LOCUS       NP_579828                514 aa            linear   ROD 03-APR-2024
DEFINITION  hemogen [Rattus norvegicus].
ACCESSION   NP_579828 XP_008761915
VERSION     NP_579828.2
DBSOURCE    REFSEQ: accession NM_133294.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 514)
  AUTHORS   Kruger,A., Somogyi,E., Christersson,C., Lundmark,C., Hultenby,K.
            and Wurtz,T.
  TITLE     Rat enamel contains RP59: a new context for a protein from
            osteogenic and haematopoietic precursor cells
  JOURNAL   Cell Tissue Res 320 (1), 141-148 (2005)
   PUBMED   15726423
REFERENCE   2  (residues 1 to 514)
  AUTHORS   Kruger,A., Ellerstrom,C., Lundmark,C., Christersson,C. and Wurtz,T.
  TITLE     RP59, a marker for osteoblast recruitment, is also detected in
            primitive mesenchymal cells, erythroid cells, and megakaryocytes
  JOURNAL   Dev Dyn 223 (3), 414-418 (2002)
   PUBMED   11891990
  REMARK    GeneRIF: RP59, a marker for osteoblast recruitment, is also
            detected in primitive mesenchymal cells, erythroid cells, and
            megakaryocytes.
REFERENCE   3  (residues 1 to 514)
  AUTHORS   Yang,L.V., Nicholson,R.H., Kaplan,J., Galy,A. and Li,L.
  TITLE     Hemogen is a novel nuclear factor specifically expressed in mouse
            hematopoietic development and its human homologue EDAG maps to
            chromosome 9q22, a region containing breakpoints of hematological
            neoplasms
  JOURNAL   Mech Dev 104 (1-2), 105-111 (2001)
   PUBMED   11404085
REFERENCE   4  (residues 1 to 514)
  AUTHORS   Wurtz,T., Kruger,A., Christersson,C. and Lundmark,C.
  TITLE     A new protein expressed in bone marrow cells and osteoblasts with
            implication in osteoblast recruitment
  JOURNAL   Exp Cell Res 263 (2), 236-242 (2001)
   PUBMED   11161722
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On or before Dec 5, 2020 this sequence version replaced
            XP_008761915.1, NP_579828.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ302650.2, SRR22582424.829361.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     Protein         1..514
                     /product="hemogen"
                     /note="hemopoietic gene protein; erythroid differentiation
                     gene 1"
                     /calculated_mol_wt=56442
     Region          1..96
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6AZ54.1)"
     Region          7..87
                     /region_name="Necessary for nuclear localization.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6AZ54.1)"
     Site            90
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q6AZ54.1)"
     Site            124
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9BXL5; propagated from
                     UniProtKB/Swiss-Prot (Q6AZ54.1)"
     Site            153
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9ERZ0; propagated from
                     UniProtKB/Swiss-Prot (Q6AZ54.1)"
     Site            166
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9ERZ0; propagated from
                     UniProtKB/Swiss-Prot (Q6AZ54.1)"
     Site            179
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q6AZ54.1)"
     Site            207
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q6AZ54.1)"
     Site            221
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q6AZ54.1)"
     Site            259
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9ERZ0; propagated from
                     UniProtKB/Swiss-Prot (Q6AZ54.1)"
     Site            264
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9BXL5; propagated from
                     UniProtKB/Swiss-Prot (Q6AZ54.1)"
     Site            277
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9BXL5; propagated from
                     UniProtKB/Swiss-Prot (Q6AZ54.1)"
     Site            305
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9ERZ0; propagated from
                     UniProtKB/Swiss-Prot (Q6AZ54.1)"
     Site            322
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q9ERZ0; propagated from
                     UniProtKB/Swiss-Prot (Q6AZ54.1)"
     Region          408..514
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6AZ54.1)"
     Site            415
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q6AZ54.1)"
     Site            422
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q6AZ54.1)"
     CDS             1..514
                     /gene="Hemgn"
                     /gene_synonym="Edag-1; Edag1; Hgn; RP59"
                     /coded_by="NM_133294.2:95..1639"
                     /db_xref="GeneID:113882"
                     /db_xref="RGD:621569"
ORIGIN      
        1 mdvrkdqshl tlnqtpeahv ekshapdiig swslrnreql kkrkaeaqgr qtsqwqlgeq
       61 kkrkyqrtgk gnrrgrkrqg nveqkaesws qtenervqev lvpaeeetey sgntatqalp
      121 lrasptkavp tehcsevpqe slqcqeitiq nhsqthqrrd kaealspttc qeigvlqysp
      181 kmcqdmaepe arspkmcqet avpqtyspka hedmaeyeal spkmcretpv pqyhsskipq
      241 dmtgpealap dmcqettvsq nhsskvpqdm agpealslkm cqeptvlqeh tlkicqdvar
      301 pdvlsskthq emtvpkalpc itpgdaagpe gcspktlpqs dvtpmsvtpg kntshpdlgt
      361 avaegcfsea gecivsedis tkthqeavep kflshktyke ftvpivsshk tiqespgpee
      421 yspgsrhems gpedlsiktc knrdgpkhsl pegaqevgga qrqdpdaqdi edagafsqdl
      481 eegnkadqdp etpagpqgpq kicpendvhs salf
//
