LOCUS       NM_001014134            3728 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus helicase, POLQ-like (Helq), mRNA.
ACCESSION   NM_001014134
VERSION     NM_001014134.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3728)
  AUTHORS   Moldovan GL, Madhavan MV, Mirchandani KD, McCaffrey RM, Vinciguerra
            P and D'Andrea AD.
  TITLE     DNA polymerase POLN participates in cross-link repair and
            homologous recombination
  JOURNAL   Mol Cell Biol 30 (4), 1088-1096 (2010)
   PUBMED   19995904
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CH474022.1.
            
            On Dec 25, 2009 this sequence version replaced NM_001014134.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132291,
                              SAMD00132298 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3728
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..3728
                     /gene="Helq"
                     /gene_synonym="Hel308"
                     /note="helicase, POLQ-like"
                     /db_xref="GeneID:360912"
                     /db_xref="RGD:1560216"
     exon            1..381
                     /gene="Helq"
                     /gene_synonym="Hel308"
                     /inference="alignment:Splign:2.1.0"
     CDS             202..3399
                     /gene="Helq"
                     /gene_synonym="Hel308"
                     /EC_number="3.6.4.12"
                     /note="gene_id=rCG37823.0 transcript_id=rCT37822.0
                     protein_id=rCP41853.0 isoform=CRA_c; DNA helicase HEL308"
                     /codon_start=1
                     /product="helicase POLQ-like"
                     /protein_id="NP_001014156.2"
                     /db_xref="GeneID:360912"
                     /db_xref="RGD:1560216"
                     /translation="MEESSPRIRRRVSLRKRNRRSLESLGAARAPAELQPAEDTEDEA
                     AAGSRRRKTGSPEPAQENDSEEDMFGDYNSFSENSFLAQVDDLEQKYIQLPDCGSRGT
                     DSGTKDLCSEGLGNSLSVPAVDFTDSETREYIKKQGDLDVPVEPEVGGDLSFDMPSSQ
                     ILYFESMQNSSKDLGDQSTKGRDGKSSNEELHHSHREQPQPKSDFSDVGGSSEASRRR
                     SIKDCLKSAMTGNARAQTPAFPRSKQLRETLLSEEISVARKAIESPSDDLGPFYSLPS
                     KVRDLYAQLKGIKRLYDWQHTCLTLSSVQERKNLIYSLPTSGGKTLVAEILMLQELLC
                     RQKDVLLILPYVAIVQEKISSLSSFGIELGFFVEEYAGSKGRFPPIKRREKKSLYIAT
                     IEKGHSLVNALIETGRMGTLGLVVVDELHMIGEGSRGATLEMTLAKVLYTSKTTQIIG
                     MSATLNNVEDLQAFLKAEYYTSQFRPVELKEFLKVNDTIYEVDSRAVDGMTFSRLLNY
                     KYSDALKKVDPDRLVALVTEVIPNYSCLVFCPSKKNCENVAEMLCKFLSRDYLNHREE
                     EKGELIKSLRNVGHGKVCPVLKRTIPFGVAYHHSGLTSDERKLLEEAYSTGVLCLFTC
                     TSTLAAGVNLPARRVILRAPYVANTFLKRNQYKQMIGRAGRAGIDTAGESILLLQEKD
                     KQQVLGLINGPLEDCHSHLVEEFTKGIQSLFLSLIGLKIAESLGDIYQFMNGTLFGVQ
                     QKTLLREKSLWEVTVGALEHLTEKGLLQKDSHGSPEESRCHFRITKLGQASFKGAIDL
                     TYCDTLYRDLKKGLEGLVLESLLHLVYLTTPYDLAAQSEPDWMVYFRQFSQLSPAEQS
                     VATLLGISESFIGRKASGQAIRKKVDKNAVNRLYLSFVLYSLLKETNVWSVSERFNMP
                     RGYIQNLLMGAASFSSCVLHFCEELEEFWVYKALLTELTKKLTYCVKAELIPLMEVTG
                     VLEGRAKQLYSAGYRSVVHLANANPEVLVKTIDHLSRRQAKQIVSSAKMLLHEKAEAL
                     QEEAEELLRLPADLPGLGGPGSERAGSHAGDLALR"
     exon            382..1078
                     /gene="Helq"
                     /gene_synonym="Hel308"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1257
                     /gene="Helq"
                     /gene_synonym="Hel308"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1458
                     /gene="Helq"
                     /gene_synonym="Hel308"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1531
                     /gene="Helq"
                     /gene_synonym="Hel308"
                     /inference="alignment:Splign:2.1.0"
     exon            1532..1629
                     /gene="Helq"
                     /gene_synonym="Hel308"
                     /inference="alignment:Splign:2.1.0"
     exon            1630..1728
                     /gene="Helq"
                     /gene_synonym="Hel308"
                     /inference="alignment:Splign:2.1.0"
     exon            1729..1874
                     /gene="Helq"
                     /gene_synonym="Hel308"
                     /inference="alignment:Splign:2.1.0"
     exon            1875..2114
                     /gene="Helq"
                     /gene_synonym="Hel308"
                     /inference="alignment:Splign:2.1.0"
     exon            2115..2256
                     /gene="Helq"
                     /gene_synonym="Hel308"
                     /inference="alignment:Splign:2.1.0"
     exon            2257..2361
                     /gene="Helq"
                     /gene_synonym="Hel308"
                     /inference="alignment:Splign:2.1.0"
     exon            2362..2581
                     /gene="Helq"
                     /gene_synonym="Hel308"
                     /inference="alignment:Splign:2.1.0"
     exon            2582..2739
                     /gene="Helq"
                     /gene_synonym="Hel308"
                     /inference="alignment:Splign:2.1.0"
     exon            2740..2838
                     /gene="Helq"
                     /gene_synonym="Hel308"
                     /inference="alignment:Splign:2.1.0"
     exon            2839..3012
                     /gene="Helq"
                     /gene_synonym="Hel308"
                     /inference="alignment:Splign:2.1.0"
     exon            3013..3126
                     /gene="Helq"
                     /gene_synonym="Hel308"
                     /inference="alignment:Splign:2.1.0"
     exon            3127..3261
                     /gene="Helq"
                     /gene_synonym="Hel308"
                     /inference="alignment:Splign:2.1.0"
     exon            3262..3728
                     /gene="Helq"
                     /gene_synonym="Hel308"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccggtgcgaa ggtagccagg atttcaatgc tccgtacctt tgtgttcccg cgctccccgg
       61 gccggaagtc acgtgacaca cgggctgtgc tgcagagaga tggagagctg atgctccgtc
      121 acttgcttac ggctccagac ccgcggcacc agctccggtc tgcaccgagg gcggctgtcg
      181 cagggactct gggccgttgt catggaggaa agttctcccc gcatccgccg gcgggtgtct
      241 ctccgcaaaa gaaaccgccg cagcctagag agcctcggtg ctgcccgggc cccagccgag
      301 ctccagcccg ccgaggacac ggaggacgaa gctgcggctg ggagccgccg gcggaaaacc
      361 gggagcccgg agcccgccca ggaaaatgac agtgaagagg acatgtttgg tgactataac
      421 agcttttcag aaaattcctt cttagctcaa gttgatgacc tggagcagaa atatatacaa
      481 ctgcctgact gtgggagccg aggtacagac tccggcacca aagacctctg ttcagaaggc
      541 ctcgggaaca gcctcagtgt tcctgctgta gatttcactg actctgaaac cagagagtac
      601 ataaagaagc agggtgatct agatgtccct gttgagccag aggtaggagg cgatctttca
      661 ttcgatatgc cttcttctca aatcttatac tttgaaagta tgcagaactc ctcaaaagat
      721 ttgggtgatc agtccaccaa gggaagagat gggaagtcat cgaatgaaga attgcatcat
      781 agccacagag agcaacccca gccaaagagc gacttctctg acgtcggcgg ctcctcagag
      841 gcgagcagga ggagaagtat caaagactgc ctgaaaagcg ccatgactgg gaatgccagg
      901 gcccagaccc cagcatttcc caggagtaaa caactcaggg agacactgct gtctgaggag
      961 atcagcgttg ctaggaaagc catcgagtca ccgtcagatg atcttggtcc cttttattca
     1021 ctacccagca aagtgagaga cctctatgct cagttgaaag gaatcaaaag actatatgac
     1081 tggcaacata cttgcttaac gttaagttct gtgcaagaaa ggaaaaattt aatatactcc
     1141 ttgccaacga gtggcggaaa gacccttgtg gccgagatct taatgctgca ggaacttctc
     1201 tgccgacaga aagacgtttt actgatcctt ccctatgtgg ccattgtgca agaaaagatt
     1261 tccagtttgt cgagtttcgg tatagaactt ggtttctttg tcgaagaata tgctggcagc
     1321 aaaggaagat ttcctccaat taaaaggagg gaaaagaagt cgctgtacat cgccaccatt
     1381 gagaaagggc atagcctggt gaacgccttg attgaaacgg gaaggatggg cactctaggc
     1441 ctggttgtcg tcgatgagtt gcacatgatt ggtgagggga gccgtggtgc cacactggag
     1501 atgaccctgg ccaaagtcct ctacaccagc aaaacaactc agattatcgg catgagtgca
     1561 acactaaaca acgtagaaga cctacaggcg ttcctgaaag ctgagtatta caccagtcag
     1621 ttcagaccag ttgaattaaa agaattcctg aaagtaaatg acacaatata tgaggtagac
     1681 agccgggctg tggacggcat gaccttttca cggctcctga attataagta ctccgatgcc
     1741 ctgaagaaag tggaccctga ccgcttggta gcattggtga cagaagtcat ccctaactac
     1801 tcctgcctgg ttttttgtcc cagtaagaag aactgtgaaa atgtagcaga aatgttgtgc
     1861 aagtttttaa gcagggacta tctaaaccac agagaggaag aaaaggggga actgattaaa
     1921 agcctgagga atgtcggcca cggtaaagtg tgccctgtcc tgaagcgcac catccctttc
     1981 ggcgtcgcct atcaccacag cggcttaact agcgatgagc ggaagcttct ggaagaggcc
     2041 tactccactg gtgtgctctg cctcttcacc tgcacgtcca ccctggcagc aggggtcaat
     2101 ctgcctgcac ggagagtcat cttaagagct ccctacgtgg ctaacacgtt cttgaagagg
     2161 aatcagtata agcagatgat tggcagggct ggccgagctg ggatagacac tgccggggag
     2221 agcatccttc tgctgcaaga gaaagacaag cagcaggtgc tgggactaat aaatggaccg
     2281 ctagaagact gccacagcca tcttgtcgag gagttcacca agggaatcca gagtttgttc
     2341 ctctccttaa ttggcctgaa gattgcagag agtctcgggg acatatatca gttcatgaat
     2401 ggcacgcttt ttggcgtcca gcaaaagact ttactgagag agaaaagcct ctgggaagtt
     2461 actgtcggcg cacttgaaca cctaacagag aaagggcttc tacagaaaga cagccacggc
     2521 agccccgagg agtcacgctg tcacttccgt attaccaaac tgggtcaagc ttcttttaag
     2581 ggggccattg acttgaccta ttgtgacact ctgtacagag acttgaagaa aggtctggaa
     2641 ggactcgtac tggaaagcct tcttcatctg gtctacctaa ccacacccta tgacctcgcc
     2701 gctcagtctg agcctgactg gatggtgtac ttcaggcagt ttagtcaact cagcccagca
     2761 gagcaaagtg tggctactct tcttggaatc tccgaaagct ttattgggag aaaggcgtca
     2821 ggacaagcca tcagaaagaa ggtggacaag aacgctgtca acaggctcta tctgtctttt
     2881 gtgctttatt ccttgctgaa agagaccaac gtttggagcg tgtctgagag atttaacatg
     2941 ccccggggat acatacagaa cctgcttatg ggagctgcct cgttctcatc ctgtgtgtta
     3001 catttctgtg aggagctgga ggagttttgg gtttacaagg ccctgttgac ggaactcacc
     3061 aagaagctga cgtactgcgt gaaggcggag ctaatccctc tcatggaggt gacaggggtc
     3121 ttagagggtc gagcaaaaca gttatacagc gctggttaca gaagtgttgt gcacttagcc
     3181 aatgccaacc cagaagtgct ggtgaagaca attgatcatc tgtccagacg ccaagccaag
     3241 cagattgttt cctcagccaa gatgctgctg catgaaaagg cagaggcgtt gcaggaagaa
     3301 gcagaagagt tgctgagatt gcctgctgac ctccctgggc tggggggtcc cggctctgaa
     3361 agggcaggaa gccatgctgg ggacctggct ctgcgatagg gcattgctga gatgcctcag
     3421 gccctgtgtt aaagcctcag tgcctccaag aaagctaggg ctggcggggc gtgaagtgca
     3481 tggcggtaag ctgtattcca gcacttggga ggcagaggga tggtgagtgt caaaggacgg
     3541 cttcagctac tcagagttgg aggctagcct gggctacata agtccctctc agaaagcaaa
     3601 actgtgcagc tgtctgatgt atgtttttta atttgactta tttattatat atcttattat
     3661 tgaaaaatcc cctgtgttag tgaaatctat tttaattata cattaaaacc cgtggatgaa
     3721 cttttaga
//
