LOCUS       NM_001191993            5259 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus hephaestin-like 1 (Hephl1), mRNA.
ACCESSION   NM_001191993 XM_039081904 XM_576357
VERSION     NM_001191993.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5259)
  AUTHORS   Sharma,P., Reichert,M., Lu,Y., Markello,T.C., Adams,D.R.,
            Steinbach,P.J., Fuqua,B.K., Parisi,X., Kaler,S.G., Vulpe,C.D.,
            Anderson,G.J., Gahl,W.A. and Malicdan,M.C.V.
  TITLE     Biallelic HEPHL1 variants impair ferroxidase activity and cause an
            abnormal hair phenotype
  JOURNAL   PLoS Genet 15 (5), e1008143 (2019)
   PUBMED   31125343
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5259)
  AUTHORS   Chen,H., Attieh,Z.K., Syed,B.A., Kuo,Y.M., Stevens,V., Fuqua,B.K.,
            Andersen,H.S., Naylor,C.E., Evans,R.W., Gambling,L., Danzeisen,R.,
            Bacouri-Haidar,M., Usta,J., Vulpe,C.D. and McArdle,H.J.
  TITLE     Identification of zyklopen, a new member of the vertebrate
            multicopper ferroxidase family, and characterization in rodents and
            human cells
  JOURNAL   J Nutr 140 (10), 1728-1735 (2010)
   PUBMED   20685892
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On or before Jun 3, 2021 this sequence version replaced
            XM_039081904.1, NM_001191993.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760389
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-182               JAXUCZ010000008.1  20246517-20246698   c
            183-427             JAXUCZ010000008.1  20229201-20229445   c
            428-640             JAXUCZ010000008.1  20219234-20219446   c
            641-820             JAXUCZ010000008.1  20218676-20218855   c
            821-1075            JAXUCZ010000008.1  20217372-20217626   c
            1076-1244           JAXUCZ010000008.1  20214504-20214672   c
            1245-1384           JAXUCZ010000008.1  20212854-20212993   c
            1385-1516           JAXUCZ010000008.1  20212601-20212732   c
            1517-1728           JAXUCZ010000008.1  20210519-20210730   c
            1729-1879           JAXUCZ010000008.1  20208358-20208508   c
            1880-2092           JAXUCZ010000008.1  20205042-20205254   c
            2093-2306           JAXUCZ010000008.1  20201074-20201287   c
            2307-2446           JAXUCZ010000008.1  20196371-20196510   c
            2447-2587           JAXUCZ010000008.1  20192868-20193008   c
            2588-2694           JAXUCZ010000008.1  20188337-20188443   c
            2695-2917           JAXUCZ010000008.1  20186991-20187213   c
            2918-3057           JAXUCZ010000008.1  20185635-20185774   c
            3058-3220           JAXUCZ010000008.1  20180747-20180909   c
            3221-3292           JAXUCZ010000008.1  20180248-20180319   c
            3293-5259           JAXUCZ010000008.1  20178190-20180156   c
FEATURES             Location/Qualifiers
     source          1..5259
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q12"
     gene            1..5259
                     /gene="Hephl1"
                     /gene_synonym="RGD1564835"
                     /note="hephaestin-like 1"
                     /db_xref="GeneID:500946"
                     /db_xref="RGD:1564835"
     exon            1..182
                     /gene="Hephl1"
                     /gene_synonym="RGD1564835"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..3495
                     /gene="Hephl1"
                     /gene_synonym="RGD1564835"
                     /EC_number="1.16.3.1"
                     /note="hephaestin-like protein 1"
                     /codon_start=1
                     /product="ferroxidase HEPHL1"
                     /protein_id="NP_001178922.2"
                     /db_xref="GeneID:500946"
                     /db_xref="RGD:1564835"
                     /translation="MFLKQPGGCILLEFLGLLGLVGAVTRTYYIGIVEEYWNYVPQGK
                     DVITGKSFSEDKLATLFLERGPNRIGGIYKKAVYRHFTDGSYSTEIPKPPWLGFLGPI
                     LRAEVGDVIVIHLKNFASRPYSLHPHGVFYNKDSEGALYPDGTSGKNKEDDMVPPGKN
                     YTYVWPVREEYAPAPADANCLTWVYHSHIDAPKDICSGLIGPLLVCKEGVLNRHSGAR
                     TDVDREFVIMFTLVDENQSWYLDDNIRQFCTNPSSVDKSDAVFQRSNKMHALNGFLFG
                     NLPEPEMCVGESVSWHLFGMGNEIDIHSIYFYGNTFITRGHRADVVNLFPATFLTTEM
                     IVENPGKWMITCQVSDHLQAGMLGQYNVGNCRGNAPHPKMRGQQRRYFIAAEKVLWDY
                     SPQGYDKFTGFPLNTSGSDSAVYFTQADNRIGGKYWKARYTEYVDATFSRRKMPSDSE
                     AHLGILGPVIKAEVGDILLVTFANKADKVYSILPHGVFYDKASDAGPNVDGFLKPGAH
                     VKPGETFTYRWTVPESVSPTDDDPPCLTYLYFSAVQPIKDTSAGLVGPLLVCKKGTLN
                     ADGTQKGIDKEFYLLFTVFDENFSSYLDENIQKFTWHPFSVDKEDKEFVKSNRMHAIN
                     GYMYGNQPGLSMCKKDRVSWHLIGMGTDTDMHGVYFQGNTIHLRGTHRDSLALFPHMS
                     TTAFMQPDHSGIFKVFCSTLHHFTRGMGQIYEVSSCGNRDPSEPPYGMLRTFYIAAEE
                     VEWDYAPNKNWEFEKQHLDAGGERHGDIFMNHTENWIGSQYRKVVYREYTNGEFVEIK
                     ARPPQEEHLQLLGPMIHAEVGDSILIIFKNKASRPYSITAQGVEDSDSGKFLDVPVTK
                     PGEIKTYRWNVPKRSGPGPSDPNCIPWVYFSTANFVKDTYSGLMGPLITCREGVLNEK
                     GRRSDVDYEFALLFLVFNENESWYLDDNIKKYLNKDPRDFRHTDDFEESNRMHAINGK
                     IFGNLPGLIMTEDSMTNWYLLGIGSEVDIHTIHYHAESFLFKIDKSYREDVYDLFPGT
                     FQTIELFADHPGTWLLHCHVSDHIHAGMETTYTVLRNIDNRIPYSTKSPSGAGPHAVT
                     VPSQEQPGQEDLYFFGKSLRPRGAKAALVILFILGLLLLVATVILALRLRSSRRQMAY
                     REVQSCALPTDAL"
     exon            183..427
                     /gene="Hephl1"
                     /gene_synonym="RGD1564835"
                     /inference="alignment:Splign:2.1.0"
     exon            428..640
                     /gene="Hephl1"
                     /gene_synonym="RGD1564835"
                     /inference="alignment:Splign:2.1.0"
     exon            641..820
                     /gene="Hephl1"
                     /gene_synonym="RGD1564835"
                     /inference="alignment:Splign:2.1.0"
     exon            821..1075
                     /gene="Hephl1"
                     /gene_synonym="RGD1564835"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1244
                     /gene="Hephl1"
                     /gene_synonym="RGD1564835"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1384
                     /gene="Hephl1"
                     /gene_synonym="RGD1564835"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..1516
                     /gene="Hephl1"
                     /gene_synonym="RGD1564835"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1728
                     /gene="Hephl1"
                     /gene_synonym="RGD1564835"
                     /inference="alignment:Splign:2.1.0"
     exon            1729..1879
                     /gene="Hephl1"
                     /gene_synonym="RGD1564835"
                     /inference="alignment:Splign:2.1.0"
     exon            1880..2092
                     /gene="Hephl1"
                     /gene_synonym="RGD1564835"
                     /inference="alignment:Splign:2.1.0"
     exon            2093..2306
                     /gene="Hephl1"
                     /gene_synonym="RGD1564835"
                     /inference="alignment:Splign:2.1.0"
     exon            2307..2446
                     /gene="Hephl1"
                     /gene_synonym="RGD1564835"
                     /inference="alignment:Splign:2.1.0"
     exon            2447..2587
                     /gene="Hephl1"
                     /gene_synonym="RGD1564835"
                     /inference="alignment:Splign:2.1.0"
     exon            2588..2694
                     /gene="Hephl1"
                     /gene_synonym="RGD1564835"
                     /inference="alignment:Splign:2.1.0"
     exon            2695..2917
                     /gene="Hephl1"
                     /gene_synonym="RGD1564835"
                     /inference="alignment:Splign:2.1.0"
     exon            2918..3057
                     /gene="Hephl1"
                     /gene_synonym="RGD1564835"
                     /inference="alignment:Splign:2.1.0"
     exon            3058..3220
                     /gene="Hephl1"
                     /gene_synonym="RGD1564835"
                     /inference="alignment:Splign:2.1.0"
     exon            3221..3292
                     /gene="Hephl1"
                     /gene_synonym="RGD1564835"
                     /inference="alignment:Splign:2.1.0"
     exon            3293..5259
                     /gene="Hephl1"
                     /gene_synonym="RGD1564835"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagttacatt cacaaatgtt tctgaagcag ccaggtggct gcatccttct tgagttcctg
       61 ggtctgcttg gactggttgg tgcagtcacc agaacatact acattgggat tgtggaagaa
      121 tactggaact atgtgcctca agggaaggat gttattactg ggaagagctt ctcggaagac
      181 aaacttgcga ccttatttct ggagcgaggg cccaacagga taggtggcat ctacaagaag
      241 gcggtttata gacacttcac agatgggagc tactccaccg agatccctaa gcccccctgg
      301 ctggggttcc tgggtcccat cctgagggca gaagtgggcg acgtgatcgt tatccacttg
      361 aagaactttg cttccagacc ttactcattg caccctcacg gtgttttcta caacaaggat
      421 tccgaaggag ccttatatcc agatgggacg tctggaaaga acaaggagga tgacatggtc
      481 ccccctggca aaaactacac ctatgtctgg ccggtgagag aagaatatgc acccgctccg
      541 gcagatgcca actgcctgac ctgggtgtac cactcacaca ttgatgcccc caaggatatc
      601 tgctctgggc taattggacc cttgctggtg tgtaaggaag gtgtactgaa cagacactca
      661 ggggcgagga ctgacgtgga ccgagagttt gtcatcatgt tcactctggt ggatgagaac
      721 cagagctggt acctggatga caacatcagg cagttctgca ctaatcccag ttctgttgac
      781 aaaagcgacg ctgttttcca gaggagcaac aagatgcatg ccctcaatgg attccttttt
      841 ggaaacttgc ccgagcctga gatgtgtgtt ggtgaatctg tgtcctggca cctgtttggg
      901 atggggaatg agatagacat ccattccatc tatttttatg gtaacacctt catcaccaga
      961 gggcaccggg cggatgttgt caacctgttt ccagccacgt tcctcacaac agaaatgata
     1021 gtggagaatc ctgggaaatg gatgataact tgccaagtta gtgaccacct gcaagctggc
     1081 atgctgggac agtacaatgt gggtaactgc aggggtaatg ctcctcaccc gaagatgcgg
     1141 ggccaacaga ggcgctactt catagcggct gaaaaagtcc tctgggatta cagtccccag
     1201 ggctacgata agttcactgg atttcccctg aatacatctg gcagtgactc tgcagtgtac
     1261 ttcacacaag ctgacaacag aataggagga aaatattgga aggctcggta cacggagtac
     1321 gtggatgcca ctttcagtag aagaaagatg ccctcagatt cagaagccca tcttggaatc
     1381 ctcggtccag tcatcaaggc agaggtgggt gacatcctgc tagtgacctt tgccaacaaa
     1441 gctgacaagg tctacagcat tttaccccat ggtgtgttct atgacaaggc atcggatgca
     1501 gggccgaatg ttgatggatt tctgaaacca ggggctcatg tcaagcccgg tgaaaccttc
     1561 acctaccggt ggacagtgcc agaaagcgtc agcccgacag atgacgaccc cccgtgcctg
     1621 acctatcttt atttctcagc ggtacagccg atcaaggaca ctagtgctgg gcttgtgggg
     1681 cctttgttgg tctgcaaaaa gggcacgctc aatgccgatg ggacacagaa aggaatagac
     1741 aaggagtttt acctactgtt cacagtcttt gatgagaatt tcagcagcta tcttgatgaa
     1801 aacatccaga agtttacttg gcatcccttc agtgtcgaca aagaagacaa ggagttcgtg
     1861 aaatccaacc ggatgcatgc tattaatggc tacatgtatg gcaaccagcc aggcctaagc
     1921 atgtgcaaga aggacagagt ttcctggcac ttaattggaa tgggcaccga cacagacatg
     1981 catggagttt atttccaagg caacaccatc cacctacgag ggactcatcg ggactccttg
     2041 gctctgtttc cccatatgtc cacaacggca ttcatgcagc cagaccattc aggtattttc
     2101 aaggtgttct gctccacctt gcaccacttc acgagaggca tgggtcagat ctatgaggtc
     2161 agcagctgtg gcaacaggga cccttctgag ccgccctacg ggatgctaag aaccttttac
     2221 atcgccgctg aagaggtaga atgggattat gcccctaaca aaaactggga gttcgaaaag
     2281 cagcacttgg acgcaggagg ggaaagacat ggagatatat ttatgaacca cactgaaaac
     2341 tggattggct ctcagtacag gaaggtggtt tatagggaat acacaaacgg agaatttgtg
     2401 gagattaaag cccggccacc tcaagaggag caccttcaac tcctgggacc aatgatccat
     2461 gctgaggtgg gggactccat tctcattatc tttaagaaca aagccagccg gccctactcc
     2521 atcacagccc agggtgtgga ggactcagac agtggaaaat tccttgacgt gccagtcaca
     2581 aagccagggg aaataaaaac gtacagatgg aatgtcccaa agagatcagg tcctgggccc
     2641 tctgatccca actgtatccc gtgggtgtac ttttcaacag caaactttgt gaaggatacg
     2701 tacagtgggt tgatggggcc tctgatcaca tgccgagagg gggtgctaaa cgagaagggg
     2761 agaagaagtg acgttgacta cgagtttgcg ctgctcttcc tggtcttcaa tgagaacgag
     2821 tcgtggtatc tggatgacaa catcaagaag tacctcaaca aagatccacg ggatttcagg
     2881 cacaccgatg actttgaaga gagcaacaga atgcacgcca ttaatggaaa gatttttgga
     2941 aacctccctg gcctcataat gactgaagac tcaatgacca actggtattt gctgggcatc
     3001 ggaagcgaag tggacataca cacgatccat taccatgcag agagctttct gttcaaaatt
     3061 gataagtcct accgagaaga tgtgtatgat ctctttcctg ggacatttca aaccatcgag
     3121 ctgtttgctg atcacccggg gacgtggctc cttcactgcc acgtgtccga ccacatccat
     3181 gctggcatgg agaccacgta cactgtcctc aggaacatag acaacaggat tccatattct
     3241 accaagtccc cttctggagc aggaccccat gcagtcacag tgccctccca ggaacaacct
     3301 ggacaggaag acctctactt ctttggcaag agtctgcgtc caagaggagc caaggcagcg
     3361 ctggtcatcc ttttcatcct gggactcctc ctcctggtgg ccaccgtgat tctcgccctc
     3421 agactccgct cttcaaggag gcagatggct tacagggagg tccagtcctg tgcactcccc
     3481 acagatgctc tgtgaatgct ctgaccttcc tcggcaggaa tgggtcaggt tccacaactg
     3541 gacacacact agctaacagg gaaactggac cgatgcattg ttcaccaagg aactcggaca
     3601 ctgtatccta gatcaggctt cttcggagcc tcggaatggg tcatccaaag caatgtgctt
     3661 ttatttattt atttttttta actggctgtg aatgattctc aggtgtaaaa cacatgaaca
     3721 gggagaatgc actggattga gagctgctga ccctcagtct gttttgtgaa cagctcaccc
     3781 agggggttac cctctgaaag atgttttcac tgatttaagt caaacaacgc tgcctcacct
     3841 accccaaggt ttctagatga gtagcttcta gaaaacgtta cggtgccttg gacatctgtc
     3901 cgtctggagt cacactggtg ctaaacactg tcacatgaaa ttgcgccctc agttgtttca
     3961 gggttagcaa gcttccgagg agtttgtggg aacgtccaag tcagtatgtg ctgatggaaa
     4021 tggatctcct gaatcttctg gaggcttcca gcagttctcc tgatctttcc cctttaacat
     4081 agagagccca tgcattgttt gttatacaag tcaaagctat atggttattt atttcattgc
     4141 tgctgatttt aactcaacct gttgggatac ttgaatgttt acaattcacc tcacgctaca
     4201 tttttttttt accatgtgtc tccttggcaa cttctgtact ttcaaaaaaa atcaactagg
     4261 gcatttttta tttcaggatg tgggagggct agaatcagtc aaggagcagg cttgacttcc
     4321 tcctcataag ctagagactc cctgtctctg ccggaacctc gagtctcact tttcattcat
     4381 ttaggggcat ttcttcatct tctatgaaag ttcgtcatct gaggggtggc aggaggcata
     4441 catcaatgca gcggattgac taggagaaag gtctctcaaa atcctgcatt catgcttgtt
     4501 aaagacatga ccccgagagg aggggggcag ctagaaaata gtagtcctgg tggtttttaa
     4561 actgttaaat cagtgttaga aattagtgct atagctgcta agactcacac acaaatacaa
     4621 aatgcccagc aagaaagctg agcctataag gacacaatgc accctctctt tcagctccct
     4681 agacattaga tgtaagattg ataaaagcaa cattgtttat tatagactgg gaattctacc
     4741 ttagctcagg gcatgctgcc ctgggatgct gttgccagac acgtgatgtt agaccactgc
     4801 ctttgcggtg ggtcacttga atgtccaggt gaacgagtag gacctaataa acactctggt
     4861 gaagggatct tttgtgcctt tttaaaatta ttattactgt tggtgagggg aaattgacag
     4921 aagccatagt cttagataaa aatgacacaa ccactaatag ttgtttgtag ttcgcttgac
     4981 tgcgtcgaca aacagggtac ccaagtgatt ctgaactcca gcctgctgac tgccgacaag
     5041 gtgattgcgt agtttatcga accacctgct ctgtggagtt cgttcctagt aggttgtaca
     5101 acaagaacaa gaagtatggc aagcatctat gactgatctt caatatgtca aaatctgttt
     5161 agttgtaaaa gttttttcct ccctttttca cttatttttt tttttaagga caacaaacca
     5221 caaagtagtt ttgtttcgct atttctcttt ttaataaag
//
