LOCUS       NM_001399836            4485 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus DNA helicase B (Helb), mRNA.
ACCESSION   NM_001399836 XM_006241426
VERSION     NM_001399836.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4485)
  AUTHORS   Topalidou,I., Cattin-Ortola,J., Pappas,A.L., Cooper,K.,
            Merrihew,G.E., MacCoss,M.J. and Ailion,M.
  TITLE     The EARP Complex and Its Interactor EIPR-1 Are Required for Cargo
            Sorting to Dense-Core Vesicles
  JOURNAL   PLoS Genet 12 (5), e1006074 (2016)
   PUBMED   27191843
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4485)
  AUTHORS   Tkac,J., Xu,G., Adhikary,H., Young,J.T.F., Gallo,D.,
            Escribano-Diaz,C., Krietsch,J., Orthwein,A., Munro,M., Sol,W.,
            Al-Hakim,A., Lin,Z.Y., Jonkers,J., Borst,P., Brown,G.W.,
            Gingras,A.C., Rottenberg,S., Masson,J.Y. and Durocher,D.
  TITLE     HELB Is a Feedback Inhibitor of DNA End Resection
  JOURNAL   Mol Cell 61 (3), 405-418 (2016)
   PUBMED   26774285
REFERENCE   3  (bases 1 to 4485)
  AUTHORS   Gu,J., Xia,X., Yan,P., Liu,H., Podust,V.N., Reynolds,A.B. and
            Fanning,E.
  TITLE     Cell cycle-dependent regulation of a human DNA helicase that
            localizes in DNA damage foci
  JOURNAL   Mol Biol Cell 15 (7), 3320-3332 (2004)
   PUBMED   15146062
REFERENCE   4  (bases 1 to 4485)
  AUTHORS   Taneja,P., Gu,J., Peng,R., Carrick,R., Uchiumi,F., Ott,R.D.,
            Gustafson,E., Podust,V.N. and Fanning,E.
  TITLE     A dominant-negative mutant of human DNA helicase B blocks the onset
            of chromosomal DNA replication
  JOURNAL   J Biol Chem 277 (43), 40853-40861 (2002)
   PUBMED   12181327
REFERENCE   5  (bases 1 to 4485)
  AUTHORS   Tada,S., Kobayashi,T., Omori,A., Kusa,Y., Okumura,N., Kodaira,H.,
            Ishimi,Y., Seki,M. and Enomoto,T.
  TITLE     Molecular cloning of a cDNA encoding mouse DNA helicase B, which
            has homology to Escherichia coli RecD protein, and identification
            of a mutation in the DNA helicase B from tsFT848
            temperature-sensitive DNA replication mutant cells
  JOURNAL   Nucleic Acids Res 29 (18), 3835-3840 (2001)
   PUBMED   11557815
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Jan 18, 2022 this sequence version replaced XM_006241426.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.28133.1,
                                           SRR26643429.26839.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-228               JAXUCZ010000007.1  57500998-57501225   c
            229-624             JAXUCZ010000007.1  57498992-57499387   c
            625-794             JAXUCZ010000007.1  57497357-57497526   c
            795-1685            JAXUCZ010000007.1  57494137-57495027   c
            1686-1857           JAXUCZ010000007.1  57491995-57492166   c
            1858-1999           JAXUCZ010000007.1  57490643-57490784   c
            2000-2154           JAXUCZ010000007.1  57487711-57487865   c
            2155-2245           JAXUCZ010000007.1  57484730-57484820   c
            2246-2305           JAXUCZ010000007.1  57483993-57484052   c
            2306-2510           JAXUCZ010000007.1  57482693-57482897   c
            2511-2654           JAXUCZ010000007.1  57481920-57482063   c
            2655-3155           JAXUCZ010000007.1  57480190-57480690   c
            3156-4485           JAXUCZ010000007.1  57474184-57475513   c
FEATURES             Location/Qualifiers
     source          1..4485
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     gene            1..4485
                     /gene="Helb"
                     /gene_synonym="RGD1560103"
                     /note="DNA helicase B"
                     /db_xref="GeneID:500837"
                     /db_xref="RGD:1560103"
     exon            1..228
                     /gene="Helb"
                     /gene_synonym="RGD1560103"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..3317
                     /gene="Helb"
                     /gene_synonym="RGD1560103"
                     /EC_number="3.6.4.12"
                     /note="helicase (DNA) B"
                     /codon_start=1
                     /product="DNA helicase B"
                     /protein_id="NP_001386765.1"
                     /db_xref="GeneID:500837"
                     /db_xref="RGD:1560103"
                     /translation="MAGQGVLRELLGPLNPYKSDDEEEDCAQEEGEQDSEFVDAEELC
                     SGGIKAGSLPGRMRVSIPDENTKEKCTVYGRFPLKDPWWRVRVRVVKHAQSSKSYQVQ
                     GFPSYFLQSDMSPPDQKSICSLFLKECNFTPERIQEFLKWVDKVSSFENLNFENLRET
                     FRNFCRETTKKDKMQSTQSDQGDEQKLEKSFPFVIAMTALQFPKVMEFLPTLFPRHFK
                     SLISSCSETVLGHIEEALGTQPWKLGFRRITYREMKLLSCEASWTSFSQCPSLLQLMT
                     ALQKNALVLYSKLRQTCREDGHTYIKVKDLTWGLSEHMSFEEACQSLDFLRTIDVITY
                     EKDFIFLSELYQAEHDIASFICELMNRPPWHLKVDVRNVLASIGGAKSTDSGSTEAVE
                     GSKPDEVEVEVAAEQGDSVLGAQDSGDHVRSNGEHVTSAEINRVPLDRDQVVALETIC
                     TNAVTVLSGKGGCGKTTIVSRLFKHVEQLEEREVQQACEDFEQDQGASEEWLDFPKQS
                     PAGVDKAIEVLLTAPTGKAAGLLRQKTHLPAYTLCQVNYSFYMWKKNEADKPWKFSTV
                     RVLVVDEGSLVSVAIFKSVLKLLREHSKLSKLVILGDVRQLPSIEPGNMLQDVFETLK
                     SRQCAIELKTNHRTESQLIVDNAARISRRQFPEFDAEINISDNSTLPNSIQDKTFIFV
                     RLPEEDSSSQSSKGKHQADLYSAVKTLLQGKDFCSPESAKTSQFIAFRRQDCDLINDC
                     CSKHYTDHLIKDHKKKLIFAVGDKICCTRNAYLSDLLPDRDQEANGKGFGDAPDDNAK
                     GKQDFESSIRLCNGEIFFITRDVTDVTSKRKRLLTISNDAGLEVTVDFNKLMTNCQIK
                     HAWARTIHTFQGSEEKTVAYVVGKAGRQHWQHVYTAVTRGRSRVYIIAEESELRSAIR
                     KRSFPRQTRLKHFLQKKLSSSCASSEGLPSQPSSPRVGGRPDTQPLASPLCTTPGSKA
                     TANSARGEASPATKERFALDGRWLSTCFSDMDTDEESEQLRGSKRTGDGFPFEEESPS
                     KFRMVEESSPQVSSIFQSLRLNNLTRRQLFKPSDNQETAKSGVVDHTNNASNQETEP"
     exon            229..624
                     /gene="Helb"
                     /gene_synonym="RGD1560103"
                     /inference="alignment:Splign:2.1.0"
     exon            625..794
                     /gene="Helb"
                     /gene_synonym="RGD1560103"
                     /inference="alignment:Splign:2.1.0"
     exon            795..1685
                     /gene="Helb"
                     /gene_synonym="RGD1560103"
                     /inference="alignment:Splign:2.1.0"
     exon            1686..1857
                     /gene="Helb"
                     /gene_synonym="RGD1560103"
                     /inference="alignment:Splign:2.1.0"
     exon            1858..1999
                     /gene="Helb"
                     /gene_synonym="RGD1560103"
                     /inference="alignment:Splign:2.1.0"
     exon            2000..2154
                     /gene="Helb"
                     /gene_synonym="RGD1560103"
                     /inference="alignment:Splign:2.1.0"
     exon            2155..2245
                     /gene="Helb"
                     /gene_synonym="RGD1560103"
                     /inference="alignment:Splign:2.1.0"
     exon            2246..2305
                     /gene="Helb"
                     /gene_synonym="RGD1560103"
                     /inference="alignment:Splign:2.1.0"
     exon            2306..2510
                     /gene="Helb"
                     /gene_synonym="RGD1560103"
                     /inference="alignment:Splign:2.1.0"
     exon            2511..2654
                     /gene="Helb"
                     /gene_synonym="RGD1560103"
                     /inference="alignment:Splign:2.1.0"
     exon            2655..3155
                     /gene="Helb"
                     /gene_synonym="RGD1560103"
                     /inference="alignment:Splign:2.1.0"
     exon            3156..4485
                     /gene="Helb"
                     /gene_synonym="RGD1560103"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agttttggac agtgcgaggg gtttttgtta gtgtagtttg ggcagagaag ataatggctg
       61 ggcagggtgt tctgcgcgaa ctgctgggcc ctttgaaccc atacaagagc gacgacgagg
      121 aggaggactg tgctcaggag gaaggggagc aggactcaga gtttgtggat gcggaggagc
      181 tctgcagcgg gggcatcaag gcgggtagcc ttcctgggcg aatgcgagtg tctattcctg
      241 atgaaaatac taaagaaaaa tgtaccgtgt atgggcgttt cccactcaaa gatccgtggt
      301 ggcgcgtgag ggtccgggtt gtgaaacacg cgcagtcctc caagagctac caagttcaag
      361 gctttccgtc ctactttcta cagtctgata tgtcgccacc agatcaaaag tctatctgtt
      421 cgctttttct taaagaatgc aactttactc ctgagcgcat acaggagttt ttaaagtggg
      481 tagataaagt gtcaagcttt gaaaatctaa actttgaaaa tcttcgggaa acatttagaa
      541 atttctgcag agaaaccaca aagaaagata aaatgcagtc tacacaaagt gaccagggcg
      601 atgagcagaa actggaaaaa tcattcccgt ttgtaattgc aatgacggct ttgcagttcc
      661 ccaaagtcat ggaattcctt ccaacgcttt ttcctcgaca cttcaaaagt cttatcagtt
      721 cctgttctga aacagtgctg gggcacatag aagaggctct ggggacacag ccatggaagc
      781 tcggcttccg gaggataacc tacagagaga tgaagctgct atcctgtgag gccagctgga
      841 cctcattcag tcagtgcccc tcgctgctcc agctcatgac tgccctgcag aagaacgctt
      901 tggtcctgta ttctaagctg aggcagacat gcagagaaga tggacacacg tacatcaaag
      961 taaaagactt gacctggggc ttgtcagagc atatgtcctt cgaggaagca tgtcagtctc
     1021 tggactttct gaggaccatt gacgtgataa cctatgagaa ggacttcatt tttctttctg
     1081 aactgtacca ggctgagcac gacatcgcct ccttcatatg tgagctgatg aacagacccc
     1141 catggcattt aaaagtagac gtgaggaatg tcctggcgtc aattggtggt gcaaagagca
     1201 ctgattcagg cagtacagag gcagtggaag ggagcaagcc agacgaggtg gaggtggagg
     1261 tggcggcaga gcagggtgac agtgttttag gtgcacaaga cagcggtgac catgttagaa
     1321 gcaatggcga acacgtcacg agtgcagaaa taaacagagt cccactggat cgagatcagg
     1381 tggtcgccct ggaaacgatc tgcaccaatg cggtgaccgt cctcagcggg aaaggcggct
     1441 gtgggaagac cactattgtt agccgtcttt tcaagcatgt ggagcagctg gaagaaaggg
     1501 aagtgcagca agcctgtgaa gactttgaac aagaccaggg ggcctcagaa gaatggcttg
     1561 actttcctaa gcagagtcca gccggggtgg acaaggctat agaagttttg ctcaccgcac
     1621 ctacggggaa ggcagctggc ttattgaggc agaagaccca tcttccggct tatacgctgt
     1681 gtcaggtcaa ctacagtttc tatatgtgga agaaaaatga ggcagacaag ccgtggaaat
     1741 tctctacagt tcgagttctg gttgtggacg aagggagttt ggtgtctgta gcaatcttca
     1801 aatcggtttt aaagttactg cgtgaacact ccaaactgtc taagctagta atccttggcg
     1861 atgttagaca gttacccagt attgaacctg gtaacatgct gcaggatgtt tttgagactc
     1921 ttaagtcaag acagtgtgcc atcgaactaa agacaaacca caggacagag tctcagctga
     1981 tcgtggacaa tgccgcaaga atctccagac gtcagtttcc agaatttgat gcagaaataa
     2041 acatctctga taattccaca ttacccaact ccattcaaga taagacattc attttcgtga
     2101 gactccctga agaggacagc agttctcagt cgtctaaagg caaacaccaa gctgatttat
     2161 attctgcagt taaaactttg cttcaaggga aggacttctg cagtcctgaa agtgcaaaaa
     2221 catcgcaatt tattgcattt agaaggcaag actgtgacct catcaatgac tgctgctcca
     2281 agcactacac agaccacctc atcaaagacc ataagaagaa actcatcttt gctgttggtg
     2341 ataagatctg ttgtacccgg aatgcgtacc tctcagattt actccctgac agagaccagg
     2401 aagccaacgg gaaaggcttt ggagatgccc cagacgataa tgctaaaggc aaacaggatt
     2461 ttgaaagtag catacgactg tgcaatgggg agatattttt cataacacgg gatgtaactg
     2521 acgtaacttc caaaagaaaa agacttttga ccattagtaa tgacgctgga ttggaagtga
     2581 ctgtggactt taacaaacta atgacaaact gtcagataaa gcacgcgtgg gcaaggacca
     2641 ttcatacttt tcaggggtcc gaggagaaaa cagtcgccta tgtagtgggg aaggcaggcc
     2701 gccagcactg gcaacatgtc tacactgcgg tgactcgggg ccgctccagg gtgtacatca
     2761 ttgcggaaga gtctgaactc aggagtgcca tccggaagcg cagtttcccc aggcagacgc
     2821 gtctgaaaca cttcttgcag aagaagctct ccagcagctg tgcctcctca gagggtctcc
     2881 catctcagcc ttcgagccct agagtaggag gaagacctga cacacagcct ctggcgtcac
     2941 ccctgtgtac aaccccaggc agcaaagcta ccgcaaacag cgccaggggt gaagcgtctc
     3001 cagccacaaa ggagaggttt gccttagacg gaagatggct gtcaacttgt tttagcgaca
     3061 tggatacaga tgaggagtca gaacagcttc gagggtccaa aagaacaggc gatggcttcc
     3121 catttgaaga agaaagcccc agtaaattcc gtatggttga agaatcatct ccacaagtgt
     3181 cttctatatt tcagagtctg aggttgaata acttaactcg cagacaactt ttcaaaccct
     3241 ctgacaatca agaaacagct aagtcaggtg tggtggatca caccaataat gccagcaatc
     3301 aggagactga gccctgagga ttgtgagttc aagaccagcc tgggcagtat cacaagaccc
     3361 tgttcagacc ataccaccac ccacaaaagc ctcaaaacag aaaaaaaata tttacttcgt
     3421 gttgctcaag aaattttttt tttacctctt tcaagacaag atgaacattt tagcttcaaa
     3481 gtttcaagct atgagagggc agccaacact gggcatttta gtttggggca tttgtatttt
     3541 gggcacatga cccaaaataa gatttttatg ttatttttaa acctgagttt gaaagcagat
     3601 attttaaatc cacccaatcc aagcaaactg tgaggatttc agcctccgtc ctcatgagag
     3661 cagtgaatag gggacgtagc tgggggaaag ttctgcttga aacactccca tgttaggggc
     3721 tgctggacct tttgtgataa tgccacgtga tcactgtgga tcccctctgc cagcgccctg
     3781 aaccagcaaa ggtggactga tcgtacctgc tgatggtaac acatttaagt ttgtcacagc
     3841 atccctgccg tgatgctgtg gccgtcactc catcccggcg cctgggactc ggtgcacttg
     3901 ggacttggat atgcctttct gagttgggag tgagttttgc atatatccca ttgtaggggg
     3961 gctttctctt aaagcagatg atttttaagt atttattgcc aagtggtact gtgaaggtgt
     4021 ctccccagcc ctgtgtgggt tttaccgtgg cagtggatgc ctggtcaaag tggctttttg
     4081 ctgtcttgag tcctcttggc cgttgttgct gtgggagggc ctcactagat gtgtatacct
     4141 tgtctttcca gccctctgat tacagttctt agtaggttgc ttataagtta tccctctcca
     4201 acagctcagg tcatggaaac ttctagccag tgtgtgcaca tcatgtgctt ttttatatac
     4261 tctgctgttt acctcttgga ctgtcagaat agtacaaaga gaatttttct atctttcctc
     4321 cttctttttg tgctgggact gaagccaagg actcgtgcct gctaagaaag cactttactg
     4381 ctgactttca ttcctggtcc taaacatgac ttttatatgt accaggaagt aaacagaacc
     4441 aatcatgtta tccatctgat tgtaactttg tttttattgt tgtac
//
