LOCUS       NM_001200045            3503 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus histone deacetylase 9 (Hdac9), mRNA.
ACCESSION   NM_001200045 XM_001076680
VERSION     NM_001200045.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3503)
  AUTHORS   Yang,L., Wu,C., Cui,Y. and Dong,S.
  TITLE     Knockdown of histone deacetylase 9 attenuates sepsis-induced
            myocardial injury and inflammatory response
  JOURNAL   Exp Anim 72 (3), 356-366 (2023)
   PUBMED   36927982
  REMARK    GeneRIF: Knockdown of histone deacetylase 9 attenuates
            sepsis-induced myocardial injury and inflammatory response.
REFERENCE   2  (bases 1 to 3503)
  AUTHORS   Shen,J., Han,Q., Li,W., Chen,X., Lu,J., Zheng,J. and Xue,S.
  TITLE     miR-383-5p Regulated by the Transcription Factor CTCF Affects
            Neuronal Impairment in Cerebral Ischemia by Mediating Deacetylase
            HDAC9 Activity
  JOURNAL   Mol Neurobiol 59 (10), 6307-6320 (2022)
   PUBMED   35927544
  REMARK    GeneRIF: miR-383-5p Regulated by the Transcription Factor CTCF
            Affects Neuronal Impairment in Cerebral Ischemia by Mediating
            Deacetylase HDAC9 Activity.
REFERENCE   3  (bases 1 to 3503)
  AUTHORS   Cai,Y., Huang,D., Ma,W., Wang,M., Qin,Q., Jiang,Z. and Liu,M.
  TITLE     Histone deacetylase 9 inhibition upregulates microRNA-92a to
            repress the progression of intracranial aneurysm via silencing
            Bcl-2-like protein 11
  JOURNAL   J Drug Target 29 (7), 761-770 (2021)
   PUBMED   33480300
  REMARK    GeneRIF: Histone deacetylase 9 inhibition upregulates microRNA-92a
            to repress the progression of intracranial aneurysm via silencing
            Bcl-2-like protein 11.
REFERENCE   4  (bases 1 to 3503)
  AUTHORS   Cheng,H.P., Gong,D., Zhao,Z.W., He,P.P., Yu,X.H., Ye,Q., Huang,C.,
            Zhang,X., Chen,L.Y., Xie,W., Zhang,M., Li,L., Xia,X.D.,
            Ouyang,X.P., Tan,Y.L., Wang,Z.B., Tian,G.P., Zheng,X.L., Yin,W.D.
            and Tang,C.K.
  TITLE     MicroRNA-182 Promotes Lipoprotein Lipase Expression and
            Atherogenesisby Targeting Histone Deacetylase 9 in Apolipoprotein
            E-Knockout Mice
  JOURNAL   Circ J 82 (1), 28-38 (2017)
   PUBMED   28855441
  REMARK    Erratum:[Circ J. 2022;86(2):364. doi: 10.1253/circj.CJ-66-0201.
            PMID: 35082228]
REFERENCE   5  (bases 1 to 3503)
  AUTHORS   Bourgeois,C.T., Satou,R. and Prieto,M.C.
  TITLE     HDAC9 is an epigenetic repressor of kidney angiotensinogen
            establishing a sex difference
  JOURNAL   Biol Sex Differ 8, 18 (2017)
   PUBMED   28572913
  REMARK    GeneRIF: Results indicate that histone deacetylase 9 is a novel
            suppressing factor involved in angiotensinogen (AGT) regulation in
            renal proximal tubular cells, leading to low levels of intrarenal
            AGT in females.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3503)
  AUTHORS   Zhou,X., Marks,P.A., Rifkind,R.A. and Richon,V.M.
  TITLE     Cloning and characterization of a histone deacetylase, HDAC9
  JOURNAL   Proc Natl Acad Sci U S A 98 (19), 10572-10577 (2001)
   PUBMED   11535832
REFERENCE   7  (bases 1 to 3503)
  AUTHORS   Zhang,C.L., McKinsey,T.A. and Olson,E.N.
  TITLE     The transcriptional corepressor MITR is a signal-responsive
            inhibitor of myogenesis
  JOURNAL   Proc Natl Acad Sci U S A 98 (13), 7354-7359 (2001)
   PUBMED   11390982
REFERENCE   8  (bases 1 to 3503)
  AUTHORS   Zhang,C.L., McKinsey,T.A., Lu,J.R. and Olson,E.N.
  TITLE     Association of COOH-terminal-binding protein (CtBP) and
            MEF2-interacting transcription repressor (MITR) contributes to
            transcriptional repression of the MEF2 transcription factor
  JOURNAL   J Biol Chem 276 (1), 35-39 (2001)
   PUBMED   11022042
REFERENCE   9  (bases 1 to 3503)
  AUTHORS   Lemercier,C., Verdel,A., Galloo,B., Curtet,S., Brocard,M.P. and
            Khochbin,S.
  TITLE     mHDA1/HDAC5 histone deacetylase interacts with and represses MEF2A
            transcriptional activity
  JOURNAL   J Biol Chem 275 (20), 15594-15599 (2000)
   PUBMED   10748098
REFERENCE   10 (bases 1 to 3503)
  AUTHORS   Zhou,X., Richon,V.M., Rifkind,R.A. and Marks,P.A.
  TITLE     Identification of a transcriptional repressor related to the
            noncatalytic domain of histone deacetylases 4 and 5
  JOURNAL   Proc Natl Acad Sci U S A 97 (3), 1056-1061 (2000)
   PUBMED   10655483
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB558551.1.
            
            On Jan 14, 2011 this sequence version replaced XM_001076680.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB558551.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132263,
                                           SAMD00132284 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..3503
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q16"
     gene            1..3503
                     /gene="Hdac9"
                     /gene_synonym="MITR; RGD1310748; RGD1563092"
                     /note="histone deacetylase 9"
                     /db_xref="GeneID:687001"
                     /db_xref="RGD:1310748"
     exon            1..206
                     /gene="Hdac9"
                     /gene_synonym="MITR; RGD1310748; RGD1563092"
                     /inference="alignment:Splign:2.1.0"
     exon            207..269
                     /gene="Hdac9"
                     /gene_synonym="MITR; RGD1310748; RGD1563092"
                     /inference="alignment:Splign:2.1.0"
     CDS             248..3454
                     /gene="Hdac9"
                     /gene_synonym="MITR; RGD1310748; RGD1563092"
                     /EC_number="3.5.1.98"
                     /note="MEF2-interacting transcriptional repressor"
                     /codon_start=1
                     /product="histone deacetylase 9"
                     /protein_id="NP_001186974.1"
                     /db_xref="GeneID:687001"
                     /db_xref="RGD:1310748"
                     /translation="MHSMISSVDVKSEVPMGLEPISPLDLRTDLRMMMPVVDPVVREK
                     QLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKLQQELLAIKQQQEL
                     LEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSAT
                     KDTPTNGKNHSVGRHPKLWYTAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDTKDDFPL
                     RKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGNLVTSFKKRVFEVAESSVSSSSPGS
                     GPSSPNNGPAGNVTENEASVLPPTPHPEQLVPQQRILIHEDSMNLLSLYTSPSLPNIT
                     LGLPAVPSPLSASNSLKDKQKCETQMLRQGVPLPGQYGSGIAASSSHAHVAMEGKPNS
                     SHQALLQHLLLKEQMRQQKLLVAGGVPLHPQSPLATKERISPGIRGTHKLPRHRPLNR
                     TQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQQIHMNKLLSKSIEQLKQPGSHLEEAE
                     EELQGDQAMEERATSKDSGTGKDSSACVEDTLGQVGAVKVKEEPVDSDEDAQMQEMEC
                     GEQAAFMQQTPLLESSHTRALSVHQARLAAAGIDGLEKHGLLSRTHSSPAPSMSPHPA
                     ADCPRQPASATGIAYDCLMLKHQCICGNSTTHPEHAGRIQSIWSRLQETGLLNKCERI
                     QGRKASLEEIQLVHSEHHSLLYGTSPLDGQKLDPRTLLGDDSRKFFSSLPCGGLGVDS
                     DTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVVRPPGHHAEESAAMGFCFFN
                     SVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFPGS
                     GAPNEVGVGLGEGYNVNIAWTGGLDPPMGDVEYLEAFRTVVMPVAREFDPDMVLVSAG
                     FDALEGHTPPLGGYKVTAKCFGHLTKQLMTLANGRVALALEGGHDLTAICDASEACIN
                     ALLGNEPGSLEEDVLHQSVNTNAAASLQKTIEIQSKYWKSIKMVAVARGCALPASQLQ
                     EETETVSALASLTVDVEQPFAQEDGRTAGEPMEEEPAL"
     exon            270..511
                     /gene="Hdac9"
                     /gene_synonym="MITR; RGD1310748; RGD1563092"
                     /inference="alignment:Splign:2.1.0"
     exon            512..662
                     /gene="Hdac9"
                     /gene_synonym="MITR; RGD1310748; RGD1563092"
                     /inference="alignment:Splign:2.1.0"
     exon            663..789
                     /gene="Hdac9"
                     /gene_synonym="MITR; RGD1310748; RGD1563092"
                     /inference="alignment:Splign:2.1.0"
     exon            790..911
                     /gene="Hdac9"
                     /gene_synonym="MITR; RGD1310748; RGD1563092"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1043
                     /gene="Hdac9"
                     /gene_synonym="MITR; RGD1310748; RGD1563092"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1159
                     /gene="Hdac9"
                     /gene_synonym="MITR; RGD1310748; RGD1563092"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1282
                     /gene="Hdac9"
                     /gene_synonym="MITR; RGD1310748; RGD1563092"
                     /inference="alignment:Splign:2.1.0"
     exon            1283..1493
                     /gene="Hdac9"
                     /gene_synonym="MITR; RGD1310748; RGD1563092"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..1711
                     /gene="Hdac9"
                     /gene_synonym="MITR; RGD1310748; RGD1563092"
                     /inference="alignment:Splign:2.1.0"
     exon            1712..1972
                     /gene="Hdac9"
                     /gene_synonym="MITR; RGD1310748; RGD1563092"
                     /inference="alignment:Splign:2.1.0"
     exon            1973..2153
                     /gene="Hdac9"
                     /gene_synonym="MITR; RGD1310748; RGD1563092"
                     /inference="alignment:Splign:2.1.0"
     exon            2154..2287
                     /gene="Hdac9"
                     /gene_synonym="MITR; RGD1310748; RGD1563092"
                     /inference="alignment:Splign:2.1.0"
     exon            2288..2408
                     /gene="Hdac9"
                     /gene_synonym="MITR; RGD1310748; RGD1563092"
                     /inference="alignment:Splign:2.1.0"
     exon            2409..2458
                     /gene="Hdac9"
                     /gene_synonym="MITR; RGD1310748; RGD1563092"
                     /inference="alignment:Splign:2.1.0"
     exon            2459..2566
                     /gene="Hdac9"
                     /gene_synonym="MITR; RGD1310748; RGD1563092"
                     /inference="alignment:Splign:2.1.0"
     exon            2567..2622
                     /gene="Hdac9"
                     /gene_synonym="MITR; RGD1310748; RGD1563092"
                     /inference="alignment:Splign:2.1.0"
     exon            2623..2710
                     /gene="Hdac9"
                     /gene_synonym="MITR; RGD1310748; RGD1563092"
                     /inference="alignment:Splign:2.1.0"
     exon            2711..2830
                     /gene="Hdac9"
                     /gene_synonym="MITR; RGD1310748; RGD1563092"
                     /inference="alignment:Splign:2.1.0"
     exon            2831..2928
                     /gene="Hdac9"
                     /gene_synonym="MITR; RGD1310748; RGD1563092"
                     /inference="alignment:Splign:2.1.0"
     exon            2929..3047
                     /gene="Hdac9"
                     /gene_synonym="MITR; RGD1310748; RGD1563092"
                     /inference="alignment:Splign:2.1.0"
     exon            3048..3181
                     /gene="Hdac9"
                     /gene_synonym="MITR; RGD1310748; RGD1563092"
                     /inference="alignment:Splign:2.1.0"
     exon            3182..3266
                     /gene="Hdac9"
                     /gene_synonym="MITR; RGD1310748; RGD1563092"
                     /inference="alignment:Splign:2.1.0"
     exon            3267..3414
                     /gene="Hdac9"
                     /gene_synonym="MITR; RGD1310748; RGD1563092"
                     /inference="alignment:Splign:2.1.0"
     exon            3415..3503
                     /gene="Hdac9"
                     /gene_synonym="MITR; RGD1310748; RGD1563092"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaagctgca cttgcaagca ttgggctata cttggttacc ccaaggagct tccaaattgc
       61 agtcttcaac agtttcacct accgacagta gcagccctgg tatgatacta cttgactaaa
      121 acccagcatc tgacctccac tgcatggatc accttgggca agtgtcttaa cctctctcct
      181 ctcaatcaga tgcttttctc aatcagatgg agtggccgga cgggagcagc tcttggctca
      241 gcaaagaatg cacagtatga tcagctcagt ggacgtgaaa tcagaggttc ctatgggact
      301 ggagcccatc tcacctttag acctaaggac agacctcagg atgatgatgc ctgtggtgga
      361 tcctgtcgtc cgcgagaagc aactgcagca agagttactt cttatccaac agcagcagca
      421 aatccagaag cagctcctga tagccgagtt tcagaagcag cacgagaatt tgacaaggca
      481 gcatcaagca caacttcagg agcacatcaa gttacaacag gaacttctag ccataaaaca
      541 acagcaagaa ctcctagaaa aggagcagaa actggagcag cagaggcaag aacaggaagt
      601 agagaggcat cgcagagagc agcagcttcc tcctctcaga ggcaaagata gaggacgaga
      661 aagggcggtg gcaagcacag aggttaagca gaagcttcaa gaattcctat tgagtaaatc
      721 agcaacgaaa gacactccaa ccaatggaaa gaatcattcc gtgggccgcc atcccaagct
      781 ctggtacacg gctgcccacc acacatcact ggatcaaagc tctccacccc tcagtggaac
      841 gtctccatcc tacaaataca cattaccagg agcccaagat accaaggatg atttcccctt
      901 gcgaaaaaca gcctcagagc ccaacttgaa ggtgcggtcc aggttaaaac agaaagtggc
      961 agagaggaga agcagcccct tactcaggcg gaaggatgga aatcttgtca cttcattcaa
     1021 gaagcgagtg tttgaggtgg cagaatcctc ggtcagtagc agctctccag ggtcaggtcc
     1081 cagttcacca aacaatgggc ctgctggaaa tgttaccgaa aacgaggctt cagttctgcc
     1141 tcccacgcct caccccgagc agctggttcc acagcagcgc attctgattc acgaagattc
     1201 catgaacctg ctgagtctct acacctcccc gtccctgccc aatatcaccc tgggacttcc
     1261 agcagtgcca tccccactca gtgcttctaa ttccctcaaa gacaagcaga agtgtgagac
     1321 acagatgctc agacaaggtg tccctctgcc cggccagtat ggaagtggca ttgcagcatc
     1381 ctccagccat gctcatgtag caatggaggg caaaccgaac agcagtcacc aagctctcct
     1441 gcagcacctc ctgctgaagg aacaaatgag acagcaaaag cttcttgtgg ctggcggagt
     1501 tccattacac ccccagtctc ctttggcaac aaaagaaaga atttcaccag gcattagagg
     1561 tacccacaaa ttgccccgcc acagacccct caatcgaact cagtctgcac ctttgcctca
     1621 gagcacactg gctcagctgg tcattcagca gcagcaccag cagttcctgg agaagcagaa
     1681 gcaataccag cagcagatcc acatgaacaa actgctatcg aaatctattg agcaactgaa
     1741 gcaaccaggc agccatcttg aagaggcaga ggaggagctt cagggggacc aagccatgga
     1801 agagagagca acgtctaagg acagcggtac cgggaaggac agcagtgctt gtgtggagga
     1861 cacactggga caagttgggg ctgtgaaggt caaggaggaa cccgtggaca gcgacgaaga
     1921 tgctcagatg caggaaatgg aatgtgggga gcaggctgct tttatgcaac agacgccctt
     1981 gctggagtcc tcacacacgc gtgcactctc agtgcaccag gctcggctgg ctgcagctgg
     2041 catcgatgga ttagagaaac atggactcct ctccaggacc cattcttctc ctgcaccctc
     2101 catgtcacct cacccagccg cagactgtcc ccgccagcct gcctctgcca ctggaattgc
     2161 ctatgactgt ctgatgctga aacaccagtg catctgtggc aattccacca cccaccctga
     2221 gcatgctggg cgaatacaga gcatctggtc acggctgcaa gaaaccgggc tgctaaataa
     2281 atgtgagcga attcaaggtc gaaaagccag cctggaggaa attcagcttg ttcattctga
     2341 acatcactca ctactgtatg gcaccagccc cctggacgga cagaagctgg accccaggac
     2401 actcctaggt gatgattctc gaaaattctt ttcctcgtta ccttgtggtg gactcggggt
     2461 ggacagtgac accatttgga atgagctgca ctcgtccggt gctgcacgca tggctgttgg
     2521 ctgtgtcatt gagctggctt ccaaagtggc ctcaggagag ctgaagaatg ggtttgctgt
     2581 tgtgaggccc ccaggccatc atgctgaaga atctgcagcc atggggttct gcttttttaa
     2641 ttcagtcgca attacggcca aatacttgag agaccaacta aatataagca agatattgat
     2701 cgtagatctg gatgttcacc atggaaacgg tacacagcag gccttttatg ctgaccccag
     2761 catcctgtac atttcactcc atcgctatga tgaagggaac tttttccctg gcagtggcgc
     2821 cccgaatgag gttggagtag gtctgggaga aggctacaat gtaaacattg cctggacagg
     2881 cggccttgac ccccctatgg gagatgttga gtaccttgaa gcattcagga ctgtcgtgat
     2941 gcctgtggcc agagagtttg atccagacat ggtcctggtt tctgctggat ttgatgcatt
     3001 ggaaggccac acccctcccc tagggggtta caaagtgaca gcaaaatgct ttggtcattt
     3061 gacgaagcag ctgatgacat tggctaatgg acgtgtggca ttggctcttg aagggggaca
     3121 tgatctgaca gccatctgtg atgcctcgga ggcctgcata aatgcccttc taggaaatga
     3181 gcccgggtct cttgaggaag atgttctcca ccagtctgtg aatacgaatg cagccgcttc
     3241 tttacagaag accattgaaa tccaaagcaa gtattggaag tcgatcaaga tggtggctgt
     3301 tgcaaggggc tgtgctctgc ctgcttctca gctgcaagag gagacagaga ccgtttctgc
     3361 attagcctcc ctgacggtag atgtggaaca gccatttgct caggaagatg gcagaactgc
     3421 tggtgagccc atggaagagg agccagcctt gtgaagtgcc aagtctcccc cgatatttcc
     3481 tgtgtgtgac atcattgtgt atc
//
