LOCUS       NM_001106371            3164 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus helicase, lymphoid specific (Hells), mRNA.
ACCESSION   NM_001106371 XM_001080666 XM_220062
VERSION     NM_001106371.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3164)
  AUTHORS   Xiao D, Huang J, Pan Y, Li H, Fu C, Mao C, Cheng Y, Shi Y, Chen L,
            Jiang Y, Yang R, Liu Y, Zhou J, Cao Y, Liu S and Tao Y.
  TITLE     Chromatin Remodeling Factor LSH is Upregulated by the
            LRP6-GSK3beta-E2F1 Axis Linking Reversely with Survival in Gliomas
  JOURNAL   Theranostics 7 (1), 132-143 (2017)
   PUBMED   28042322
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3164)
  AUTHORS   Tarantino C, Paolella G, Cozzuto L, Minopoli G, Pastore L, Parisi S
            and Russo T.
  TITLE     miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic
            stem cells
  JOURNAL   FASEB J 24 (9), 3255-3263 (2010)
   PUBMED   20439489
REFERENCE   3  (bases 1 to 3164)
  AUTHORS   Fan T, Hagan JP, Kozlov SV, Stewart CL and Muegge K.
  TITLE     Lsh controls silencing of the imprinted Cdkn1c gene
  JOURNAL   Development 132 (4), 635-644 (2005)
   PUBMED   15647320
REFERENCE   4  (bases 1 to 3164)
  AUTHORS   Huang J, Fan T, Yan Q, Zhu H, Fox S, Issaq HJ, Best L, Gangi L,
            Munroe D and Muegge K.
  TITLE     Lsh, an epigenetic guardian of repetitive elements
  JOURNAL   Nucleic Acids Res 32 (17), 5019-5028 (2004)
   PUBMED   15448183
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3164)
  AUTHORS   Sun LQ, Lee DW, Zhang Q, Xiao W, Raabe EH, Meeker A, Miao D, Huso
            DL and Arceci RJ.
  TITLE     Growth retardation and premature aging phenotypes in mice with
            disruption of the SNF2-like gene, PASG
  JOURNAL   Genes Dev 18 (9), 1035-1046 (2004)
   PUBMED   15105378
REFERENCE   6  (bases 1 to 3164)
  AUTHORS   Yan Q, Cho E, Lockett S and Muegge K.
  TITLE     Association of Lsh, a regulator of DNA methylation, with
            pericentromeric heterochromatin is dependent on intact
            heterochromatin
  JOURNAL   Mol Cell Biol 23 (23), 8416-8428 (2003)
   PUBMED   14612388
REFERENCE   7  (bases 1 to 3164)
  AUTHORS   Dennis K, Fan T, Geiman T, Yan Q and Muegge K.
  TITLE     Lsh, a member of the SNF2 family, is required for genome-wide
            methylation
  JOURNAL   Genes Dev 15 (22), 2940-2944 (2001)
   PUBMED   11711429
REFERENCE   8  (bases 1 to 3164)
  AUTHORS   Sutherland HG, Mumford GK, Newton K, Ford LV, Farrall R, Dellaire
            G, Caceres JF and Bickmore WA.
  TITLE     Large-scale identification of mammalian proteins localized to
            nuclear sub-compartments
  JOURNAL   Hum Mol Genet 10 (18), 1995-2011 (2001)
   PUBMED   11555636
REFERENCE   9  (bases 1 to 3164)
  AUTHORS   Geiman TM, Tessarollo L, Anver MR, Kopp JB, Ward JM and Muegge K.
  TITLE     Lsh, a SNF2 family member, is required for normal murine
            development
  JOURNAL   Biochim Biophys Acta 1526 (2), 211-220 (2001)
   PUBMED   11325543
REFERENCE   10 (bases 1 to 3164)
  AUTHORS   Geiman TM and Muegge K.
  TITLE     Lsh, an SNF2/helicase family member, is required for proliferation
            of mature T lymphocytes
  JOURNAL   Proc Natl Acad Sci U S A 97 (9), 4772-4777 (2000)
   PUBMED   10781083
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473953.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001080666.1, XM_220062.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3164
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q53"
     gene            1..3164
                     /gene="Hells"
                     /note="helicase, lymphoid specific"
                     /db_xref="GeneID:294071"
                     /db_xref="RGD:1309820"
     exon            1..117
                     /gene="Hells"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..2600
                     /gene="Hells"
                     /note="TBC1D12: TBC1 domain family, member 12;
                     lymphocyte-specific helicase-like"
                     /codon_start=1
                     /product="lymphoid-specific helicase"
                     /protein_id="NP_001099841.1"
                     /db_xref="GeneID:294071"
                     /db_xref="RGD:1309820"
                     /translation="MPAERPASSSGPLAPEMAEQTEPAVITPAMLEEEEQLEAEGLEK
                     ERKMLEEARKSWDRESTEIRYRRLQHLLEKSNIYSKFLLTKMEQQQLEEQKKKEKLEK
                     KKRSLKVTEGKNLIDGNEENTVMKKKRGREDESYNISEVMSKEEILSVAKKHKDNEDE
                     NSSTTNLCVEDLQKNKDSNSMIKDRLSQTVRQNSKFFFDPVRKCNGQPVPFQQPKHFT
                     GGVMRWYQVEGMEWLRMLWENGINGILADEMGLGKTVQCIATIALMIQRGVPGPFLVC
                     GPLSTLPNWMAEFKRFTPEIPTLLYHGNRQERRKLVKNIHKRQGTLQIHPVVITSFEI
                     AMRDQNALQHCYWKYLIVDEGHRIKNMKCRLIRELKRFNADNKLLLTGTPLQNNLSEL
                     WSLLNFLLPDVFDDLKSFESWFDITSLSETAEDIIAKEREQNVLHMLHQILTPFLLRR
                     LKSDVALEVPPKREVVVYAPLCNKQEIFYTAIVNRTIANMFGSCEKETVELSPTGRPK
                     RRSRKSINYSELDQFPSELEKLISQIQPEVKRERTVVEGNIPIESEVNLKLQNIMMLL
                     RKCCNHPYMIEYPIDPVTQEFKIDEELVTNSGKFLILDRMLPELKKRCHKVLVFSQMT
                     SMLDILMDYCHLRNFTFSRLDGSMSYSEREKNIYSFNTDPEVFLFLVSTRAGGLGINL
                     TAADTVIIYDSDWNPQSDLQAQDRCHRIGQTKPVVVYRLVTANTIDQKIVERAAAKRK
                     LEKLIIHKNHFKGGQSGLSQSKNFLDAKELMELLKSRDYEREVKGSREKVISDEDLEL
                     LLDRSDLIDQMKASRPIKEKTGIFKILENSEDSSAECLF"
     exon            118..239
                     /gene="Hells"
                     /inference="alignment:Splign:2.1.0"
     exon            240..362
                     /gene="Hells"
                     /inference="alignment:Splign:2.1.0"
     exon            363..419
                     /gene="Hells"
                     /inference="alignment:Splign:2.1.0"
     exon            420..456
                     /gene="Hells"
                     /inference="alignment:Splign:2.1.0"
     exon            457..521
                     /gene="Hells"
                     /inference="alignment:Splign:2.1.0"
     exon            522..560
                     /gene="Hells"
                     /inference="alignment:Splign:2.1.0"
     exon            561..788
                     /gene="Hells"
                     /inference="alignment:Splign:2.1.0"
     exon            789..971
                     /gene="Hells"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1115
                     /gene="Hells"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1312
                     /gene="Hells"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1409
                     /gene="Hells"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..1571
                     /gene="Hells"
                     /inference="alignment:Splign:2.1.0"
     exon            1572..1711
                     /gene="Hells"
                     /inference="alignment:Splign:2.1.0"
     exon            1712..1850
                     /gene="Hells"
                     /inference="alignment:Splign:2.1.0"
     exon            1851..1934
                     /gene="Hells"
                     /inference="alignment:Splign:2.1.0"
     exon            1935..2054
                     /gene="Hells"
                     /inference="alignment:Splign:2.1.0"
     exon            2055..2171
                     /gene="Hells"
                     /inference="alignment:Splign:2.1.0"
     exon            2172..2331
                     /gene="Hells"
                     /inference="alignment:Splign:2.1.0"
     exon            2332..2428
                     /gene="Hells"
                     /inference="alignment:Splign:2.1.0"
     exon            2429..2505
                     /gene="Hells"
                     /inference="alignment:Splign:2.1.0"
     exon            2506..3164
                     /gene="Hells"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcgcgcggt ggggtgagtg agccgaccta ccttgcagca ctgtgaggag ttagctcgcg
       61 gcgtttgagg cgaccagagt ccagccatgc ctgcggagcg gcccgcgagc agcagcgggc
      121 ccttggctcc agaaatggct gagcaaacgg agcctgcagt gattacccca gccatgctgg
      181 aggaggaaga acagctcgag gctgagggac ttgagaagga acggaagatg ttagaagagg
      241 ctcgaaagtc ttgggacaga gagtccactg aaattcggta ccgcagactg caacatttgc
      301 ttgaaaaaag caatatctac tcaaaatttt tgttgactaa aatggaacaa cagcagttgg
      361 aggaacagaa gaaaaaagag aagttggaga aaaaaaaacg gtcattaaaa gttacagagg
      421 gtaaaaattt aattgatgga aatgaagaga atacagtcat gaaaaagaaa agaggaagag
      481 aagatgaatc ttataatatt tcagaggtca tgtcaaaaga ggaaattttg tcagtggcta
      541 aaaaacataa ggataatgag gatgaaaact cttccactac taatctttgt gtagaagatc
      601 ttcagaaaaa taaggattca aatagtatga ttaaagatag attgtctcaa actgttaggc
      661 agaattctaa attctttttt gatccagttc ggaaatgtaa tggacagcct gtaccctttc
      721 aacaacccaa gcatttcaca ggaggagtga tgaggtggta ccaagtagaa ggcatggaat
      781 ggcttaggat gctttgggaa aatggaatta atggcatttt agcagatgaa atgggtttgg
      841 gaaagacggt tcagtgcatt gctacaattg cattgatgat tcagagggga gtacctggac
      901 ctttccttgt ttgtggccct ttgtctacac ttcctaactg gatggctgag ttcaaaagat
      961 ttactccaga aattcctact ttgctgtatc atggaaaccg gcaggaacgt cgaaaattag
     1021 taaagaatat tcacaaaaga caagggacgt tgcagattca tcctgttgta atcacatcat
     1081 ttgaaatagc tatgagagac cagaatgctt tacagcattg ctattggaaa tacttaatag
     1141 tagatgaagg acacaggatt aagaatatga agtgccggct aatcagggag ttaaaacggt
     1201 tcaatgctga taacaaactt cttttgactg gtactccctt gcaaaacaat ttatcagaac
     1261 tttggtcatt gctaaacttt ttgttaccag atgtatttga tgacttgaaa agctttgagt
     1321 cttggtttga tatcactagt ctttctgaaa ctgctgaaga tattatagct aaagaaagag
     1381 aacagaacgt tttacatatg ctgcaccaga ttttaacgcc tttcctactg agaagactga
     1441 agtctgatgt tgctcttgaa gtccctccta agcgggaagt ggttgtttat gcaccacttt
     1501 gcaataaaca agagatcttc tatacagcta ttgtgaaccg cacaattgca aacatgtttg
     1561 gatcttgtga gaaggaaaca gttgagttaa gtcctactgg aagaccaaaa cggcgaagta
     1621 gaaagtcaat aaattacagc gaactggatc agttccctag tgaattagaa aaactaataa
     1681 gtcaaataca gccagaagta aaaagagaga ggactgttgt ggaaggtaat atccctatag
     1741 aatctgaagt taatctgaag ctgcagaata taatgatgct acttcgaaag tgctgcaatc
     1801 atccatatat gattgagtac cctatagacc ctgtcacaca ggagtttaag attgatgaag
     1861 aattggtaac aaattctggg aagttcctaa ttttggatcg aatgctgcca gaacttaaaa
     1921 aaagatgtca caaggttctg gttttttcac aaatgacaag catgttggac atcttgatgg
     1981 attattgcca tcttagaaac tttaccttta gcagacttga tgggtccatg tcttattcgg
     2041 aaagagaaaa aaatatatac agtttcaaca cggatccaga ggtttttctt ttcttagtga
     2101 gtacacgagc tggtggctta ggcattaatt tgactgcagc agatacagtg atcatttatg
     2161 acagtgattg gaatcctcag tctgatctcc aggcccaaga tagatgtcat agaattggtc
     2221 agacaaagcc agttgttgtc tatcgcctcg tgacagcaaa tactattgac cagaaaattg
     2281 tggaaagagc agctgctaaa agaaagttgg agaagctgat aatccataaa aatcatttca
     2341 aaggtggtca gtctgggtta agtcaatcta agaatttctt agatgcaaag gaattaatgg
     2401 agttattaaa atctagagat tatgaaaggg aagtaaaagg atccagagag aaggtcatta
     2461 gtgatgaaga tctagaattg ttattagatc gaagtgatct cattgatcaa atgaaggctt
     2521 caagaccaat taaagagaaa acggggatat tcaaaatact agaaaattct gaagattcca
     2581 gtgctgaatg tttgttttaa agggaagcaa aatggatttt aaaaactttt gtttacatcc
     2641 attctggtaa tttgcctgtt tgctttgaaa ttcatattgt tcactttact tttacgatta
     2701 tatcagttaa tatactgtaa ctactattat tgcatacttg ataattttgt ggattttatt
     2761 tagtataaaa ttcttgtaaa tttagatttt cagttagttt ttgggactgg gtagtacttt
     2821 tgagttttgt tattatgtac ttaaccattg ccaagtttat cagtcttcct gtggaagttt
     2881 agtaagtttc tcccccaccc cctttagtaa tataattcat gggatttttg acttcagtta
     2941 tggagcaggc ttttggtagg ggagagattg attgaaattg tactttctgt tgctgaagta
     3001 aagtttttga gttttgagtc aataagatga cttatcaaat aaatgtttat tgtaatatga
     3061 tctggttaca ttattttgtc agaaaactta atgatttagt taaaatagta aggcttattt
     3121 aatactagga ttcaacagta ttgtctgaac tgacttcatt gttt
//
