LOCUS       XM_006248443            9163 bp    mRNA    linear   ROD 11-JUN-2023
DEFINITION  PREDICTED: Rattus norvegicus heart development protein with
            EGF-like domains 1 (Heg1), transcript variant X1, mRNA.
ACCESSION   XM_006248443
VERSION     XM_006248443.4
DBLINK      BioProject: PRJNA677964
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_051346.1) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            [WARNING] On Feb 3, 2024 this sequence was replaced by
            NM_001427854.1.
            
            On Jan 21, 2021 this sequence version replaced XM_006248443.3.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_015227675.2-RS_2023_06
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 06/06/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..9163
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN/NHsdMcwi"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /sex="male"
                     /tissue_type="kidney"
                     /geo_loc_name="USA: Wisconsin, Milwaukee, Medical College
                     of Wisconsin"
                     /collection_date="2019-03-08"
                     /collected_by="Rebecca Schilling"
     gene            1..9163
                     /gene="Heg1"
                     /note="heart development protein with EGF-like domains 1;
                     Derived by automated computational analysis using gene
                     prediction method: Gnomon. Supporting evidence includes
                     similarity to: 59 ESTs, 2 Proteins, and 100% coverage of
                     the annotated genomic feature by RNAseq alignments,
                     including 85 samples with support for all annotated
                     introns"
                     /db_xref="GeneID:689710"
                     /db_xref="RGD:1564641"
     CDS             154..4398
                     /gene="Heg1"
                     /codon_start=1
                     /product="protein HEG homolog 1 isoform X1"
                     /protein_id="XP_006248505.1"
                     /db_xref="GeneID:689710"
                     /db_xref="RGD:1564641"
                     /translation="MATPRAPRWPPPPLLLLLLLPLLLLRPAASGAQSPLPSPAHRTL
                     LRAAGPLSPPGAGHTVPGPGVATRRGRSGRVPRGVSAATARNHWPERNNTEPHMGYTP
                     VYQSQEDHLGSRKGVTAQTARMSHSSSEAPENPSLLSETSAEWRTMSSGRADIAALQL
                     GSSPKIATARTAPSSLSSLENLPQPHSSSRSQRRIPSSQTESETSPGFPERTRQEGTV
                     HTQVAGTWVSSRTSVPALETGEPTVLSQERDSSGQEYSGPPFSWTQSHPPPSDHPSSS
                     GSMRNGNNFTALQNPSITQTKSMLITDTFTNGVPRTPRSLPVSVEPTNETEGFPERSR
                     LAITSVSVHSSPSAKDSRTDSRLTEHLGDGEGAELFTENGYGFPSIRWQSDAPSFGGH
                     QLASSSEAGNGRTVPLTETGSKSVSSIDSGESSEPWFPAKNRTSTDMAGSSALHPEAG
                     GPWGLTQSSLDARQPQGGASGLGGRSYAESSSSSSTSSSESLDSPAPGRAHSTPEDGA
                     LLSDSSALADSTSGARAPHTSAMFTRSGERTQRSLDLSRAATRSARPTPRGNVTEHAG
                     LLSGPPTLGVTGLSYTQEHGSDAGQRTSSDHTDHAYVPSTFTKGERTLLSITDNTSYS
                     EAGESSTSSIKISDSTHLDSPSQAQPKQSSQSSYNGEPAQSSTESPVLPTSSLPPHTP
                     TVNMPNTSVLDTSTEPVEDPSDSGVPSMPPSPSQPQPFSSALPSTGSPIQQLKSTSET
                     ATSSPSASPVSLMVSTLVPYPVSQTTFTHLSSTLAPHQAREPRVTSVQMSTTVAAVVL
                     IPSNQTADPKNQSTPQQEKPITGAKSPSFVSPPTDSTRAVTVSLPPGAPGAPALTGFS
                     TEPALPATSTSLAQRSPALTSTMSHTTTNSPVTSPSTPSRVEALTPDPVAVHTTPKKQ
                     YLPTNPEILVPQISTKGAITTEGNQGYTDPTTHSIPLTTSTIPAEEMITEIGHAEESS
                     PVSHFLRPSSPQTTDVSTAEMLTFKYTTFAAQSTLQSPTALSPLTPVHSCPVNPCLHD
                     GKCIVDLAGRGYRCVCPPAWQGENCSVDVNECHSSPCPPLAVCNNTQGSFTCRCPVGY
                     QLEKGICSLVRTFVTEFKLKKTFLNTTAENHSSTHELEKELAQTLNVCFSTLPGYIRT
                     TVGASREPSTVVISLQTTFVLASNVTLFDLADRIQKYVNSCRSSAEVCQLLGSQKRVF
                     RAGSLCKRKSPECDKETSICTDLDGVALCQCKSGYFQFNKMDHSCRACEDGYRLENET
                     CMSCPFGLGGLNCGNPYQLITVVIAAAGGGLLLILGLALIVTCCRKSKNDISKLIFKS
                     GDFQMSPYAEYPKNPRSQEWGREAIEMHENNGSTKNLLQTTDVRSPTNVRNPELERNG
                     LYPAYTGLPGSRHSCIFPGQYNPSFISDESRRRDYF"
ORIGIN      
        1 ccgggctgat tggcgtgtgg cagcaacggg gccgcctccg ccctcccgcg gctcgcacaa
       61 cttttgcggc tgagagcgcg ctcgcatccc gctccgctcg ccgccgccct ccgcccggca
      121 cccggcatgt gagcgcgggc ggccgccgcc accatggcca cgccgcgcgc cccgcggtgg
      181 ccgccgccac cgctgctgct gctgctgctg ctaccgctgc tgctgctgcg gcccgccgcc
      241 tccggggcgc agagcccgct tccctccccg gcccaccgta cactcctccg ggccgcgggg
      301 ccgctttcgc cgcctggcgc tggacacacg gtccccgggc ccggcgtcgc gacccggcgg
      361 ggacgttccg gacgtgtccc cagaggcgtg agcgcggcca ctgcaaggaa ccattggccg
      421 gaaagaaaca acactgaacc ccacatggga tacacccccg tttatcagag tcaagaggac
      481 catctgggtt ccagaaaggg agtgacagct cagactgcca gaatgagtca cagttcctca
      541 gaagccccag aaaacccctc tctcctctct gaaacaagtg ctgagtggag gaccatgtct
      601 tccggcagag cagacatcgc ggctctgcaa ctcggatcct cgcccaagat cgccacggcg
      661 cggaccgccc ccagcagctt gtcgtccttg gaaaaccttc ctcagccaca cagcagttcc
      721 aggtcccaaa gaagaatccc ctcttctcaa acagagagtg aaacatcccc aggcttcccg
      781 gagaggacca ggcaagaagg gactgtgcac acacaagtgg ctggcacctg ggtttccagc
      841 cgcacctccg ttcctgctct ggaaactggg gagccaactg tactctccca ggagagagat
      901 tcatctggcc aggaatactc cgggccacca ttctcctgga ctcagagtca ccctcctcct
      961 tcagaccacc cctcgtcttc tggaagtatg aggaatggga ataacttcac cgctctccaa
     1021 aacccatcaa tcacccagac aaagagcatg ctcatcactg acacattcac caatggcgtc
     1081 ccaagaacgc cccggtctct gcctgtcagt gtggagccta caaacgagac agagggcttc
     1141 cccgagcgct cccgacttgc tataacttca gtgtcggtcc actcttcgcc ctctgcgaag
     1201 gactcaagga cggacagcag actaactgag catctgggag atggagaagg tgctgagctg
     1261 tttacagaaa atggatatgg cttcccatct atacgctggc aaagtgatgc cccctccttc
     1321 ggaggacacc agctcgccag cagctccgaa gcaggaaatg gaaggaccgt gcctctgact
     1381 gagactgggt ctaagtcagt ctcctccatt gatagtggag agagctcaga accatggttc
     1441 cccgccaaga acagaacatc tacagatatg gcaggaagct cggctttgca tccagaagct
     1501 gggggtcctt ggggtttgac tcagtcctca ctcgatgcac gacagccgca aggtggtgcc
     1561 tcggggttgg gtgggaggag ctacgcagag tcttcatctt cttcatctac atcttcttcc
     1621 gagagtctgg attccccagc acctggaaga gcgcattcaa ctccggaaga tggtgcgttg
     1681 ctaagcgaca gctccgctct ggcagacagc acttcggggg cgcgcgctcc tcacacatca
     1741 gcaatgttca cccggagcgg ggagcgcacg cagcggtccc ttgacctctc gcgtgcagcg
     1801 acccgctctg cacgccccac tccacgcggg aacgtgacgg agcacgctgg cctgctatcc
     1861 gggccaccaa ccctcggagt cactggactt agctacactc aagagcatgg ctcagacgct
     1921 ggacaaagga cttccagcga ccacacagac catgcctatg ttccgtctac tttcaccaaa
     1981 ggagaacgga cgttgctgtc cattacagat aacacttcct actcggaggc cggcgagagc
     2041 tcaacctctt ccattaagat ctcagactct acacacttgg actctccttc tcaggctcag
     2101 cctaagcaaa gtagccagtc ctcctacaat ggtgagcctg ctcagtcttc caccgagtca
     2161 ccggttctgc ctacgtccag ccttccaccc cacacaccca ccgttaatat gccaaacacc
     2221 tcagttctcg ataccagcac cgaacctgtt gaggacccat ctgattcagg ggtgccttca
     2281 atgccgccct caccgtcaca gccccagccg ttctcatcag ccttaccgtc aaccgggtct
     2341 cccatacagc agctaaagtc tacctctgag acagccacgt cctcaccgtc agcttcaccg
     2401 gtctccttaa tggtgtcgac tctcgtccca tatcctgtct cacagacaac tttcacacat
     2461 ctgtcttcca ccctagcccc tcaccaggca agggagccac gtgtgacttc agtccaaatg
     2521 tcaacgacgg tagcagccgt tgtgttgatc cccagcaacc aaaccgcaga ccccaagaac
     2581 cagagcaccc cacagcaaga gaaacccatc acaggagcta agtcaccaag cttcgtgtct
     2641 ccgcccacag actctaccag agcagtaaca gtgagccttc ctccaggggc cccaggggcc
     2701 ccagccttaa cagggttctc cacagagcca gcccttccag ccacaagcac cagcttagcc
     2761 cagaggtctc cagctttgac atccaccatg tcccatacta ctactaactc tcctgtgacc
     2821 agtcccagta ccccgtcacg tgtagaagct ttgaccccag atcctgtagc tgtgcacact
     2881 accccgaaga aacaatacct cccaaccaac cctgaaattc tagtgccaca aatctcaact
     2941 aaaggggcca tcaccacaga agggaaccag ggttatacgg atcctaccac tcactcaatc
     3001 cctctgacca catcaaccat accagcagaa gaaatgatca cggagattgg ccatgcggaa
     3061 gagtccagcc cggtttcaca ttttcttaga ccgtcttcac ctcagaccac agatgtttcc
     3121 acagctgaaa tgttgacttt caaatatacc acctttgctg ctcagagcac cctgcagtca
     3181 ccaacagcac tgtcacctct aaccccagtc cacagctgtc ccgtgaaccc ttgtcttcac
     3241 gacggcaaat gcattgtgga cctcgccggt cgtgggtatc gatgtgtgtg cccgcctgcc
     3301 tggcaagggg agaactgcag cgtggatgtg aacgaatgcc actccagccc ctgtcctccc
     3361 ctggccgtgt gcaacaatac tcagggatct ttcacctgca gatgcccagt cgggtaccag
     3421 ttggagaaag ggatatgcag tctggttaga accttcgtga ccgagtttaa gttaaagaag
     3481 acttttctca atactactgc agaaaaccat tccagcactc acgaacttga aaaggagctc
     3541 gctcaaacat tgaacgtatg tttttcaaca ttgcctggtt atatccgaac tacagtcggg
     3601 gcgtctagag agcccagtac agtggtcatc tcactacaaa ccacctttgt cctggcctcc
     3661 aatgtgacgc tgtttgacct ggctgacagg atccagaaat acgtcaactc ctgcaggtcc
     3721 tctgctgaag tctgccagct cttggggtct cagaagcggg tctttcgagc gggcagcttg
     3781 tgtaagcgga agagtccaga atgtgacaaa gagacctcca tctgcaccga cctggatggc
     3841 gtcgcactgt gtcaatgcaa atctggctac tttcagttca acaagatgga tcactcttgc
     3901 cgagcctgtg aagatggata taggcttgaa aatgaaacct gtatgagttg cccattcggc
     3961 ctcggtggtc tcaactgtgg aaacccctat cagctcatca ccgtggtgat cgcagcggca
     4021 ggaggtggcc tcctgctcat cctgggcctt gcactcattg ttacctgttg tagaaagagt
     4081 aaaaatgaca taagtaaact catcttcaaa agtggggact tccaaatgtc cccatacgcc
     4141 gagtacccca agaatcctcg ctcacaggag tggggccggg aagccattga gatgcacgag
     4201 aacaacggaa gcaccaaaaa cctcctgcag acgacagacg tgcgctcgcc cacaaacgta
     4261 aggaaccctg aacttgaacg caacggactg tacccagcct acactggatt gcccggatca
     4321 aggcactctt gcattttccc aggacagtat aacccatctt tcatcagcga cgagagcagg
     4381 aggagagact acttctgatt ccaggagaca ggggggtccc ccgtttctct gagccacttc
     4441 ccggaatgtc tggcttggaa gactataccg gaagggagta acatgcacta gctcctcaga
     4501 gccatgcttg aggggagtga ccgaggtgga aaggacagat ggatgcggaa ctgcaggcca
     4561 ctcattcagc gctgttgcta ctgtgaacgt ggtcgtgggc cagtaccgag tctctaaatg
     4621 cctggcacgt agaactggat ggcttccgta acagaccact aggcttcact tccaggatcc
     4681 agttttcccc ttgatttgca ctttaataga ttgggcaggg aggctgcaat ttggacacat
     4741 ttccagacta ttccagaaag cctttctttt ccaggatatt tccacaggcc tcggtttggt
     4801 ttgattggca gccaggggct ggcacttatg ttttcctgcc tggcgccttg tgctaaacaa
     4861 cagatggagg tcaacgccac tgtgatggcg tggccaagca gcgcagagta ttttaaggtt
     4921 tctaggttgt cagtgttcat ctccatgcca taaatgagac cgtggcattc gcaaggctca
     4981 gcacaaaact tgttttaagt caaggggaca cataggcttt acaatgtgtt agttttactt
     5041 tcccgagcaa gtatgactaa tcagggcaaa acagcattcc tttggttttc attagaagca
     5101 tccaggtgcc ccttcgtgtg ttccagcagg caatgtcagt caggcaggtc ctacccggag
     5161 ccagagtctg caggctgtag taggagaggc agtcgcaggt gtgtctgagc tagtgtctca
     5221 ccgctggagg gaaagcagtc tgtgtcacag cagagcgtgg cagaggagtg aacctgacac
     5281 gttcccgaac cccagcagaa actgggggct cccccaagaa gaatggggag ctaggaggaa
     5341 gccacaggta agggtgcaca cctgccagcc ttggagccca taaaattatc tgcaaactca
     5401 atggaaactt gtaaccactt agagctattt attcactgaa gagagaactt aatttctctc
     5461 acccagtcac tgatacatct gtgttcttgt gcagtgttcc cctcaagact ctgttatggt
     5521 ctgagtcagc tctggagaac taaaacctgg ccagctaggg tctgagatct tggtttgggg
     5581 gaaggaagtt ctgtcttttg tttcttgtat tgtgggatcc tgggggcggg agggctgtgt
     5641 ggtgttccat cccctgtggt accatcagca tgtgggatgt cctggttctg gatgaggtga
     5701 agaggtcgaa gcgttatccc caccctgaag ctgggggctc agcagcattt atttctggaa
     5761 atgggacagc tgttggaaat ggttccgtat gtgtttcttt gacgttctct ggttcctcca
     5821 aaatttacaa aggttcccat cctcttttaa gtatacactg tgtcccatgg tctggtgaca
     5881 tgtgtcaccg gtgaactgtc accaatcact ctcaccccct acagcaggac catgaatcgg
     5941 gtgcagagga tttttaacca agtcacattc cttagtacag aggattctgc tgttcctgat
     6001 tgatgctaac ttaaaagttg caaagcactg tcttctcgaa gccgggggtc ttgtttgtgt
     6061 ctctttgggg gaaccaatgg ccccttgtgt ttttgtgagc ccctgtgctt gccttccctg
     6121 agcccagatt cctttcgagg tagccaggtt ctatcccttc cagtagtatt caggcttgtc
     6181 ccaagcctca ttgctgtggg aagagccagt gtgatggctg ttcccagcca cacgtctaat
     6241 gccttcagct agcatcgcag ctggtgagca cctgtgtagg gggcagactc ccagctgggt
     6301 gagcacctgg gtagggggca gactcccagc tgggtgagca cctgggtagg gggcagactc
     6361 ccagctggtg agcagctata tagggccagg aacttccagc cctacagaat gaagtgctct
     6421 gtttctagga agaattccaa catccagaaa agagtcctgt gagttttcca aaaatgcctg
     6481 ctgactcatg agtttggccc aaatagagcg gagtgaaagt gtttttgttt tgttcttttt
     6541 tttttttttt tttaactgtg aaagacacaa ggagagcccc caaacaaggg tgctgttaca
     6601 ctgggtctat agtttgtggg tgggggagga gcttgcagta gaaaggcctc tgcccaccat
     6661 tgggaggagt ggagtgtagg tgctctccta cttggggtta catccagaag ctagcccaga
     6721 gaggacacca gcaacccatg agaaagacag acaggatgag cccatgtctg gacatgcaga
     6781 gtctatggtt ttactcagag tctgtcccca cccctagaac gaataattcg tgtgcataga
     6841 agtgtcacag tcctgaattg gggttccacg atgagggaag tgggcagaaa ggaaaagcta
     6901 cactgcctag gagatgcttg tatggggaag atccaggcca ggtagaactt gtctaccgtg
     6961 gggcattcag gaacagggct aagaaaaggg tttttctgga gctggcctga gcattgtata
     7021 aactccaagg gtttttgatt ttgttgttgt ttgttgtttg attttttttc tttctgcttc
     7081 atgtgttccc accatgggcc aggctttatg caaggtatct ggccttacag cacctgtgtt
     7141 agccaatgat gaacatccag agaagaggca tgggaatgta gcttcgatgg cagagtgctt
     7201 gcctagcagg tacagagccc tgagttttat cctcaggacc gcataaacag ggtgcagtgg
     7261 tacactcttg taatcccagc cctcagaagt ttgaggcagg aggatcagga gttcaaggcc
     7321 ttcctggaga acatggcacc ttgtcttaaa aagggaacta ttggctggtt tgtggttggc
     7381 aagaggcata ttggtatgtg gcgtgggccc tcagaagtga aagggtgtgg tctaggtggg
     7441 gtttttgaca agcacagcca ggccgaggca cccatgtgag ggttgctgcc tcattctcag
     7501 aatgaggcca taacccccaa gtagtagaaa tgtgaacctg tgtgggctgg ggacagagct
     7561 gagtgtctga ggtgctgaat gatcttccta accggggagg ctatttctaa aagcatccaa
     7621 gtcatgttga accagaacta ctatatgatc ggtgcagtca agctgcctgg tggtatttga
     7681 ggtcaaagac taagagctga ctattagact attatggtct aaaagaggaa gtcgtaaaag
     7741 ctggcccata gtagaacgta gcattgttgg gaaaagactg tagttaaagt cttttagaga
     7801 tgctgtgtct attcaagagt gagattccag ggtgggcaca ttagcttttg gatgcccgct
     7861 taagccgctt tgcccagtag tgaagtgtat gggtgtctat aacaatggga ctttgtctaa
     7921 agcaatgaag ctatacagcc aagttgccct tggtttagtg tttcacaacg cactcaaaag
     7981 caggggcttt acccttattt ctaaatttat atcgattttt cttttgagac caaagcactt
     8041 ctttgggagg aagaagaata cgaagttttg tattttgaca ttttatttaa aacagtccat
     8101 aagagcaaat agttgtttat ctacctgaaa gctgtttttc ttcttctgct tctttgggag
     8161 gggagagcct cgcacatacc agacaagtgc cgtcctgtgg cgctgcacac cccggccctc
     8221 tcatttcttc ttgacagtat catcctaagg ttcaccccag cacgtctgga tacgaaaatg
     8281 attctgtagt ttgtctttgg gaatgtgtgt tctttttttc tttccttttc tttttctttt
     8341 tctttttttt ttccctcaaa tccccaaagg ggaaaaacaa taggagcatt gaagttaaaa
     8401 taataacttt aaactttaaa aaaaaaataa ctggttaaaa tcataggaac attaaagtgt
     8461 taaatgccaa ccaattcatt gtacttcagt gtctccatga agtcacacct ctttaggtct
     8521 ggaagcttta acctgcacaa tagcccgtga aacccaaggg ggactgttta ggtctgaaag
     8581 gaggcaggtc ctggcctgcc tctgtcacgt gggcatcttc aaagaaaaca tttccagtga
     8641 ggccgcctgg tagattgtgc tataatttta aatgatggtc tcaatgtcct tgacctgact
     8701 tgttgaggac agggtgaaaa tcggggtggg atggagccac tttgtcaggg gaaactgaac
     8761 ccactccctt aactttctct ctacagagag aaggatagtt caccacgagc tgctgtgagt
     8821 tttggtgact tctatgtgtg ttgctggtgt tacaggtcaa tggagatgag gctgcagtac
     8881 aaactctgtt ccgtttgtcc tggattttgt tctgtatacc tttaatgctg acacctgcgg
     8941 gttgactgtg cgagacccat catgagaatg ttatttaaag ttgtattata atgtcacctc
     9001 cactaattat tcagtactgt agcagcaatg tattatttgt aagaatttgg ttatttttat
     9061 acttatatcc actctaagtc tggcgttcta gtcagcaaaa aaaaaaaaaa aaatgcaata
     9121 aaattagtaa ggttcccatt ggttttctct taaaacaagc aaa
//
