LOCUS       XM_039089878           15455 bp    mRNA    linear   ROD 11-JUN-2023
DEFINITION  PREDICTED: Rattus norvegicus HECT domain E3 ubiquitin protein
            ligase 4 (Hectd4), transcript variant X7, mRNA.
ACCESSION   XM_039089878
VERSION     XM_039089878.1
DBLINK      BioProject: PRJNA677964
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_051347.1) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            [WARNING] On Feb 22, 2024 this sequence was replaced by
            XM_039089878.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_015227675.2-RS_2023_06
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 06/06/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..15455
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN/NHsdMcwi"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /sex="male"
                     /tissue_type="kidney"
                     /geo_loc_name="USA: Wisconsin, Milwaukee, Medical College
                     of Wisconsin"
                     /collection_date="2019-03-08"
                     /collected_by="Rebecca Schilling"
     gene            1..15455
                     /gene="Hectd4"
                     /note="HECT domain E3 ubiquitin protein ligase 4; Derived
                     by automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 48 ESTs, 1 Protein, and 100% coverage of the annotated
                     genomic feature by RNAseq alignments, including 155
                     samples with support for all annotated introns"
                     /db_xref="GeneID:304503"
                     /db_xref="RGD:1309762"
     CDS             237..13493
                     /gene="Hectd4"
                     /codon_start=1
                     /product="probable E3 ubiquitin-protein ligase HECTD4
                     isoform X7"
                     /protein_id="XP_038945806.1"
                     /db_xref="GeneID:304503"
                     /db_xref="RGD:1309762"
                     /translation="MGSSAAAAAAAAAAAADSAQWLSVKEETIFLHDGLIRVTDLAEL
                     PSEILGAPEAADTDLEILTFETKNPTELAERLRSVCGNQSNAYARLLEYRLNALRGLW
                     NAQRQLALEEQHEREGSGDEETLALLKRQGLLQQPEQAPFTSRVGLLLVFPLIQSQSR
                     TDPSLCNITAEVLLNCLRDCQPLSLTKEPADCLSGIETLLCSWLEETSDTGRHIPHKQ
                     KENAAAALVALACARGSLKTFVHTVHLLQRQTELGSLPVADVLYRLLLLEGGPGSPSC
                     LLGGKHIVSWGYEDMLPAPDSNPGSSSENKDADLGRCLTADGHYLYTTNSAGRGLSKL
                     GSGLHGTLRGFVYCRNEELEPGWVAYGSGHLLHRPVSFDNKPHSLFQVIDQNTLQVCQ
                     TVPMPASPLPVGSTMSTVHLSSDGTYFYWIWSPASLNEKTPKGHSVFMDIFELVVENG
                     VFVANPLQERTILMRKEGESAKSINEMLLSRLSRYRASPSATLAALTGSTISNTLKED
                     QAANTSCGLPLKTLRRTPMYTCGTYLVMLVPPPGGSGSSATRSLFGGTSGLSSLKILA
                     SSLVYNISDGQFASRADLIDAAGSSLGRGALVPGLGACYDTVNNMLWTCSNDYIDQWC
                     NPGNQAFHYVCQRLGVSHIIPEPKEEAISTNEVINQLLHHVGAMCIHQLNLLATNPNL
                     PITSVLGKQHPIEARHLSSICDIMEKAMVNGDTCIVRCILVVFQVVFKFFFSPQTERN
                     RDIIRRSGLLLWQLLMAPKDQICPEIQKEVCLAISSGLNILYPGETEINNLLKLVLTE
                     GERNSGLSQLRDVILTNLAEQLQNNRFGSDEDDHYRLNDELLHYILKIVVRESCILIT
                     KCQTVSKDDFQKLLSTVPAASSCLRYLMAVQNHLLSNTVLIKPDDNEDSDSSLQGETL
                     KVQELKTSILALATQVLTGCDEVLEMLQQVTTALINSDMPDREQRLKGLEQVTKATML
                     GHLLPVLLTSLMHPNLQTLTMADALMPQLVQLVLYTSQTALLLKTQCPVFAEVGCSPC
                     GTSDQKCRLFPDERMLEEKEEPGFLTGLKIPAPWAAGKTVETVHPVRDNYKFKETVHI
                     PGARCLYLRFDTRCSSQYDYDKLVIYAGPNTNSRKVAEYGGNTLGYGSRSVLGTGWPK
                     DLVKVEGDTVTFSFEMRSGREHNTPDKAMWGFACTVRAQESSEDVSGGLPFLVDLALG
                     LSVLACSMLRILYNGPEITKEEEACQDLLRSKLLQRCQWQVEANGVISPALTPSPSPL
                     PLTIEEDREFTYPSDVLVPPVGNYFDLPRIRLPPGIMIKLREISGRARPQFRPSIKEV
                     IQPDVMEEMVVSCVIKHLNLVDALQSLINFQYQEEHAEEYDLLCKIMGETFKKLNAME
                     RQLQSVAELEQKWQSEAEDAMQGKLENNMPFFYDYHFNENKMKELELLCSMKEVSFDG
                     NDLENMVLSLREKFLQEVNSLTQKPSHPLAKTKTLVKSLMNRAELLLHVTIAAQSGLT
                     RSISGTPAETPACKSASETKVASHAVRQPVFLRSMSAPSDLEMIGNEDLEFTRANQRR
                     RHVTSHRSSSFTLLQSLAIEDSRDKPTYSVLLGQLFAFIGTNPDQAVSSSSFLLAAQT
                     RWRRGNTRKQALVHMRELLTAAVRVGGVTHLVGPVTMVLQGGPRIEELTCGGMVEQVQ
                     EAFGETMTSVVSLCARYPIACANSIGLLCTIPYTRSEEKCLVRSGLVQLMDRLCSLSS
                     QTESSSSEKQTKKQKVATMAWAAFQVLANRCVEWEKEEGGSTEAVHSGLARQVSSLLT
                     NHLARATECCGNQAAGNDALQDVLSLLNDLSRSHIGKAILSQPACVSKLLSLLLDQRP
                     SPKLVLIILQLCRAALPLMSVEDCGNVELPPWSYSVPSLNSEQEDPSDPASKIASLLL
                     AKLADYVVPGCQTVLSPTASEPDTTLTKTSPKNSLKGDKDPGEESEAVDGKLSIFIHK
                     REDQSSHEVLQPLLSSSEGRPFRLGTGANMEKVVKMDRDMTKGGCCEVITEEASAALR
                     KATKWAQSGLIVSVGPPVESINPETVSGLSTGDKKKTAQTSICRERNSELARTDPVRP
                     FISGHVANSMAAEVIALLHSLLMAPESNAAQIWTTTAEKVLSRALMYIPQLGKYAESI
                     LENGSSSGRKLAKLQRIARQAVAALCALGGFKETIKIGSEVQVLGRGISGSIGVVASI
                     NEQEGIATVRFPPVDCRRTSQAADTLTIPLSRLCVPRSEALPLHKLSITEKVVQAVQS
                     MLLPQEGSLSIHTSLPATGDGSAPVMAVVRLLAEIRTRACLVMAQLLEDSLFCEEFIQ
                     QCPAAVEVLNLVAQECSAGERLAVVEVQCERLRMLYRDCARPPPPPLQADRRQPKEIT
                     WSPSRVFPPVRACMFSSHLTSVTFLADPSAGGGLPRGTFIYATSPLPVQAPSFYWEIE
                     IVSYGDTDDDTGPIVSFGFATEAEKRDGAWTNPVGTCLFHNNGRAVHYNGSSLLQWKS
                     VRLDVTLCPGDVAGIGWERTEGTPPPPGQPAKGRVYFTYCGQRLTPYLEDVSGGMWPV
                     VHIQKKNTKTRANFGSRPFAYAEGQAHRNAADLCTDLAEEISANFEALPFAMASDSDN
                     DAGTSIASDPGTHGPPCRIAAVATAQQQYDSDTSCHYKVELSYENFITSGPDPHPPPI
                     ADDESDDDDDDDIPQEDHYALLVKAWETKVFPTIRRRFRNEAERKSGLDQIKGALQLG
                     MVDIARQTVEFLYEENGGIPRDLYLPTIEDIKDEANKFTIDKVRKGLTVVTRSPDSSN
                     VASSAVGTALPKFAIRGMLKTFGLHGVVLDVDSVNELVQVETYLRSEGVLVRYWYPID
                     MLERPPAGYRRTATNGLVTLDNTNLQIHRELLRCEAALARLYCRMALLNIFAPKLPHL
                     FTRLFHIPAIRDITLEHLQLLSNQLLAPPLPDGTISSSSILLAQSLQHCIHSQSCSAT
                     DLFYQGNSQTLREWLSVAITRTLHQGEDSLLELTKQICAFLQTAPEQFPSEEFPVSES
                     KVSMDVNFPGAAFVVVSCKESQSGFRKDSSLYKAPWARVLVYGLGHKVKRTGQLNLIE
                     AACYPRDASPANTGLAPPPTADQYPSVVLSTDKVHIKLGVSPPPGAVLVLHSLPLEFP
                     LAMAFAEQLLSWKSEDSEGKSEDEPDSIPTSVLLHVVELLGNFLWTTDMAACVKELVF
                     HLLAELLRTVHTLEQRKHPAGLSSSIALQLNPCLAMLMALQSELHKLYDEETQGWVSS
                     STCGGSGAAAVGDQGRFSTYFHALMEGCLAVAEVTLPTNISVTASGVTSTTTPNLSDS
                     SSSSSSSPGQTPQSPSLLSKRKKVKMKREKASSSNKRQSSRATDADSTVLSIGGSKPE
                     DMLWFHRALTLLIILRHLTKKDPQGLGVTSDAIADACQALVGPTAHSRLLVISGIPTH
                     LDEAVVRGAIRKACNAHGGVFKDEIYIPLQDEDPKRPKDKAEGGDSKVESEKLLGFPS
                     VDSLEGSTSSSLAPAMSISASASTSQASVCSSQCVSQTASDLSVDPLPSGLELPVPPV
                     LLEPHVVSSQESLDISLCSTGSLGSLGSLGEPLDNPETASVSDVGSMYTVTSLDTQPL
                     TTRPIKGFAVVEIRSRAKIEKVRASLFNNNDLIGLSSLDGEEELMEMSTEEILTVSVV
                     NQSLFDTQGSPGLEDYFNDKSIKGEKLVPGAREVLTEIFKSCAHSEQTLSLTPAKPIR
                     VSDIYLSKEQINSQTPGNLLHLFFTNVRPPKKVLEDQLTQILRKYGVPKPKLDKSKYS
                     KAGKEQHPVKVVSTKRPVTKPPAKDKAVLSSLSRTALSEKKPTVKPKSPEKSKPDEKD
                     PEKSPTKKQEVPEEKYLTLEGFHKFVIDRAKQDIRSVWRAILSCGYDLHFERCACIDV
                     RHAQKASRKWALEMDVALVQYINRLCRHLAITPARLHPHEVYLDPADATDPRMACLSN
                     VPIESLRLRFALLQSLNTTLETFFLPLVELRQTPMYAHSIAALLKEAKGLIFYDTKVT
                     VMNRVLNATVQRTADHAAPEITLDPLETVGGEIRASENSYFCQAARQLASVPSSQLCV
                     KLASGGDPTYAFNIRFTGEEVHGTSGSFRHFLWQVCKELQSSSLSLLLLCPSSAVNKN
                     KGKYILTPSPITYGEEQLLHFLGQLLGIAIRADVPLPLDLLPSFWKTLVGEPLDPDQD
                     LQEADILTYNYVKKFESINDESELEALCAEIASQHLATDSPEGPKPCCRFTYLTMTGE
                     EVELCSRGRHIPVAWENKDIYAAAIRSLRLRELQNMECVTAVRAGLGSIIPLQLLTTL
                     SPLEMELRTCGLPYVNLEFLKAHTMYQVGLMETDQHIELFWGALETFTQEELCKFIKF
                     ACNQERIPFTCPCKDGGPDTAHVPPYPMKIAPPDGTAGPPDSRYIRVETCMFMIKLPQ
                     YSSLEIMLEKLRCAIHYREDPLSG"
ORIGIN      
        1 cgcccccaag atggcgtctt actgacagtt ggctgcggag cggcagaggc ggatcctgct
       61 cgtcagggcg gcggcggcgg cggcggcggc ggggccgggg tctcccgggc cggggttggc
      121 gtgtggaggg atggcggtgc ggaacgccta gggcggagcc gcgcgggcga ggcgggcgcg
      181 gcggtcggcc atgggttgct gaagcggcag ggtctccgca gcgccttctc ttaaccatgg
      241 gctcgtcggc agccgcggcg gcggcggcag cggcggcggc ggcggactcg gcgcagtggc
      301 tctcggtgaa ggaggagacc atctttctgc acgacgggct tatccgggtc accgacctgg
      361 ccgagctgcc cagcgagata ctcggcgccc cggaggccgc cgacaccgac ctggagattt
      421 taacatttga gaccaaaaac ccaacggaat tagcagaacg tttgcgctct gtttgtggga
      481 accagagcaa tgcctatgcc cgcctgctgg aataccgcct gaacgccttg cgtggactgt
      541 ggaatgccca gcgccagctg gccctggagg agcaacacga aagggaaggc tcaggtgatg
      601 aagagacctt ggccctgctc aagcggcagg gcttgctgca gcaacccgaa caagcgccct
      661 tcacgtcccg ggtgggcctc ctgttggtct tccccctcat tcagtcccag agtagaacag
      721 acccttccct ctgtaacata actgctgagg tgctactaaa ctgcctgcgg gactgtcagc
      781 ctctgagcct gaccaaggag cctgctgact gtctcagtgg gatagaaacc ttgctgtgct
      841 cttggctgga ggagacctcg gacacaggcc gacacatccc ccacaagcag aaggagaatg
      901 ctgctgctgc cctggtggcg ttggcgtgtg ccaggggatc cctgaagacc tttgtccaca
      961 cagttcacct gctacagaga cagactgagc tgggctccct gcctgtcgcc gatgttttgt
     1021 ataggctgct gcttttggaa ggggggccag gatccccttc ctgtttgctt gggggcaagc
     1081 acatagtatc gtgggggtat gaagacatgc tgccagcacc ggacagcaac cctggctcca
     1141 gctctgaaaa caaagacgct gatttgggcc gctgtctcac cgctgatggg cattacctgt
     1201 acactaccaa ctccgctggg agaggactga gcaagctggg ctctggactg cacggcacgc
     1261 tcagagggtt tgtttactgt cgcaacgagg agctggagcc agggtgggtg gcgtacggca
     1321 gcggccactt gctccaccgg cctgtgtctt ttgacaataa acctcactcc cttttccagg
     1381 tcatagacca gaacactctg caggtgtgcc agacagtgcc catgccagcc agcccccttc
     1441 ctgtgggcag caccatgagc actgtgcacc tctcctcaga cggcacttac ttctactgga
     1501 tctggtcccc tgccagttta aatgagaaaa ccccaaaggg acattccgtc ttcatggaca
     1561 tttttgaact tgtggtggaa aatggggtat ttgtagccaa cccgcttcag gaacgcacaa
     1621 tcctaatgag aaaagagggt gagtctgcca aaagcatcaa tgagatgctc ctgagcaggc
     1681 tgtcccggta cagagcctct ccgtcggcga ctctcgcggc cctgaccggc tccaccatct
     1741 ccaacacgct gaaggaggat caagcagcaa atactagctg cggccttcct ctgaagacgc
     1801 tgcggaggac acccatgtac acctgcggca cttacttggt gatgctggtc ccacctccgg
     1861 gagggtccgg cagctctgcc acccgctctc tttttggtgg aaccagtggt ctgtcatctt
     1921 taaaaatcct ggcctccagt ttggtgtata acatttctga tggccagttt gcaagtcgtg
     1981 cagacctcat agatgctgct ggaagctcgc tggggcgtgg tgctctcgta ccaggattgg
     2041 gtgcctgtta cgataccgtg aacaacatgc tgtggacctg ctcaaatgac tacattgacc
     2101 agtggtgcaa tcctggcaac caggccttcc attacgtgtg ccagaggctg ggtgtcagcc
     2161 atatcatccc cgagcccaaa gaagaggcca ttagcacaaa tgaagtcata aaccagttac
     2221 tgcaccatgt tggcgccatg tgcattcacc agctcaacct tctagccacg aaccctaacc
     2281 ttcccatcac aagtgtcctg ggcaagcagc acccaatcga ggcacgccat ctgagcagca
     2341 tctgtgacat catggagaag gccatggtta atggtgacac ctgcatcgtg cgctgcatcc
     2401 tcgtcgtctt tcaggtggtg tttaaatttt tcttcagccc acaaactgaa aggaaccgtg
     2461 acatcattcg gcggtcagga ttgcttcttt ggcagttgtt gatggcacca aaggatcaaa
     2521 tctgtcctga aattcagaag gaggtctgtc ttgctatcag ctctggctta aatattttat
     2581 acccaggtga aacggaaatc aataacttac ttaagctggt cttaacagaa ggagagagaa
     2641 acagtggact ctcccagctt cgggatgtga tcctcaccaa cttagcagag cagcttcaga
     2701 acaaccggtt cggcagcgat gaggacgatc actacagact caatgacgag ctcttacact
     2761 acatcctgaa gattgttgtg cgagaatcct gtatcctcat caccaagtgc cagacagtct
     2821 ccaaggatga tttccagaag ctcctttcaa cggtgcctgc tgcatcctcc tgcctgcgct
     2881 atctgatggc ggttcagaat caccttctca gtaacactgt tttgattaag cctgatgaca
     2941 atgaggacag tgacagctcc ttgcagggag agacattgaa ggtacaggag ttaaagacca
     3001 gtattttggc tcttgccacc caggtcctga ctggatgtga tgaggtactg gaaatgttgc
     3061 agcaggtcac cactgccctc atcaacagtg acatgcctga ccgagagcag aggttaaaag
     3121 gcttggagca agttaccaag gccactatgc ttggtcacct ccttccggtg ttgctgacct
     3181 ccctgatgca ccccaatcta cagaccctga ccatggccga cgccttgatg cctcagctcg
     3241 tgcaactggt gctgtacacc agccagacgg ccttgctgct taaaacccag tgtccggtgt
     3301 ttgccgaggt gggctgttcc ccgtgtggca cctcagacca gaagtgcagg cttttccctg
     3361 atgagagaat gctagaagaa aaggaagagc caggctttct caccggctta aagatccctg
     3421 ccccgtgggc tgctgggaag accgtggaaa cagtacaccc tgtcagagac aactataagt
     3481 ttaaagagac tgttcatatc ccaggagctc gctgcctcta tctacgattt gacaccagat
     3541 gctcgtcaca gtacgactat gacaaattgg tgatatacgc ggggcctaac acaaacagta
     3601 ggaaggttgc tgagtacgga ggcaacactc tgggatatgg cagccggagt gtcttaggaa
     3661 cgggttggcc gaaggacttg gtgaaggttg aaggcgatac agtcaccttc tcctttgaaa
     3721 tgagaagtgg ccgtgaacac aacactcctg acaaagctat gtggggcttt gcttgcacag
     3781 tccgcgctca ggagtcctca gaagatgtct caggaggctt gcccttcctg gtagacctgg
     3841 ccttaggtct gtctgtgtta gcttgttcca tgttaagaat cctatacaat ggaccagaaa
     3901 ttaccaaaga agaggaagcc tgtcaggacc tgttgcgatc caaacttcta caaaggtgcc
     3961 aatggcaggt ggaggccaac ggtgtcatct cccctgccct tactccgagt ccctctccac
     4021 tgccgctgac catagaagaa gacagagaat tcacctaccc ctcggatgtc cttgtgcctc
     4081 ccgttgggaa ctactttgac ctgcctcgga tcaggctgcc tccaggaatc atgataaagc
     4141 tcagggaaat ttctgggcga gcacgacctc agtttagacc aagtataaaa gaggtgatcc
     4201 agcccgatgt catggaggaa atggtggtgt catgtgttat taagcacttg aacttggttg
     4261 atgcgctgca gtccctaatc aatttccagt atcaggaaga gcatgctgag gaatatgatt
     4321 tattgtgtaa aatcatggga gagaccttta agaagctcaa tgccatggag agacagctgc
     4381 agagtgtggc tgagctggaa cagaagtggc aaagtgaggc tgaggatgcc atgcagggga
     4441 agctggagaa caacatgcct ttcttttatg actaccattt taatgagaac aaaatgaaag
     4501 aactagagct tttgtgttca atgaaggaag tctccttcga cggaaatgat cttgaaaaca
     4561 tggtcctctc actgagggag aagttcctcc aagaagtgaa ttctcttact cagaaaccct
     4621 cccacccgct ggccaaaaca aagacactgg tgaagagtct gatgaaccga gcagagctgc
     4681 tgctgcatgt taccattgca gcccagtcgg gcctcaccag gagcatctca ggaacaccag
     4741 cagagacgcc tgcatgcaaa tcagcttcag aaacaaaggt ggcgtctcat gctgtccggc
     4801 agcctgtttt ccttcgcagc atgtctgctc cttctgacct ggaaatgatt ggtaatgaag
     4861 acttggaatt tactagagcc aatcagaggc gtcgccatgt gaccagccac cgcagcagct
     4921 cctttacact cttacagtca ctggccatcg aggacagcag ggacaagccc acttacagcg
     4981 tcctgcttgg gcagctgttt gctttcattg gcaccaaccc tgaccaagcg gtgtctagta
     5041 gcagcttcct tttggctgca cagacaagat ggcggcgcgg gaacactcgg aagcaggccc
     5101 tggtgcatat gcgggagttg ctgactgctg ctgtgcgagt tggaggagtg acacacctgg
     5161 tagggccagt gacaatggtc cttcaggggg gacccagaat tgaagagctc acctgtggtg
     5221 ggatggtgga gcaggtccag gaagcctttg gggagaccat gacgtctgtt gtgtctctgt
     5281 gtgctcggta ccctattgct tgtgcgaaca gcattggact cctgtgtacc ataccttaca
     5341 ccaggagtga agagaagtgc ctggtccgca gtggccttgt gcagctcatg gaccgactct
     5401 gcagcttgag cagtcagacc gagtccagct ccagcgagaa gcagacgaag aagcagaagg
     5461 tggccaccat ggcctgggct gccttccaag tgttggctaa ccgctgtgtg gagtgggaga
     5521 aagaggaagg tggctccaca gaggctgtgc actcggggct ggcccggcag gtgtccagtc
     5581 tcctcaccaa tcaccttgcc cgagctactg agtgctgtgg caaccaggct gctgggaacg
     5641 acgccctgca ggacgtcctg agtcttctca atgacctttc caggagccac atagggaagg
     5701 ccatcttgag ccagccagcc tgcgtttcta agctcctctc tctactgctg gaccagcgtc
     5761 catccccaaa gctggtgttg atcattcttc agttatgccg ggctgctctg cctttgatga
     5821 gcgtggagga ctgtgggaat gtggagctcc cgccctggag ctactccgtc ccctccctga
     5881 acagtgagca ggaggacccc agtgaccctg cttccaagat cgcctctctg ctcttagcca
     5941 agctggcaga ctatgtggtc ccaggatgtc agacggttct ctctccaact gcttctgaac
     6001 ctgacaccac actgacaaaa accagtccta agaattcctt aaaaggagat aaagatcctg
     6061 gagaagagag tgaagcggtg gatggcaagc tctccatatt tatccacaag cgggaagacc
     6121 agtcctccca tgaggtcctg cagccattgc tgagcagctc agaaggacgg ccctttcgac
     6181 ttggtactgg tgccaacatg gaaaaagttg tgaagatgga ccgagacatg accaagggtg
     6241 gctgctgtga agtgatcaca gaagaggcct cagccgccct caggaaagca accaagtggg
     6301 cacagtcggg cctcattgtc agtgtcgggc caccagtgga atccatcaac ccagagactg
     6361 tgagtgggct gtccacaggt gacaagaaga aaacggccca aacctccatc tgccgagaaa
     6421 ggaactcgga actggccaga actgaccccg tgcgcccctt catcagtggg catgtagcaa
     6481 acagtatggc cgcagaagtg atcgccttgc ttcatagcct gctaatggca ccagaatcta
     6541 atgctgctca gatatggacc acaacggcag aaaaggtttt gtctcgagcg ttgatgtaca
     6601 ttccacaact agggaaatat gcagaaagca tcctggaaaa tgggagcagc agtggcagga
     6661 aactcgccaa gcttcagagg attgcacgcc aggctgttgc cgccctctgt gcactgggag
     6721 gctttaaaga gaccatcaag attggctccg aggtccaggt tttaggtaga ggaatatcgg
     6781 gaagcattgg agttgtggct tctatcaatg aacaggaagg catagctaca gtcagattcc
     6841 ctcctgtgga ctgcagaagg acgtcacaag ctgcagacac gctgactatt cctttgtcta
     6901 gactctgtgt tccacggtca gaggcactgc ctcttcataa gctgtccatt actgagaagg
     6961 tagtccaggc agtgcagtcc atgctgctcc ctcaggaagg cagcctctct atccacacct
     7021 ctcttcctgc aacaggagat ggctcggcac ctgtcatggc agttgtccgg cttctggctg
     7081 aaatcagaac cagagcctgc ctggtcatgg cacagctttt agaagacagc ctgttttgtg
     7141 aggaattcat acagcagtgt ccagcagcag tggaagtcct gaatctcgta gcccaggagt
     7201 gcagtgcagg cgagcggctt gcagttgtag aggtgcagtg cgagaggctc aggatgctct
     7261 atcgggactg cgctcggcct cctccacctc cgctgcaggc cgaccggaga cagcccaaag
     7321 agatcacctg gagcccttct cgagtgttcc ctccagttcg cgcctgcatg ttttcatctc
     7381 acctcacctc tgtcaccttc ctggctgacc ccagtgctgg aggaggtctt ccccggggca
     7441 cattcatcta tgccacctcc ccgctgccag ttcaggcccc gtctttctac tgggaaattg
     7501 agattgtttc ctatggagac actgatgacg acactggacc aatcgtctca tttggctttg
     7561 ctacagaggc tgagaagcgt gatggggcat ggaccaatcc ggtgggcact tgcctcttcc
     7621 acaacaatgg ccgagctgtg cactacaatg gctccagtct gctgcagtgg aagagcgtcc
     7681 gcttagatgt cacactctgt cctggtgatg tggcagggat cggctgggaa cggaccgagg
     7741 ggactccacc tcctccaggg cagccagcca aaggtcgggt gtacttcaca tactgcgggc
     7801 agcgcctcac accgtaccta gaagatgtct ctggcgggat gtggcctgtg gttcacattc
     7861 agaagaagaa cacaaaaact cgagccaatt ttggctcccg cccgtttgcg tatgctgaag
     7921 gacaggccca ccgtaacgct gctgacctgt gcactgacct ggcagaggag atcagcgcta
     7981 acttcgaggc cttgccattc gccatggcat ctgacagtga caacgatgct ggcaccagta
     8041 ttgcgtcaga cccaggcact catgggccac catgccggat tgcagcagtg gccacagccc
     8101 agcagcaata tgacagtgac acctcctgcc attataaagt cgagctcagc tatgagaatt
     8161 tcatcacctc tggcccagac ccccacccac ctcccattgc agatgatgaa agcgacgatg
     8221 atgacgatga tgacatccct caggaggacc actacgcgct gctggtgaaa gcatgggaga
     8281 ccaaggtttt ccctaccatc cggagacgct tccgaaatga agctgagcgg aagtcgggcc
     8341 tggaccagat caagggtgct ttacaactag gcatggtgga catcgcccgg cagacagttg
     8401 agtttctcta tgaggagaat ggcggcatcc ccagagacct ttatcttccc accattgagg
     8461 acattaaaga cgaagcaaac aagttcacaa ttgacaaagt tcgaaaaggt ctcacggttg
     8521 taacccgctc tccagacagc agcaatgtag ctagcagtgc tgtgggaact gctttgccaa
     8581 aatttgccat ccgagggatg ctaaaaacct tcggccttca tggagtcgtc ctagatgttg
     8641 actcagtgaa tgagttggtg caggtggaga catacctccg gagtgaaggg gtgctggtgc
     8701 ggtactggta ccccatcgac atgctagaaa ggccccctgc gggctaccgc aggacggcca
     8761 ctaacgggct ggtcacactg gacaatacca accttcagat tcacagagag ctgctgcggt
     8821 gcgaggctgc gctggcccgg ttgtactgtc gcatggccct gctcaacatc ttcgccccca
     8881 agctacctca cttattcact cggctcttcc acatccctgc catccgagac atcaccttag
     8941 agcacctgca gctcctgtcc aatcagctcc ttgctcctcc cctcccagat ggcaccatca
     9001 gctccagctc catcctcctg gcacagtctc tgcagcactg catccactcg cagagctgct
     9061 ctgccaccga cctcttctac cagggcaact cccagacgct gagggagtgg ctcagcgtgg
     9121 ccatcacccg caccctgcac cagggcgagg acagccttct ggagctgaca aagcagatct
     9181 gcgccttcct gcagacagca ccagagcagt tcccctccga ggaattccca gtttccgagt
     9241 ccaaagtcag tatggatgtg aatttccccg gagcagcttt tgttgttgtg tcttgcaaag
     9301 aaagtcagtc tggattccgc aaagactcct ctctgtacaa ggctccgtgg gcacgtgtgc
     9361 tcgtctatgg gctcggccac aaagtgaagc gcactggcca gctgaacctc attgaagccg
     9421 cctgctaccc tcgagacgcc tccccagcca acactgggct cgcccctcca cctacagctg
     9481 accagtaccc ttctgtggtt ctctccacag acaaagtcca cataaaacta ggagtgtccc
     9541 cacctcctgg agcagtgctg gtcttgcact ctctgcccct ggagttccct ctggcgatgg
     9601 cctttgctga gcagctgctg tcctggaagt cggaggacag cgaagggaag tcagaggacg
     9661 agcctgacag catccctacc tccgtcctcc tgcacgtggt ggaactgcta ggaaacttcc
     9721 tatggactac agacatggcg gcctgtgtga aggagttggt cttccacctc ttggctgagc
     9781 tcttgcgtac agtacatacc ctggagcagc ggaagcaccc agccggcctg tcctcctcta
     9841 tcgccctcca gctcaatccc tgcctggcca tgctgatggc cttgcagtcg gaactgcaca
     9901 agctgtacga cgaggagacc cagggctggg tctcgagcag cacctgtggg ggctccggag
     9961 cagcagccgt gggcgaccag ggcaggtttt ccacctactt ccacgctctc atggaaggct
    10021 gcctggcagt tgcggaagtg accctaccta ccaacatcag tgtcacagct agcggggtga
    10081 cctcaacgac cactccaaac ctcagtgact cgtcctcttc ctcctcctcc tccccaggac
    10141 agacaccaca gagccctagc ctcctgtcta agagaaagaa agtcaagatg aagcgggaga
    10201 aggcctcctc ctccaacaag cgccagtcct cccgtgccac ggatgcagac tccactgtgc
    10261 ttagcattgg gggtagcaag cctgaggaca tgttatggtt ccaccgtgct ctcaccttgc
    10321 ttatcatcct ccggcacctt acgaaaaagg acccacaggg cttgggtgtc accagcgatg
    10381 ccattgctga tgcctgccag gccctggtcg gccccactgc ccatagccgc ctgctggtga
    10441 tctctggcat tcccacccac ctggatgagg ctgtcgtcag aggggctatc cgcaaggcct
    10501 gcaatgccca tggcggcgtc ttcaaagatg agatctacat cccactgcag gacgaggacc
    10561 ccaagaggcc aaaagacaag gctgagggtg gcgacagcaa ggtggaatct gagaagttgc
    10621 tgggattccc cagtgtggac agcctggagg ggagcacatc aagcagcctg gcccctgcca
    10681 tgagcatcag cgcctcagct tccaccagcc aggcctcagt ctgcagctcc cagtgtgttt
    10741 cacagaccgc tagtgacctc tcagtagacc ccctgccctc aggcctggag cttcctgtcc
    10801 ctcctgtcct gttggaaccc catgtagtgt ccagccagga gagcctggac atttccttat
    10861 gcagcactgg cagcctgggc agcctgggca gcctggggga gcctctagac aatccagaga
    10921 cagcatctgt gtccgacgtg ggctccatgt acacggtcac gtccctggat actcagcctc
    10981 tcacaacgcg ccctatcaaa ggctttgcag tggtggagat aaggtcccga gccaaaatcg
    11041 agaaagtcag agcaagttta tttaacaata acgatctgat cggcctgtcc agtctggacg
    11101 gtgaagagga gctgatggaa atgtccacag aggagatcct gacggtgtct gtggtcaatc
    11161 agagtctgtt tgacacacaa gggagcccag gactagaaga ttacttcaat gacaagtcca
    11221 ttaaaggtga gaaactggtg cctggggcca gagaggtcct gacagaaata tttaaaagct
    11281 gcgcccactc agagcagacg ctgagcctga caccagccaa acccatcagg gtctccgaca
    11341 tctatcttag caaagaacag atcaactccc agaccccggg caacctcctt cacctcttct
    11401 tcaccaatgt ccggcctcca aagaaggtgc tggaggacca gctcacacag atcctgagga
    11461 aatatggcgt gcccaagccc aaactggata agagcaaata cagcaaagcc gggaaggagc
    11521 agcacccagt gaaggtggtg agcacgaagc ggccagtcac caagccgcct gccaaggaca
    11581 aagctgtgct cagcagcctc agcaggaccg cactaagtga gaagaagcca accgtgaagc
    11641 ccaagtcacc tgagaagagc aaaccggatg aaaaggatcc agaaaagtca cccaccaaaa
    11701 aacaagaagt tcctgaggaa aagtacctaa ctctagaagg atttcacaaa ttcgtcattg
    11761 accgtgccaa gcaagacatc cgcagtgtct ggagggcaat cctgtcctgt gggtatgacc
    11821 ttcattttga gaggtgtgcc tgcattgatg tccggcacgc acagaaggcc tcccggaagt
    11881 gggctctgga gatggatgtg gctctcgtgc agtacatcaa ccggctgtgc cgccacctcg
    11941 ctatcacacc agcacggctc catcctcatg aagtgtacct tgacccagct gatgccactg
    12001 accccaggat ggcctgcctt tccaatgtgc ctatcgagag cttgcgtctg cgctttgcac
    12061 tgctccagtc tctcaacacc acactggaga ccttcttcct gcccctggtg gagctgcgtc
    12121 agacacccat gtacgcacac agcatcgccg ccttgctgaa ggaggcaaaa gggctgatct
    12181 tctatgacac aaaagtgact gtgatgaacc gggtgctaaa tgcgactgtg cagaggacag
    12241 ctgaccacgc ggcgcccgag atcaccttag acccactgga aactgtggga ggggaaatca
    12301 gagcttctga aaactcctac ttctgccagg ctgcccggca gctggcctcc gtgccatctt
    12361 ctcagctctg tgtcaagttg gccagtgggg gtgaccccac gtatgccttc aatatccgct
    12421 tcactgggga ggaggttcat ggcaccagtg gctccttccg ccacttcctg tggcaggtgt
    12481 gtaaagaact gcagagctcc tcactgtcgc tgctcctgct gtgccccagc tctgctgtca
    12541 acaagaacaa gggcaagtac atcctgaccc caagccccat cacctatggg gaggagcaac
    12601 tgctacactt cttgggccag ctgctgggaa tcgccatccg tgcagatgtg cctctccccc
    12661 tggacctgct gccctccttc tggaagacgc tggttggcga gcctcttgac cctgaccagg
    12721 acctgcagga ggcagacatc ctcacctaca attatgtcaa gaagtttgag agtatcaacg
    12781 atgagagcga gctggaggcc ctgtgtgccg agatcgcctc ccagcacctg gccactgaca
    12841 gcccggaagg ccccaagccc tgctgccgct tcacctacct gaccatgact ggcgaggagg
    12901 tggagctgtg cagccgtggc cggcacatcc ctgtggcttg ggagaacaag gatatctacg
    12961 cggcagccat ccggagccta cgcctgcgtg agctacagaa catggagtgc gtgactgctg
    13021 tgcgtgctgg cctgggctcc atcatccccc tgcagctgct caccaccctc agcccactgg
    13081 agatggaatt gcgtacctgt ggcctcccgt acgtcaacct agagttcctg aaggcccaca
    13141 ccatgtacca ggtggggctg atggagacag accagcacat cgagctcttc tggggggctc
    13201 tggagacgtt cacccaggag gaactgtgca agttcatcaa gttcgcctgc aatcaggagc
    13261 gcatcccctt cacctgccct tgcaaggacg gcggtcctga cacagcccat gtgccgccgt
    13321 accccatgaa gattgcccct ccagatggca cagcaggtcc tcccgactcc cgctacatcc
    13381 gagtggagac ctgcatgttc atgatcaagc ttccccagta ctcctccctg gagatcatgc
    13441 tggagaagct gcgctgtgcc attcactacc gtgaagaccc cctaagtggc tgatgggagt
    13501 gggccagaag attaggctat caccaaggca cccttctgcc ggcttgggaa gccagtccag
    13561 gcgcatccct ccagggcctc aagtgaggag ctggcgacat ttgcattctg aactttcgtc
    13621 cgtgtcccag gaccacctgg aagacacttt gtatgtgtcc attttgtgag ggtccgttcc
    13681 tttgctgctg tctgtggtac atttgtagga tagttaattc ccgacagttt atgtctaact
    13741 tgatcttcct ggacactgtt ttggtggcta ccagactgct gtgatgccac aggttcaggt
    13801 ggctcgtcat cagagagcca ccagtggaaa gctgagggtt gaggtgacct cagccacaca
    13861 aagtatcctg ttctcttaca gagtgtctcc acaaatgtgt gagcagtcct cagtcctgcc
    13921 ctcctgccct gagctggctt ctcccagagg cagcgtctgc agggctccct ccttccgtct
    13981 tgagtggttg agctagtgct caaacattca agagacacgg ggaactcatg tgttaacctt
    14041 cctgctttac tgtgtgtccc tgccttgttt gtttggggtt ttttttgttt gtttgttttt
    14101 gtttttttgt tgtttttttt tttaggaaat cccacagagg ccccttgtct cctcccatcg
    14161 aggcagccct atctgccacc tgtctcttct gggcacctgg gctgaatggc ctgaggatac
    14221 ctcaggagca gacacccagg ggctactcca ggccttagtt cacagacagg ttgggcacgt
    14281 cttggtggct ggagctgaaa gacagtggag ctagagggat agtgctgagt gggcctttct
    14341 acagctgact gcacaggaaa gcacatgact caagcctacc ccactctgtg ctcagagagg
    14401 gcccacctca ccacactgct gtaaggagcc caggaaaggg ttacagccca tctctaaaga
    14461 ctgtctgagg tgctctgccc acacagggct gcatcagtga cccaggcaga gactgcaggg
    14521 gattcctctg tgccctggct ggcctgccca gcaccctcta caaccaacgt gtgtgccagg
    14581 gctgagcttc ctgcaggctc acccactacc ccagtgcatt tgtgccccaa ataagtcttt
    14641 gtccaatggt actttgttca agagcagcac atgccaactg ttggacactg tcacttgggc
    14701 ctcaccagtt gtcacagaat ggcagcgctg tagctattgt atgatattgt gcacacagaa
    14761 gttctaagga aagtgaggag gatgtgctcc tctccacagc acccggcctg cttgggaggc
    14821 cgtgcaagcc ttagggctgg catccatctc ctcctcgtta cacttaggaa acgcattgag
    14881 gaccatgaca gaaaacaccc cacccaaccc cacccgggga agtgatatgc cccagctcag
    14941 tgtgctggcc acgccagtca cagggctgca agccctgctc tcacagaaga tcgtggccgc
    15001 tgtgtgggac caccccagcg acctcaagga tcctgactct gttcgacaga aggcaggagc
    15061 ctctgaattt taaagtgagt tttcattcct gtaccttcag atccttggtt cccttctatc
    15121 cttgtcccac gaatggactt gggattctgt cagctacctc cccaggaggg ttctggaagc
    15181 ttctgttggc ccattccttg attagatgac agctgtgagt gagatatctg ctgctaactc
    15241 agctgctgct cctagagagc gcactgaggt ccagacagat cccagtcttg gccctgaaca
    15301 atgtgtgctg taaagttact tgatgtatat ttattataat tatttatgac tgcattaaca
    15361 gcccccattc agtctgatgc tacttacact atgctgtgta aaggaagctc actacggaaa
    15421 aagtcacacc aataaataac cttcatctga ctgac
//
