LOCUS       NM_001305276           10042 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus helicase with zinc finger 2 (Helz2), mRNA.
ACCESSION   NM_001305276 XM_001057758 XM_230961
VERSION     NM_001305276.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 10042)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   2  (bases 1 to 10042)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   3  (bases 1 to 10042)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   4  (bases 1 to 10042)
  AUTHORS   Tomaru,T., Satoh,T., Yoshino,S., Ishizuka,T., Hashimoto,K.,
            Monden,T., Yamada,M. and Mori,M.
  TITLE     Isolation and characterization of a transcriptional cofactor and
            its novel isoform that bind the deoxyribonucleic acid-binding
            domain of peroxisome proliferator-activated receptor-gamma
  JOURNAL   Endocrinology 147 (1), 377-388 (2006)
   PUBMED   16239304
REFERENCE   5  (bases 1 to 10042)
  AUTHORS   Surapureddi,S., Yu,S., Bu,H., Hashimoto,T., Yeldandi,A.V.,
            Kashireddy,P., Cherkaoui-Malki,M., Qi,C., Zhu,Y.J., Rao,M.S. and
            Reddy,J.K.
  TITLE     Identification of a transcriptionally active peroxisome
            proliferator-activated receptor alpha -interacting cofactor complex
            in rat liver and characterization of PRIC285 as a coactivator
  JOURNAL   Proc Natl Acad Sci U S A 99 (18), 11836-11841 (2002)
   PUBMED   12189208
  REMARK    GeneRIF: characterization of Pric285 as a coactivator and as a
            transcriptionally active peroxisome proliferator-activated receptor
            alpha-interacting cofactor complex in rat liver.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On or before Mar 7, 2015 this sequence version replaced
            XM_230961.7, XM_001057758.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments and orthologous data.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760386
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-59                JAXUCZ010000003.1  188730658-188730716 c
            60-1148             JAXUCZ010000003.1  188728626-188729714 c
            1149-1332           JAXUCZ010000003.1  188728163-188728346 c
            1333-1437           JAXUCZ010000003.1  188727985-188728089 c
            1438-1955           JAXUCZ010000003.1  188726901-188727418 c
            1956-2597           JAXUCZ010000003.1  188726160-188726801 c
            2598-3381           JAXUCZ010000003.1  188724431-188725214 c
            3382-3457           JAXUCZ010000003.1  188724197-188724272 c
            3458-7139           JAXUCZ010000003.1  188720373-188724054 c
            7140-7411           JAXUCZ010000003.1  188719947-188720218 c
            7412-7543           JAXUCZ010000003.1  188719724-188719855 c
            7544-7705           JAXUCZ010000003.1  188719469-188719630 c
            7706-7853           JAXUCZ010000003.1  188719243-188719390 c
            7854-7970           JAXUCZ010000003.1  188719046-188719162 c
            7971-8163           JAXUCZ010000003.1  188718778-188718970 c
            8164-8517           JAXUCZ010000003.1  188718277-188718630 c
            8518-8674           JAXUCZ010000003.1  188717944-188718100 c
            8675-8842           JAXUCZ010000003.1  188717671-188717838 c
            8843-10042          JAXUCZ010000003.1  188716370-188717569 c
FEATURES             Location/Qualifiers
     source          1..10042
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q43"
     gene            1..10042
                     /gene="Helz2"
                     /gene_synonym="Pric285; RGD1306056"
                     /note="helicase with zinc finger 2"
                     /db_xref="GeneID:296474"
                     /db_xref="RGD:1306056"
     exon            1..59
                     /gene="Helz2"
                     /gene_synonym="Pric285; RGD1306056"
                     /inference="alignment:Splign:2.1.0"
     exon            60..1148
                     /gene="Helz2"
                     /gene_synonym="Pric285; RGD1306056"
                     /inference="alignment:Splign:2.1.0"
     CDS             133..8967
                     /gene="Helz2"
                     /gene_synonym="Pric285; RGD1306056"
                     /note="peroxisomal proliferator-activated receptor
                     A-interacting complex 285 kDa protein; peroxisomal
                     proliferator-activated receptor A interacting complex 285;
                     helicase with zinc finger domain 2; helicase with zinc
                     finger 2, transcriptional coactivator"
                     /codon_start=1
                     /product="3'-5' exoribonuclease HELZ2"
                     /protein_id="NP_001292205.1"
                     /db_xref="GeneID:296474"
                     /db_xref="RGD:1306056"
                     /translation="MASVGCGLRSTSTSTTNGLSLAELCAKVDLHLGCSRCTEYLNES
                     TYILREVEHTCSREILLARFKQAAKNKVWRKVGLRPSFPIPVRYQVCRYYSPGLGCKR
                     HWNRCTFASSPEEALVWTFELKNNLTRLKLKEAVQGTRAPDRLQTPADTIRAEFGGHF
                     QLLCALCFKCRPPCLCPVDSRGHCPKHQICPTLLIHVIVEGQKRQFVEVRPLPQKRHP
                     LNYCMFVGRGVPCRHGASRCGYAHSAVEMAVWKAEQLDGLQRGDLLTYPLFGEDKQKA
                     SHGQPPAVKLYCHACLVTCSSQEAFENHCSSLEHAQMVAFDQVVPRKHRAPPMGLSKF
                     ELCPRPDLCEYGEVCIKAHSKQELQEWVQRAQDMELREQAAWQDGLVPYQARLLAEYR
                     RSSKEVLVMAETVHGVSVTCQQPLVHQAQEKIQHKWVFTIHSEDPLLHVALLKQEPGA
                     AFSLVAPHLPPHQLYAQGKHFCVPNSPAQFQVGVLVQAASFGSFEQWVVFDFGRRPVL
                     LQKLKLQLGQTHSLGLNGKPAPSHPQERECWHTGNRHVVLEVDWTPEQEALMAKYKLP
                     SLALEFSHNVVVWGPISRTNYRQRMHKFLYEEEAAQQQLVAKLAMKGQVSLKTALETP
                     ALGMLFAPPGALYAEVPFPSSLLPDTDQGFLMSRAVSTALVAPAPAPDSKVYQVRLEA
                     RASSEHALWLLLPARCCMALGLQAQDSPVLEVQFQIDPLIFRFWHRAVDALPEVCLVV
                     PDLPACTLPHPWPTPPSFRGNHKQKLAVGLIAGRRPEGSKHIPPLLIYGPFGTGKTYT
                     LAMAALEVVQQPHTKVLICTHTNSAADIYVREYFHGYVNSGHQEAAPLRVMYADRPPR
                     QTDSTTLQYCCLTEDRQAFRPPTFPELLRHRLVVTTTSQARELQVPAGFFSHIFIDEA
                     AQMLECEALIPLSYALTLTRVVLAGDHMQVTPRLFSVPRDKAAGHMLLHRLFLYYQQE
                     VHKIAQHSRIVFHENYRSTAAIINFVSRHFYVAKGNPIQASGKVPRHPQHYPLMFCHV
                     AGSPEQDMSRTSWLNSAEVTQVVEKVQEIYNTWPHCWGPREQRHICAVSHGAQVSALR
                     QELRRRNLGEVSVGSFEILPGREFRVVVLSSVHNRNSLLSPGAPTSEFFTEPRVLNTV
                     MTRAQSQLVAVGDAVALCSSGACRKLWKNFIRECIEHHSIFPEDLSLEQIEQGVAQRQ
                     NWASLMLRAWDTEAEHKPTAQDLQRPIAEGTMVTVKAETRARAAATAQTEAVAAGGTA
                     RRNSASTDAAAEVSTLEGYEEDSESDLWPSDWELNADDAILKELLDESRQMTVTVRED
                     GLLDTMVCPASSQKARQYINLPSSALRKYLRLDPKQYRRCSFLQETFERALATPLDDM
                     ASSPIQVRGRLNCGMAFTGDEVLVQILGPAVDDKSIPGSLLGRVMGVLKRRRRELAFV
                     CRMDEWDPHIMIPINSSVTKIFVAGLKDPQQVPIHCLIEGKVKHVRHETLKREDRSTR
                     LFWVRIVLWRERFYYPLGIVLEVLPKAVTWEQGLHILDLEHGLKAHTPDPASVSKALQ
                     KYHSEIDMAASHREDYRRFLTFTVDPQGACNLDDALSVRDLGPVYEVAVHIADVASLV
                     PKDGALDVEARQQGTVFYAPSREPVLMLPASLCQEALSLLPGQDRLAISLFLTMEKGG
                     GGQIRSLRFAPSIVRSDRQLSYEEAEELIKRHPGAGLKLPAHLDSVEACVVAACYFSW
                     MLRRQRLPADCYYEPPDEDSVLGFRTAHIMVQEYMIQFNSRVAEFLVGDKHTQTLTPL
                     RWQPTPSRQQLDSVFKKHRGLVPLSLHLCHHSNTHYTPNKRLYLLTSLWKQVQLAAGT
                     RDYSQMVDLIATEDMHPSLAPACLDFRRALGRSVFGRSSQGRQRPAGHYSLQVDWYTW
                     ASSPIRRYLDVVLQRLILLALGHKSSTYSNRDIDGLCQDFSRQYACAQSYQRRACSLH
                     LAIQLKTQPQNKLGFVVDVETGARCFKVLFPINRETLPDPCPIHYHSLQLAENPEELV
                     GQTGLRLVWRRRTYSVQASKLPLPHLGTSFDPLTQTIDAALWMKLLVLLKEERWPEVA
                     ALIQEQDKLSRQREKAQVHQSRCGHFIEVAYELGSGDTLQVQLGSSLQRGFLAPTLQL
                     WTVVPGFSLCLEHMERPGDCFSGHVHQPLQDQYLEVSQYSGVWGPRCALESLMSAVAE
                     NDSIVLQDVHIYWDTSQEQLQGTFQLEAAFLQEKCINIHFGCCYLCIRLEGLPLPLAS
                     SLPGPSDLGPFLNIDPNTYTWVAHGLSGDWDHELAGDWDQECVDDRQEVPKQVHFFIH
                     HMTMEKVPEEVLRPSTRFTVEVLSKQLPDLRKEEAVRGLKNASPLVISIALGLPILEP
                     HWPIPEPRHQISWPRHQISWPRHPISGPCLPVSGLCLPVSGLCHPIPEPCRRGWPPQH
                     SSRKVPTSRFLERKNYNIPGGHHKLNQSQDKAVRSALQKQFTVIQGPPGTGKTVVGFH
                     IVYWFHRSNQEQMPTGSSPSEEEKLGGPCVLYCGPSNKSVDVLGGLLLRKKTEMRPLR
                     VYGEQAEATEFPLPGVSNRSLFGKISQEGRPNQSLRSITLHHRIRQAPNPYAAEIRKF
                     DAQLREGKIFSKDDLLVYRRVLGKARKYELERHSVILCTCSCAASGSLKALNVRQILI
                     DEAGMATEPETLIPLVCFSKTEKVVLLGDHKQLRPVVKNEQLRNLGMDRSLFERYHRD
                     AIMLDTQYRMHKDICSFPSMEFYGGKLKTWSDLKRPPSLLGHVGKQSCPVIFGSVQGY
                     EQKLLVSTEEGNENSRANPEEVTEVVRIIKQLTLDRTVDPKDVAVLTPYNAQAAAISR
                     GLMQRGVTGVTVTSITKSQGSEWRYVIVSTVRTCPRSDMDQRPTKSWLKKFLGFVVDP
                     HQVNVAITRAQEGLCIIGDHLLLRCCPLWHRLLGFCEAQNSLVPAERVRVQRKSALSS
                     "
     exon            1149..1332
                     /gene="Helz2"
                     /gene_synonym="Pric285; RGD1306056"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1437
                     /gene="Helz2"
                     /gene_synonym="Pric285; RGD1306056"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..1955
                     /gene="Helz2"
                     /gene_synonym="Pric285; RGD1306056"
                     /inference="alignment:Splign:2.1.0"
     exon            1956..2597
                     /gene="Helz2"
                     /gene_synonym="Pric285; RGD1306056"
                     /inference="alignment:Splign:2.1.0"
     exon            2598..3381
                     /gene="Helz2"
                     /gene_synonym="Pric285; RGD1306056"
                     /inference="alignment:Splign:2.1.0"
     exon            3382..3457
                     /gene="Helz2"
                     /gene_synonym="Pric285; RGD1306056"
                     /inference="alignment:Splign:2.1.0"
     exon            3458..7139
                     /gene="Helz2"
                     /gene_synonym="Pric285; RGD1306056"
                     /inference="alignment:Splign:2.1.0"
     exon            7140..7411
                     /gene="Helz2"
                     /gene_synonym="Pric285; RGD1306056"
                     /inference="alignment:Splign:2.1.0"
     exon            7412..7543
                     /gene="Helz2"
                     /gene_synonym="Pric285; RGD1306056"
                     /inference="alignment:Splign:2.1.0"
     exon            7544..7705
                     /gene="Helz2"
                     /gene_synonym="Pric285; RGD1306056"
                     /inference="alignment:Splign:2.1.0"
     exon            7706..7853
                     /gene="Helz2"
                     /gene_synonym="Pric285; RGD1306056"
                     /inference="alignment:Splign:2.1.0"
     exon            7854..7970
                     /gene="Helz2"
                     /gene_synonym="Pric285; RGD1306056"
                     /inference="alignment:Splign:2.1.0"
     exon            7971..8163
                     /gene="Helz2"
                     /gene_synonym="Pric285; RGD1306056"
                     /inference="alignment:Splign:2.1.0"
     exon            8164..8517
                     /gene="Helz2"
                     /gene_synonym="Pric285; RGD1306056"
                     /inference="alignment:Splign:2.1.0"
     exon            8518..8674
                     /gene="Helz2"
                     /gene_synonym="Pric285; RGD1306056"
                     /inference="alignment:Splign:2.1.0"
     exon            8675..8842
                     /gene="Helz2"
                     /gene_synonym="Pric285; RGD1306056"
                     /inference="alignment:Splign:2.1.0"
     exon            8843..10042
                     /gene="Helz2"
                     /gene_synonym="Pric285; RGD1306056"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcgccccag gggcagaatc gaaactgatc gctgctctaa gtcgatgctg gtgcactggg
       61 gctaacagtt tcagcagaac agctgcccag aaacgttgct cacaatcctg aaggacctgg
      121 ccctcatctg acatggcatc cgtggggtgt ggcctgaggt cgaccagcac atccaccacc
      181 aatgggctat ccttggctga actctgtgct aaggtagacc ttcacctggg ctgctcccgc
      241 tgtactgagt acctcaatga gagcacctat attctacgtg aggtagagca tacctgctcc
      301 agggagatct tgctggcccg cttcaagcaa gcagccaaga acaaggtctg gcgtaaggtg
      361 ggcctcaggc ccagctttcc aatacctgtg cgctatcaag tctgtcgcta ttatagccca
      421 gggttgggct gtaagcggca ctggaacaga tgcacttttg ccagcagccc agaggaggca
      481 ctggtctgga catttgagct caagaacaac cttacccgac tgaaactgaa agaggctgtg
      541 cagggcacca gagccccaga taggctgcag accccagccg acaccatccg agcagagttt
      601 ggtggccact tccagctgct ctgtgccctg tgcttcaagt gtcgtccccc atgcctctgc
      661 cccgtggatt ccaggggcca ttgccctaag caccaaatct gccccacact ccttatccat
      721 gttatagttg agggccaaaa gcgacagttt gtggaggtgc gtccactgcc acaaaaaagg
      781 catcctttaa actactgcat gtttgtgggc cgtggggtac catgccgcca cggggcctca
      841 cgctgtgggt atgcacacag tgctgtggag atggctgtgt ggaaggctga gcagctggat
      901 gggcttcaga gaggagatct gctcacatac cctctctttg gggaagacaa acagaaagcc
      961 agccatggtc agcctcctgc ggtcaaacta tactgccatg cctgcctggt cacctgtagt
     1021 tctcaggagg catttgagaa ccactgctcc tccctggagc acgcacagat ggtggccttt
     1081 gaccaggttg taccccggaa gcaccgtgcc ccaccaatgg ggctctccaa gttcgagctc
     1141 tgccccagac ctgacctctg tgagtatgga gaggtctgca tcaaggccca ctcaaaacag
     1201 gagttacagg agtgggttca gcgggcacaa gacatggagc tgcgagaaca ggccgcctgg
     1261 caggacgggc tggtacctta ccaggcacga cttcttgcag aataccggcg cagcagcaaa
     1321 gaggtcttgg tgatggctga gaccgtccat ggagtgtctg tcacttgcca acagccactg
     1381 gtgcatcagg cccaggagaa gatccagcac aagtgggtgt tcaccatcca ctctgaggat
     1441 cccttgctac acgtggccct actcaagcaa gagcctggag cagccttctc actggtggcc
     1501 ccccatctcc caccacacca gctctatgca cagggaaagc acttctgtgt gcccaactcc
     1561 ccagcccaat tccaggtagg ggtgcttgtg caggctgcct cctttggcag cttcgagcaa
     1621 tgggtcgtct ttgacttcgg tcgcaggcca gtgcttctcc aaaagctgaa gttgcagcta
     1681 ggccagacac acagcctggg gctcaatggg aagccagcac caagccaccc ccaggagcgg
     1741 gaatgctggc acacaggcaa ccgccatgtg gtgcttgagg tagattggac acctgagcag
     1801 gaagccctga tggccaagta caagttaccc tccctggccc tggagttcag tcacaatgtt
     1861 gtggtctggg ggcccatctc tcgtacgaac taccgacaga ggatgcacaa atttctctat
     1921 gaagaggaag cagcccagca gcagctggta gccaagctgg ctatgaaggg ccaggtgtcc
     1981 ctgaagacag cactggagac accagcactg ggcatgctct ttgcaccacc aggggccctc
     2041 tatgccgagg tccccttccc ctcctctctg ttgccagaca ctgaccaggg cttcctgatg
     2101 agccgagcag tcagcacagc ccttgtggct cctgcgcctg cgccggacag taaagtatac
     2161 caagtgcggc tggaggcacg ggccagttca gagcatgcac tgtggctgct gttaccagca
     2221 cgatgctgta tggctttggg gctgcaggca caagacagcc ctgtcttgga ggtgcagttc
     2281 cagatcgacc ccctgatctt ccggttctgg catcgggcag ttgatgcact gcctgaggtg
     2341 tgcctggttg ttcctgacct gcccgcctgc accctgcccc acccctggcc caccccgccc
     2401 tcattccgtg gcaatcacaa acagaagctg gctgtggggc tcatcgcggg cagaagaccg
     2461 gagggctcaa agcacattcc gccgctgctc atctatggcc ccttcggcac tggcaagacc
     2521 tacacgttgg ccatggcagc ccttgaggtt gtccagcagc cccacaccaa ggtgctcatc
     2581 tgcacacaca ccaacagcgc tgcagacatc tatgtccggg agtatttcca cggctatgtc
     2641 aacagtggcc accaagaagc ggctccactc agggtgatgt atgcagatcg tcctccaaga
     2701 cagacggatt caaccacatt gcagtactgc tgcctaactg aggaccgcca ggcctttcgc
     2761 ccacccacat tcccagagct gttacgacac cgtttggtgg tcaccaccac ctctcaggct
     2821 cgtgagctcc aggtgccagc cggcttcttc tcccacattt tcattgatga ggcagcccaa
     2881 atgctggagt gtgaggccct tatcccactc tcctatgcct tgacgctgac ccgtgtagtg
     2941 ctggcagggg accacatgca ggtcacacct aggctcttca gcgtgcccag ggacaaggca
     3001 gcagggcaca tgctgctgca ccgcctcttc ctgtactacc agcaggaggt acacaagatc
     3061 gcccagcaca gtcgcattgt cttccacgag aactaccgtt cgacggcagc catcatcaac
     3121 tttgtctccc gtcatttcta tgtagccaag ggcaacccca tccaggccag tggcaaagtc
     3181 ccacgtcacc cccaacacta ccctctcatg ttctgccatg tggcaggcag ccctgagcaa
     3241 gacatgtcca ggacatcctg gcttaactca gctgaggtca cacaggtcgt ggagaaggtg
     3301 caggagatct acaacacttg gcctcattgc tggggacccc gggagcagag acacatctgc
     3361 gctgtctctc atggtgccca ggttagtgca ctgaggcagg aactaaggag gcggaacctt
     3421 ggtgaggtgt ctgtgggcag ctttgagatc ctgccagggc gtgagttccg ggtggtggta
     3481 ctgagctctg tccacaaccg aaacagtctg ctcagccctg gggcaccaac ctcagagttc
     3541 tttactgagc cccgtgtgct gaacacagtc atgacccgtg cccagtctca gctggtggct
     3601 gtgggagacg ccgtggctct ctgttcctct ggagcctgca gaaagctctg gaaaaacttc
     3661 atccgtgagt gcatagagca tcatagcatc ttcccagagg atctgtcgct ggagcagata
     3721 gagcagggtg tggcccagag acagaactgg gcctcgttga tgctcagagc ttgggacaca
     3781 gaggcggaac acaaacccac tgcacaggac ctccaaaggc ccatagctga agggaccatg
     3841 gtcacagtga aggcagagac tagagccagg gcagcagcca cagcacagac cgaagcagta
     3901 gcagcagggg gcacagcaag aaggaactca gcctctacag atgcagccgc agaagtgtcc
     3961 accctggaag ggtatgagga agactccgag tctgacttat ggccctccga ctgggagctc
     4021 aatgctgatg atgccatcct gaaggaactc ctagatgaga gccggcaaat gactgtgact
     4081 gtgagggagg acggacttct ggacaccatg gtttgccctg catcctcaca aaaggcccga
     4141 caatacataa acctaccctc atctgcgctg cggaagtacc tgcgtctaga ccccaaacaa
     4201 taccgccgct gcagcttcct gcaggagacc tttgagagag cattggccac tccactggat
     4261 gacatggcct ctagccctat ccaggtcagg ggtcgtctga actgtgggat ggccttcaca
     4321 ggggatgagg tgctagtaca gatcctggga ccagcagtcg atgacaagag catccctgga
     4381 agcctgctgg gtcgtgtgat gggcgtgctg aagaggaggc ggcgtgaact ggccttcgtg
     4441 tgtcggatgg atgagtggga cccccacatt atgatcccca tcaatagttc tgtgactaag
     4501 atttttgtgg cagggttgaa ggacccacag caagttccca tccactgcct cattgaaggc
     4561 aaggtaaagc atgtgaggca cgagactctc aagcgggagg accggagcac ccgacttttc
     4621 tgggtccgca tcgtcctttg gcgggaacgt ttctactatc cactaggcat tgtgctggag
     4681 gtgctgccca aggctgtcac ctgggaacag ggccttcata tccttgacct agagcatggc
     4741 ctgaaggccc acacaccaga cccagcttct gtttccaagg ctttgcagaa ataccactca
     4801 gagatagaca tggccgctag tcaccgagag gactaccgcc gcttcctgac cttcactgtg
     4861 gacccccagg gtgcctgcaa cctcgatgac gctcttagtg tccgggacct aggcccagtg
     4921 tatgaggtgg cagtgcatat tgctgatgtg gccagcttgg tgcccaagga tggggcgctg
     4981 gatgtggaag cccgccagca gggcactgtg ttctatgccc ccagcaggga gccagttctc
     5041 atgctacccg ccagcttgtg ccaggaggcg ctcagccttc taccaggtca ggaccgcctt
     5101 gccatttctc tcttcctcac catggagaaa ggtggtggtg gccagatcag gagtctgcga
     5161 tttgcaccct ccatagtccg ctctgaccgc cagctgtcgt acgaggaagc cgaagaactg
     5221 atcaagagac accctggggc tggcctgaag ctaccagccc acctggactc tgtggaggcc
     5281 tgcgttgtgg ctgcctgcta cttctcttgg atgttacgtc gtcaacgcct cccagctgac
     5341 tgttactatg agccgccaga tgaggacagt gtgctgggct tccgcacagc ccacatcatg
     5401 gtccaagagt acatgatcca gtttaacagc cgtgtggccg aattccttgt gggcgataag
     5461 cacacacaga cgctcacacc actaaggtgg cagcccacac ccagtaggca gcagcttgac
     5521 agtgttttca agaagcacag aggactggtg cctctgtcgc tgcacctgtg ccaccactcg
     5581 aacacccact atacccccaa caagcggctg tacctcctga cttccctctg gaaacaagtg
     5641 cagcttgcag ctggtactcg ggactacagc cagatggtgg accttattgc tacagaggac
     5701 atgcaccctt cgctggctcc tgcttgcctg gacttccgaa gggctctagg ccgctctgtg
     5761 tttggtcgct ccagccaggg taggcagcga cctgctggcc actactcact gcaggtggat
     5821 tggtacacat gggcatcctc acccatccgt aggtatctgg atgtggtgct gcagcggcta
     5881 atcctgctgg cactaggcca caagagctct acatattcta acagggacat cgatgggctc
     5941 tgccaggact ttagtcgcca gtatgcgtgt gcccagagct accaacggcg ggcctgcagc
     6001 ctgcacctcg ccatccagct caagacccag cctcaaaaca agctgggctt tgtggtggat
     6061 gtcgagacgg gtgcccgctg cttcaaagtg ctttttccta taaatcggga aaccctgcct
     6121 gatccctgcc ctatccacta ccattccctg cagttagctg aaaaccccga ggagcttgtg
     6181 ggccagacag gcttgcggct tgtatggcgg cgccgcacgt actcggtgca ggcttccaag
     6241 ctgcctttac cacatctggg cacaagtttt gatccactca cccagactat agacgcagcc
     6301 ctgtggatga agctactggt gctgctgaag gaggagcgct ggcctgaggt cgctgccctc
     6361 atccaggagc aagataagct ttctcgtcaa agggagaaag cacaggtaca ccagagccgc
     6421 tgtggacact ttatagaggt ggcctatgag ctgggcagtg gagataccct gcaggttcag
     6481 ctcggttcca gcctgcagcg gggcttcctg gcaccaaccc tgcagctgtg gaccgtggta
     6541 cctggcttca gcctatgtct ggagcacatg gaacggccgg gtgactgctt ttcaggccat
     6601 gtgcaccagc ccctgcaaga ccagtacctc gaagtcagcc agtactcagg tgtgtggggg
     6661 ccacgctgtg ccctggagtc gctcatgagt gcggttgcag aaaatgactc catcgtgctg
     6721 caggatgtgc atatctactg ggacacatca caggagcaac tgcagggtac cttccagctg
     6781 gaagctgctt ttctccagga gaaatgtatc aacatccact ttggctgttg ctacctgtgc
     6841 attcggctcg aggggctccc tcttcccctg gctagctcac tccctggacc tagtgacctt
     6901 ggccccttcc tgaacattga ccccaataca tatacctggg tggcccatgg gctgtctggt
     6961 gactgggacc atgaactggc tggtgactgg gaccaggagt gtgtggatga tcggcaggaa
     7021 gttcccaaac aggtacattt cttcatccac cacatgacca tggagaaggt tccagaagag
     7081 gtgctgagac ctagcactcg gttcactgtg gaagtgctat ctaagcagct tcctgacctc
     7141 cgcaaggaag aagctgtgcg tggactgaaa aacgcatccc cactggtcat tagcatcgcc
     7201 ttgggcttgc cgatccttga gccccattgg ccgatccctg agccccgtca ccagatatcc
     7261 tggccccgtc accagatatc ctggccccgt cacccaatat ctgggccctg tctcccagta
     7321 tctgggctct gtctcccagt atccgggctc tgccatccaa tccctgagcc ctgtcgccgc
     7381 ggctggcctc cccagcattc ttcccgcaag gtacctacca gcaggttctt ggagcggaag
     7441 aactacaaca tccccggtgg acatcataag ctgaaccaga gccaggacaa ggctgtcagg
     7501 agtgctctgc agaagcaatt cacagtcatc cagggcccac caggcacagg gaagacggtt
     7561 gtgggcttcc acatcgtgta ctggttccac aggtcaaacc aggagcagat gccaactggc
     7621 agcagcccta gtgaagagga aaaactgggg ggcccgtgtg tcctatactg tggtccctcc
     7681 aacaagtccg tggatgtcct gggaggactg ctcctgagga agaagacgga gatgaggccc
     7741 ctgcgtgtgt atggggaaca ggcagaggcc actgaattcc cgctgccagg agtgagcaac
     7801 aggagtctgt ttggcaagat ctctcaggaa ggaagaccga atcagagcct caggagtatt
     7861 acccttcacc accggatccg ccaggccccc aacccgtatg cagcagagat cagaaaattc
     7921 gatgcccagc ttcgggaagg gaaaatattc tcaaaagatg atcttttggt atacaggaga
     7981 gtcttgggga aggcacgcaa atatgagctc gagcggcact cagtcatcct gtgcacatgc
     8041 tcctgtgcag catcaggaag cctgaaagct ctcaatgttc gacagatcct tattgacgag
     8101 gcaggcatgg ccactgagcc agaaaccctt attccgttgg tgtgcttctc aaagaccgag
     8161 aaggtggttc tgctgggaga ccacaagcag cttcggcctg tggtcaagaa cgaacagctg
     8221 cgaaacctgg ggatggaccg gtcactcttt gagaggtacc acagggatgc catcatgctg
     8281 gacacacagt accgtatgca taaggacatc tgctcctttc cctccatgga gttctatggg
     8341 ggaaagctaa agacctggtc cgacctgaag cgtccaccca gcctcctagg tcatgtcggc
     8401 aagcagagct gccccgtcat cttcggctct gtgcagggct acgagcagaa gctgctggtg
     8461 tccaccgagg aaggcaatga gaactcccgg gccaacccgg aggaggtaac agaggtggtc
     8521 cgaatcatca agcagttgac cctggaccgg acagtggatc ccaaagatgt cgcggtcctt
     8581 acaccttaca atgcacaggc tgcagcaatc agcaggggcc tcatgcaaag aggggtcact
     8641 ggagtgactg tgacctctat caccaagagc caggggagtg agtggcgcta tgtgatagtg
     8701 agcacggttc gaacatgccc cagaagtgat atggaccagc ggccaaccaa gagctggctc
     8761 aagaagtttc tgggctttgt tgtggacccc caccaagtaa acgtggccat cacccgggcc
     8821 caggaggggc tgtgcatcat tggggaccac ctgctgctac gctgctgccc actctggcac
     8881 cgtctcctag gcttctgtga ggcccagaac agcctcgtgc ctgctgagag ggtgcgggtc
     8941 cagagaaagt ctgctctgtc ttcgtgagga acccccacct gcccggccct cgatgtgcca
     9001 tcagctgatg tccctcattc ttctctgcca aaggcctggg tgtatagagg atcaccacag
     9061 ctcacagtca cagctcaaat tagtcaacca cctctgcttt cttcttggga aagtccctgg
     9121 tattggctgc agtcatgaag cagtgacagt cttatgggtg gtgactactt cctgtgccgg
     9181 aagcaggttt aataacgatg accttcctgt ttgtgcttgg acttgagggg aaaaagctgg
     9241 aggccagtgc ttttgcttcc aactgccttt gcttaatgaa tgggacacct cttagtggcc
     9301 acagaggacc ccaggacatg cccatgctat tacagggact ccttagaggc tacactttga
     9361 cgctaagatc catccatggt tgcactgagc accacatact catttgtctt attttctagt
     9421 cttaaaaacc taaagccagc atctcttaca gggacactca gagcaggcaa ggaaaccttc
     9481 ccgggagaaa gactttttct cttgcactgt ttactgcctt gtatcctgca gggctgcccg
     9541 ctagcacagg ggcaggacga tcagagctga accaaacgct cacacagccc tacctcctgg
     9601 gatgtgaaat agctggcagg cagcagggaa tgaggtaccc agtacctctg agcctgtgct
     9661 ccttcaccat gcttccatac ctgtgtccag ggctttaggg tgaccttcct ggcaccaacc
     9721 ttttctacta gactgagcag gtgaaatctc tcccatcatg tctccctctt atacgttcac
     9781 ctcctggcaa ttccaaggct ggaatcagct cccccttcag tgtgacaacc ccccccccca
     9841 atctcctgag gtcagagatg ctgcaagtga aatatacacc aggacagctg gggttcctaa
     9901 ggcctggctg cggagcctcc tgtgagacta tctggtgttt tctacattcc aatgaagctt
     9961 ctacattcca atttttgtat cttttctcag gttatgcctt acataactgg ataattttat
    10021 tataaaaact gctctgaaag tt
//
