LOCUS       NP_446159                237 aa            linear   ROD 08-APR-2024
DEFINITION  hepatoma-derived growth factor [Rattus norvegicus].
ACCESSION   NP_446159
VERSION     NP_446159.1
DBSOURCE    REFSEQ: accession NM_053707.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 237)
  AUTHORS   Cheng,C.I., Tai,M.H., Chang,H.R., Chou,M.H., Chen,G.T., Chen,P.H.
            and Kao,Y.H.
  TITLE     Oxidized low-density lipoprotein induced hepatoma-derived growth
            factor upregulation mediates foam cell formation of cultured rat
            aortic vascular smooth muscle cells
  JOURNAL   Eur J Cell Biol 100 (5-6), 151169 (2021)
   PUBMED   34273665
  REMARK    GeneRIF: Oxidized low-density lipoprotein induced hepatoma-derived
            growth factor upregulation mediates foam cell formation of cultured
            rat aortic vascular smooth muscle cells.
REFERENCE   2  (residues 1 to 237)
  AUTHORS   Aiello,F.B., Guszczynski,T., Li,W., Hixon,J.A., Jiang,Q.,
            Hodge,D.L., Massignan,T., Di Lisio,C., Merchant,A., Procopio,A.D.,
            Bonetto,V. and Durum,S.K.
  TITLE     IL-7-induced phosphorylation of the adaptor Crk-like and other
            targets
  JOURNAL   Cell Signal 47, 131-141 (2018)
   PUBMED   29581031
REFERENCE   3  (residues 1 to 237)
  AUTHORS   Nusse,J., Blumrich,E.M., Mirastschijski,U., Kappelmann,L., Kelm,S.
            and Dietz,F.
  TITLE     Intra- or extra-exosomal secretion of HDGF isoforms: the
            extraordinary function of the HDGF-A N-terminal peptide
  JOURNAL   Biol Chem 398 (7), 793-811 (2017)
   PUBMED   27926477
REFERENCE   4  (residues 1 to 237)
  AUTHORS   Barallobre-Barreiro,J., Gupta,S.K., Zoccarato,A.,
            Kitazume-Taneike,R., Fava,M., Yin,X., Werner,T., Hirt,M.N.,
            Zampetaki,A., Viviano,A., Chong,M., Bern,M., Kourliouros,A.,
            Domenech,N., Willeit,P., Shah,A.M., Jahangiri,M., Schaefer,L.,
            Fischer,J.W., Iozzo,R.V., Viner,R., Thum,T., Heineke,J.,
            Kichler,A., Otsu,K. and Mayr,M.
  TITLE     Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin
            Activity in Human Atrial Fibrillation
  JOURNAL   Circulation 134 (11), 817-832 (2016)
   PUBMED   27559042
REFERENCE   5  (residues 1 to 237)
  AUTHORS   Barallobre-Barreiro,J., Oklu,R., Lynch,M., Fava,M., Baig,F.,
            Yin,X., Barwari,T., Potier,D.N., Albadawi,H., Jahangiri,M.,
            Porter,K.E., Watkins,M.T., Misra,S., Stoughton,J. and Mayr,M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   6  (residues 1 to 237)
  AUTHORS   Lukasik,S.M., Cierpicki,T., Borloz,M., Grembecka,J., Everett,A. and
            Bushweller,J.H.
  TITLE     High resolution structure of the HDGF PWWP domain: a potential DNA
            binding domain
  JOURNAL   Protein Sci 15 (2), 314-323 (2006)
   PUBMED   16384999
REFERENCE   7  (residues 1 to 237)
  AUTHORS   Moser,K. and White,F.M.
  TITLE     Phosphoproteomic analysis of rat liver by high capacity IMAC and
            LC-MS/MS
  JOURNAL   J Proteome Res 5 (1), 98-104 (2006)
   PUBMED   16396499
REFERENCE   8  (residues 1 to 237)
  AUTHORS   Zhou,Z., Yamamoto,Y., Sugai,F., Yoshida,K., Kishima,Y., Sumi,H.,
            Nakamura,H. and Sakoda,S.
  TITLE     Hepatoma-derived growth factor is a neurotrophic factor harbored in
            the nucleus
  JOURNAL   J Biol Chem 279 (26), 27320-27326 (2004)
   PUBMED   15140875
REFERENCE   9  (residues 1 to 237)
  AUTHORS   Abouzied,M.M., Baader,S.L., Dietz,F., Kappler,J., Gieselmann,V. and
            Franken,S.
  TITLE     Expression patterns and different subcellular localization of the
            growth factors HDGF (hepatoma-derived growth factor) and HRP-3
            (HDGF-related protein-3) suggest functions in addition to their
            mitogenic activity
  JOURNAL   Biochem J 378 (Pt 1), 169-176 (2004)
   PUBMED   14572309
REFERENCE   10 (residues 1 to 237)
  AUTHORS   Everett,A.D., Stoops,T. and McNamara,C.A.
  TITLE     Nuclear targeting is required for hepatoma-derived growth
            factor-stimulated mitogenesis in vascular smooth muscle cells
  JOURNAL   J Biol Chem 276 (40), 37564-37568 (2001)
   PUBMED   11481329
  REMARK    GeneRIF: HDGF contains a true bipartite nuclear localization
            sequence with all three lysines necessary for nuclear targeting.
            Nuclear targeting of HDGF is required for HDGF stimulation of DNA
            replication in VSM.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC070943.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC070943.1, AF389348.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..237
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     Protein         1..237
                     /product="hepatoma-derived growth factor"
                     /calculated_mol_wt=26357
     Region          10..96
                     /region_name="PWWP_HDGF"
                     /note="PWWP domain found in Hepatoma-derived growth factor
                     (HDGF); cd20148"
                     /db_xref="CDD:438976"
     Site            order(10,15..20,22..33,44..50,57..58,62..66,73..74,77,
                     79..82,85..86,89)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:438976"
     Site            order(22,24,77..80)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:438976"
     Site            order(23,26,49)
                     /site_type="other"
                     /note="putative methyl-histone binding site [polypeptide
                     binding]"
                     /db_xref="CDD:438976"
     Site            24..27
                     /site_type="other"
                     /note="PWWP sequence motif"
                     /db_xref="CDD:438976"
     Site            44
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P51858; propagated from
                     UniProtKB/Swiss-Prot (Q8VHK7.2)"
     Region          69..237
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VHK7.2)"
     Region          75..80
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VHK7.2)"
     Site            132
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:16396499,
                     ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q8VHK7.2)"
     Site            133
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:16396499,
                     ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q8VHK7.2)"
     Region          155..170
                     /region_name="Bipartite nuclear localization signal.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VHK7.2)"
     Site            165
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:16641100,
                     ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q8VHK7.2)"
     Site            199
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q8VHK7.2)"
     Site            200
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q8VHK7.2)"
     Site            202
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q8VHK7.2)"
     Site            206
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q8VHK7.2)"
     Site            236
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P51858; propagated from
                     UniProtKB/Swiss-Prot (Q8VHK7.2)"
     CDS             1..237
                     /gene="Hdgf"
                     /coded_by="NM_053707.3:272..985"
                     /db_xref="GeneID:114499"
                     /db_xref="RGD:70961"
ORIGIN      
        1 msrsnrqkey kcgdlvfakm kgyphwpari dempeaavks tankyqvfff gthetaflgp
       61 kdlfpyeesk ekfgkpnkrk gfseglweie nnptvkasgy qssqkkscae epevepeahe
      121 gdgdkkgnae gssdeegklv idepakekne kgmlkrragd mledspkrpk esgdheeeek
      181 eiaalegerp lpvemeknst psepdsgqgp ppeeeegeee aakeeaeaqg vrdhesl
//
