LOCUS       NM_001107608            4607 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus HECT domain E3 ubiquitin protein ligase 2
            (Hectd2), mRNA.
ACCESSION   NM_001107608 XM_001080559 XM_220050
VERSION     NM_001107608.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4607)
  AUTHORS   Ebstein,F., Lange,N., Urban,S., Seifert,U., Kruger,E. and
            Kloetzel,P.M.
  TITLE     Maturation of human dendritic cells is accompanied by functional
            remodelling of the ubiquitin-proteasome system
  JOURNAL   Int J Biochem Cell Biol 41 (5), 1205-1215 (2009)
   PUBMED   19028597
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Oct 7, 2014 this sequence version replaced NM_001107608.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.7820.1,
                                           SRR26643296.4388.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-149               JAXUCZ010000001.1  243688290-243688438
            150-279             JAXUCZ010000001.1  243702117-243702246
            280-418             JAXUCZ010000001.1  243717568-243717706
            419-521             JAXUCZ010000001.1  243718512-243718614
            522-611             JAXUCZ010000001.1  243718966-243719055
            612-676             JAXUCZ010000001.1  243721795-243721859
            677-722             JAXUCZ010000001.1  243730114-243730159
            723-832             JAXUCZ010000001.1  243731708-243731817
            833-981             JAXUCZ010000001.1  243733481-243733629
            982-1105            JAXUCZ010000001.1  243734171-243734294
            1106-1202           JAXUCZ010000001.1  243736645-243736741
            1203-1310           JAXUCZ010000001.1  243739479-243739586
            1311-1443           JAXUCZ010000001.1  243740354-243740486
            1444-1532           JAXUCZ010000001.1  243741401-243741489
            1533-1691           JAXUCZ010000001.1  243744366-243744524
            1692-1766           JAXUCZ010000001.1  243746360-243746434
            1767-1854           JAXUCZ010000001.1  243747119-243747206
            1855-1961           JAXUCZ010000001.1  243747291-243747397
            1962-2077           JAXUCZ010000001.1  243749069-243749184
            2078-2221           JAXUCZ010000001.1  243749624-243749767
            2222-4607           JAXUCZ010000001.1  243753684-243756069
FEATURES             Location/Qualifiers
     source          1..4607
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q53"
     gene            1..4607
                     /gene="Hectd2"
                     /note="HECT domain E3 ubiquitin protein ligase 2"
                     /db_xref="GeneID:309514"
                     /db_xref="RGD:1305536"
     exon            1..149
                     /gene="Hectd2"
                     /inference="alignment:Splign:2.1.0"
     CDS             18..2342
                     /gene="Hectd2"
                     /EC_number="6.3.2.-"
                     /note="HECT domain containing E3 ubiquitin protein ligase
                     2; HECT domain containing 2"
                     /codon_start=1
                     /product="probable E3 ubiquitin-protein ligase HECTD2"
                     /protein_id="NP_001101078.3"
                     /db_xref="GeneID:309514"
                     /db_xref="RGD:1305536"
                     /translation="MSEAARDLSPGAPPAVAAAASEERKGKEPEREKLPPIVTAGAAA
                     GLDRGSKGQISTFSSFVSSVTQKKEAAENRSSPTHLALPNIRNVRDLPPICLDVRQKQ
                     RMSMDSLSSEVKVPPLPEPILPSQPKTVKDFEEDLEKAEATGNWKTVHAFYITAFDSF
                     TELNAAFKKDATASFNTIEDSGINANLVNAVFDALLNTPQDIQKSVLKGIINSLLQEW
                     KGPRTKDDLRAYFILLQNPQFNITSTYVIYAHLLRQIATLVEADHHFLVHWLKKLSQK
                     KFKQLVERLLQFVSLRLFPAKPEEFPPLTKCTWWIPSAAKVLALLNTANNLVHPPLVP
                     YTDFYNSTLDHIDLMEEYHTWQSFGNSHRFSFCQYPFVISITAKKIIIQRDSEQQMIS
                     IARQSLVDKVSRRQRPDMNMLFLNMKVRRTHLVSDSLDELTRKRADLKKKLKVTFVGE
                     AGLDMGGLTKEWFLLLIRQIFHPDYGMFTYHKDSHCHWFSSFKCDNYSEFRLVGILMG
                     LAVYNSITLDIRFPPCCYKKLLSPPVVPSDQSTPVGICSVTIDDLCQIMPELAHGLKE
                     LLSYEGNVEEDFYSTFQVFQEEFGVIKSYNLKPGGDKIPVTNQNRREYVQLYTDFLLN
                     KSIYKQFAAFYCGFHSVCASNALMLLRPEEVEILVCGSPELDMHALQRSTQYDGYAKT
                     DLTIRYFWDVVLGFPLELQKKLLHFTTGSDRVPVGGMADLNFKISKNETSTNWLPVAH
                     TCFNQLCLPPYKSKKDLKQKLIIGISNSEGFGLE"
     exon            150..279
                     /gene="Hectd2"
                     /inference="alignment:Splign:2.1.0"
     exon            280..418
                     /gene="Hectd2"
                     /inference="alignment:Splign:2.1.0"
     exon            419..521
                     /gene="Hectd2"
                     /inference="alignment:Splign:2.1.0"
     exon            522..611
                     /gene="Hectd2"
                     /inference="alignment:Splign:2.1.0"
     exon            612..676
                     /gene="Hectd2"
                     /inference="alignment:Splign:2.1.0"
     exon            677..722
                     /gene="Hectd2"
                     /inference="alignment:Splign:2.1.0"
     exon            723..832
                     /gene="Hectd2"
                     /inference="alignment:Splign:2.1.0"
     exon            833..981
                     /gene="Hectd2"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1105
                     /gene="Hectd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1202
                     /gene="Hectd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1310
                     /gene="Hectd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1443
                     /gene="Hectd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1532
                     /gene="Hectd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1533..1691
                     /gene="Hectd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1692..1766
                     /gene="Hectd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1767..1854
                     /gene="Hectd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1855..1961
                     /gene="Hectd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1962..2077
                     /gene="Hectd2"
                     /inference="alignment:Splign:2.1.0"
     exon            2078..2221
                     /gene="Hectd2"
                     /inference="alignment:Splign:2.1.0"
     exon            2222..4607
                     /gene="Hectd2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagccgcccg gccagacatg agtgaggcgg ctcgggatct ctcgcccgga gcgccgccgg
       61 cggtggccgc ggccgcctct gaggagagga aggggaaaga gcccgagcgc gagaagctgc
      121 cgcccatcgt gacggccggc gcagccgcgg gcttggacag aggatccaag ggccagattt
      181 ccacttttag cagcttcgtt tcaagtgtta cccagaagaa agaagccgct gaaaatagaa
      241 gctcgcctac ccatcttgct ctccctaaca tcaggaatgt gagagaccta ccaccaattt
      301 gtcttgacgt tagacaaaaa cagcgcatgt ctatggattc attatcatct gaagtgaagg
      361 tcccacccct tccagaacct attcttccta gccagcccaa aactgtgaaa gactttgagg
      421 aagatttaga aaaagctgag gccacaggaa attggaaaac agtacatgct ttttatataa
      481 ctgcatttga ttctttcaca gaattaaatg ctgcatttaa gaaagatgcc acagcctcat
      541 ttaatactat tgaggactct gggattaatg ccaatttggt gaatgctgta tttgatgcct
      601 tacttaatac tcctcaagat attcagaagt cagtattgaa gggaatcatt aacagcttgt
      661 tacaagaatg gaaaggtcca cgaacaaaag atgatcttag agcatatttt atactgttac
      721 agaatcctca atttaatatc acatctacat atgtcatcta tgctcacttg ctacgacaga
      781 tagctacctt agtggaagct gaccaccatt tcctagttca ctggcttaaa aaattatccc
      841 agaagaaatt caagcaactg gtagagagat tgctgcaatt tgtttcttta cgcctgtttc
      901 cagcaaaacc tgaagaattc ccgcctctaa caaagtgtac ctggtggatt ccatcagctg
      961 ctaaagttct ggctttactt aatactgcca acaatttggt tcacccaccc cttgttcctt
     1021 acactgattt ctataattct accttggatc acattgatct catggaagag tatcatactt
     1081 ggcagagctt tgggaattct cacaggtttt ccttctgtca gtacccattc gttatttcta
     1141 taactgcaaa aaaaatcatt attcaaagag actcagaaca acagatgata agcatcgcaa
     1201 ggcaaagtct ggtggataaa gtatcacgaa gacaaagacc tgatatgaat atgttatttc
     1261 taaatatgaa agtaaggagg acacatctgg ttagcgactc acttgatgag ctgacccgga
     1321 aaagagctga cttgaagaag aaattgaaag ttacatttgt aggtgaagct ggtttggata
     1381 tgggtggctt gactaaagaa tggttccttc ttctaattcg ccagattttc catccagatt
     1441 atggcatgtt tacataccac aaggattcac actgccattg gtttagcagc tttaagtgtg
     1501 ataactattc tgagttccga ttggttggaa ttctcatggg actagctgtt tataacagca
     1561 tcaccttgga tattcgtttt cctccctgct gttacaaaaa gttactgagc cctcctgttg
     1621 tacctagtga tcagagtaca ccagtaggca tctgcagtgt taccattgac gacttgtgcc
     1681 aaattatgcc tgagttggcc catggattaa aggaactctt atcatatgaa ggcaatgttg
     1741 aagaagattt ctattcaaca ttccaggttt ttcaagaaga atttggagta attaaatcct
     1801 ataacttaaa gccagggggt gataagattc cagttaccaa tcagaataga agagaatatg
     1861 tacagcttta tactgacttc cttttgaaca aatctatcta taagcaattt gctgcatttt
     1921 actgtggatt tcatagcgtg tgtgcttcaa atgccctaat gctgcttcgt ccagaagagg
     1981 ttgaaattct ggtttgtgga agtcctgaac tggatatgca cgcactgcag aggagtacac
     2041 agtatgatgg ctatgcaaaa acagacctga ccataagata cttttgggat gttgtgcttg
     2101 gatttcctct tgaacttcag aagaagctgc tacactttac cacaggaagc gacagagtac
     2161 ctgttggagg gatggctgat ttgaatttta aaatttcaaa gaatgaaact tctactaact
     2221 ggttacctgt ggcacacact tgcttcaatc aactctgcct tcccccatac aagagcaaaa
     2281 aagatctgaa acagaaactg attattggaa tttcaaattc agaagggttt ggacttgagt
     2341 aacctagaag acttgaaata cagtattcta tatgtagcac tcagttccct cttactgtgc
     2401 ctttaaaact ttcatgtttc ggtttcaaaa cattttcaca aagctcacca cttttaaaat
     2461 aatgagggtc tttttttttt tttactgaga tacgaaatat gtgtagtgaa ggcatgattt
     2521 aatatatata aatatatata tttccgaaat gtattcagtg agaaaaagag cctatggcag
     2581 aaacaggtct gagtccagca gtctttttat agcactttgt tgttgtccat atatagtttg
     2641 tcacaggtgt ccactgggaa agccaagtgc agtaagagtg tttctgtgac gtgatggaac
     2701 ccagtggcag atgtgtgctg gcagcacact gtagcagagc agagagctac attatcttta
     2761 ccttaaagca tgtagccata ttttcataca aaggtaacaa cagtataact gcaagtgcag
     2821 ttcacagggt cttttgatac atcggtttgg ggtcctctaa gatcttttca ccgttgctga
     2881 aaagcatgta aataacacta cacagcagcc gaagaatcat gggattttga tagtgccatt
     2941 tattgctaaa gatttatttt tacaaagtaa atttagggtt ttagatgtgt atacagcttt
     3001 tacaaatcaa caaagatgat tgtacaagag tattttcaga ccaattggat tcatggttat
     3061 attcttttaa gtattgttag tctgcatgct ccctgacagt aaattggtta cttgagtatc
     3121 ctgtcatgtt tgtataatgg tatttctcct taaaaatcaa tatagtagag caaattagac
     3181 caaactagtc attgactact taaaataatt acaagcacaa aagaaacccg gctattttat
     3241 atattttgat gtacaactta tatctacatt tttgatcacc agttatacaa aaacactaat
     3301 ttttggaaaa tgtaggataa gatatttgac aaaagtgaaa tacaattaaa aacatttatg
     3361 tcaaaatgat gtagaagttt gacattttgg ctaaaatgtt tgttttttca ctggattcta
     3421 aatatagtaa attcaaaagt acctttgttt tctatttata ataaaatagc atgtaaaaac
     3481 tgcattttta agccccagag tttttgtttt gttttaattt atagtgaagc agttttatta
     3541 gcatgttaca aacttttcca tctcaagact ttttctttga tagcttttct tcagaaaact
     3601 ctgaagtgac attcgcaata agaatgaaac cagcatttag taccagcaca tgacccacag
     3661 gcaagtaaca cttggccccc ttcctgagct aggcatttcc ttgttgctat gcttcctgca
     3721 cccaaccagc agaactcagg gtgcagcagt tcgtcagtgt gcccatagtt ctgacgttca
     3781 cccacgtgtg ttagagaacc caacttcctt tcctgtgagg cttgagactg caaatgacta
     3841 cgttcccatt tgagtatacc aaaaggatac ttcttcttta aaatcttgga aagcctaaga
     3901 cagctaaagg tacgtttgct ttggtgtgta tattgtttta aatccatatg caaataaaac
     3961 tgcttctctc ttgcacttcg tagagatgtt taatgtaggt tcctactaac aagcacaaag
     4021 aattatgtat aggaaaccag atttaagtgt tttcagtaaa atgtaaacga agtttttatt
     4081 tgttaaggct gactcatgga aatagtattg gtttggtttg gtttggtttg catgtctaac
     4141 gatgtatgtt gatagctatg tcacttttgc aagtacacag gcaagccaaa ttgtaagtga
     4201 caaagtccat aaataatggg aaatttgttg tcttttatta agttgaagtt tataaccatt
     4261 aattgctaag tcatatattt atgctctgtt ttggtttaca atgtaataat acctcatttt
     4321 aaaagtaaaa actactactg ttacatttta ttttaatcag ctagaaaatt catgtagctt
     4381 tttaaatata caacctgtta atgatttctt gagtttttct atctgccata gtaaattaaa
     4441 gcattgcaca gtatttatta gtatttataa aatgtcttgt ccttttttaa aaaacctatt
     4501 atttattttt cttctgtgtt tttagcagtc cttcttttgt acaaatctgt attgtattga
     4561 gtttatctgt gtacattttc aagtattaaa attatacagt cagtcaa
//
