LOCUS       NM_001108218            5296 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus HECT, C2 and WW domain containing E3 ubiquitin
            protein ligase 2 (Hecw2), mRNA.
ACCESSION   NM_001108218 XM_001062004 XM_237139
VERSION     NM_001108218.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5296)
  AUTHORS   Lu L, Hu S, Wei R, Qiu X, Lu K, Fu Y, Li H, Xing G, Li D, Peng R,
            He F and Zhang L.
  TITLE     The HECT type ubiquitin ligase NEDL2 is degraded by
            anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight
            regulation maintains the metaphase to anaphase transition
  JOURNAL   J Biol Chem 288 (50), 35637-35650 (2013)
   PUBMED   24163370
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473965.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_237139.4, XM_001062004.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132303, SAMD00132306
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..5296
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q31"
     gene            1..5296
                     /gene="Hecw2"
                     /note="HECT, C2 and WW domain containing E3 ubiquitin
                     protein ligase 2"
                     /db_xref="GeneID:316395"
                     /db_xref="RGD:1593244"
     exon            1..331
                     /gene="Hecw2"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..4776
                     /gene="Hecw2"
                     /EC_number="2.3.2.26"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase HECW2"
                     /protein_id="NP_001101688.1"
                     /db_xref="GeneID:316395"
                     /db_xref="RGD:1593244"
                     /translation="MASSAREHLLFVRRRNPQMRYTLSPENLQSLATQNSMPENMALQ
                     RANSDTDLVTSESRSSLTASMYEYTLGQAQNLIIFWDIKEEVDPSDWIGLYHIDENSP
                     ANFWDSKNRGVTGTQKGQIVWRIEPGPYFMEPEIKICFKYYHGISGALRATTPCITVK
                     NPAVMMGAEGMEGCASGSLHSRKLVSFTLSDLRAVGLKKGMFFNPDPYLKMSIQPGKK
                     SSFPTCAHHGQERRSTIISNTTNPIWHREKYSFFALLTDVLEIEIKDKFAKSRPIIKR
                     FLGKLTIPVQRLLERQAVGDQMLSYNLGRRLPADHVSGYLQFRVEVPSSAQEDASPEA
                     VGTILGVHTVNGDLGSPSDDEDMPGSHHDSTICANGPVSEDSVADGTPKHSFRTSSTL
                     EIDTEDLISTSSRNSPPRGRQDSLNDYLDAIEHNGPSRPGTASSSERPMGASPKLRSS
                     FPTDTRLNAMLHIDSDEEDHDFQQDLGYPSSLEEEGGLIMCSRTSRIDDGSLTSQTKP
                     EDDNPVENEDASVHETASLEERPENLPEVEDGSLPSGTAPDENEASVEPQPSADQGST
                     ELCSSQEVDQPTSGTDAGASDTSVGSRRAASETESLDQGSEPSQVSSETEPSDPARTE
                     SVSEASTRPEGESDLEGADSSCNESVTTQLSSVETRCSSLESARFPETPAFSSQEEED
                     GACAAEPTSSGPTEGSQESVCTPGSLPAVQVPSREEEGSGAEATALSEQGELGEVWQR
                     RGSLEGAAAAATAAATDSQPQEDGDPGDTQGACEGATAQEEGATGGSQTNGHQPLRSL
                     PSVRQDVSRYQRVDEALPPNWEARIDSHGRIFYVDHVNRTTTWQRPTAPPAPQVLQRS
                     NSIQQMEQLNRRYQSIRRTMTNERPEENTSAIDGAGEEADFHQASADFRRENVLPHST
                     SRSRLTLLLQSPPVKFLISPEFFTVLHSNPSAYRMFTNNTCLKHMITKVRRDTHHFER
                     YQHNRDLVGFLNMFANKQLELPRGWEMKHDHQGKAFFVDHNSRTTTFIDPRLPLQSSR
                     PTSALVHRQHLTRQRSHSAGEVGEDSRHAGPPVLPRPASTFNTVSRPQYQDMVPVAYN
                     DKIVAFLRQPNILEILQERQPDLARNHSLREKIQFIRTEGTPGLVRLSSDADLVMLLS
                     LFEEEIMSYVPPHALLHPSYCQSPRGSPVSSPQNSPGTQRANARAPAPYKRDFEAKLR
                     NFYRKLETKGYGQGPGKLKLIIRRDHLLEDAFNQIMGYSRKDLQRNKLYVTFVGEEGL
                     DYSGPSREFFFLVSRELFNPYYGLFEYSANDTYTVQISPMSAFVDNHHEWFRFSGRIL
                     GLALIHQYLLDAFFTRPFYKALLRILCDLSDLEYLDEEFHQSLQWMKDNDIHDILDLT
                     FTVNEEVFGQITERELKPGGANIPVTEKNKKEYIERMVKWRIERGVVQQTESLVRGFY
                     EVVDARLVSVFDARELELVIAGTAEIDLNDWRNNTEYRGGYHDNHIVIRWFWAAVERF
                     NNEQRLRLLQFVTGTSSIPYEGFASLRGSNGPRRFCVEKWGKITALPRAHTCFNRLDL
                     PPYPSFSMLYEKLLTAVEETSTFGLE"
     exon            332..439
                     /gene="Hecw2"
                     /inference="alignment:Splign:2.1.0"
     exon            440..534
                     /gene="Hecw2"
                     /inference="alignment:Splign:2.1.0"
     exon            535..610
                     /gene="Hecw2"
                     /inference="alignment:Splign:2.1.0"
     exon            611..780
                     /gene="Hecw2"
                     /inference="alignment:Splign:2.1.0"
     exon            781..923
                     /gene="Hecw2"
                     /inference="alignment:Splign:2.1.0"
     exon            924..1024
                     /gene="Hecw2"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..2395
                     /gene="Hecw2"
                     /inference="alignment:Splign:2.1.0"
     exon            2396..2491
                     /gene="Hecw2"
                     /inference="alignment:Splign:2.1.0"
     exon            2492..2642
                     /gene="Hecw2"
                     /inference="alignment:Splign:2.1.0"
     exon            2643..2746
                     /gene="Hecw2"
                     /inference="alignment:Splign:2.1.0"
     exon            2747..2871
                     /gene="Hecw2"
                     /inference="alignment:Splign:2.1.0"
     exon            2872..3057
                     /gene="Hecw2"
                     /inference="alignment:Splign:2.1.0"
     exon            3058..3192
                     /gene="Hecw2"
                     /inference="alignment:Splign:2.1.0"
     exon            3193..3295
                     /gene="Hecw2"
                     /inference="alignment:Splign:2.1.0"
     exon            3296..3392
                     /gene="Hecw2"
                     /inference="alignment:Splign:2.1.0"
     exon            3393..3476
                     /gene="Hecw2"
                     /inference="alignment:Splign:2.1.0"
     exon            3477..3586
                     /gene="Hecw2"
                     /inference="alignment:Splign:2.1.0"
     exon            3587..3707
                     /gene="Hecw2"
                     /inference="alignment:Splign:2.1.0"
     exon            3708..3821
                     /gene="Hecw2"
                     /inference="alignment:Splign:2.1.0"
     exon            3822..3974
                     /gene="Hecw2"
                     /inference="alignment:Splign:2.1.0"
     exon            3975..4073
                     /gene="Hecw2"
                     /inference="alignment:Splign:2.1.0"
     exon            4074..4203
                     /gene="Hecw2"
                     /inference="alignment:Splign:2.1.0"
     exon            4204..4350
                     /gene="Hecw2"
                     /inference="alignment:Splign:2.1.0"
     exon            4351..4465
                     /gene="Hecw2"
                     /inference="alignment:Splign:2.1.0"
     exon            4466..4551
                     /gene="Hecw2"
                     /inference="alignment:Splign:2.1.0"
     exon            4552..4664
                     /gene="Hecw2"
                     /inference="alignment:Splign:2.1.0"
     exon            4665..5296
                     /gene="Hecw2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagctttgt aggaaaacaa cctcagagag gcagacagga tggcaagctc agcccgggag
       61 catttgcttt ttgtgcggcg tcgaaatcca cagatgcggt acacactgag cccagagaac
      121 cttcagagcc tcgcaaccca gaactcaatg cccgagaaca tggccctgca gcgagccaac
      181 agtgacaccg acctcgtgac ctccgagagc cgctccagcc tgactgccag catgtatgag
      241 tacacactgg ggcaagccca gaacctcatt atcttctggg acattaagga agaggttgac
      301 cccagcgatt ggatcggact ctatcacata gacgagaatt ctccagccaa cttctgggat
      361 tctaaaaaca ggggcgtgac tggaacccaa aaaggacaaa ttgtatggcg gattgagccc
      421 gggccctact tcatggaacc ggagatcaaa atctgtttca aatactacca tggcattagc
      481 ggagccctgc gagccacaac cccctgtatt actgtgaaga acccggctgt gatgatgggt
      541 gcagaaggca tggaaggatg tgcttcagga agcctgcact ctaggaaact cgtcagcttc
      601 acattgtcag atctcagggc agttgggctc aagaaaggga tgttcttcaa tcctgaccct
      661 tatcttaaga tgtccattca gccagggaag aagagcagtt tccctacctg tgcccaccac
      721 gggcaggaga gaagatccac tatcatcagt aacaccacca atccaatctg gcacagagag
      781 aaatactcct tttttgcact tttgaccgat gtcttagaaa ttgaaatcaa agacaaattt
      841 gccaagagcc ggcccatcat caaacgcttc ctgggaaaat taaccattcc agtgcagagg
      901 ctgttggaga ggcaggctgt cggtgaccag atgctcagct acaaccttgg cagaaggctc
      961 cccgctgatc acgtgagtgg ctacctccag tttagagtgg aagtcccatc ctctgcccag
     1021 gaagatgcat ctccagaggc cgttggcacc atcctcggtg tccacactgt gaatggagac
     1081 ctgggcagcc cttctgatga tgaggacatg ccagggagcc atcatgacag caccatttgt
     1141 gctaacgggc cagtgtctga ggacagtgtt gctgacggaa cccccaagca ttctttcagg
     1201 actagctcta ccctggagat tgacacagag gacttgatct ctacttcttc aagaaattca
     1261 ccccccaggg gccgccagga ttcactcaat gattacttag atgctattga acacaatggc
     1321 ccctctaggc cagggacagc ctcctcctct gagcggccca tgggagcctc tcccaaactg
     1381 aggagtagtt ttcccactga caccagactc aatgcgatgc ttcatataga ctcagatgaa
     1441 gaagaccatg attttcagca agacctaggc tacccatcct ccttggagga ggaaggaggc
     1501 ctgatcatgt gcagcaggac atcgaggatc gatgatggga gcctgacgtc tcagaccaaa
     1561 ccagaggatg acaaccctgt tgagaacgag gatgcctccg tacatgaaac tgcttcctta
     1621 gaggagaggc cagagaatct tcccgaggtt gaagatggct ccttgccgtc aggtacagcc
     1681 cctgatgaaa atgaagccag cgtagagcct cagcccagtg ctgaccaggg cagcactgaa
     1741 ttgtgtagct ctcaagaagt cgatcagccc acaagtggca cggacgcagg agcttctgac
     1801 acatctgtag gaagccgcag agctgccagt gagactgagt ccctggacca gggatccgaa
     1861 ccttcccagg tgtcctctga gacagaaccc agtgaccctg caaggacaga gagtgtgagt
     1921 gaggccagta ccagacccga gggagagagt gacctggaag gtgcagacag ctcatgcaat
     1981 gagagcgtga ccacacagct gtcctccgtg gagacacggt gctcatctct agagagtgca
     2041 cgatttccag aaaccccggc cttttcttct caggaagagg aagatggggc ctgcgcagct
     2101 gagccgacca gcagcggccc cacagagggg tcgcaggagt ctgtctgcac tcccggttct
     2161 ttacctgctg tgcaggtgcc cagcagggaa gaggaagggt cgggggctga agctactgct
     2221 ttatctgagc agggggagct gggggaggtc tggcagagga ggggcagtct tgagggagca
     2281 gctgctgctg ccactgctgc tgccaccgat agccagcccc aggaagacgg ggatcctggt
     2341 gatacacaag gtgcctgcga aggggccacc gctcaggagg agggcgccac tggaggttct
     2401 caaaccaatg gccatcagcc cttgaggtca ctaccttcag tgcgccagga cgtcagccga
     2461 taccagaggg tggacgaggc tctcccacca aactgggaag cacgtattga cagccacggc
     2521 agaatcttct acgtggacca tgtaaacaga accacgacgt ggcagcggcc tacagctccc
     2581 cctgccccac aggtcctgca gagatctaac tccatacagc aaatggagca gctaaaccgg
     2641 cgttatcaga gcatccgcag aaccatgacg aatgagaggc ctgaggaaaa taccagtgct
     2701 atcgatgggg caggggaaga agccgacttt caccaagcca gcgcagactt ccgtcgggag
     2761 aacgtcctgc cccactctac ctccagatcc aggctcacgc tgctgttaca gtcgccccct
     2821 gtgaagttcc tcatcagccc agagttcttc accgtgctgc attctaaccc tagtgcctac
     2881 cgcatgttta caaacaacac gtgtttgaag cacatgatca ccaaagtccg gcgggacacc
     2941 caccactttg aacgctatca gcataacagg gacctcgtgg gattcctcaa catgtttgct
     3001 aacaaacagc tggaactacc aaggggctgg gagatgaaac acgatcatca gggcaaggca
     3061 ttttttgtcg accacaactc ccgaaccacc acgttcattg atcctcggct cccacttcag
     3121 agcagtaggc ccacgagtgc gctggttcat cgacaacacc tgacgaggca acgcagtcac
     3181 agcgcgggtg aggtaggaga agactctcgg catgcaggac cacccgttct tcccaggcca
     3241 gccagtacat tcaatacggt cagtaggcca cagtaccagg acatggttcc agtggcctac
     3301 aatgacaaaa ttgttgcgtt tttgcgtcaa cctaacatcc ttgaaattct gcaagagcgt
     3361 caacctgatc ttgccagaaa ccactcactc agggagaaga tccaatttat ccgaactgaa
     3421 gggacccctg gattggtgcg gctctcaagt gatgcagatc ttgtcatgtt actgagctta
     3481 tttgaggaag aaataatgtc atatgtgcct cctcatgcct tactccaccc cagctactgt
     3541 cagtccccgc gtggctcccc tgtgtcatct ccccagaatt caccaggtac tcagcgtgcc
     3601 aatgcccggg ctcctgcacc ttacaagaga gattttgaag ccaaactaag gaacttttat
     3661 aggaagttag aaactaaagg atacggacaa ggcccaggaa aattaaagtt aattatccga
     3721 agagaccact tgctggaaga tgcttttaat cagattatgg gctactccag aaaggacctg
     3781 cagaggaata aactgtacgt cacctttgtc ggggaggaag ggttggatta cagtgggcct
     3841 tccagagagt ttttcttcct ggtatcccga gaactcttta acccctatta cggcttattt
     3901 gaatattcag ccaatgacac atacacagta caaataagtc ctatgtctgc ctttgtagac
     3961 aatcatcatg aatggtttcg attcagtggg aggatcctcg gtcttgcact aatacaccag
     4021 tacttgttgg acgccttctt tacgcgaccc ttctataagg ctcttctcag aatcctgtgt
     4081 gacctgagtg atctggaata ccttgatgag gagttccacc agagccttca atggatgaaa
     4141 gacaatgaca tccatgacat cctagacctc acgttcactg tgaacgaaga agtttttggg
     4201 cagattactg aacgagagtt aaaaccaggg ggagccaata ttccagtgac ggagaagaac
     4261 aagaaggagt acattgagag gatggtgaag tggaggattg agaggggcgt ggtgcagcag
     4321 acagagagct tagtccgcgg tttctatgag gtagtagatg ccaggctagt gtctgtcttt
     4381 gatgcaagag aactggagct ggtcattgct ggcacagctg agatagatct caatgactgg
     4441 aggaacaaca ctgaatacag aggcgggtac catgacaatc acattgtaat tcggtggttc
     4501 tgggctgcag tagaacgatt caacaatgaa caacgactaa ggttgttaca gtttgttaca
     4561 ggcacatcta gcattcccta tgaaggattt gcttctctcc gagggagtaa tggtccaaga
     4621 agattctgtg tggaaaaatg gggaaaaatc accgctcttc ccagagctca cacgtgtttt
     4681 aaccgcctgg atctccctcc atacccttcc ttttccatgc tttatgaaaa actcttgaca
     4741 gcagttgaag agaccagtac cttcggactc gagtgaccca gaagcacgat gctcagtgct
     4801 ttacggacag gcagttccag aagccggcct cccatagagt gacccagcat tggtagtctc
     4861 ggagccttgg ctttcattac gacaaactga gcgctgctct ctgggaacac atgctcctgt
     4921 gtttggggac tggctgtgag ttcttttgga aggattgggg tgagcttggt gcccatggaa
     4981 caacccaaca gtctttcaat caacagttct tgactgccaa acctttccca tttgtcccca
     5041 tgttccgaga aaaagatgaa cctgcacacg atcaactcca tggtgacttt tagggactcc
     5101 ggagaatctt tcaactctcc cgtaaacaca cttcaagcca aactggcagc actgacccaa
     5161 tctctaaatt tgcgcaagtg aaagaatatc attaaaaaat atatatattt cctggaagta
     5221 catttgttta agccctaagt tatagcagaa tatttatttc ttgcttatga gtgcctgcat
     5281 ggtgtgcaca acaggt
//
