LOCUS       NM_017016               2367 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus histidine decarboxylase (Hdc), mRNA.
ACCESSION   NM_017016 XM_346674
VERSION     NM_017016.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2367)
  AUTHORS   Hoffman,G.E. and Koban,M.
  TITLE     Hypothalamic L-Histidine Decarboxylase Is Up-Regulated During
            Chronic REM Sleep Deprivation of Rats
  JOURNAL   PLoS One 11 (12), e0152252 (2016)
   PUBMED   27997552
  REMARK    GeneRIF: results suggest that up-regulation of L-HDC within the
            tuberomammillary complex during chronic REM Sleep Deprivation may
            be responsible for maintaining wakefulness.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2367)
  AUTHORS   Komori,H., Nitta,Y., Ueno,H. and Higuchi,Y.
  TITLE     Structural study reveals that Ser-354 determines substrate
            specificity on human histidine decarboxylase
  JOURNAL   J Biol Chem 287 (34), 29175-29183 (2012)
   PUBMED   22767596
REFERENCE   3  (bases 1 to 2367)
  AUTHORS   Krusong,K., Ercan-Sencicek,A.G., Xu,M., Ohtsu,H., Anderson,G.M.,
            State,M.W. and Pittenger,C.
  TITLE     High levels of histidine decarboxylase in the striatum of mice and
            rats
  JOURNAL   Neurosci Lett 495 (2), 110-114 (2011)
   PUBMED   21440039
  REMARK    GeneRIF: Histidine decarboxylase was found at comparably high
            levels in rat striatum.
REFERENCE   4  (bases 1 to 2367)
  AUTHORS   Gervasini,G., Agundez,J.A., Garcia-Menaya,J., Martinez,C.,
            Cordobes,C., Ayuso,P., Cornejo,J.A., Blanca,M. and Garcia-Martin,E.
  TITLE     Variability of the L-Histidine decarboxylase gene in allergic
            rhinitis
  JOURNAL   Allergy 65 (12), 1576-1584 (2010)
   PUBMED   20608921
REFERENCE   5  (bases 1 to 2367)
  AUTHORS   Moya-Garcia,A.A., Ruiz-Pernia,J., Marti,S., Sanchez-Jimenez,F. and
            Tunon,I.
  TITLE     Analysis of the decarboxylation step in mammalian histidine
            decarboxylase. A computational study
  JOURNAL   J Biol Chem 283 (18), 12393-12401 (2008)
   PUBMED   18310073
  REMARK    GeneRIF: A hybrid quantum mechanics/molecular mechanics theoretical
            study on the reaction mechanism of mammalian histidine
            decarboxylase, is reported.
REFERENCE   6  (bases 1 to 2367)
  AUTHORS   Sullivan,P.M., Petrusz,P., Szpirer,C. and Joseph,D.R.
  TITLE     Alternative processing of androgen-binding protein RNA transcripts
            in fetal rat liver. Identification of a transcript formed by trans
            splicing
  JOURNAL   J Biol Chem 266 (1), 143-154 (1991)
   PUBMED   1702422
REFERENCE   7  (bases 1 to 2367)
  AUTHORS   Joseph,D.R., Sullivan,P.M., Wang,Y.M., Kozak,C.,
            Fenstermacher,D.A., Behrendsen,M.E. and Zahnow,C.A.
  TITLE     Characterization and expression of the complementary DNA encoding
            rat histidine decarboxylase
  JOURNAL   Proc Natl Acad Sci U S A 87 (2), 733-737 (1990)
   PUBMED   2300558
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1990 Sep;87(18):7346]
REFERENCE   8  (bases 1 to 2367)
  AUTHORS   Wouterlood,F.G. and Gaykema,R.P.
  TITLE     Innervation of histaminergic neurons in the posterior hypothalamic
            region by medial preoptic neurons. Anterograde tracing with
            Phaseolus vulgaris leucoagglutinin combined with
            immunocytochemistry of histidine decarboxylase in the rat
  JOURNAL   Brain Res 455 (1), 170-176 (1988)
   PUBMED   2458167
REFERENCE   9  (bases 1 to 2367)
  AUTHORS   Heald,J.I. and Hollis,T.M.
  TITLE     Histidine decarboxylase-mediated histamine synthesis in glomeruli
            from rat kidneys
  JOURNAL   Am J Physiol 230 (5), 1349-1353 (1976)
   PUBMED   5898
REFERENCE   10 (bases 1 to 2367)
  AUTHORS   Hakanson,R., Kroesen,J.H., Liedberg,G., Oscarson,J., Rehfeld,J.F.
            and Stadil,F.
  TITLE     Correlation between serum gastrin concentration and rat stomach
            histidine decarboxylase activity
  JOURNAL   J Physiol 243 (2), 483-498 (1974)
   PUBMED   4449071
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC128724.1.
            
            On Oct 12, 2007 this sequence version replaced NM_017016.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC128724.1, M29591.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2367
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q36"
     gene            1..2367
                     /gene="Hdc"
                     /note="histidine decarboxylase"
                     /db_xref="GeneID:24443"
                     /db_xref="RGD:2790"
     exon            1..108
                     /gene="Hdc"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..2039
                     /gene="Hdc"
                     /EC_number="4.1.1.22"
                     /codon_start=1
                     /product="histidine decarboxylase"
                     /protein_id="NP_058712.2"
                     /db_xref="GeneID:24443"
                     /db_xref="RGD:2790"
                     /translation="MMEPSEYREYQARGKEMVDYICQYLSTLRERQVTPNVKPGYLRA
                     QIPSSAPEEPDSWDSIFGDIEQIIMPGVVHWQSPHMHAYYPALTSWPSLLGDMLADAI
                     NCLGFTWASSPACTELEMNIMDWLAKMLGLPDFFLHHHPSSQGGGVLQSTVSESTLIA
                     LLAARKNKILEMKAHEPNADESSLNARLVAYASDQAHSSVEKAGLISLVKIKFLPVDD
                     NFSLRGEALQKAIEEDKQQGLVPVFVCATLGTTGVCAFDKLSELGPICAREGLWLHVD
                     AAYAGTAFLCPELRGFLKGIEYADSFTFNPSKWMMVHFDCTGFWVKDKYKLQQTFSVN
                     PIYLRHANSGVATDFMHWQIPLSRRFRSIKLWFVIRSFGVKNLQAHVRHGTDMAKYFE
                     SLVRSDPVFEIPAERHLGLVVFRLKGPNCLTESVLKEIAKTGQVFLIPATIQDKLIIR
                     FTVTSQFTTKDDILRDWNLIREAANLVLSQHCTSQPSPRAKNLIPPPVTRDSKDLTNG
                     LSLESVNEGGDDPVQVRKIFRLPGDSLETTMDPFDDCFSEEASDTTKHKLSSFLFSYL
                     SVQNKKKTMRSLSCNSMPMSAQKSPPPDASVKHGGFFRARIFSGFPEEMMMMKKGGFK
                     KLIKFYSVPSFPECSSQCGTLQLPCCPLQAMV"
     exon            109..281
                     /gene="Hdc"
                     /inference="alignment:Splign:2.1.0"
     exon            282..395
                     /gene="Hdc"
                     /inference="alignment:Splign:2.1.0"
     exon            396..518
                     /gene="Hdc"
                     /inference="alignment:Splign:2.1.0"
     exon            519..653
                     /gene="Hdc"
                     /inference="alignment:Splign:2.1.0"
     exon            654..797
                     /gene="Hdc"
                     /inference="alignment:Splign:2.1.0"
     exon            798..864
                     /gene="Hdc"
                     /inference="alignment:Splign:2.1.0"
     exon            865..1027
                     /gene="Hdc"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1118
                     /gene="Hdc"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1217
                     /gene="Hdc"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..1319
                     /gene="Hdc"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..2342
                     /gene="Hdc"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caatagtgag taagaagccc ggctgccttc cggtctcctc tttctgtctg caagccaagt
       61 caagaaagat gatggagccc agtgaatacc gtgaatacca agctagaggg aaagagatgg
      121 tggattacat ctgccagtac ctgagcaccc tgcgggagag gcaggtgacc ccaaatgtga
      181 agcctgggta cctgcgagcc cagatacctt caagtgctcc tgaggaaccc gacagctggg
      241 atagcatctt tggggacatt gagcaaatca tcatgcctgg ggtggttcac tggcagagcc
      301 cccacatgca cgcctactat ccggctctca cctcttggcc atccctgcta ggagatatgc
      361 tggctgacgc catcaactgc ttggggttca cgtgggcttc cagcccggcc tgcacagagc
      421 tggagatgaa catcatggac tggctggcga agatgctggg gctcccggac ttcttcctgc
      481 accaccatcc cagcagccag gggggaggcg tcttgcagag cactgtcagc gaatccactt
      541 taattgccct gctggcagca aggaagaaca aaatcctaga aatgaaagcg catgagccca
      601 atgctgatga gtcctctctg aacgctcgtc ttgttgccta tgcctctgac caggctcact
      661 cttcagtgga gaaggctggc ttgatttccc ttgtgaagat caaatttctg cctgtggatg
      721 acaacttctc actccgagga gaagctctcc agaaggccat cgaggaagac aagcaacagg
      781 gcttggtgcc tgtgtttgtc tgtgcaacct tagggaccac tggagtctgt gcatttgata
      841 agctgtcaga gctggggccc atctgtgcca gggagggact gtggctccac gtcgatgctg
      901 cttatgcagg aacagccttt ctgtgccctg agctccgggg cttcctgaag ggcattgagt
      961 acgccgactc cttcaccttt aacccttcca agtggatgat ggtgcacttt gactgcactg
     1021 ggttctgggt caaggacaag tacaagctac agcagacctt cagtgtgaac cccatctacc
     1081 tcagacatgc gaactctggt gtcgccactg acttcatgca ttggcagatc cccttgagcc
     1141 ggcgctttcg ctccattaag ctgtggtttg tgattcggtc cttcggggtg aagaatcttc
     1201 aagcacatgt cagacacggt acagacatgg ctaaatactt tgaatctctg gtcaggagcg
     1261 accctgtttt cgaaattcct gctgagaggc accttggtct ggtggttttt cgtctgaagg
     1321 gtcccaactg tctcacagaa agtgtgttaa aggaaatagc caaaactggc caggtcttcc
     1381 tcatcccagc cactatccag gacaagctga tcatccgttt caccgtgacg tcccagttca
     1441 ccaccaagga tgacatcctg agagattgga acctcatccg agaggctgct aaccttgtcc
     1501 tgagccagca ctgcacttct cagccgagcc ctcgggccaa gaaccttatt ccaccgccgg
     1561 tgaccagaga ctccaaagac ctgaccaatg ggctatccct ggagtctgtc aacgagggag
     1621 gagatgaccc agtacaggtc cggaagatct tcaggctgcc aggagacagt ctggaaacga
     1681 caatggatcc ctttgatgat tgcttctcag aagaggcctc cgataccacc aagcacaagc
     1741 tgtcgtcctt tctgttcagt tacttgtcgg tacagaacaa gaagaagaca atgcggtccc
     1801 tcagctgcaa cagtatgcct atgagtgccc agaagtcacc tcccccagat gcttccgtga
     1861 agcatggggg cttcttccgg gccagaatct tttctgggtt cccagaagaa atgatgatga
     1921 tgaagaaagg tggcttcaaa aagctgatca agttctacag tgttcccagc tttcctgaat
     1981 gcagctctca gtgtggtacc ctccagctgc cctgctgccc tctgcaggcc atggtgtagg
     2041 tgacgggagt cttcaatcag aatgcaaggg tgtgcttcag ggagttcggg aacccttgaa
     2101 attgtgtgca gtttgtgtgc ttattatgta tgtgtgtgca tcttgaggga agtaagccca
     2161 taattttgat catagcctca caggggttca tgacccacaa tagattggaa ttgggcagtt
     2221 taagctggca tgcttcagag ggttgcaggg gcttgtgtga cagaaggggc tgagagagca
     2281 gtgtcctgtt aagcttgtaa tgtaaaaaac aacctagaaa taaattgtgc ctatatctaa
     2341 aaaaaaaaaa aaaaaaaaaa aaaaaaa
//
