LOCUS       NM_001126373            2002 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus histone deacetylase 8 (Hdac8), mRNA.
ACCESSION   NM_001126373 XM_001070606 XM_343804
VERSION     NM_001126373.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2002)
  AUTHORS   Wang,P., Mao,Z., Pan,Q., Lu,R., Huang,X., Shang,X., Zhang,R. and
            You,H.
  TITLE     Histone deacetylase-4 and histone deacetylase-8 regulate
            interleukin-1beta-induced cartilage catabolic degradation through
            MAPK/JNK and ERK pathways
  JOURNAL   Int J Mol Med 41 (4), 2117-2127 (2018)
   PUBMED   29393346
  REMARK    GeneRIF: These results suggest that HDAC4 and HDAC8 may serve as
            key upstream mediators of MAPK in regulating the IL1betainduced
            cartilage catabolic and degradation.
REFERENCE   2  (bases 1 to 2002)
  AUTHORS   Nakayama,T. and Akagawa,K.
  TITLE     Transcription regulation mechanism of the syntaxin 1A gene via
            protein kinase A
  JOURNAL   Biochem J 474 (14), 2465-2473 (2017)
   PUBMED   28559304
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2002)
  AUTHORS   Kee,H.J., Kim,G.R., Lin,M.Q., Choi,S.Y., Ryu,Y., Jin,L., Piao,Z.H.
            and Jeong,M.H.
  TITLE     Expression of Class I and Class II a/b Histone Deacetylase is
            Dysregulated in Hypertensive Animal Models
  JOURNAL   Korean Circ J 47 (3), 392-400 (2017)
   PUBMED   28567090
REFERENCE   4  (bases 1 to 2002)
  AUTHORS   Li,R.F., Cao,S.S., Fang,W.J., Song,Y., Luo,X.T., Wang,H.Y. and
            Wang,J.G.
  TITLE     Roles of HDAC2 and HDAC8 in Cardiac Remodeling in Renovascular
            Hypertensive Rats and the Effects of Valproic Acid Sodium
  JOURNAL   Pharmacology 99 (1-2), 27-39 (2017)
   PUBMED   27673327
REFERENCE   5  (bases 1 to 2002)
  AUTHORS   Nakayama,T., Mikoshiba,K. and Akagawa,K.
  TITLE     The cell- and tissue-specific transcription mechanism of the
            TATA-less syntaxin 1A gene
  JOURNAL   FASEB J 30 (2), 525-543 (2016)
   PUBMED   26391271
REFERENCE   6  (bases 1 to 2002)
  AUTHORS   Deardorff,M.A., Bando,M., Nakato,R., Watrin,E., Itoh,T.,
            Minamino,M., Saitoh,K., Komata,M., Katou,Y., Clark,D., Cole,K.E.,
            De Baere,E., Decroos,C., Di Donato,N., Ernst,S., Francey,L.J.,
            Gyftodimou,Y., Hirashima,K., Hullings,M., Ishikawa,Y., Jaulin,C.,
            Kaur,M., Kiyono,T., Lombardi,P.M., Magnaghi-Jaulin,L.,
            Mortier,G.R., Nozaki,N., Petersen,M.B., Seimiya,H., Siu,V.M.,
            Suzuki,Y., Takagaki,K., Wilde,J.J., Willems,P.J., Prigent,C.,
            Gillessen-Kaesbach,G., Christianson,D.W., Kaiser,F.J.,
            Jackson,L.G., Hirota,T., Krantz,I.D. and Shirahige,K.
  TITLE     HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin
            acetylation cycle
  JOURNAL   Nature 489 (7415), 313-317 (2012)
   PUBMED   22885700
REFERENCE   7  (bases 1 to 2002)
  AUTHORS   Peserico,A. and Simone,C.
  TITLE     Physical and functional HAT/HDAC interplay regulates protein
            acetylation balance
  JOURNAL   J Biomed Biotechnol 2011, 371832 (2011)
   PUBMED   21151613
  REMARK    Review article
REFERENCE   8  (bases 1 to 2002)
  AUTHORS   Lee,H., Sengupta,N., Villagra,A., Rezai-Zadeh,N. and Seto,E.
  TITLE     Histone deacetylase 8 safeguards the human ever-shorter telomeres
            1B (hEST1B) protein from ubiquitin-mediated degradation
  JOURNAL   Mol Cell Biol 26 (14), 5259-5269 (2006)
   PUBMED   16809764
  REMARK    Erratum:[Mol Cell Biol. 2006 Oct;26(19):7342]
REFERENCE   9  (bases 1 to 2002)
  AUTHORS   Wedel,T., Van Eys,G.J., Waltregny,D., Glenisson,W., Castronovo,V.
            and Vanderwinden,J.M.
  TITLE     Novel smooth muscle markers reveal abnormalities of the intestinal
            musculature in severe colorectal motility disorders
  JOURNAL   Neurogastroenterol Motil 18 (7), 526-538 (2006)
   PUBMED   16771768
REFERENCE   10 (bases 1 to 2002)
  AUTHORS   Ito,K., Ito,M., Elliott,W.M., Cosio,B., Caramori,G., Kon,O.M.,
            Barczyk,A., Hayashi,S., Adcock,I.M., Hogg,J.C. and Barnes,P.J.
  TITLE     Decreased histone deacetylase activity in chronic obstructive
            pulmonary disease
  JOURNAL   N Engl J Med 352 (19), 1967-1976 (2005)
   PUBMED   15888697
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FM086081.1 and BC162023.1.
            
            On Dec 5, 2009 this sequence version replaced NM_001126373.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC162023.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 FM086081.1         1-7
            8-2002              BC162023.1         1-1995
FEATURES             Location/Qualifiers
     source          1..2002
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq22"
     gene            1..2002
                     /gene="Hdac8"
                     /gene_synonym="HD8; RGD1562895"
                     /note="histone deacetylase 8"
                     /db_xref="GeneID:363481"
                     /db_xref="RGD:1562895"
     exon            1..444
                     /gene="Hdac8"
                     /gene_synonym="HD8; RGD1562895"
                     /inference="alignment:Splign:2.1.0"
     CDS             334..1467
                     /gene="Hdac8"
                     /gene_synonym="HD8; RGD1562895"
                     /EC_number="3.5.1.98"
                     /note="protein deacetylase HDAC8; protein decrotonylase
                     HDAC8"
                     /codon_start=1
                     /product="histone deacetylase 8"
                     /protein_id="NP_001119845.2"
                     /db_xref="GeneID:363481"
                     /db_xref="RGD:1562895"
                     /translation="MEIPEEPANSGHSLPPVYIYSPEYVSICDSLVKVPKRASMVHSL
                     IEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDEDHPDSIEYGLGYDC
                     PATEGIFDYAAAIGGGTITAAQCLIDGKCKVAINWSGGWHHAKKDEASGFCYLNDAVL
                     GILRLRRKFDRILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDMSDVG
                     LGKGRYYSVNVPIQDGIQDEKYYHICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCS
                     FNMTPVGIGKCLKYVLQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDH
                     EFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV"
     exon            445..497
                     /gene="Hdac8"
                     /gene_synonym="HD8; RGD1562895"
                     /inference="alignment:Splign:2.1.0"
     exon            498..628
                     /gene="Hdac8"
                     /gene_synonym="HD8; RGD1562895"
                     /inference="alignment:Splign:2.1.0"
     exon            629..770
                     /gene="Hdac8"
                     /gene_synonym="HD8; RGD1562895"
                     /inference="alignment:Splign:2.1.0"
     exon            771..883
                     /gene="Hdac8"
                     /gene_synonym="HD8; RGD1562895"
                     /inference="alignment:Splign:2.1.0"
     exon            884..961
                     /gene="Hdac8"
                     /gene_synonym="HD8; RGD1562895"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1070
                     /gene="Hdac8"
                     /gene_synonym="HD8; RGD1562895"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1243
                     /gene="Hdac8"
                     /gene_synonym="HD8; RGD1562895"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1338
                     /gene="Hdac8"
                     /gene_synonym="HD8; RGD1562895"
                     /inference="alignment:Splign:2.1.0"
     exon            1339..1444
                     /gene="Hdac8"
                     /gene_synonym="HD8; RGD1562895"
                     /inference="alignment:Splign:2.1.0"
     exon            1445..1972
                     /gene="Hdac8"
                     /gene_synonym="HD8; RGD1562895"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tggccccgta gggcaacaag gctggttact tttgaccgtg ctacttgtgt catgaaaaaa
       61 atcgatccca attggcagtt atttggcttt tatatctgtc aggcccccct tttgaactgt
      121 tgtcattaat agaatgttcc taatctggat gggcccatcc atccccgcag ttggacgagg
      181 gactagggaa actgtctcca gcgatctaaa taggagggaa tgttgactag ggagcaccgc
      241 tggggccgaa cagaggagca ggaaccggag ctcaggctga gtctgaaaac tgttggctcc
      301 agactttggc tcggggacga ttggaagtag gagatggaga taccagagga acccgccaat
      361 agtgggcatt cgctaccccc ggtttatatt tacagtcccg agtatgtcag catctgcgat
      421 tcccttgtga aggtccccaa acgggccagt atggttcact ctctgatcga agcatatgcc
      481 ctgcataaac aaatgaggat agtgaagccc aaagtggcct ccatggagga gatggccacc
      541 ttccacactg atgcctatct tcaacatctc cagaaggtca gccaagaagg ggatgaggac
      601 catccagact ccatagaata tggactaggt tatgactgcc cagccacaga agggatattt
      661 gactatgcag cagctatagg aggaggtaca atcacagctg cccagtgcct gattgacggg
      721 aagtgtaaag tagccattaa ctggtctgga gggtggcatc atgcaaagaa agatgaagca
      781 tctggtttct gttatctcaa tgatgctgtc ctaggaatat tacgattgcg acggaaattt
      841 gaccggattc tctatgtgga cttggatcta caccatggag atggtgtaga agatgccttc
      901 agttttacat ctaaagttat gactgtgtcc ctgcacaagt tctctccagg atttttccca
      961 ggaacaggtg acatgtctga tgttggcctg gggaaaggac ggtactacag tgtcaatgtg
     1021 cccattcagg atggcatcca ggatgagaag tactatcaca tctgtgaaag tgtactaaag
     1081 gaagtatacc aggccttcaa tccgaaggca gtggttctac agctgggagc agataccatt
     1141 gctggagatc caatgtgctc ctttaacatg acaccagtgg gaattggcaa gtgtctgaag
     1201 tatgtccttc agtggcagtt ggcaactctg attttaggag gaggaggcta caaccttgcc
     1261 aacacggctc gttgctggac atacttgacc ggggtcatcc tagggaaaac actatcctct
     1321 gagatcccag atcatgagtt tttcacagca tatggtcctg attatgtgct ggaaatcacg
     1381 ccaagctgcc ggccagaccg caatgagccc catcgaatcc agcaaatcct caactacatc
     1441 aaagggaatc tgaagcatgt ggtctagttg acaaaaagag atcaagtttc cagagctggg
     1501 cagaacccat aatgaagaca gtgtgttgat gcaagcagtt tgtgggattt gtgactgcag
     1561 gggaaatttg gaagaaatta cttcctgaaa atttccaagg ggcaccaagt ggcagctggc
     1621 ctcctggggt gaggaggcag acacctcaga gccaggccta gggggaaaga gggagatatc
     1681 cagtgttgaa tgtgtcttat tttaaaacac aaacactgtt tttaatgttt caaaattatt
     1741 tttaagcaag ttgggggaat aattttatct ttataaaggg gacaagtcag gagctgcagt
     1801 caagtggagc tgggtagggg aacagcagat gggcaggttt ggacctcagg gccatttaga
     1861 tagagacaca tcggggaggg gtgtcagcag actgggaggt aaagaggagt ctaccacttt
     1921 tgttttggta ctatgcactc aagttgttct taataaaatt tttgaaactc taaaaaaaaa
     1981 aaaaaaaaaa aaaaaaaaaa aa
//
