LOCUS       XM_039089873           15495 bp    mRNA    linear   ROD 11-JUN-2023
DEFINITION  PREDICTED: Rattus norvegicus HECT domain E3 ubiquitin protein
            ligase 4 (Hectd4), transcript variant X2, mRNA.
ACCESSION   XM_039089873
VERSION     XM_039089873.1
DBLINK      BioProject: PRJNA677964
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_051347.1) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            [WARNING] On Feb 22, 2024 this sequence was replaced by
            XM_039089873.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_015227675.2-RS_2023_06
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 06/06/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..15495
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN/NHsdMcwi"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /sex="male"
                     /tissue_type="kidney"
                     /geo_loc_name="USA: Wisconsin, Milwaukee, Medical College
                     of Wisconsin"
                     /collection_date="2019-03-08"
                     /collected_by="Rebecca Schilling"
     gene            1..15495
                     /gene="Hectd4"
                     /note="HECT domain E3 ubiquitin protein ligase 4; Derived
                     by automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 47 ESTs, 1 Protein, and 100% coverage of the annotated
                     genomic feature by RNAseq alignments, including 64 samples
                     with support for all annotated introns"
                     /db_xref="GeneID:304503"
                     /db_xref="RGD:1309762"
     CDS             238..13533
                     /gene="Hectd4"
                     /codon_start=1
                     /product="probable E3 ubiquitin-protein ligase HECTD4
                     isoform X2"
                     /protein_id="XP_038945801.1"
                     /db_xref="GeneID:304503"
                     /db_xref="RGD:1309762"
                     /translation="MGSSAAAAAAAAAAAADSAQWLSVKEETIFLHDGLIRVTDLAEL
                     PSEILGAPEAADTDLEILTFETKNPTELAERLRSVCGNQSNAYARLLEYRLNALRGLW
                     NAQRQLALEEQHEREGSGDEETLALLKRQGLLQQPEQAPFTSRVGLLLVFPLIQSQSR
                     TDPSLCNITAEVLLNCLRDCQPLSLTKEPADCLSGIETLLCSWLEETSDTGRHIPHKQ
                     KENAAAALVALACARGSLKTFVHTVHLLQRQTELGSLPVADVLYRLLLLEGGPGSPSC
                     LLGGKHIVSWGYEDMLPAPDSNPGSSSENKDADLGRCLTADGHYLYTTNSAGRGLSKL
                     GSGLHGTLRGFVYCRNEELEPGWVAYGSGHLLHRPVSFDNKPHSLFQVIDQNTLQVCQ
                     TVPMPASPLPVGSTMSTVHLSSDGTYFYWIWSPASLNEKTPKGHSVFMDIFELVVENG
                     VFVANPLQERTILMRKEGESAKSINEMLLSRLSRYRASPSATLAALTGSTISNTLKED
                     QAANTSCGLPLKTLRRTPMYTCGTYLVMLVPPPGGSGSSATRSLFGGTSGLSSLKILA
                     SSLVYNISDGQFASRADLIDAAGSSLGRGALVPGLGACYDTVNNMLWTCSNDYIDQWC
                     NPGNQAFHYVCQRLGVSHIIPEPKEEAISTNEVINQLLHHVGAMCIHQLNLLATNPNL
                     PITSVLGKQHPIEARHLSSICDIMEKAMVNGDTCIVRCILVVFQVVFKFFFSPQTERN
                     RDIIRRSGLLLWQLLMAPKDQICPEIQKEVCLAISSGLNILYPGETEINNLLKLVLTE
                     GERNSGLSQLRDVILTNLAEQLQNNRFGSDEDDHYRLNDELLHYILKIVVRESCILIT
                     KCQTVSKDDFQKLLSTVPAASSCLRYLMAVQNHLLSNTVLIKPDDNEDSDSSLQGETL
                     KVQELKTSILALATQVLTGCDEVLEMLQQVTTALINSDMPDREQRLKGLEQVTKATML
                     GHLLPVLLTSLMHPNLQTLTMADALMPQLVQLVLYTSQTALLLKTQCPVFAEVGCSPC
                     GTSDQKCRLFPDERMLEEKEEPGFLTGLKIPAPWAAGKTVETVHPVRDNYKFKETVHI
                     PGARCLYLRFDTRCSSQYDYDKSNGLFSVLKLVIYAGPNTNSRKVAEYGGNTLGYGSR
                     SVLGTGWPKDLVKVEGDTVTFSFEMRSGREHNTPDKAMWGFACTVRAQESSEDVSGGL
                     PFLVDLALGLSVLACSMLRILYNGPEITKEEEACQDLLRSKLLQRCQWQVEANGVISP
                     ALTPSPSPLPLTIEEDREFTYPSDVLVPPVGNYFDLPRIRLPPGIMIKLREISGRARP
                     QFRPSIKEVIQPDVMEEMVVSCVIKHLNLVDALQSLINFQYQEEHAEEYDLLCKIMGE
                     TFKKLNAMERQLQSVAELEQKWQSEAEDAMQGKLENNMPFFYDYHFNENKMKELELLC
                     SMKEVSFDGNDLENMVLSLREKFLQEVNSLTQKPSHPLAKTKTLVKSLMNRAELLLHV
                     TIAAQSGLTRSISGTPAETPACKSASETKVASHAVRQPVFLRSMSAPSDLEMIGNEDL
                     EFTRANQSSVFCRRRHVTSHRSSSFTLLQSLAIEDSRDKPTYSVLLGQLFAFIGTNPD
                     QAVSSSSFLLAAQTRWRRGNTRKQALVHMRELLTAAVRVGGVTHLVGPVTMVLQGGPR
                     IEELTCGGMVEQVQEAFGETMTSVVSLCARYPIACANSIGLLCTIPYTRSEEKCLVRS
                     GLVQLMDRLCSLSSQTESSSSEKQTKKQKVATMAWAAFQVLANRCVEWEKEEGGSTEA
                     VHSGLARQVSSLLTNHLARATECCGNQAAGNDALQDVLSLLNDLSRSHIGKAILSQPA
                     CVSKLLSLLLDQRPSPKLVLIILQLCRAALPLMSVEDCGNVELPPWSYSVPSLNSEQE
                     DPSDPASKIASLLLAKLADYVVPGCQTVLSPTASEPDTTLTKTSPKNSLKGDKDPGEE
                     SEAVDGKLSIFIHKREDQSSHEVLQPLLSSSEGRPFRLGTGANMEKVVKMDRDMTKGG
                     CCEVITEEASAALRKATKWAQSGLIVSVGPPVESINPETVSGLSTGDKKKTAQTSICR
                     ERNSELARTDPVRPFISGHVANSMAAEVIALLHSLLMAPESNAAQIWTTTAEKVLSRA
                     LMYIPQLGKYAESILENGSSSGRKLAKLQRIARQAVAALCALGGFKETIKIGSEVQVL
                     GRGISGSIGVVASINEQEGIATVRFPPVDCRRTSQAADTLTIPLSRLCVPRSEALPLH
                     KLSITEKVVQAVQSMLLPQEGSLSIHTSLPATGDGSAPVMAVVRLLAEIRTRACLVMA
                     QLLEDSLFCEEFIQQCPAAVEVLNLVAQECSAGERLAVVEVQCERLRMLYRDCARPPP
                     PPLQADRRQPKEITWSPSRVFPPVRACMFSSHLTSVTFLADPSAGGGLPRGTFIYATS
                     PLPVQAPSFYWEIEIVSYGDTDDDTGPIVSFGFATEAEKRDGAWTNPVGTCLFHNNGR
                     AVHYNGSSLLQWKSVRLDVTLCPGDVAGIGWERTEGTPPPPGQPAKGRVYFTYCGQRL
                     TPYLEDVSGGMWPVVHIQKKNTKTRANFGSRPFAYAEGQAHRNAADLCTDLAEEISAN
                     FEALPFAMASDSDNDAGTSIASDPGTHGPPCRIAAVATAQQQYDSDTSCHYKVELSYE
                     NFITSGPDPHPPPIADDESDDDDDDDIPQEDHYALLVKAWETKVFPTIRRRFRNEAER
                     KSGLDQIKGALQLGMVDIARQTVEFLYEENGGIPRDLYLPTIEDIKDEANKFTIDKVR
                     KGLTVVTRSPDSSNVASSAVGTALPKFAIRGMLKTFGLHGVVLDVDSVNELVQVETYL
                     RSEGVLVRYWYPIDMLERPPAGYRRTATNGLVTLDNTNLQIHRELLRCEAALARLYCR
                     MALLNIFAPKLPHLFTRLFHIPAIRDITLEHLQLLSNQLLAPPLPDGTISSSSILLAQ
                     SLQHCIHSQSCSATDLFYQGNSQTLREWLSVAITRTLHQGEDSLLELTKQICAFLQTA
                     PEQFPSEEFPVSESKVSMDVNFPGAAFVVVSCKESQSGFRKDSSLYKAPWARVLVYGL
                     GHKVKRTGQLNLIEAACYPRDASPANTGLAPPPTADQYPSVVLSTDKVHIKLGVSPPP
                     GAVLVLHSLPLEFPLAMAFAEQLLSWKSEDSEGKSEDEPDSIPTSVLLHVVELLGNFL
                     WTTDMAACVKELVFHLLAELLRTVHTLEQRKHPAGLSSSIALQLNPCLAMLMALQSEL
                     HKLYDEETQGWVSSSTCGGSGAAAVGDQGRFSTYFHALMEGCLAVAEVTLPTNISVTA
                     SGVTSTTTPNLSDSSSSSSSSPGQTPQSPSLLSKRKKVKMKREKASSSNKRQSSRATD
                     ADSTVLSIGGSKPEDMLWFHRALTLLIILRHLTKKDPQGLGVTSDAIADACQALVGPT
                     AHSRLLVISGIPTHLDEAVVRGAIRKACNAHGGVFKDEIYIPLQDEDPKRPKDKAEGG
                     DSKVESEKLLGFPSVDSLEGSTSSSLAPAMSISASASTSQASVCSSQCVSQTASDLSV
                     DPLPSGLELPVPPVLLEPHVVSSQESLDISLCSTGSLGSLGSLGEPLDNPETASVSDV
                     GSMYTVTSLDTQPLTTRPIKGFAVVEIRSRAKIEKVRASLFNNNDLIGLSSLDGEEEL
                     MEMSTEEILTVSVVNQSLFDTQGSPGLEDYFNDKSIKGEKLVPGAREVLTEIFKSCAH
                     SEQTLSLTPAKPIRVSDIYLSKEQINSQTPGNLLHLFFTNVRPPKKVLEDQLTQILRK
                     YGVPKPKLDKSKYSKAGKEQHPVKVVSTKRPVTKPPAKDKAVLSSLRTALSEKKPTVK
                     PKSPEKSKPDEKDPEKSPTKKQEVPEEKYLTLEGFHKFVIDRAKQDIRSVWRAILSCG
                     YDLHFERCACIDVRHAQKASRKWALEMDVALVQYINRLCRHLAITPARLHPHEVYLDP
                     ADATDPRMACLSNVPIESLRLRFALLQSLNTTLETFFLPLVELRQTPMYAHSIAALLK
                     EAKGLIFYDTKVTVMNRVLNATVQRTADHAAPEITLDPLETVGGEIRASENSYFCQAA
                     RQLASVPSSQLCVKLASGGDPTYAFNIRFTGEEVHGTSGSFRHFLWQVCKELQSSSLS
                     LLLLCPSSAVNKNKGKYILTPSPITYGEEQLLHFLGQLLGIAIRADVPLPLDLLPSFW
                     KTLVGEPLDPDQDLQEADILTYNYVKKFESINDESELEALCAEIASQHLATDSPEGPK
                     PCCRFTYLTMTGEEVELCSRGRHIPVAWENKDIYAAAIRSLRLRELQNMECVTAVRAG
                     LGSIIPLQLLTTLSPLEMELRTCGLPYVNLEFLKAHTMYQVGLMETDQHIELFWGALE
                     TFTQEELCKFIKFACNQERIPFTCPCKDGGPDTAHVPPYPMKIAPPDGTAGPPDSRYI
                     RVETCMFMIKLPQYSSLEIMLEKLRCAIHYREDPLSG"
ORIGIN      
        1 ccgcccccaa gatggcgtct tactgacagt tggctgcgga gcggcagagg cggatcctgc
       61 tcgtcagggc ggcggcggcg gcggcggcgg cggggccggg gtctcccggg ccggggttgg
      121 cgtgtggagg gatggcggtg cggaacgcct agggcggagc cgcgcgggcg aggcgggcgc
      181 ggcggtcggc catgggttgc tgaagcggca gggtctccgc agcgccttct cttaaccatg
      241 ggctcgtcgg cagccgcggc ggcggcggca gcggcggcgg cggcggactc ggcgcagtgg
      301 ctctcggtga aggaggagac catctttctg cacgacgggc ttatccgggt caccgacctg
      361 gccgagctgc ccagcgagat actcggcgcc ccggaggccg ccgacaccga cctggagatt
      421 ttaacatttg agaccaaaaa cccaacggaa ttagcagaac gtttgcgctc tgtttgtggg
      481 aaccagagca atgcctatgc ccgcctgctg gaataccgcc tgaacgcctt gcgtggactg
      541 tggaatgccc agcgccagct ggccctggag gagcaacacg aaagggaagg ctcaggtgat
      601 gaagagacct tggccctgct caagcggcag ggcttgctgc agcaacccga acaagcgccc
      661 ttcacgtccc gggtgggcct cctgttggtc ttccccctca ttcagtccca gagtagaaca
      721 gacccttccc tctgtaacat aactgctgag gtgctactaa actgcctgcg ggactgtcag
      781 cctctgagcc tgaccaagga gcctgctgac tgtctcagtg ggatagaaac cttgctgtgc
      841 tcttggctgg aggagacctc ggacacaggc cgacacatcc cccacaagca gaaggagaat
      901 gctgctgctg ccctggtggc gttggcgtgt gccaggggat ccctgaagac ctttgtccac
      961 acagttcacc tgctacagag acagactgag ctgggctccc tgcctgtcgc cgatgttttg
     1021 tataggctgc tgcttttgga aggggggcca ggatcccctt cctgtttgct tgggggcaag
     1081 cacatagtat cgtgggggta tgaagacatg ctgccagcac cggacagcaa ccctggctcc
     1141 agctctgaaa acaaagacgc tgatttgggc cgctgtctca ccgctgatgg gcattacctg
     1201 tacactacca actccgctgg gagaggactg agcaagctgg gctctggact gcacggcacg
     1261 ctcagagggt ttgtttactg tcgcaacgag gagctggagc cagggtgggt ggcgtacggc
     1321 agcggccact tgctccaccg gcctgtgtct tttgacaata aacctcactc ccttttccag
     1381 gtcatagacc agaacactct gcaggtgtgc cagacagtgc ccatgccagc cagccccctt
     1441 cctgtgggca gcaccatgag cactgtgcac ctctcctcag acggcactta cttctactgg
     1501 atctggtccc ctgccagttt aaatgagaaa accccaaagg gacattccgt cttcatggac
     1561 atttttgaac ttgtggtgga aaatggggta tttgtagcca acccgcttca ggaacgcaca
     1621 atcctaatga gaaaagaggg tgagtctgcc aaaagcatca atgagatgct cctgagcagg
     1681 ctgtcccggt acagagcctc tccgtcggcg actctcgcgg ccctgaccgg ctccaccatc
     1741 tccaacacgc tgaaggagga tcaagcagca aatactagct gcggccttcc tctgaagacg
     1801 ctgcggagga cacccatgta cacctgcggc acttacttgg tgatgctggt cccacctccg
     1861 ggagggtccg gcagctctgc cacccgctct ctttttggtg gaaccagtgg tctgtcatct
     1921 ttaaaaatcc tggcctccag tttggtgtat aacatttctg atggccagtt tgcaagtcgt
     1981 gcagacctca tagatgctgc tggaagctcg ctggggcgtg gtgctctcgt accaggattg
     2041 ggtgcctgtt acgataccgt gaacaacatg ctgtggacct gctcaaatga ctacattgac
     2101 cagtggtgca atcctggcaa ccaggccttc cattacgtgt gccagaggct gggtgtcagc
     2161 catatcatcc ccgagcccaa agaagaggcc attagcacaa atgaagtcat aaaccagtta
     2221 ctgcaccatg ttggcgccat gtgcattcac cagctcaacc ttctagccac gaaccctaac
     2281 cttcccatca caagtgtcct gggcaagcag cacccaatcg aggcacgcca tctgagcagc
     2341 atctgtgaca tcatggagaa ggccatggtt aatggtgaca cctgcatcgt gcgctgcatc
     2401 ctcgtcgtct ttcaggtggt gtttaaattt ttcttcagcc cacaaactga aaggaaccgt
     2461 gacatcattc ggcggtcagg attgcttctt tggcagttgt tgatggcacc aaaggatcaa
     2521 atctgtcctg aaattcagaa ggaggtctgt cttgctatca gctctggctt aaatatttta
     2581 tacccaggtg aaacggaaat caataactta cttaagctgg tcttaacaga aggagagaga
     2641 aacagtggac tctcccagct tcgggatgtg atcctcacca acttagcaga gcagcttcag
     2701 aacaaccggt tcggcagcga tgaggacgat cactacagac tcaatgacga gctcttacac
     2761 tacatcctga agattgttgt gcgagaatcc tgtatcctca tcaccaagtg ccagacagtc
     2821 tccaaggatg atttccagaa gctcctttca acggtgcctg ctgcatcctc ctgcctgcgc
     2881 tatctgatgg cggttcagaa tcaccttctc agtaacactg ttttgattaa gcctgatgac
     2941 aatgaggaca gtgacagctc cttgcaggga gagacattga aggtacagga gttaaagacc
     3001 agtattttgg ctcttgccac ccaggtcctg actggatgtg atgaggtact ggaaatgttg
     3061 cagcaggtca ccactgccct catcaacagt gacatgcctg accgagagca gaggttaaaa
     3121 ggcttggagc aagttaccaa ggccactatg cttggtcacc tccttccggt gttgctgacc
     3181 tccctgatgc accccaatct acagaccctg accatggccg acgccttgat gcctcagctc
     3241 gtgcaactgg tgctgtacac cagccagacg gccttgctgc ttaaaaccca gtgtccggtg
     3301 tttgccgagg tgggctgttc cccgtgtggc acctcagacc agaagtgcag gcttttccct
     3361 gatgagagaa tgctagaaga aaaggaagag ccaggctttc tcaccggctt aaagatccct
     3421 gccccgtggg ctgctgggaa gaccgtggaa acagtacacc ctgtcagaga caactataag
     3481 tttaaagaga ctgttcatat cccaggagct cgctgcctct atctacgatt tgacaccaga
     3541 tgctcgtcac agtacgacta tgacaaatct aacggtctat tttctgtttt gaagttggtg
     3601 atatacgcgg ggcctaacac aaacagtagg aaggttgctg agtacggagg caacactctg
     3661 ggatatggca gccggagtgt cttaggaacg ggttggccga aggacttggt gaaggttgaa
     3721 ggcgatacag tcaccttctc ctttgaaatg agaagtggcc gtgaacacaa cactcctgac
     3781 aaagctatgt ggggctttgc ttgcacagtc cgcgctcagg agtcctcaga agatgtctca
     3841 ggaggcttgc ccttcctggt agacctggcc ttaggtctgt ctgtgttagc ttgttccatg
     3901 ttaagaatcc tatacaatgg accagaaatt accaaagaag aggaagcctg tcaggacctg
     3961 ttgcgatcca aacttctaca aaggtgccaa tggcaggtgg aggccaacgg tgtcatctcc
     4021 cctgccctta ctccgagtcc ctctccactg ccgctgacca tagaagaaga cagagaattc
     4081 acctacccct cggatgtcct tgtgcctccc gttgggaact actttgacct gcctcggatc
     4141 aggctgcctc caggaatcat gataaagctc agggaaattt ctgggcgagc acgacctcag
     4201 tttagaccaa gtataaaaga ggtgatccag cccgatgtca tggaggaaat ggtggtgtca
     4261 tgtgttatta agcacttgaa cttggttgat gcgctgcagt ccctaatcaa tttccagtat
     4321 caggaagagc atgctgagga atatgattta ttgtgtaaaa tcatgggaga gacctttaag
     4381 aagctcaatg ccatggagag acagctgcag agtgtggctg agctggaaca gaagtggcaa
     4441 agtgaggctg aggatgccat gcaggggaag ctggagaaca acatgccttt cttttatgac
     4501 taccatttta atgagaacaa aatgaaagaa ctagagcttt tgtgttcaat gaaggaagtc
     4561 tccttcgacg gaaatgatct tgaaaacatg gtcctctcac tgagggagaa gttcctccaa
     4621 gaagtgaatt ctcttactca gaaaccctcc cacccgctgg ccaaaacaaa gacactggtg
     4681 aagagtctga tgaaccgagc agagctgctg ctgcatgtta ccattgcagc ccagtcgggc
     4741 ctcaccagga gcatctcagg aacaccagca gagacgcctg catgcaaatc agcttcagaa
     4801 acaaaggtgg cgtctcatgc tgtccggcag cctgttttcc ttcgcagcat gtctgctcct
     4861 tctgacctgg aaatgattgg taatgaagac ttggaattta ctagagccaa tcagagttct
     4921 gttttctgta ggcgtcgcca tgtgaccagc caccgcagca gctcctttac actcttacag
     4981 tcactggcca tcgaggacag cagggacaag cccacttaca gcgtcctgct tgggcagctg
     5041 tttgctttca ttggcaccaa ccctgaccaa gcggtgtcta gtagcagctt ccttttggct
     5101 gcacagacaa gatggcggcg cgggaacact cggaagcagg ccctggtgca tatgcgggag
     5161 ttgctgactg ctgctgtgcg agttggagga gtgacacacc tggtagggcc agtgacaatg
     5221 gtccttcagg ggggacccag aattgaagag ctcacctgtg gtgggatggt ggagcaggtc
     5281 caggaagcct ttggggagac catgacgtct gttgtgtctc tgtgtgctcg gtaccctatt
     5341 gcttgtgcga acagcattgg actcctgtgt accatacctt acaccaggag tgaagagaag
     5401 tgcctggtcc gcagtggcct tgtgcagctc atggaccgac tctgcagctt gagcagtcag
     5461 accgagtcca gctccagcga gaagcagacg aagaagcaga aggtggccac catggcctgg
     5521 gctgccttcc aagtgttggc taaccgctgt gtggagtggg agaaagagga aggtggctcc
     5581 acagaggctg tgcactcggg gctggcccgg caggtgtcca gtctcctcac caatcacctt
     5641 gcccgagcta ctgagtgctg tggcaaccag gctgctggga acgacgccct gcaggacgtc
     5701 ctgagtcttc tcaatgacct ttccaggagc cacataggga aggccatctt gagccagcca
     5761 gcctgcgttt ctaagctcct ctctctactg ctggaccagc gtccatcccc aaagctggtg
     5821 ttgatcattc ttcagttatg ccgggctgct ctgcctttga tgagcgtgga ggactgtggg
     5881 aatgtggagc tcccgccctg gagctactcc gtcccctccc tgaacagtga gcaggaggac
     5941 cccagtgacc ctgcttccaa gatcgcctct ctgctcttag ccaagctggc agactatgtg
     6001 gtcccaggat gtcagacggt tctctctcca actgcttctg aacctgacac cacactgaca
     6061 aaaaccagtc ctaagaattc cttaaaagga gataaagatc ctggagaaga gagtgaagcg
     6121 gtggatggca agctctccat atttatccac aagcgggaag accagtcctc ccatgaggtc
     6181 ctgcagccat tgctgagcag ctcagaagga cggccctttc gacttggtac tggtgccaac
     6241 atggaaaaag ttgtgaagat ggaccgagac atgaccaagg gtggctgctg tgaagtgatc
     6301 acagaagagg cctcagccgc cctcaggaaa gcaaccaagt gggcacagtc gggcctcatt
     6361 gtcagtgtcg ggccaccagt ggaatccatc aacccagaga ctgtgagtgg gctgtccaca
     6421 ggtgacaaga agaaaacggc ccaaacctcc atctgccgag aaaggaactc ggaactggcc
     6481 agaactgacc ccgtgcgccc cttcatcagt gggcatgtag caaacagtat ggccgcagaa
     6541 gtgatcgcct tgcttcatag cctgctaatg gcaccagaat ctaatgctgc tcagatatgg
     6601 accacaacgg cagaaaaggt tttgtctcga gcgttgatgt acattccaca actagggaaa
     6661 tatgcagaaa gcatcctgga aaatgggagc agcagtggca ggaaactcgc caagcttcag
     6721 aggattgcac gccaggctgt tgccgccctc tgtgcactgg gaggctttaa agagaccatc
     6781 aagattggct ccgaggtcca ggttttaggt agaggaatat cgggaagcat tggagttgtg
     6841 gcttctatca atgaacagga aggcatagct acagtcagat tccctcctgt ggactgcaga
     6901 aggacgtcac aagctgcaga cacgctgact attcctttgt ctagactctg tgttccacgg
     6961 tcagaggcac tgcctcttca taagctgtcc attactgaga aggtagtcca ggcagtgcag
     7021 tccatgctgc tccctcagga aggcagcctc tctatccaca cctctcttcc tgcaacagga
     7081 gatggctcgg cacctgtcat ggcagttgtc cggcttctgg ctgaaatcag aaccagagcc
     7141 tgcctggtca tggcacagct tttagaagac agcctgtttt gtgaggaatt catacagcag
     7201 tgtccagcag cagtggaagt cctgaatctc gtagcccagg agtgcagtgc aggcgagcgg
     7261 cttgcagttg tagaggtgca gtgcgagagg ctcaggatgc tctatcggga ctgcgctcgg
     7321 cctcctccac ctccgctgca ggccgaccgg agacagccca aagagatcac ctggagccct
     7381 tctcgagtgt tccctccagt tcgcgcctgc atgttttcat ctcacctcac ctctgtcacc
     7441 ttcctggctg accccagtgc tggaggaggt cttccccggg gcacattcat ctatgccacc
     7501 tccccgctgc cagttcaggc cccgtctttc tactgggaaa ttgagattgt ttcctatgga
     7561 gacactgatg acgacactgg accaatcgtc tcatttggct ttgctacaga ggctgagaag
     7621 cgtgatgggg catggaccaa tccggtgggc acttgcctct tccacaacaa tggccgagct
     7681 gtgcactaca atggctccag tctgctgcag tggaagagcg tccgcttaga tgtcacactc
     7741 tgtcctggtg atgtggcagg gatcggctgg gaacggaccg aggggactcc acctcctcca
     7801 gggcagccag ccaaaggtcg ggtgtacttc acatactgcg ggcagcgcct cacaccgtac
     7861 ctagaagatg tctctggcgg gatgtggcct gtggttcaca ttcagaagaa gaacacaaaa
     7921 actcgagcca attttggctc ccgcccgttt gcgtatgctg aaggacaggc ccaccgtaac
     7981 gctgctgacc tgtgcactga cctggcagag gagatcagcg ctaacttcga ggccttgcca
     8041 ttcgccatgg catctgacag tgacaacgat gctggcacca gtattgcgtc agacccaggc
     8101 actcatgggc caccatgccg gattgcagca gtggccacag cccagcagca atatgacagt
     8161 gacacctcct gccattataa agtcgagctc agctatgaga atttcatcac ctctggccca
     8221 gacccccacc cacctcccat tgcagatgat gaaagcgacg atgatgacga tgatgacatc
     8281 cctcaggagg accactacgc gctgctggtg aaagcatggg agaccaaggt tttccctacc
     8341 atccggagac gcttccgaaa tgaagctgag cggaagtcgg gcctggacca gatcaagggt
     8401 gctttacaac taggcatggt ggacatcgcc cggcagacag ttgagtttct ctatgaggag
     8461 aatggcggca tccccagaga cctttatctt cccaccattg aggacattaa agacgaagca
     8521 aacaagttca caattgacaa agttcgaaaa ggtctcacgg ttgtaacccg ctctccagac
     8581 agcagcaatg tagctagcag tgctgtggga actgctttgc caaaatttgc catccgaggg
     8641 atgctaaaaa ccttcggcct tcatggagtc gtcctagatg ttgactcagt gaatgagttg
     8701 gtgcaggtgg agacatacct ccggagtgaa ggggtgctgg tgcggtactg gtaccccatc
     8761 gacatgctag aaaggccccc tgcgggctac cgcaggacgg ccactaacgg gctggtcaca
     8821 ctggacaata ccaaccttca gattcacaga gagctgctgc ggtgcgaggc tgcgctggcc
     8881 cggttgtact gtcgcatggc cctgctcaac atcttcgccc ccaagctacc tcacttattc
     8941 actcggctct tccacatccc tgccatccga gacatcacct tagagcacct gcagctcctg
     9001 tccaatcagc tccttgctcc tcccctccca gatggcacca tcagctccag ctccatcctc
     9061 ctggcacagt ctctgcagca ctgcatccac tcgcagagct gctctgccac cgacctcttc
     9121 taccagggca actcccagac gctgagggag tggctcagcg tggccatcac ccgcaccctg
     9181 caccagggcg aggacagcct tctggagctg acaaagcaga tctgcgcctt cctgcagaca
     9241 gcaccagagc agttcccctc cgaggaattc ccagtttccg agtccaaagt cagtatggat
     9301 gtgaatttcc ccggagcagc ttttgttgtt gtgtcttgca aagaaagtca gtctggattc
     9361 cgcaaagact cctctctgta caaggctccg tgggcacgtg tgctcgtcta tgggctcggc
     9421 cacaaagtga agcgcactgg ccagctgaac ctcattgaag ccgcctgcta ccctcgagac
     9481 gcctccccag ccaacactgg gctcgcccct ccacctacag ctgaccagta cccttctgtg
     9541 gttctctcca cagacaaagt ccacataaaa ctaggagtgt ccccacctcc tggagcagtg
     9601 ctggtcttgc actctctgcc cctggagttc cctctggcga tggcctttgc tgagcagctg
     9661 ctgtcctgga agtcggagga cagcgaaggg aagtcagagg acgagcctga cagcatccct
     9721 acctccgtcc tcctgcacgt ggtggaactg ctaggaaact tcctatggac tacagacatg
     9781 gcggcctgtg tgaaggagtt ggtcttccac ctcttggctg agctcttgcg tacagtacat
     9841 accctggagc agcggaagca cccagccggc ctgtcctcct ctatcgccct ccagctcaat
     9901 ccctgcctgg ccatgctgat ggccttgcag tcggaactgc acaagctgta cgacgaggag
     9961 acccagggct gggtctcgag cagcacctgt gggggctccg gagcagcagc cgtgggcgac
    10021 cagggcaggt tttccaccta cttccacgct ctcatggaag gctgcctggc agttgcggaa
    10081 gtgaccctac ctaccaacat cagtgtcaca gctagcgggg tgacctcaac gaccactcca
    10141 aacctcagtg actcgtcctc ttcctcctcc tcctccccag gacagacacc acagagccct
    10201 agcctcctgt ctaagagaaa gaaagtcaag atgaagcggg agaaggcctc ctcctccaac
    10261 aagcgccagt cctcccgtgc cacggatgca gactccactg tgcttagcat tgggggtagc
    10321 aagcctgagg acatgttatg gttccaccgt gctctcacct tgcttatcat cctccggcac
    10381 cttacgaaaa aggacccaca gggcttgggt gtcaccagcg atgccattgc tgatgcctgc
    10441 caggccctgg tcggccccac tgcccatagc cgcctgctgg tgatctctgg cattcccacc
    10501 cacctggatg aggctgtcgt cagaggggct atccgcaagg cctgcaatgc ccatggcggc
    10561 gtcttcaaag atgagatcta catcccactg caggacgagg accccaagag gccaaaagac
    10621 aaggctgagg gtggcgacag caaggtggaa tctgagaagt tgctgggatt ccccagtgtg
    10681 gacagcctgg aggggagcac atcaagcagc ctggcccctg ccatgagcat cagcgcctca
    10741 gcttccacca gccaggcctc agtctgcagc tcccagtgtg tttcacagac cgctagtgac
    10801 ctctcagtag accccctgcc ctcaggcctg gagcttcctg tccctcctgt cctgttggaa
    10861 ccccatgtag tgtccagcca ggagagcctg gacatttcct tatgcagcac tggcagcctg
    10921 ggcagcctgg gcagcctggg ggagcctcta gacaatccag agacagcatc tgtgtccgac
    10981 gtgggctcca tgtacacggt cacgtccctg gatactcagc ctctcacaac gcgccctatc
    11041 aaaggctttg cagtggtgga gataaggtcc cgagccaaaa tcgagaaagt cagagcaagt
    11101 ttatttaaca ataacgatct gatcggcctg tccagtctgg acggtgaaga ggagctgatg
    11161 gaaatgtcca cagaggagat cctgacggtg tctgtggtca atcagagtct gtttgacaca
    11221 caagggagcc caggactaga agattacttc aatgacaagt ccattaaagg tgagaaactg
    11281 gtgcctgggg ccagagaggt cctgacagaa atatttaaaa gctgcgccca ctcagagcag
    11341 acgctgagcc tgacaccagc caaacccatc agggtctccg acatctatct tagcaaagaa
    11401 cagatcaact cccagacccc gggcaacctc cttcacctct tcttcaccaa tgtccggcct
    11461 ccaaagaagg tgctggagga ccagctcaca cagatcctga ggaaatatgg cgtgcccaag
    11521 cccaaactgg ataagagcaa atacagcaaa gccgggaagg agcagcaccc agtgaaggtg
    11581 gtgagcacga agcggccagt caccaagccg cctgccaagg acaaagctgt gctcagcagc
    11641 ctcaggaccg cactaagtga gaagaagcca accgtgaagc ccaagtcacc tgagaagagc
    11701 aaaccggatg aaaaggatcc agaaaagtca cccaccaaaa aacaagaagt tcctgaggaa
    11761 aagtacctaa ctctagaagg atttcacaaa ttcgtcattg accgtgccaa gcaagacatc
    11821 cgcagtgtct ggagggcaat cctgtcctgt gggtatgacc ttcattttga gaggtgtgcc
    11881 tgcattgatg tccggcacgc acagaaggcc tcccggaagt gggctctgga gatggatgtg
    11941 gctctcgtgc agtacatcaa ccggctgtgc cgccacctcg ctatcacacc agcacggctc
    12001 catcctcatg aagtgtacct tgacccagct gatgccactg accccaggat ggcctgcctt
    12061 tccaatgtgc ctatcgagag cttgcgtctg cgctttgcac tgctccagtc tctcaacacc
    12121 acactggaga ccttcttcct gcccctggtg gagctgcgtc agacacccat gtacgcacac
    12181 agcatcgccg ccttgctgaa ggaggcaaaa gggctgatct tctatgacac aaaagtgact
    12241 gtgatgaacc gggtgctaaa tgcgactgtg cagaggacag ctgaccacgc ggcgcccgag
    12301 atcaccttag acccactgga aactgtggga ggggaaatca gagcttctga aaactcctac
    12361 ttctgccagg ctgcccggca gctggcctcc gtgccatctt ctcagctctg tgtcaagttg
    12421 gccagtgggg gtgaccccac gtatgccttc aatatccgct tcactgggga ggaggttcat
    12481 ggcaccagtg gctccttccg ccacttcctg tggcaggtgt gtaaagaact gcagagctcc
    12541 tcactgtcgc tgctcctgct gtgccccagc tctgctgtca acaagaacaa gggcaagtac
    12601 atcctgaccc caagccccat cacctatggg gaggagcaac tgctacactt cttgggccag
    12661 ctgctgggaa tcgccatccg tgcagatgtg cctctccccc tggacctgct gccctccttc
    12721 tggaagacgc tggttggcga gcctcttgac cctgaccagg acctgcagga ggcagacatc
    12781 ctcacctaca attatgtcaa gaagtttgag agtatcaacg atgagagcga gctggaggcc
    12841 ctgtgtgccg agatcgcctc ccagcacctg gccactgaca gcccggaagg ccccaagccc
    12901 tgctgccgct tcacctacct gaccatgact ggcgaggagg tggagctgtg cagccgtggc
    12961 cggcacatcc ctgtggcttg ggagaacaag gatatctacg cggcagccat ccggagccta
    13021 cgcctgcgtg agctacagaa catggagtgc gtgactgctg tgcgtgctgg cctgggctcc
    13081 atcatccccc tgcagctgct caccaccctc agcccactgg agatggaatt gcgtacctgt
    13141 ggcctcccgt acgtcaacct agagttcctg aaggcccaca ccatgtacca ggtggggctg
    13201 atggagacag accagcacat cgagctcttc tggggggctc tggagacgtt cacccaggag
    13261 gaactgtgca agttcatcaa gttcgcctgc aatcaggagc gcatcccctt cacctgccct
    13321 tgcaaggacg gcggtcctga cacagcccat gtgccgccgt accccatgaa gattgcccct
    13381 ccagatggca cagcaggtcc tcccgactcc cgctacatcc gagtggagac ctgcatgttc
    13441 atgatcaagc ttccccagta ctcctccctg gagatcatgc tggagaagct gcgctgtgcc
    13501 attcactacc gtgaagaccc cctaagtggc tgatgggagt gggccagaag attaggctat
    13561 caccaaggca cccttctgcc ggcttgggaa gccagtccag gcgcatccct ccagggcctc
    13621 aagtgaggag ctggcgacat ttgcattctg aactttcgtc cgtgtcccag gaccacctgg
    13681 aagacacttt gtatgtgtcc attttgtgag ggtccgttcc tttgctgctg tctgtggtac
    13741 atttgtagga tagttaattc ccgacagttt atgtctaact tgatcttcct ggacactgtt
    13801 ttggtggcta ccagactgct gtgatgccac aggttcaggt ggctcgtcat cagagagcca
    13861 ccagtggaaa gctgagggtt gaggtgacct cagccacaca aagtatcctg ttctcttaca
    13921 gagtgtctcc acaaatgtgt gagcagtcct cagtcctgcc ctcctgccct gagctggctt
    13981 ctcccagagg cagcgtctgc agggctccct ccttccgtct tgagtggttg agctagtgct
    14041 caaacattca agagacacgg ggaactcatg tgttaacctt cctgctttac tgtgtgtccc
    14101 tgccttgttt gtttggggtt ttttttgttt gtttgttttt gtttttttgt tgtttttttt
    14161 tttaggaaat cccacagagg ccccttgtct cctcccatcg aggcagccct atctgccacc
    14221 tgtctcttct gggcacctgg gctgaatggc ctgaggatac ctcaggagca gacacccagg
    14281 ggctactcca ggccttagtt cacagacagg ttgggcacgt cttggtggct ggagctgaaa
    14341 gacagtggag ctagagggat agtgctgagt gggcctttct acagctgact gcacaggaaa
    14401 gcacatgact caagcctacc ccactctgtg ctcagagagg gcccacctca ccacactgct
    14461 gtaaggagcc caggaaaggg ttacagccca tctctaaaga ctgtctgagg tgctctgccc
    14521 acacagggct gcatcagtga cccaggcaga gactgcaggg gattcctctg tgccctggct
    14581 ggcctgccca gcaccctcta caaccaacgt gtgtgccagg gctgagcttc ctgcaggctc
    14641 acccactacc ccagtgcatt tgtgccccaa ataagtcttt gtccaatggt actttgttca
    14701 agagcagcac atgccaactg ttggacactg tcacttgggc ctcaccagtt gtcacagaat
    14761 ggcagcgctg tagctattgt atgatattgt gcacacagaa gttctaagga aagtgaggag
    14821 gatgtgctcc tctccacagc acccggcctg cttgggaggc cgtgcaagcc ttagggctgg
    14881 catccatctc ctcctcgtta cacttaggaa acgcattgag gaccatgaca gaaaacaccc
    14941 cacccaaccc cacccgggga agtgatatgc cccagctcag tgtgctggcc acgccagtca
    15001 cagggctgca agccctgctc tcacagaaga tcgtggccgc tgtgtgggac caccccagcg
    15061 acctcaagga tcctgactct gttcgacaga aggcaggagc ctctgaattt taaagtgagt
    15121 tttcattcct gtaccttcag atccttggtt cccttctatc cttgtcccac gaatggactt
    15181 gggattctgt cagctacctc cccaggaggg ttctggaagc ttctgttggc ccattccttg
    15241 attagatgac agctgtgagt gagatatctg ctgctaactc agctgctgct cctagagagc
    15301 gcactgaggt ccagacagat cccagtcttg gccctgaaca atgtgtgctg taaagttact
    15361 tgatgtatat ttattataat tatttatgac tgcattaaca gcccccattc agtctgatgc
    15421 tacttacact atgctgtgta aaggaagctc actacggaaa aagtcacacc aataaataac
    15481 cttcatctga ctgac
//
