LOCUS       NM_001412498            2140 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus haloacid dehalogenase-like hydrolase domain
            containing 2 (Hdhd2), transcript variant 2, mRNA.
ACCESSION   NM_001412498 XM_006254966
VERSION     NM_001412498.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2140)
  AUTHORS   Chauvet,C., Menard,A. and Deng,A.Y.
  TITLE     Two candidate genes for two quantitative trait loci epistatically
            attenuate hypertension in a novel pathway
  JOURNAL   J Hypertens 33 (9), 1791-801 (2015)
   PUBMED   26103128
  REMARK    GeneRIF: Hdhd2 appears to act from upstream in a pathway by
            regulating Tcof1/treacle possibly at the level of post-translation.
REFERENCE   2  (bases 1 to 2140)
  AUTHORS   Havugimana,P.C., Hart,G.T., Nepusz,T., Yang,H., Turinsky,A.L.,
            Li,Z., Wang,P.I., Boutz,D.R., Fong,V., Phanse,S., Babu,M.,
            Craig,S.A., Hu,P., Wan,C., Vlasblom,J., Dar,V.U., Bezginov,A.,
            Clark,G.W., Wu,G.C., Wodak,S.J., Tillier,E.R., Paccanaro,A.,
            Marcotte,E.M. and Emili,A.
  TITLE     A census of human soluble protein complexes
  JOURNAL   Cell 150 (5), 1068-1081 (2012)
   PUBMED   22939629
REFERENCE   3  (bases 1 to 2140)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Oct 3, 2022 this sequence version replaced XM_006254966.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.54756.1,
                                           SRR26360186.457776.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-160               JAXUCZ010000018.1  72777343-72777502
            161-271             JAXUCZ010000018.1  72779426-72779536
            272-480             JAXUCZ010000018.1  72783354-72783562
            481-565             JAXUCZ010000018.1  72786531-72786615
            566-782             JAXUCZ010000018.1  72795350-72795566
            783-846             JAXUCZ010000018.1  72797389-72797452
            847-2140            JAXUCZ010000018.1  72800386-72801679
FEATURES             Location/Qualifiers
     source          1..2140
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.3"
     gene            1..2140
                     /gene="Hdhd2"
                     /gene_synonym="Ier3ip1; LRRG00122; RGD1308579"
                     /note="haloacid dehalogenase-like hydrolase domain
                     containing 2"
                     /db_xref="GeneID:361351"
                     /db_xref="RGD:1308579"
     exon            1..160
                     /gene="Hdhd2"
                     /gene_synonym="Ier3ip1; LRRG00122; RGD1308579"
                     /inference="alignment:Splign:2.1.0"
     exon            161..271
                     /gene="Hdhd2"
                     /gene_synonym="Ier3ip1; LRRG00122; RGD1308579"
                     /inference="alignment:Splign:2.1.0"
     CDS             171..950
                     /gene="Hdhd2"
                     /gene_synonym="Ier3ip1; LRRG00122; RGD1308579"
                     /note="immediate early response 3-interacting protein 1"
                     /codon_start=1
                     /product="haloacid dehalogenase-like hydrolase
                     domain-containing protein 2"
                     /protein_id="NP_001399427.1"
                     /db_xref="GeneID:361351"
                     /db_xref="RGD:1308579"
                     /translation="MAARRVLKAVLVDLSGTLHIEDAAVPGAQEALKRLRAASVMVRF
                     VTNTTKESKRDLLERLRKLEFDISEEEIFTSLTAARNLIEQRQVRPMLLVDDRALPDF
                     TGVQTHDPNAVVIGLAPEHFHYQLLNEAFRLLLDGAPLIAIHKARYYKRKDGLALGPG
                     PFVTALEYATDTKAVVVGKPEKTFFLEALRDTDCAPEEAVMIGDDCRDDVDGAQNIGM
                     LGILVKTGKYKAADEEKINPPPYLTCESFPHAVDHILQHLL"
     exon            272..480
                     /gene="Hdhd2"
                     /gene_synonym="Ier3ip1; LRRG00122; RGD1308579"
                     /inference="alignment:Splign:2.1.0"
     exon            481..565
                     /gene="Hdhd2"
                     /gene_synonym="Ier3ip1; LRRG00122; RGD1308579"
                     /inference="alignment:Splign:2.1.0"
     exon            566..782
                     /gene="Hdhd2"
                     /gene_synonym="Ier3ip1; LRRG00122; RGD1308579"
                     /inference="alignment:Splign:2.1.0"
     exon            783..846
                     /gene="Hdhd2"
                     /gene_synonym="Ier3ip1; LRRG00122; RGD1308579"
                     /inference="alignment:Splign:2.1.0"
     exon            847..2140
                     /gene="Hdhd2"
                     /gene_synonym="Ier3ip1; LRRG00122; RGD1308579"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caaactgaaa ggaagagggg aggggtgttg taagagccag ggccttgtgg aggacatggc
       61 aggctgaaga atcagggctc tgggatttag gatccaactc acagacaact gaggattaga
      121 ttagcagcct ggtttgcagt gaccattgta gctaaaacag ggaatgaagg atggcagcac
      181 gccgtgtgtt aaaagctgtt ttggtagatc tcagtggcac acttcacatt gaagatgcag
      241 ctgtgccagg cgcacaggaa gctcttaaaa ggttacgtgc cgcttctgtg atggttcggt
      301 ttgtgaccaa cacaaccaaa gagagcaaga gagacctact ggaaagattg cgaaaactgg
      361 agtttgatat ctccgaagag gagatcttca cctctctgac cgcagcccga aacttaatag
      421 agcagagaca agtcaggccc atgctactgg ttgatgaccg tgcactgcct gatttcacag
      481 gagttcaaac ccacgatccc aacgctgtgg tcataggact ggccccagag cattttcact
      541 accagcttct gaatgaagca tttcggctgc ttctggatgg agcccctctg atagctatcc
      601 acaaggccag gtactacaag agaaaagatg gcttagccct gggaccagga ccatttgtga
      661 ctgccttaga gtatgccaca gacacgaaag ccgtggtagt gggaaagcca gagaagacat
      721 tctttctgga agcattgagg gacaccgact gtgcaccaga ggaggccgtc atgataggag
      781 atgattgcag ggatgatgtt gatggggctc agaacattgg catgctgggc atcttagtta
      841 aaactgggaa atacaaagca gcagatgaag agaaaattaa tccacctccc tacctaacgt
      901 gcgagagctt ccctcacgct gtggaccaca tcctgcagca tctcctgtga tccagcgtgt
      961 gttgtccgga ctggatgcca tttctaacaa gatggcatca gcaggctgcg ccatgcagtg
     1021 ctcatcctgt ttaacccttt cattacacat taattaggaa caggggtatt gaattgcagc
     1081 cagccctaaa ccttgctaat ctctcttgtc ttataaaaga tgagacctga agaaagggag
     1141 agctggtatt ccatgccatt gagttaagat gctcatcggg gtcacggggc tgggaggacg
     1201 gttcctgcta gtgtggagaa acagcagtgg ttctccattt ctctatggtg gaagcgagag
     1261 ggatcctctg tatgactggc tcacacagag gtgccctgag aggtgcatta ggctgtcatc
     1321 aagatgccgg agtcagccgt ggaggccagc agacaaatca cagagcagca aggtagcagc
     1381 agcacggcga gcccttcagc tgaggtgcag tgaagctgct ttaacagatg tggagagcca
     1441 gatcttccac tgtattccca gcacagatga cttttttctc ttcattagcc agagatgact
     1501 aatttaaatt tagaacccga atttaattta aaataatatt tccattaata acctattcat
     1561 tgcagatacc tattatactg tgtaacagtt gttttggaaa ttttatgtaa aattaaaact
     1621 atcagtattt tacagatgtt ttaattagac attgttatta acaggaacag tgcagaaacc
     1681 aaaatcaagc ctttaatgtc ttatagaccg tgcatttttg aagttagtgt ccaccaggga
     1741 cctattaact gtacatttgc aagatttcat tatttttgcc tctgacacta tgggagaaat
     1801 cttttaggaa ctattgggac agattcaagc ttttatgtac ttcttactac aattgtaaaa
     1861 tgagatctcg tctcggtgcc tggattattc ttctcatgtt aaacccaccc aaatgaagga
     1921 gacgaagtag gtaatgattt tcctggtgca tttgcatgct gttctaatcc aaggccgtgg
     1981 caattgtttt acagggctct tgggcactga attattagaa tgtaattgtg catcatcaca
     2041 gtgctcacct tattgaggca cacgctaatg ttaatgagct tcaggctttg atgcttgttt
     2101 agagatcagc tctgtcttag aacaaagcta aagaaatggc
//
