LOCUS       XP_038945800            4432 aa            linear   ROD 22-FEB-2024
DEFINITION  probable E3 ubiquitin-protein ligase HECTD4 isoform X1 [Rattus
            norvegicus].
ACCESSION   XP_038945800
VERSION     XP_038945800.1
DBLINK      BioProject: PRJNA1074393
DBSOURCE    REFSEQ: accession XM_039089872.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_086030) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_036323735.1-RS_2024_02
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.2
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 02/09/2024
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4432
                     /organism="Rattus norvegicus"
                     /strain="BN/NHsdMcwi"
                     /bio_material="RGD 61498"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /sex="male"
                     /tissue_type="kidney, spleen, liver"
                     /geo_loc_name="USA: Wisconsin, Milwaukee"
                     /lat_lon="43.05 N 88.04 W"
                     /collected_by="Rebecca Schilling, Melinda Dwinell"
     Protein         1..4432
                     /product="probable E3 ubiquitin-protein ligase HECTD4
                     isoform X1"
                     /calculated_mol_wt=485468
     Region          2414..2569
                     /region_name="SPRY_HECT_like"
                     /note="SPRY domain in HECT E3; cd13735"
                     /db_xref="CDD:293970"
     Region          4034..4427
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cl27008"
                     /db_xref="CDD:474882"
     Site            order(4039,4079,4090,4155,4350,4394..4395,4398..4402,4422)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(4184,4187..4188,4190..4191,4194,4208,4210,
                     4214..4215,4217,4233,4238,4255,4259)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..4432
                     /gene="Hectd4"
                     /coded_by="XM_039089872.2:232..13530"
                     /db_xref="GeneID:304503"
                     /db_xref="RGD:1309762"
ORIGIN      
        1 mgssaaaaaa aaaaaadsaq wlsvkeetif lhdglirvtd laelpseilg apeaadtdle
       61 iltfetknpt elaerlrsvc gnqsnayarl leyrlnalrg lwnaqrqlal eeqheregsg
      121 deetlallkr qgllqqpeqa pftsrvglll vfpliqsqsr tdpslcnita evllnclrdc
      181 qplsltkepa dclsgietll cswleetsdt grhiphkqke naaaalvala cargslktfv
      241 htvhllqrqt elgslpvadv lyrllllegg pgspscllgg khivswgyed mlpapdsnpg
      301 sssenkdadl grcltadghy lyttnsagrg lsklgsglhg tlrgfvycrn eelepgwvay
      361 gsghllhrpv sfdnkphslf qvidqntlqv cqtvpmpasp lpvgstmstv hlssdgtyfy
      421 wiwspaslne ktpkghsvfm difelvveng vfvanplqer tilmrkeges aksinemlls
      481 rlsryrasps atlaaltgst isntlkedqa antscglplk tlrrtpmytc gtylvmlvpp
      541 pggsgssatr slfggtsgls slkilasslv ynisdgqfas radlidaags slgrgalvpg
      601 lgacydtvnn mlwtcsndyi dqwcnpgnqa fhyvcqrlgv shiipepkee aistnevinq
      661 llhhvgamci hqlnllatnp nlpitsvlgk qhpiearhls sicdimekam vngdtcivrc
      721 ilvvfqvvfk fffspqtern rdiirrsgll lwqllmapkd qicpeiqkev claissglni
      781 lypgeteinn llklvltege rnsglsqlrd viltnlaeql qnnrfgsded dhyrlndell
      841 hyilkivvre scilitkcqt vskddfqkll stvpaasscl rylmavqnhl lsntvlikpd
      901 dnedsdsslq getlkvqelk tsilalatqv ltgcdevlem lqqvttalin sdmpdreqrl
      961 kgleqvtkat mlghllpvll tslmhpnlqt ltmadalmpq lvqlvlytsq talllktqcp
     1021 vfaevgcspc gtsdqkcrlf pdermleeke epgfltglki papwaagktv etvhpvrdny
     1081 kfketvhipg arclylrfdt rcssqydydk snglfsvlkl viyagpntns rkvaeyggnt
     1141 lgygsrsvlg tgwpkdlvkv egdtvtfsfe mrsgrehntp dkamwgfact vraqessedv
     1201 sgglpflvdl alglsvlacs mlrilyngpe itkeeeacqd llrskllqrc qwqveangvi
     1261 spaltpspsp lpltieedre ftypsdvlvp pvgnyfdlpr irlppgimik lreisgrarp
     1321 qfrpsikevi qpdvmeemvv scvikhlnlv dalqslinfq yqeehaeeyd llckimgetf
     1381 kklnamerql qsvaeleqkw qseaedamqg klennmpffy dyhfnenkmk elellcsmke
     1441 vsfdgndlen mvlslrekfl qevnsltqkp shplaktktl vkslmnrael llhvtiaaqs
     1501 gltrsisgtp aetpacksas etkvashavr qpvflrsmsa psdlemigne dleftranqs
     1561 svfcrrrhvt shrsssftll qslaiedsrd kptysvllgq lfafigtnpd qavssssfll
     1621 aaqtrwrrgn trkqalvhmr elltaavrvg gvthlvgpvt mvlqggprie eltcggmveq
     1681 vqeafgetmt svvslcaryp iacansigll ctipytrsee kclvrsglvq lmdrlcslss
     1741 qtessssekq tkkqkvatma waafqvlanr cvewekeegg steavhsgla rqvsslltnh
     1801 larateccgn qaagndalqd vlsllndlsr shigkailsq pacvskllsl lldqrpspkl
     1861 vliilqlcra alplmsvedc gnvelppwsy svpslnseqe dpsdpaskia slllaklady
     1921 vvpgcqtvls ptasepdttl tktspknslk gdkdpgeese avdgklsifi hkredqsshe
     1981 vlqpllssse grpfrlgtga nmekvvkmdr dmtkggccev iteeasaalr katkwaqsgl
     2041 ivsvgppves inpetvsgls tgdkkktaqt sicrernsel artdpvrpfi sghvansmaa
     2101 eviallhsll mapesnaaqi wtttaekvls ralmyipqlg kyaesileng sssgrklakl
     2161 qriarqavaa lcalggfket ikigsevqvl grgisgsigv vasineqegi atvrfppvdc
     2221 rrtsqaadtl tiplsrlcvp rsealplhkl sitekvvqav qsmllpqegs lsihtslpat
     2281 gdgsapvmav vrllaeirtr aclvmaqlle dslfceefiq qcpaavevln lvaqecsage
     2341 rlavvevqce rlrmlyrdca rppppplqad rrqpkeitws psrvfppvra cmfsshltsv
     2401 tfladpsagg glprgtfiya tsplpvqaps fyweieivsy gdtdddtgpi vsfgfateae
     2461 krdgawtnpv gtclfhnngr avhyngssll qwksvrldvt lcpgdvagig wertegtppp
     2521 pgqpakgrvy ftycgqrltp yledvsggmw pvvhiqkknt ktranfgsrp fayaegqahr
     2581 naadlctdla eeisanfeal pfamasdsdn dagtsiasdp gthgppcria avataqqqyd
     2641 sdtschykve lsyenfitsg pdphpppiad desddddddd ipqedhyall vkawetkvfp
     2701 tirrrfrnea erksgldqik galqlgmvdi arqtveflye enggiprdly lptiedikde
     2761 ankftidkvr kgltvvtrsp dssnvassav gtalpkfair gmlktfglhg vvldvdsvne
     2821 lvqvetylrs egvlvrywyp idmlerppag yrrtatnglv tldntnlqih rellrceaal
     2881 arlycrmall nifapklphl ftrlfhipai rditlehlql lsnqllappl pdgtissssi
     2941 llaqslqhci hsqscsatdl fyqgnsqtlr ewlsvaitrt lhqgedslle ltkqicaflq
     3001 tapeqfpsee fpvseskvsm dvnfpgaafv vvsckesqsg frkdsslyka pwarvlvygl
     3061 ghkvkrtgql nlieaacypr daspantgla ppptadqyps vvlstdkvhi klgvspppga
     3121 vlvlhslple fplamafaeq llswksedse gksedepdsi ptsvllhvve llgnflwttd
     3181 maacvkelvf hllaellrtv htleqrkhpa glsssialql npclamlmal qselhklyde
     3241 etqgwvssst cggsgaaavg dqgrfstyfh almegclava evtlptnisv tasgvtsttt
     3301 pnlsdsssss ssspgqtpqs psllskrkkv kmkrekasss nkrqssratd adstvlsigg
     3361 skpedmlwfh raltlliilr hltkkdpqgl gvtsdaiada cqalvgptah srllvisgip
     3421 thldeavvrg airkacnahg gvfkdeiyip lqdedpkrpk dkaeggdskv esekllgfps
     3481 vdslegstss slapamsisa sastsqasvc ssqcvsqtas dlsvdplpsg lelpvppvll
     3541 ephvvssqes ldislcstgs lgslgslgep ldnpetasvs dvgsmytvts ldtqplttrp
     3601 ikgfavveir srakiekvra slfnnndlig lssldgeeel memsteeilt vsvvnqslfd
     3661 tqgspgledy fndksikgek lvpgarevlt eifkscahse qtlsltpakp irvsdiylsk
     3721 eqinsqtpgn llhlfftnvr ppkkvledql tqilrkygvp kpkldkskys kagkeqhpvk
     3781 vvstkrpvtk ppakdkavls slsrtalsek kptvkpkspe kskpdekdpe ksptkkqevp
     3841 eekyltlegf hkfvidrakq dirsvwrail scgydlhfer cacidvrhaq kasrkwalem
     3901 dvalvqyinr lcrhlaitpa rlhphevyld padatdprma clsnvpiesl rlrfallqsl
     3961 nttletfflp lvelrqtpmy ahsiaallke akglifydtk vtvmnrvlna tvqrtadhaa
     4021 peitldplet vggeirasen syfcqaarql asvpssqlcv klasggdpty afnirftgee
     4081 vhgtsgsfrh flwqvckelq ssslsllllc pssavnknkg kyiltpspit ygeeqllhfl
     4141 gqllgiaira dvplpldllp sfwktlvgep ldpdqdlqea diltynyvkk fesindesel
     4201 ealcaeiasq hlatdspegp kpccrftylt mtgeevelcs rgrhipvawe nkdiyaaair
     4261 slrlrelqnm ecvtavragl gsiiplqllt tlsplemelr tcglpyvnle flkahtmyqv
     4321 glmetdqhie lfwgaletft qeelckfikf acnqeripft cpckdggpdt ahvppypmki
     4381 appdgtagpp dsryirvetc mfmiklpqys sleimleklr caihyredpl sg
//
