LOCUS       NM_145785               2735 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus HDGF like 3 (Hdgfl3), mRNA.
ACCESSION   NM_145785
VERSION     NM_145785.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2735)
  AUTHORS   Kerman,B.E., Genoud,S., Kurt Vatandaslar,B., Denli,A.M., Georges
            Ghosh,S., Xu,X., Yeo,G.W., Aimone,J.B. and Gage,F.H.
  TITLE     Motoneuron expression profiling identifies an association between
            an axonal splice variant of HDGF-related protein 3 and peripheral
            myelination
  JOURNAL   J Biol Chem 295 (34), 12233-12246 (2020)
   PUBMED   32647008
  REMARK    GeneRIF: Motoneuron expression profiling identifies an association
            between an axonal splice variant of HDGF-related protein 3 and
            peripheral myelination.
REFERENCE   2  (bases 1 to 2735)
  AUTHORS   Barallobre-Barreiro,J., Oklu,R., Lynch,M., Fava,M., Baig,F.,
            Yin,X., Barwari,T., Potier,D.N., Albadawi,H., Jahangiri,M.,
            Porter,K.E., Watkins,M.T., Misra,S., Stoughton,J. and Mayr,M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   3  (bases 1 to 2735)
  AUTHORS   El-Tahir,H.M., Abouzied,M.M., Gallitzendoerfer,R., Gieselmann,V.
            and Franken,S.
  TITLE     Hepatoma-derived growth factor-related protein-3 interacts with
            microtubules and promotes neurite outgrowth in mouse cortical
            neurons
  JOURNAL   J Biol Chem 284 (17), 11637-11651 (2009)
   PUBMED   19237540
REFERENCE   4  (bases 1 to 2735)
  AUTHORS   El-Tahir,H.M., Dietz,F., Dringen,R., Schwabe,K., Strenge,K.,
            Kelm,S., Abouzied,M.M., Gieselmann,V. and Franken,S.
  TITLE     Expression of hepatoma-derived growth factor family members in the
            adult central nervous system
  JOURNAL   BMC Neurosci 7, 6 (2006)
   PUBMED   16430771
  REMARK    GeneRIF: HRP-3 was expressed in the bulbus olfactorius, piriform
            cortex and amygdala complex. Expression was mainly in neurons and
            some brain stem oligodendrocytes.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2735)
  AUTHORS   Abouzied,M.M., Baader,S.L., Dietz,F., Kappler,J., Gieselmann,V. and
            Franken,S.
  TITLE     Expression patterns and different subcellular localization of the
            growth factors HDGF (hepatoma-derived growth factor) and HRP-3
            (HDGF-related protein-3) suggest functions in addition to their
            mitogenic activity
  JOURNAL   Biochem J 378 (Pt 1), 169-176 (2004)
   PUBMED   14572309
REFERENCE   6  (bases 1 to 2735)
  AUTHORS   Ikegame,K., Yamamoto,M., Kishima,Y., Enomoto,H., Yoshida,K.,
            Suemura,M., Kishimoto,T. and Nakamura,H.
  TITLE     A new member of a hepatoma-derived growth factor gene family can
            translocate to the nucleus
  JOURNAL   Biochem Biophys Res Commun 266 (1), 81-87 (1999)
   PUBMED   10581169
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 27, 2020 this sequence version replaced NM_145785.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF389347.1, SRR26643298.3690.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840115 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-207               JAXUCZ010000001.1  145285719-145285925 c
            208-284             JAXUCZ010000001.1  145257557-145257633 c
            285-423             JAXUCZ010000001.1  145252656-145252794 c
            424-579             JAXUCZ010000001.1  145252049-145252204 c
            580-726             JAXUCZ010000001.1  145246385-145246531 c
            727-2735            JAXUCZ010000001.1  145236758-145238766 c
FEATURES             Location/Qualifiers
     source          1..2735
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q31"
     gene            1..2735
                     /gene="Hdgfl3"
                     /gene_synonym="Hdgfrp3"
                     /note="HDGF like 3"
                     /db_xref="GeneID:252941"
                     /db_xref="RGD:628773"
     exon            1..207
                     /gene="Hdgfl3"
                     /gene_synonym="Hdgfrp3"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..732
                     /gene="Hdgfl3"
                     /gene_synonym="Hdgfrp3"
                     /note="HRP-3; hepatoma-derived growth factor, related
                     protein 3"
                     /codon_start=1
                     /product="hepatoma-derived growth factor-related protein
                     3"
                     /protein_id="NP_665728.1"
                     /db_xref="GeneID:252941"
                     /db_xref="RGD:628773"
                     /translation="MARPRPREYKAGDLVFAKMKGYPHWPARIDELPEGAVKPPANKY
                     PIFFFGTHETAFLGPKDLFPYKEYKDKFGKSNKRKGFNEGLWEIENNPGVKFTGYQTI
                     QQQSSSETEGEGGNTADASSEEEGDRVEDGKGKRKNEKGGSKRKKSYTSKKSSKQSRK
                     SPGDEDDKDCKEEENKSSSEGGDAGNDTRNTTSDLQKAGEGT"
     exon            208..284
                     /gene="Hdgfl3"
                     /gene_synonym="Hdgfrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            285..423
                     /gene="Hdgfl3"
                     /gene_synonym="Hdgfrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            424..579
                     /gene="Hdgfl3"
                     /gene_synonym="Hdgfrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            580..726
                     /gene="Hdgfl3"
                     /gene_synonym="Hdgfrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            727..2735
                     /gene="Hdgfl3"
                     /gene_synonym="Hdgfrp3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggccgctcg agcgcccggc tcgaggcccg cgggaagcgc ggcgcggtcc gtcgtcccgc
       61 ggaggggcgg cctcccggca tcttcgcggc gaccaaggac cagcgggcag gggaaccaac
      121 gggatggcgc gtccgcggcc ccgcgagtac aaagcgggag acctggtctt cgccaaaatg
      181 aagggctacc cgcactggcc cgcccggatt gatgaactcc cagagggcgc cgtgaagcct
      241 ccagcaaaca agtaccctat cttctttttc ggaacccatg aaactgcatt tctaggtcct
      301 aaagaccttt tcccatataa ggaatacaaa gacaagtttg gaaagtcaaa caaacggaaa
      361 ggatttaatg aaggattatg ggaaattgaa aataatccag gagtgaaatt tactgggtac
      421 cagacaattc agcaacagag ctcttcagaa actgagggag aaggagggaa cactgcagat
      481 gcaagcagtg aggaagaagg tgacagagta gaagatggaa aaggcaagag aaagaatgaa
      541 aaaggaggct caaaacggaa aaagtcctac acttcaaaga agtcttctaa acagtcccgg
      601 aaatctccag gagacgaaga tgacaaagac tgcaaagaag aggagaacaa aagcagctct
      661 gagggcggag atgctggcaa tgacacaaga aacacgactt cagacttgca gaaagccggt
      721 gaagggacct aactaccgta atgaatgctg catattgaga gaaaccacaa gaaggttaac
      781 tgtttgattg tctgattctt ggatttgata tgaaccaaca gtctttgttg tcactgacaa
      841 agccccagtg tgtgtgtgca ttacattcct ctctgttctg ctgaagggaa aaaagagaca
      901 ttttaacctt tttaaggtta ttgacttaat tttatgttat ttggttgcat gaagttgccc
      961 ttaaccacta agaatgatca agattttgca gacttctccg tgtctaggct ccttttccaa
     1021 ggcagtccaa gtcatcagct ttctgcctct atcccaccat catcaaacac tcagcgaaat
     1081 agtaattcgt atttttagat aattactcaa cataatactt caggatggga ttttctttat
     1141 agcagaactc aagaaccaac tcctagatac atactgttgg tatatggaga tgaaattaca
     1201 gtcatctttc agttttaagg ccatgtgtaa agtttaacca cattgtacaa tacctattct
     1261 gtattagaaa tagctagttg aaacttatac ttctcaaaac tcatgttcct gtgtacacaa
     1321 gctgagttta catgtgaact tagtgagtct ttttatgtca taccaaaata aagcaaggat
     1381 ttattttttt cccaaagcca atacgatttg agctaatcac tcaagatggt cactttacac
     1441 ttgaaagctg aaatcagcag gagcactatg ggaaaacaaa gcattgactc ttgaagatag
     1501 acttttaaac taaacttttc ttttagaact agaattagag tagttaccat tcatccacca
     1561 agcattatta tgtgtacatt atcgtcgctg ctgtgctaat agagtcttat ttatttttat
     1621 gccagcttat actgtgagaa cacattagtc agtttgggtt tccctagccc tgctatgctt
     1681 gtccttggaa gatcttttgt gtatgtctga ggtttgtagc cgaaaagttt actgtaaaaa
     1741 aaaaaaatca aaaacaacaa aaaaatgtat tgtttttaca gaataaattt attggaatgt
     1801 gtcctgggag taaggtttga ggttgtaaac acctgagtca gtgtcatttg gctccatatg
     1861 tgtaatgtga agtattgatg taattcttgt gttatagcga aggtggacag caaactgaca
     1921 ttagaataag tgcaggtgag aatcttattt tttctatcat ttttctttta aatactctgg
     1981 atgttaggtt aatcgaaaac actgggaggg acaggaggga gaaaccgtag catctgtctg
     2041 catgtctaag aaaacaccag ctcagtggac actgtgttta cacacagcct tacgtgcatc
     2101 ctgtttgctt tgggtgttct taccgtgttg aagaactaat gaacatgaag agaaaacaga
     2161 agaagactta aatcccagcg tggtcgtgat gatgaaggtg atgcagggct ctgaggctta
     2221 gatgcaccag tcagtctact gcccctgcga catcaccgtc cttcaggctt attcctgtca
     2281 tttagctatc aatggctccc caacgtactc acacatttcc aagtatggaa aattcgttaa
     2341 agacaggctg tcaagtcagc tattttcttt aaaaggtact ttttcatttt aagtatttta
     2401 ttttaaaatg aaatttgtca aaagatatct tcattgtaat gcaaaacata tggagaactt
     2461 agataacaat ttaaattgga agatataaca aaggtttttt gtttgtttgt ttgagacagg
     2521 gtttctctgt gtagccctgg tttcctggaa ctcactctgt agaccaggcc ggccttgaac
     2581 tcagatatca gcctgtctct gaatcctgag tgctgggatt aaaggtgtgt gccaccatta
     2641 cctggcacag atttcttaaa taaaaagttc aaaatttgtc atgaaaatgt atatataaaa
     2701 tgcttcaaaa ttaataaagt ttatcttcat aagca
//
