LOCUS       NM_001399212            3503 bp    mRNA    linear   ROD 17-SEP-2024
DEFINITION  Rattus norvegicus HECT domain E3 ubiquitin protein ligase 3
            (Hectd3), mRNA.
ACCESSION   NM_001399212 XM_008764069
VERSION     NM_001399212.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3503)
  AUTHORS   Ruan,Z., Li,Y. and Chen,Y.
  TITLE     HECTD3 promotes NLRP3 inflammasome and pyroptosis to exacerbate
            diabetes-related cognitive impairment by stabilising MALT1 to
            regulate JNK pathway
  JOURNAL   Arch Physiol Biochem 130 (4), 373-384 (2024)
   PUBMED   35913790
  REMARK    GeneRIF: HECTD3 promotes NLRP3 inflammasome and pyroptosis to
            exacerbate diabetes-related cognitive impairment by stabilising
            MALT1 to regulate JNK pathway.
REFERENCE   2  (bases 1 to 3503)
  AUTHORS   Zhang,L., Kang,L., Bond,W. and Zhang,N.
  TITLE     Interaction between syntaxin 8 and HECTd3, a HECT domain ligase
  JOURNAL   Cell Mol Neurobiol 29 (1), 115-121 (2009)
   PUBMED   18821010
REFERENCE   3  (bases 1 to 3503)
  AUTHORS   Yu,J., Lan,J., Zhu,Y., Li,X., Lai,X., Xue,Y., Jin,C. and Huang,H.
  TITLE     The E3 ubiquitin ligase HECTD3 regulates ubiquitination and
            degradation of Tara
  JOURNAL   Biochem Biophys Res Commun 367 (4), 805-812 (2008)
   PUBMED   18194665
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Jan 4, 2022 this sequence version replaced XM_008764069.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.666793.1,
                                           SRR26360186.465431.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-472               JAXUCZ010000005.1  135706437-135706908
            473-633             JAXUCZ010000005.1  135707098-135707258
            634-726             JAXUCZ010000005.1  135707521-135707613
            727-862             JAXUCZ010000005.1  135707691-135707826
            863-978             JAXUCZ010000005.1  135708075-135708190
            979-1092            JAXUCZ010000005.1  135708279-135708392
            1093-1175           JAXUCZ010000005.1  135708527-135708609
            1176-1341           JAXUCZ010000005.1  135709014-135709179
            1342-1423           JAXUCZ010000005.1  135709382-135709463
            1424-1606           JAXUCZ010000005.1  135710623-135710805
            1607-1659           JAXUCZ010000005.1  135710937-135710989
            1660-1724           JAXUCZ010000005.1  135711136-135711200
            1725-1828           JAXUCZ010000005.1  135711296-135711399
            1829-1948           JAXUCZ010000005.1  135711660-135711779
            1949-2038           JAXUCZ010000005.1  135711885-135711974
            2039-2245           JAXUCZ010000005.1  135713008-135713214
            2246-2375           JAXUCZ010000005.1  135713405-135713534
            2376-2450           JAXUCZ010000005.1  135713633-135713707
            2451-2532           JAXUCZ010000005.1  135713832-135713913
            2533-2604           JAXUCZ010000005.1  135714086-135714157
            2605-3503           JAXUCZ010000005.1  135714275-135715173
FEATURES             Location/Qualifiers
     source          1..3503
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..3503
                     /gene="Hectd3"
                     /gene_synonym="RGD1309823"
                     /note="HECT domain E3 ubiquitin protein ligase 3"
                     /db_xref="GeneID:313525"
                     /db_xref="RGD:1309823"
     exon            1..472
                     /gene="Hectd3"
                     /gene_synonym="RGD1309823"
                     /inference="alignment:Splign:2.1.0"
     CDS             104..2689
                     /gene="Hectd3"
                     /gene_synonym="RGD1309823"
                     /EC_number="2.3.2.26"
                     /note="HECT domain containing E3 ubiquitin protein ligase
                     3"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase HECTD3"
                     /protein_id="NP_001386141.1"
                     /db_xref="GeneID:313525"
                     /db_xref="RGD:1309823"
                     /translation="MAGPGPGAALESPRQLLGRVRFLAEAARSLRAGLPLPAALAFVP
                     REVLYKLYKDPAGPSRVLLPVWEAEGLGLRVGAAGPAPGTGSGPLRAARDSIELRRGA
                     CVRTTGEELCNGHGLWVKLTKEQLAEHLSDCSLDEGWLLVCRPAEGGARLVPIDTPDH
                     LQRQQQLFGVDYRPVLRWEQVVDLTYSHRLGSRPQPAEAYTEAVQRLLYVPPTWTYEC
                     DEDLIHFLYDHLGKEDENLGSVKQYVESIDVSSYTEEFNVSCLTDSNADTYWESDGSQ
                     CQHWVRLTMKKGTIVKKLLLTVDTTDDNFMPKRVVVYGGEGDNLKKLSDVNIDETLIG
                     DVCVLEDMTVHLPVIEIRIVECRDDGIDVRLRGVKIKSSRQRELGLNADLFQPASLVR
                     YPRLEGTDPEVLYRRAVLLQRFIKILDSVLHHLVPAWDHTLGTFSEIKQVKQFLLLSR
                     QRPSLVTQCLRDSESSKPSFMPRLYINRRLAMEHRACPSRDPACKNAVFTQVYEGLKP
                     SDKYEKPLDYRWPMRYDQWWECKFIAEGIIDQGGGFRDSLADMSEELCPSSADTPVPL
                     PFFVRTANQGNGTGEARDMYVPNPSCRDFAKYEWIGQLMGAALRGKEFLVLALPGFVW
                     KQLSGEEVSWSKDFPAVDSVLVKLLEVMEGVDKETFEFKFGKELTFTTVLSDQQVVEL
                     IPGGTGIVVGYEDRLRFIQLVQKARLEESKEQVAAMQAGLLKVVPQAVLDLLTWQELE
                     KKVCGDPEVTVDALRKLTRFEDFEPSDTRVQYFWEALNNFTNEDRSRFLRFVTGRSRL
                     PARIYIYPDKLGYETTDALPESSTCSSTLFLPHYASAKVCEEKLRYAAYNCVAIDTDM
                     SPWEE"
     exon            473..633
                     /gene="Hectd3"
                     /gene_synonym="RGD1309823"
                     /inference="alignment:Splign:2.1.0"
     exon            634..726
                     /gene="Hectd3"
                     /gene_synonym="RGD1309823"
                     /inference="alignment:Splign:2.1.0"
     exon            727..862
                     /gene="Hectd3"
                     /gene_synonym="RGD1309823"
                     /inference="alignment:Splign:2.1.0"
     exon            863..978
                     /gene="Hectd3"
                     /gene_synonym="RGD1309823"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1092
                     /gene="Hectd3"
                     /gene_synonym="RGD1309823"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1175
                     /gene="Hectd3"
                     /gene_synonym="RGD1309823"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1341
                     /gene="Hectd3"
                     /gene_synonym="RGD1309823"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1423
                     /gene="Hectd3"
                     /gene_synonym="RGD1309823"
                     /inference="alignment:Splign:2.1.0"
     exon            1424..1606
                     /gene="Hectd3"
                     /gene_synonym="RGD1309823"
                     /inference="alignment:Splign:2.1.0"
     exon            1607..1659
                     /gene="Hectd3"
                     /gene_synonym="RGD1309823"
                     /inference="alignment:Splign:2.1.0"
     exon            1660..1724
                     /gene="Hectd3"
                     /gene_synonym="RGD1309823"
                     /inference="alignment:Splign:2.1.0"
     exon            1725..1828
                     /gene="Hectd3"
                     /gene_synonym="RGD1309823"
                     /inference="alignment:Splign:2.1.0"
     exon            1829..1948
                     /gene="Hectd3"
                     /gene_synonym="RGD1309823"
                     /inference="alignment:Splign:2.1.0"
     exon            1949..2038
                     /gene="Hectd3"
                     /gene_synonym="RGD1309823"
                     /inference="alignment:Splign:2.1.0"
     exon            2039..2245
                     /gene="Hectd3"
                     /gene_synonym="RGD1309823"
                     /inference="alignment:Splign:2.1.0"
     exon            2246..2375
                     /gene="Hectd3"
                     /gene_synonym="RGD1309823"
                     /inference="alignment:Splign:2.1.0"
     exon            2376..2450
                     /gene="Hectd3"
                     /gene_synonym="RGD1309823"
                     /inference="alignment:Splign:2.1.0"
     exon            2451..2532
                     /gene="Hectd3"
                     /gene_synonym="RGD1309823"
                     /inference="alignment:Splign:2.1.0"
     exon            2533..2604
                     /gene="Hectd3"
                     /gene_synonym="RGD1309823"
                     /inference="alignment:Splign:2.1.0"
     exon            2605..3503
                     /gene="Hectd3"
                     /gene_synonym="RGD1309823"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggtgtgagg tggggcaggg tgtggtggga agctctgctt gcagtccccg ggctgcggcg
       61 gggcagggtt tccctggacg agtctcactt cacgggcttc actatggccg gcccgggccc
      121 cggcgcagcg cttgagtccc cgcgacagct cctgggtcgc gtgcgcttcc tggccgaggc
      181 ggcgcggagc ctccgggccg ggctgccact gcctgcggcg ctggctttcg tgccgcgaga
      241 ggtgctctac aagctttaca aggacccagc gggaccctcg cgcgtgctgc tgcctgtgtg
      301 ggaggcagag ggcctgggac ttcgtgtggg tgctgcgggc cctgccccgg gcacaggctc
      361 gggaccgctg cgcgccgccc gtgacagtat cgagcttcgg cgaggcgcct gcgtacgcac
      421 caccggcgag gagctgtgca acggccacgg gctctgggtg aagttaacca aggagcagct
      481 ggctgaacac ctgagtgact gtagtttgga cgaaggctgg cttctagtgt gtcgcccagc
      541 ggagggcgga gcccgccttg tacctatcga cactccagac cacctgcaac ggcagcagca
      601 gctatttggc gtggactacc ggccggtgct cagatgggaa caggtggtgg acctgacgta
      661 ctcacatcgc ctgggctcca ggcctcagcc agcagaggca tacacagaag ctgtacaaag
      721 actactctat gtaccaccaa cgtggacata tgagtgcgac gaagacctga tccacttctt
      781 atatgaccac ctgggcaaag aagatgagaa cctgggtagc gtgaagcagt atgtggagag
      841 catagatgtt tcttcctata cggaggagtt caatgtatcc tgcctgacag atagtaatgc
      901 agatacctac tgggagagcg atgggtccca gtgccaacac tgggtacggc ttaccatgaa
      961 gaaaggcaca attgtcaaga agctgctact cacagtggat accacagatg acaacttcat
     1021 gccgaagcgg gttgtggtct atgggggtga aggggacaac ctgaagaagc tgagtgacgt
     1081 gaacattgac gagaccctga tcggggatgt ctgtgtatta gaggacatga ccgtccacct
     1141 tccagtcatt gagatccgaa tcgttgagtg tcgagatgat gggatagatg ttcgtcttcg
     1201 aggggtcaag atcaagtcat ctagacagcg ggagctaggg ctgaatgcag acctgttcca
     1261 gccggccagt ctggtgcgat atccacgcct ggaaggcact gaccctgaag tgctgtaccg
     1321 cagagctgtc cttctgcaga gattcatcaa aatcctggac agtgtcctgc accacctagt
     1381 acctgcatgg gaccacacac tgggcacctt cagtgagatt aagcaagtga aacagttcct
     1441 gctgctgtca cgccagcggc ccagcctggt aacacagtgc ctgcgcgatt cagaaagcag
     1501 caagcccagc ttcatgccga ggctgtacat caaccggcgc cttgccatgg aacaccgtgc
     1561 ctgcccttct cgggacccag cctgcaagaa tgcagttttc acccaggttt atgaaggcct
     1621 caagccttcc gacaagtatg agaaaccctt ggactacagg tggcccatgc gctatgacca
     1681 gtggtgggaa tgtaaattca ttgcggaagg aatcattgac caaggcggtg gtttccgtga
     1741 cagcctggca gatatgtcag aagagctgtg ccccagctca gccgacaccc cagtgcctct
     1801 gcccttcttt gtgcgcacgg cgaaccaggg caatggcacc ggtgaggccc gggacatgta
     1861 tgtgccaaat ccttcttgcc gagactttgc caagtatgag tggattggac agttgatggg
     1921 ggctgccctt cggggtaagg agttcctggt gctggccctg cctgggttcg tgtggaagca
     1981 gctgtctggt gaggaggtga gctggagcaa agacttccca gctgtggact ccgtgctggt
     2041 gaagctcctg gaagtgatgg aaggagtgga caaggagacg tttgagttca agtttgggaa
     2101 ggagctaaca ttcaccacgg tcctgagtga tcaacaggtc gtggagctga ttcctggggg
     2161 cacaggcatc gtggtgggat acgaggaccg cttgcgtttc atccagctgg tgcagaaggc
     2221 gcggttagag gagagcaagg agcaggtggc agccatgcag gcaggtctgc tgaaggtggt
     2281 accacaggct gtgctggact tgctgacctg gcaagagctg gaaaagaagg tgtgtgggga
     2341 cccagaggtc actgtggatg ctctgcgcaa gctcactcgg tttgaggact tcgaaccatc
     2401 tgacacccga gtgcagtact tttgggaggc tctgaacaat ttcaccaatg aggaccggag
     2461 ccgtttcctg cgctttgtca ctgggcgcag ccgcctccca gctcggatct acatctaccc
     2521 ggacaaacta ggctatgaga ccacagatgc tctgccagag tcttccacct gctccagcac
     2581 gctcttcctc ccacactatg ccagtgccaa ggtatgtgag gagaagctgc gctatgctgc
     2641 gtacaactgt gtggccatcg acactgacat gagtccctgg gaggagtaag gccgtgccaa
     2701 gcgtgtcctg ctgccctcac ccaggccagc ccggtttggg tctcaacaga ggtgacgggt
     2761 tcagaaatct cagcacagtg ggccctgcgc ctgtgtatgg tcgcagtggg agccatgagt
     2821 tgaccctgat gctctagtcc ccacagaccc acaagctcta ctcgtgctgg ggcatgcttc
     2881 cccggggtat tcggcctctg agagagggaa tcttccacaa gcccagcaca agctgccagg
     2941 cctgagctac ttgaaggggg ccagctagct ccccaaccca cagactattt tttggtttcc
     3001 cctgtttttc ccctttttct agcttcagcc atggctcaaa atatttaaaa attggtagaa
     3061 tggtacttga agccaggagc caaggacaga atgtggttat cttccttggt cacggatccc
     3121 caagaaagaa gccccagttg agtaccccat cccttgcata ccggtcttct tcttcccaca
     3181 gcagaggtgt gtgggctctt cccacgactt ggcacgtcca tccactcaat gctcagtctt
     3241 tacagcagcc aaactactct tctggatcaa atccagctca actccacatc cgctccttca
     3301 ccgccaaggt ttcacagttg aggatccttc tgtcctctct ggaatttcag taattcctgt
     3361 tcatactcta acataaggcc tagatgttaa acttgctcta agggctgtgc acacccctct
     3421 attcccccca agggcctcca tgacactcct atagaatgtc ttacgttggg gaaattgaat
     3481 aaatggataa attcctctct tta
//
