LOCUS       NM_133548               2157 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus HDGF like 2 (Hdgfl2), mRNA.
ACCESSION   NM_133548
VERSION     NM_133548.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2157)
  AUTHORS   Zhuang,Z., Mei,G., Liu,W., Chen,Y., Zeng,J., Zhang,W., Yao,G. and
            Wang,X.
  TITLE     Hepatoma-derived growth factor-2 is highly expressed during
            development and in spinal cord injury
  JOURNAL   Mol Med Rep 12 (4), 6140-6144 (2015)
   PUBMED   26252862
  REMARK    GeneRIF: HDGF-2 expression was significantly upregulated in the
            embryonic spinal cord and injured spinal cord.
REFERENCE   2  (bases 1 to 2157)
  AUTHORS   Gao,K., Xu,C., Jin,X., Wumaier,R., Ma,J., Peng,J., Wang,Y.,
            Tang,Y., Yu,L. and Zhang,P.
  TITLE     HDGF-related protein-2 (HRP-2) acts as an oncogene to promote cell
            growth in hepatocellular carcinoma
  JOURNAL   Biochem Biophys Res Commun 458 (4), 849-855 (2015)
   PUBMED   25689719
REFERENCE   3  (bases 1 to 2157)
  AUTHORS   Thakar,K., Votteler,I., Kelkar,D., Shidore,T., Gupta,S., Kelm,S.
            and Dietz,F.
  TITLE     Interaction of HRP-2 isoforms with HDGF: chromatin binding of a
            specific heteromer
  JOURNAL   FEBS J 279 (5), 737-751 (2012)
   PUBMED   22212508
REFERENCE   4  (bases 1 to 2157)
  AUTHORS   El-Tahir,H.M., Dietz,F., Dringen,R., Schwabe,K., Strenge,K.,
            Kelm,S., Abouzied,M.M., Gieselmann,V. and Franken,S.
  TITLE     Expression of hepatoma-derived growth factor family members in the
            adult central nervous system
  JOURNAL   BMC Neurosci 7, 6 (2006)
   PUBMED   16430771
  REMARK    GeneRIF: HRP-2 was strongly expressed in neurons, astrocytes and
            oligodendrocytes in the thalamus, prefrontal and parietal cortex,
            neurohypophysis, and the cerebellum.
            Publication Status: Online-Only
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF355102.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF355102.1, BC071178.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2157
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q11"
     gene            1..2157
                     /gene="Hdgfl2"
                     /gene_synonym="Hdgf2; Hdgfrp2"
                     /note="HDGF like 2"
                     /db_xref="GeneID:171073"
                     /db_xref="RGD:621013"
     exon            1..76
                     /gene="Hdgfl2"
                     /gene_synonym="Hdgf2; Hdgfrp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             5..2014
                     /gene="Hdgfl2"
                     /gene_synonym="Hdgf2; Hdgfrp2"
                     /note="HRP-2; hepatoma-derived growth factor 3; HDGF-3"
                     /codon_start=1
                     /product="hepatoma-derived growth factor-related protein
                     2"
                     /protein_id="NP_598232.1"
                     /db_xref="GeneID:171073"
                     /db_xref="RGD:621013"
                     /translation="MPHAFKPGDLVFAKMKGYPHWPARIDDIADGAVKPPPNKYPIFF
                     FGTHETAFLGPKDLFPYDKCKDKYGKPNKRKGFNEGLWEIQNNPHASYSAPLPVSSSD
                     SEAPEADLGGGSDADKEKEARRVMTVTAVTTTATSGRTESDSDSDKNSDHSGLKRKTP
                     VLKMSVSKRARKASSDLDQASVSPSEEDSESPSESEKTSDQDFTPEKKTIARAPRRAP
                     LGGRKKKKVPSASDSDSRADSDGAKEEPVVTAQPSPSSASSSSSSSASDSDVSIKKPP
                     RGRKPAEKPPPKPRGRRSKPERPPSTSSSDSDSDSGEVDRISEWKRRDEERRRELEAR
                     RRREQEEELRRLREQEREEKERRKERAERGGSSGEELEDEEPVKKRSRKARGRGTPSS
                     SDSEPEGELGKEGKKLAKKSQLQGSESARKPGQKEKRGRPDEKPRARPVKVERTRKRS
                     EGLSLDRKGEKKKEPSVEERLQKLHSEIKFALKVDNPDVRRCLSALEELGTLQVTSQI
                     LQKNTDVVATLKKIRRYKANKDVMAKAAEVYTRLKSRVLGPKVEALQKVNKAGAEKER
                     ADGEKVEEQPGEQAPRELAEDEPSTDRSAPVNGEAASQKGENTEDGAQEDGQDLEDGP
                     RGGSSEELHDSPQDSSDPARPGNEHQDHERMQLASESADDDDEDS"
     exon            77..153
                     /gene="Hdgfl2"
                     /gene_synonym="Hdgf2; Hdgfrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            154..292
                     /gene="Hdgfl2"
                     /gene_synonym="Hdgf2; Hdgfrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            293..493
                     /gene="Hdgfl2"
                     /gene_synonym="Hdgf2; Hdgfrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            494..607
                     /gene="Hdgfl2"
                     /gene_synonym="Hdgf2; Hdgfrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            608..679
                     /gene="Hdgfl2"
                     /gene_synonym="Hdgf2; Hdgfrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            680..848
                     /gene="Hdgfl2"
                     /gene_synonym="Hdgf2; Hdgfrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            849..924
                     /gene="Hdgfl2"
                     /gene_synonym="Hdgf2; Hdgfrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1216
                     /gene="Hdgfl2"
                     /gene_synonym="Hdgf2; Hdgfrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1320
                     /gene="Hdgfl2"
                     /gene_synonym="Hdgf2; Hdgfrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1394
                     /gene="Hdgfl2"
                     /gene_synonym="Hdgf2; Hdgfrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..1465
                     /gene="Hdgfl2"
                     /gene_synonym="Hdgf2; Hdgfrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1466..1567
                     /gene="Hdgfl2"
                     /gene_synonym="Hdgf2; Hdgfrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1568..1778
                     /gene="Hdgfl2"
                     /gene_synonym="Hdgf2; Hdgfrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1779..1905
                     /gene="Hdgfl2"
                     /gene_synonym="Hdgf2; Hdgfrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1906..2157
                     /gene="Hdgfl2"
                     /gene_synonym="Hdgf2; Hdgfrp2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagcatgccg cacgccttca agcccgggga cttagtgttt gccaagatga agggctaccc
       61 gcactggccg gcccggatcg atgacattgc tgatggtgct gtgaagccgc cacctaacaa
      121 ataccccatc ttcttctttg gaacgcatga aacggccttt ttgggaccca aggacctgtt
      181 cccttatgac aagtgcaagg acaagtacgg aaagcccaac aagaggaaag gcttcaatga
      241 ggggctctgg gagatccaga acaaccccca cgccagctac agtgcgcctc tgcctgtgag
      301 ctcctctgac agtgaggccc ctgaagccga cctgggtggt ggcagtgacg cagacaagga
      361 aaaagaagcc cggagggtca tgactgtgac agctgtgacc accacagcca ccagtggcag
      421 gacggagagc gactccgact ctgacaagaa cagtgatcac agtggcctga agcggaagac
      481 gccagtcttg aagatgtcag tctctaaacg agctagaaag gcctccagcg acctggatca
      541 ggccagtgtt tccccatcgg aagaggactc tgagagccca tctgagtcag agaagaccag
      601 tgaccaggat tttaccccag agaagaagac aatagcccgg gctccacggc gggctcctct
      661 gggaggacgc aaaaagaaga aggtgccgtc agcctcagat tcagactcca gagccgactc
      721 agatggggcc aaggaggagc ctgtggttac agcacagccg tctccgtcgt cggcctcctc
      781 ctcatcctcc tcatccgcct cagattcaga tgtgtccatc aagaaacccc ctcgaggcag
      841 aaagccagct gagaagccac cccccaaacc ccgagggcgg agatcaaagc cagaacgacc
      901 accttccacc tccagcagtg acagtgacag tgacagtggt gaggtggacc gaatcagtga
      961 atggaagagg cgtgatgagg agcgaaggcg agagctagag gctcggaggc gacgggagca
     1021 ggaggaagag ctccggaggc ttcgagagca ggagagggaa gagaaggagc ggcgcaagga
     1081 gcgggcagag cgtgggggca gcagtgggga ggagctggag gacgaggagc ctgtgaagaa
     1141 gcgtagccgc aaggctcggg gccggggcac accatcctcc tctgactcag agcccgaagg
     1201 ggagcttggg aaagagggga agaagttggc caagaagtcc caactgcaag gctcagagtc
     1261 tgcaaggaag cctgggcaga aggagaagag agggcggcca gacgagaagc caagagccag
     1321 gcctgtgaag gtggaacgga cacggaagcg gtcagagggt ctctcactgg acaggaaggg
     1381 ggaaaagaag aaagaacctt ccgtagagga gagactgcaa aagctacaca gcgagatcaa
     1441 atttgcactg aaggttgaca acccagatgt gaggaggtgt ctgagtgcac tggaagaact
     1501 gggaaccctg caggtaacct ctcagatcct tcagaagaac acagatgtgg tagcaacgct
     1561 caagaagatt cgccggtaca aggccaacaa agatgtgatg gcgaaggcag cagaggtcta
     1621 cacccggctc aagtcgaggg tcctggggcc gaaagttgag gctctccaga aggtgaacaa
     1681 agctggagcc gagaaggaac gggccgatgg cgagaaggtg gaggaacagc ctggggagca
     1741 ggctcccaga gagctggcgg aggatgagcc cagcactgat cggtcagcac ctgtgaatgg
     1801 tgaagccgca tcccagaagg gagagaacac agaagatgga gcacaggaag acgggcagga
     1861 cttggaggat ggccccaggg gtggctcctc agaagagctg catgacagcc cacaggacag
     1921 ctctgacccc gccaggcctg ggaatgagca tcaggaccat gagaggatgc agttggcctc
     1981 tgagtctgcc gatgatgatg atgaggacag ctgagctcca gccactgtgg ccatggtgcc
     2041 atgtctgtcc ccagcctccc agggaagtgc tgcgctgttt gtatttgtgg cctgggcttt
     2101 tctgcctagt tctgtgattt caattgacat gaaatggcta taaagaattt tgtaatg
//
