LOCUS       NM_001107514            5059 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus hdc homolog, cell cycle regulator (Heca), mRNA.
ACCESSION   NM_001107514 XM_001072147 XM_039112442 XM_218660
VERSION     NM_001107514.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5059)
  AUTHORS   Dowejko A, Bauer R, Bauer K, Muller-Richter UD and Reichert TE.
  TITLE     The human HECA interacts with cyclins and CDKs to antagonize
            Wnt-mediated proliferation and chemoresistance of head and neck
            cancer cells
  JOURNAL   Exp Cell Res 318 (5), 489-499 (2012)
   PUBMED   22100912
REFERENCE   2  (bases 1 to 5059)
  AUTHORS   Ghosh D, Lippert D, Krokhin O, Cortens JP and Wilkins JA.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   3  (bases 1 to 5059)
  AUTHORS   Dowejko A, Bauer RJ, Muller-Richter UD and Reichert TE.
  TITLE     The human homolog of the Drosophila headcase protein slows down
            cell division of head and neck cancer cells
  JOURNAL   Carcinogenesis 30 (10), 1678-1685 (2009)
   PUBMED   19643820
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000008.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001107514.3.
            
            On or before Jan 5, 2023 this sequence version replaced
            XM_039112442.1, NM_001107514.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN12840116,
                              SAMN12840124 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-527               JACYVU010000008.1  10643957-10644483   c
            528-1568            JACYVU010000008.1  10607025-10608065   c
            1569-1723           JACYVU010000008.1  10600557-10600711   c
            1724-5059           JACYVU010000008.1  10594592-10597927   c
FEATURES             Location/Qualifiers
     source          1..5059
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p12"
     gene            1..5059
                     /gene="Heca"
                     /note="hdc homolog, cell cycle regulator"
                     /db_xref="GeneID:308624"
                     /db_xref="RGD:1304818"
     exon            1..527
                     /gene="Heca"
                     /inference="alignment:Splign:2.1.0"
     CDS             257..1888
                     /gene="Heca"
                     /note="headcase homolog"
                     /codon_start=1
                     /product="headcase protein homolog"
                     /protein_id="NP_001100984.2"
                     /db_xref="GeneID:308624"
                     /db_xref="RGD:1304818"
                     /translation="MPNPKNSKGGRKNKRANSSGDEQENGAGALAAAGATGAAAGGAL
                     AAAAGCGAVSLGAVGTGGAAGPGGAGTGAANATIAAGAAAAGDAKNEAPCATPLICSF
                     GRAVDLEKDDYQKVVCNNEHCPYSTWMHLQCFYEWESSILVQFNCIGRARSWNEKQCR
                     QNMWTKKGYDLAFRFCSCRCGQGHLKKDTDWYQVKRMQDEKKKKSGSEKNTARPPGEA
                     GEEAKKCRPLNKPQKGLSHDLPRRHSMDRQNSQEKTVSSAAYGARSPCGSPGQSPPTG
                     YSILSPAHFSGPRSSRYLGEFLKNAIHLEPHKKAMPGGHVFRSAHFDYSSAGLSVHRA
                     GHFDTPVQFLRRLDLSELLTHIPRHKLNTFHVRMEDDAQVGQGEDLRKFILAALSASH
                     RNVVNCALCHRALPVFEQFPLVDGTLFLSPSRHDEIEYDVPCHLQGRLMHLYAVCVDC
                     LEGVHKIICIKCKSRWDGSWHQLGTMYTYDILAASPCCQARLNCKHCGKPVIDVRIGM
                     QYFSEYSNVQQCPHCGNLDYHFVKPFSSFKVLEAY"
     exon            528..1568
                     /gene="Heca"
                     /inference="alignment:Splign:2.1.0"
     exon            1569..1723
                     /gene="Heca"
                     /inference="alignment:Splign:2.1.0"
     exon            1724..5059
                     /gene="Heca"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggctcctca gcttctcgct ccgctcgcgg gcccgttgcg cccgcgcggc tgcgagcctc
       61 gggtggccgc gcgtggccgc gccggcttct gccggggagg gcgcggcggc cggaatggcg
      121 cggcgcgggc cgcgcggcgg ggcgggcgcc tgaggagagc ggccggcccg cgctctccgt
      181 ggccgccgag gcgccgccgc ggggagccac cttcgtgggc gccggacacc gggacacccg
      241 cgagcgggtc ggggagatgc ccaaccccaa gaacagcaaa ggcggccgca aaaacaagcg
      301 cgccaacagc agcggggacg agcaggaaaa tggagccggg gccttggcgg cggcgggtgc
      361 gacaggcgcg gcggccggag gggccctggc ggcggcggcg ggctgcgggg cggtgtcgct
      421 cggcgcggtg ggcaccggcg gcgcggcggg cccgggaggt gcgggcacgg gcgccgccaa
      481 cgccaccatc gctgcggggg ctgcagccgc gggggacgcc aagaatgaag ctccttgtgc
      541 cacgcccctg atctgcagct tcgggagagc agtggacctg gagaaggatg actaccagaa
      601 ggtggtgtgc aacaatgagc actgccccta cagcacctgg atgcatcttc agtgcttcta
      661 cgagtgggag agcagcatct tggtgcagtt caactgcatt ggcagggccc gcagctggaa
      721 tgagaagcag tgccgccaga acatgtggac caagaagggc tatgacctgg ctttccgctt
      781 ctgctcctgc cgctgcgggc agggccacct aaaaaaggac acagactggt accaggtaaa
      841 gcggatgcaa gatgaaaaaa agaagaagtc tgggtcagag aagaacacgg caaggcctcc
      901 aggggaggct ggggaggagg caaaaaagtg caggcccctg aacaagcccc agaaaggcct
      961 gagccacgac cttcctcggc ggcattccat ggacaggcag aactcccagg aaaagacagt
     1021 cagttctgca gcctatgggg cccgctcccc ttgtggctcc cctggccagt ccccacccac
     1081 tggctactcc atcctttccc cggcccactt cagtggtccc cgatcctcca gataccttgg
     1141 ggaattctta aagaatgcca ttcaccttga gcctcacaaa aaggccatgc caggaggcca
     1201 cgtgttcaga agtgcccact ttgattacag ttcggctggt ctgtccgtac acagggcagg
     1261 acactttgac acccctgtac agttcctgcg gcgactggac ctctctgaac ttctcacgca
     1321 catccccagg cataagctaa acactttcca tgtccggatg gaagacgatg cccaagtggg
     1381 ccaaggcgaa gatctgcgga agttcattct cgcagccctt agtgccagcc acagaaacgt
     1441 ggtaaactgc gctttgtgcc accgggcgct cccagtgttt gaacagttcc ctctggtgga
     1501 tggaactctg ttcttaagcc cctccagaca cgatgagatt gaatatgatg ttccttgtca
     1561 ccttcaaggg agactcatgc atctgtatgc agtgtgtgtg gactgcctgg aaggggttca
     1621 caagatcatc tgcatcaagt gcaagtcacg atgggatggc agctggcacc agttgggcac
     1681 catgtacacc tacgacatcc tggccgcctc tccctgctgt caggcccgtc tgaactgcaa
     1741 gcattgtggc aagcccgtga tcgacgtgcg gatcgggatg cagtacttct ccgagtacag
     1801 caacgtccag cagtgtccac actgtgggaa cctggactac catttcgtga agccattctc
     1861 ctccttcaaa gttctcgaag cttattgatg aaagctttgc tttagtaata gctattttat
     1921 tgatattatt actttactac atatctttta taggggagca ttctgtgaca ttaatttctt
     1981 ttctaatttg aagcagagtt tactttgtat atttgtgcca ctaaaatgag ggctgcccct
     2041 tgccctttct tggttcccaa atatatatgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt
     2101 gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt tttagttaga ctggaggcca gatgggaaat
     2161 tgtgcagaac tcatgcagaa catctggtgg agttctaagg tagtaggaag gaaggatgcc
     2221 atttacggat agaaatctgg ctaagctaga ggtgtggtag gagttgggag gggcttttac
     2281 taatacgtta gctttcttga gattcattgt tagttctcgg ccttgggaaa aataaatgac
     2341 aagtgaatgt acatgtgagc tggacagcca gcactgtact gggctgtctg gactcttctt
     2401 cagcacaggc tgaggtgagg tttgctccac tgatgggtga ttgagggtag aagtgagtac
     2461 tcttcctttg accatttgtg taattaacag ttctcatact ggaagtaata tccaaattat
     2521 gcgacatgtg aaaactgtgg gtgtttaggt gagctgagtc ggacaggcct gggaaagtga
     2581 gtttggcaat gatgcccact gagtcaagcg agcagaaaga tggaactagg ttatttgaac
     2641 tctatctcca gagttggtca ggaacccaca gacgctgatg ctgcggtcct gatgcatcct
     2701 ttgcagattg cattgctgaa atgctgcctg gtacccacgt cttctcccag gtaacctctg
     2761 tctactgctg tgctgcacag ccagctgcac cacacttccc ttcctgcctc gctagtgcca
     2821 cacatgcaga actggtctga agaaggaagg ggaaatttgt taggatgacg aagaatagtt
     2881 ttattttttt aaaagaatgt tcagttttgg aaacagtaat gcaaaagagc atatctgaaa
     2941 atagatcctg aagattccca tgatccctta ctgtagttaa aaaccgtcac atgcagaaaa
     3001 ccaagtattc caaaaccagc ctctgttcag tagagtgtgg aaatatgcta aagacatggc
     3061 ctgtgcgatt agagttagag aagtacttct taggaaggag tttggtcatt ccaagtaaga
     3121 cacagacgta catataagaa tactaaacaa tcattttatg accaggcaag tttggagttc
     3181 atgtaaatat tttatatcac tttcttggtt tatcccctac aaatacaggg ggtgtttctc
     3241 ttcaaaattg tctaagcatt gttaccaatg agttttaaat tctactgctt ggtgatttgt
     3301 tggaaaccat agcattaagg aacccattta ccagctaaga gtcttcacct ttgggtggat
     3361 attctccatc agttggttcg ttacttctag tttgatgatc tgatgtttca catctacaaa
     3421 atatcaccat cctaggacaa gcagagatca ttattggtca gttggagttt aatgcaatta
     3481 catgaggtct ttatgacata gcacttgcaa aattgtctct gatgcacaaa gctgtaatta
     3541 tgaattagct gtttccctat gaatctgtta tatactcaag tttaaaattt tggtaagttt
     3601 ctatttagat tcatatttgt cttcatgttt ctgatttttt aaaataaata aaatacttgt
     3661 actgctgttc tctaacctgt tgacgttttc tagtaaaatt tcgctgtatt gttgttccaa
     3721 agtcaatcta ttcattgtac ccagtgagtt ctctagatta aaagacactg tggagctgta
     3781 agccacattc tcttctcgct ccttagattg ttttctgacc ctaaaatgaa gaggttttat
     3841 ttcaatagga taacattggc atttgatgat acgttgagga taaagcaggg ctataaatat
     3901 gtatagtctt ataaaaagag aagcattctc cctgcactcc agtactgcct cctgttagtg
     3961 cattaatttc acttgtgttt ggaaggaaaa tttggctgat atgagaataa aataccggca
     4021 ttaatacttg ctataagggt aaatttgacc ttggaaatct gctgacctta ttgttttcac
     4081 caatctttgc ctgaacacct tgattagaac tggattatgt aagaaggatc aacatttctg
     4141 ttgtagctgg gatagtaaag gttatcagtc aactaggaga tctaacttct gtttctgatg
     4201 agtagtgctc aataacccat aattttcaga ttgactaata atttagtgtt ttttaccgac
     4261 cttaacattt ttagtcattt atttttaaag tgttccatac tttgaacaag ttaaactgct
     4321 ccagttttga gagaggctaa tttcttcaga ccgtctcagc tctctgctgt ctctgatcac
     4381 ctgatcacat gggaagcact tacacagagc cttctctagc atccctcagt ttccaatttt
     4441 tgtaaaaggg attaattttt ctaagtaaga gaaatttcat acctttttgg aaaaaattaa
     4501 atcttgaaga aagaatatta tatgtttaaa tgctaaaact taatggattg agtgataact
     4561 tgctggacaa ccaagactgc ctgtctgagt tcttcacatt gtcttaccac accagtgctg
     4621 attgtgcagt ctgctctgtg cctattttct aacctgtttg attttctgtt caaatccttg
     4681 aagcagtggt tgagtaattt tagttgggat attggggaag aggtgaggag aaagcacttt
     4741 tctttaggtg tgattcccgt gacaggacgc tgcctaacct tgttcatctt cataccttgt
     4801 tgacttcatt atttttccag ataattgaaa gagaatataa tgaatggaca ccatgaaaac
     4861 cagctcaaaa atacgttgtt gtctataaag atttcttgtc gagatgtctt ggattgcact
     4921 tttgttgagg gaagccaatg taaatactta aagaatgttg attaaattga agcatttggg
     4981 ttatggagtc gtgtgatgat agagggtttc tgtatgtgaa aggtgtgtat taagaataat
     5041 aaaattttag aaacaagta
//
