LOCUS       NM_133294               2528 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus hemogen (Hemgn), transcript variant 1, mRNA.
ACCESSION   NM_133294 XM_008763693
VERSION     NM_133294.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2528)
  AUTHORS   Kruger,A., Somogyi,E., Christersson,C., Lundmark,C., Hultenby,K.
            and Wurtz,T.
  TITLE     Rat enamel contains RP59: a new context for a protein from
            osteogenic and haematopoietic precursor cells
  JOURNAL   Cell Tissue Res 320 (1), 141-148 (2005)
   PUBMED   15726423
REFERENCE   2  (bases 1 to 2528)
  AUTHORS   Kruger,A., Ellerstrom,C., Lundmark,C., Christersson,C. and Wurtz,T.
  TITLE     RP59, a marker for osteoblast recruitment, is also detected in
            primitive mesenchymal cells, erythroid cells, and megakaryocytes
  JOURNAL   Dev Dyn 223 (3), 414-418 (2002)
   PUBMED   11891990
  REMARK    GeneRIF: RP59, a marker for osteoblast recruitment, is also
            detected in primitive mesenchymal cells, erythroid cells, and
            megakaryocytes.
REFERENCE   3  (bases 1 to 2528)
  AUTHORS   Yang,L.V., Nicholson,R.H., Kaplan,J., Galy,A. and Li,L.
  TITLE     Hemogen is a novel nuclear factor specifically expressed in mouse
            hematopoietic development and its human homologue EDAG maps to
            chromosome 9q22, a region containing breakpoints of hematological
            neoplasms
  JOURNAL   Mech Dev 104 (1-2), 105-111 (2001)
   PUBMED   11404085
REFERENCE   4  (bases 1 to 2528)
  AUTHORS   Wurtz,T., Kruger,A., Christersson,C. and Lundmark,C.
  TITLE     A new protein expressed in bone marrow cells and osteoblasts with
            implication in osteoblast recruitment
  JOURNAL   Exp Cell Res 263 (2), 236-242 (2001)
   PUBMED   11161722
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On or before Dec 5, 2020 this sequence version replaced
            XM_008763693.2, NM_133294.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ302650.2, SRR22582424.829361.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-173               JAXUCZ010000005.1  65485649-65485821   c
            174-267             JAXUCZ010000005.1  65481869-65481962   c
            268-1529            JAXUCZ010000005.1  65477202-65478463   c
            1530-2528           JAXUCZ010000005.1  65475228-65476226   c
FEATURES             Location/Qualifiers
     source          1..2528
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..2528
                     /gene="Hemgn"
                     /gene_synonym="Edag-1; Edag1; Hgn; RP59"
                     /note="hemogen"
                     /db_xref="GeneID:113882"
                     /db_xref="RGD:621569"
     exon            1..173
                     /gene="Hemgn"
                     /gene_synonym="Edag-1; Edag1; Hgn; RP59"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..1639
                     /gene="Hemgn"
                     /gene_synonym="Edag-1; Edag1; Hgn; RP59"
                     /note="hemopoietic gene protein; erythroid differentiation
                     gene 1"
                     /codon_start=1
                     /product="hemogen"
                     /protein_id="NP_579828.2"
                     /db_xref="GeneID:113882"
                     /db_xref="RGD:621569"
                     /translation="MDVRKDQSHLTLNQTPEAHVEKSHAPDIIGSWSLRNREQLKKRK
                     AEAQGRQTSQWQLGEQKKRKYQRTGKGNRRGRKRQGNVEQKAESWSQTENERVQEVLV
                     PAEEETEYSGNTATQALPLRASPTKAVPTEHCSEVPQESLQCQEITIQNHSQTHQRRD
                     KAEALSPTTCQEIGVLQYSPKMCQDMAEPEARSPKMCQETAVPQTYSPKAHEDMAEYE
                     ALSPKMCRETPVPQYHSSKIPQDMTGPEALAPDMCQETTVSQNHSSKVPQDMAGPEAL
                     SLKMCQEPTVLQEHTLKICQDVARPDVLSSKTHQEMTVPKALPCITPGDAAGPEGCSP
                     KTLPQSDVTPMSVTPGKNTSHPDLGTAVAEGCFSEAGECIVSEDISTKTHQEAVEPKF
                     LSHKTYKEFTVPIVSSHKTIQESPGPEEYSPGSRHEMSGPEDLSIKTCKNRDGPKHSL
                     PEGAQEVGGAQRQDPDAQDIEDAGAFSQDLEEGNKADQDPETPAGPQGPQKICPENDV
                     HSSALF"
     exon            174..267
                     /gene="Hemgn"
                     /gene_synonym="Edag-1; Edag1; Hgn; RP59"
                     /inference="alignment:Splign:2.1.0"
     exon            268..1529
                     /gene="Hemgn"
                     /gene_synonym="Edag-1; Edag1; Hgn; RP59"
                     /inference="alignment:Splign:2.1.0"
     exon            1530..2528
                     /gene="Hemgn"
                     /gene_synonym="Edag-1; Edag1; Hgn; RP59"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tttttttttt tttaagtgtt agttttgata ttttcaaaaa gcttttaggt tgcttgtgaa
       61 gtcggagcaa ataccaagaa ggcgttgtgg caagatggat gtgaggaagg accaatctca
      121 tctgacgctc aaccagaccc ctgaagctca tgtagagaag tcccatgctc cagacatcat
      181 tggatcttgg agtttgagaa acagagaaca actgaagaag agaaaagctg aggcacaggg
      241 gaggcagacg tcacaatggc aacttggaga acagaaaaaa cgcaagtatc agagaacagg
      301 aaaaggtaat cgaagaggcc gaaagagaca agggaatgtg gaacaaaagg cagagtcttg
      361 gtcacaaaca gaaaacgaaa gggtacagga ggtattggta cctgctgagg aagaaactga
      421 gtactctgga aacactgcaa ctcaagccct tcccttgaga gcatccccca caaaagctgt
      481 gcctacagaa cactgttctg aagtacccca agaaagcttg cagtgccaag aaataactat
      541 acagaaccat tctcaaacac accaacgaag ggacaaagct gaagctctct ctcctaccac
      601 gtgccaagaa ataggagtac ttcaatattc tcctaagatg tgccaagata tggctgaacc
      661 tgaggcacgc tcacctaaaa tgtgccagga gacagctgtg ccccaaacct attctcccaa
      721 agcacacgaa gatatggctg aatatgaggc actttcgcct aaaatgtgcc gggaaacacc
      781 tgtgccacaa taccattctt ccaaaatacc ccaagatatg accggacctg aggcgttagc
      841 tcctgatatg tgccaagaaa caactgtgtc ccaaaaccat tcttccaaag taccccagga
      901 tatggctgga cctgaggcgc tctctcttaa aatgtgccag gaaccaactg tgcttcaaga
      961 acatactttg aaaatatgcc aagatgtggc cagacctgac gtcctctctt ctaaaacaca
     1021 tcaagagatg actgttccca aagcccttcc ctgtataaca cctggagatg ctgctggccc
     1081 agaaggatgc tcccccaaaa cactccccca gtcagatgta acccccatgt cagtcacacc
     1141 aggaaaaaat acttcccacc cagatctggg aacggctgtg gctgaaggct gcttttctga
     1201 agccggagaa tgcattgtat ctgaagacat ttctacaaaa acacaccaag aagcagttga
     1261 acctaaattc ctttctcaca agacttacaa agaattcact gtgcctatag tctcctctca
     1321 taaaaccatc caagaatcac ctgggcctga agaatattca cctggaagcc gtcatgaaat
     1381 gtcagggcct gaagacctct ctatcaagac ctgtaagaac agggatgggc ctaaacacag
     1441 ccttccagaa ggagcccagg aagtaggtgg ggcccagagg caggaccctg atgcacagga
     1501 tatcgaggac gctggtgctt tctctcaaga cctggaggaa ggaaacaaag cagatcaaga
     1561 cccagaaact ccagcgggtc cacagggtcc tcaaaagatc tgtccagaaa atgatgtcca
     1621 cagctctgct ctattttaac agtgctcggt gatgaagctg cagaccaact ccgtacagca
     1681 tacgtgtctc ttgtgatttt actgaaacac cgcagcgatc actaaaattt gcattgctat
     1741 tttaactcat gttttttcat ttgtagatct tatctgaagg agagaactaa catttttaag
     1801 gctctaacac atagacaata acgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt
     1861 gtttgcgcct gtgtgagcgc ctgacagtgt gtatttgtat atgggggaag acagtaagag
     1921 cggggaaagg ctgagtaatt gattttcccc tctgagaaga aacatatatt tagtgattct
     1981 gaggaaaaga tagcaattta atatgaacac ttagcatttt gaaagtatat agtttcttgt
     2041 gaattttgtc aattagtgag gttgtagcaa catcagaatt ttactcaaac tttacatgtc
     2101 tctttgagtt aatcagaaca attcttattc taaaaattct tgcaagtttt ttttttgaat
     2161 tgataaatgc catttatttc tgtgtgaacc tggacttttt atttctattt tttaaactgt
     2221 tacttgtaaa aaaaaatgta catcgtcatt tctatggctt tagctgtgtt accaagacag
     2281 catcttggtt tatgctgggg ttgtaaaacg cctaaatggc tcagtgcctt tgctcactag
     2341 gttaatctga tcacatggag gaacacagca gaaaaaaatt attccaaaag aaaagtgccg
     2401 agtgcaacag gctcctctct gagcagccta cgccctagct cttcagtggt ttcctttctg
     2461 tggctctttc tcttaaacct catgcttaaa atccatgtta aagtattatt aataaactcc
     2521 cccaaacc
//
