaatgatga
     1441 agttaatccg agaagagtcc tggaactgat gggcagtgaa gtaactcaga ttgcctgtgg
     1501 cagacagcac actctagccc ttgtgccttc ttctggactc atctatgcat ttggttgtgg
     1561 agctaaaggt cagctgggaa ccggacatac atgtaatgtc aagtgcccat ctcctgtgaa
     1621 gggccactgg gctgcgcaca gcggtcagct ttcagctcga gctgatcgct ttaagtaccg
     1681 cgtggttaag cagatcttct ccggagggga ccagacattt gtactttgct ccacatatga
     1741 gaattcttct cctgctgttg acttcagaac tgtgaaccaa gcacattata ccaacttaat
     1801 aaatgacgaa accatagcag tttggagaca aaagctcaca gaacacaaca acgcaaatac
     1861 agtcaatggt gttgttcaga tactgtcttc tgcagcttgt tggaatggaa gctttctgga
     1921 aaaaaaaatt gatgaacatt ttaaaaccag tcccaaaatc cctgggattg acctgaactc
     1981 aactagggtt ttatttgaga agttaatgca ctctcagcac tccatgattc tagagcagat
     2041 actaaacagc tttgaaagtt gcctcattcc ccagttgtca agttcacctc cagatgtgga
     2101 ggcaatgaga atctatttaa tactaccaga gtttccgctg cttcaggatt ctaagtatta
     2161 cataacgctg accattcccc tggcgatggc cattctgagg ctggaaacca accctagcaa
     2221 agtattagat aactggtggt ctcaggcatg cccaaaatac ttcatgaagc tggtaaccct
     2281 ctataaaagt gccgtccttt acctcctaag gggaaggaag acattcctaa tccctgtact
     2341 gtttaataat tacatgaccg caaccctcaa gcttctggag aaattgtaca aggtaaatct
     2401 taaggtgaag cacgtggagt acgataagtt ttatatccct gagatttcta gtctagtgga
     2461 cattcaggaa gactacctca tgtggttttt gcatcaatcc ggaatgaagg ccagaccgtc
     2521 tatcatgcag gatgctgtaa ccctttgttc ctatcctttc atctttgatg cccaagccaa
     2581 gaccaagatg ctgcagactg atgccgagtt acagatgcag gtggcagtca atggagccaa
     2641 cctgcagaat gtcttcatgc ttcttaccct ggagcctctg ctggccagaa gccccttcct
     2701 ggtccttcat gtccgcagga accaccttgt gggagatgcc ctgagagagc tgagcattca
     2761 ctctgacatt gatttgaaga agcctctcaa agtaatcttt gatggggaag aaggagtaga
     2821 tgctggtggt gttacgaagg agttctttct tttgctgcta aaagaacttt tgaatcccat
     2881 ttatgggatg tttacctact atcaagattc aaatctcttg tggttttcag acacatgttt
     2941 tgtagagcac aactggtttc acttgattgg cataacctgt ggattagcta tctacaactc
     3001 cactgtggtt gacctccact tcccgttggc tctctacaag aagttactga atgtaaagcc
     3061 cagcttggag gacttgaagg agctgtcacc aactgaagga aggagtcttc aagagcttct
     3121 agattatcct ggcgaagaca tcgaagagac cttttgcctc aacttcacgg tgtgccgaga
     3181 aagctatggg gtgatagaac agaagaaatt gatacccggg ggagacagag tggccgtgtg
     3241 caaggacaac aggcaagaat tcgtggatgc ttacgtgaat tacatcttcc aaatttcggt
     3301 tcatgagtgg tacacagcct tctccagtgg cttcctgaag gtgtgtggtg gcaaagtcct
     3361 cgagctcttc cagcctgcag aactgagggc catgatggtg gggaacagca attacaactg
     3421 ggaagagctg gaagagactg ctgtctacaa gggtgattat tcaagcacac atcccactgt
     3481 gaaactattc tgggaaacat tccacgagtt cccattagag aagaagaaga ggtttctctt
     3541 gttcctgaca ggcagtgacc ggattcccat ctatggaatg gccagtctgc agatcgtcat
     3601 ccagtctaca gccactgggg aggattactt acctgtggcc catacctgct acaaccttct
     3661 cgaccttccc aaatatagca gcaaagagat tatgaaagct cggctgaccc aggccctcga
     3721 caactatgag ggttttagtt tggcgtgagg caccccagct tccccaagac acccatccct
     3781 tccttcttct gtggccacat tgaggctgat agaaaaatat catgggaagt gatttctatt
     3841 tttttattgt ttaaatggtt tgagactttt gaatcctaaa cccttgtcaa ggcgtttctg
     3901 gggttcaata gtaaatgtct ttttgaaaaa tcagtggttg gggatgagcc aagaacaaaa
     3961 ttggctttag tatgggaagt ggattttgtt ttgttctgtt ttgttttaaa ccaaggtacc
     4021 tgttgttcct tcatctgtga atgtgttgca gtctgctgga cttaagggca gtaggtttcc
     4081 cgtctcccag atgtctgtca gccctgatgt ttcttcacca tgctttgctg ctgtcttcct
     4141 ggctcctcag tcccctgcag ggaggacttg acagataggt cccttcttgc ccgccatgta
     4201 gagcatttcc tttctcctca gcactggaag tgcatgactt gttgcagccc accccagcgc
     4261 atagagagaa cgggcttctt cagaactcct aattccaaaa agctgagcct cgccatagct
     4321 cttgagtcta tatgggaacc tttatgaaga tgtgctgctt aaagaaaata ggccatgact
     4381 gcctactgcc tgggcctcct gaaacacata caggcagcag ccgcgggtgg actgcatgtg
     4441 tcttgtccgc cgtgacccct ggatttacag tgaattggta gacccctttg accttacttt
     4501 ttgaaatgca ggttgcattt tcttgtttcc atattgccta agaacagtac aattaataaa
     4561 ggttccccct tctttattac gttatatctg ctgctttctc ctcccttctt tcctgtgctc
     4621 ccgactgtgc tcttgctctc ttactcttcc ttgtctttgc tgcttgaatc cgttccactc
     4681 ttccttctgc tagtggatgc atgctgtctt ttctgtttga aattttgtaa ggtttttttt
     4741 taaacctctg tctctaactg tgaaaatatg aagattctct ttataataga gtttttgttt
     4801 atcacatatg aaatgtgcat tgacagtgat atttcagcag ggggattacg ttaagtcaaa
     4861 tacatgtgtc tcaatagtga catgtttgac tgctcatcat tgtgtaagaa aactctacgt
     4921 ggtcaaagag tttatgtaat tctaatttta aatctgtggt agataaagta tttatttatc
     4981 taaactgaag aagtacttat agatggtgat gcagcaccaa gtcttgatga aggaatgtag
     5041 attttgcttt tccttttttg ttgttgttgt tgtttttgtt tttttaaaag tttctccaat
     5101 tgctaaattg gtagtttttc tgtccttata aatacaacat ttaaaaaaga tacacaacta
     5161 tatgaaatgt ttattttcta tgtgtctgca tatagttcaa tattatccaa taaatttggt
     5221 gttttaactt
//
