LOCUS       NM_001419534            4021 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus histone deacetylase 7 (Hdac7), mRNA.
ACCESSION   NM_001419534 XM_008765843
VERSION     NM_001419534.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4021)
  AUTHORS   Hsu,A., Duan,Q., McMahon,S., Huang,Y., Wood,S.A., Gray,N.S.,
            Wang,B., Bruneau,B.G. and Haldar,S.M.
  TITLE     Salt-inducible kinase 1 maintains HDAC7 stability to promote
            pathologic cardiac remodeling
  JOURNAL   J Clin Invest 130 (6), 2966-2977 (2020)
   PUBMED   32106109
  REMARK    GeneRIF: Salt-inducible kinase 1 maintains HDAC7 stability to
            promote pathologic cardiac remodeling.
REFERENCE   2  (bases 1 to 4021)
  AUTHORS   Wang,R., Tan,J., Chen,T., Han,H., Tian,R., Tan,Y., Wu,Y., Cui,J.,
            Chen,F., Li,J., Lv,L., Guan,X., Shang,S., Lu,J. and Zhang,Z.
  TITLE     ATP13A2 facilitates HDAC6 recruitment to lysosome to promote
            autophagosome-lysosome fusion
  JOURNAL   J Cell Biol 218 (1), 267-284 (2019)
   PUBMED   30538141
REFERENCE   3  (bases 1 to 4021)
  AUTHORS   Sadasivam,M., Ramatchandirin,B., Balakrishnan,S. and Prahalathan,C.
  TITLE     HDAC7 modulates TNF-alpha-mediated suppression of Leydig cell
            steroidogenesis
  JOURNAL   Mol Cell Biochem 406 (1-2), 83-90 (2015)
   PUBMED   25916381
  REMARK    GeneRIF: TNF-alpha-mediated suppression of steroidogenesis involves
            HDAC7 in Leydig cells.
REFERENCE   4  (bases 1 to 4021)
  AUTHORS   Zhao,X., Hsu,K.S., Lim,J.H., Bruggeman,L.A. and Kao,H.Y.
  TITLE     alpha-Actinin 4 potentiates nuclear factor
            kappa-light-chain-enhancer of activated B-cell (NF-kappaB) activity
            in podocytes independent of its cytoplasmic actin binding function
  JOURNAL   J Biol Chem 290 (1), 338-349 (2015)
   PUBMED   25411248
REFERENCE   5  (bases 1 to 4021)
  AUTHORS   Stypula-Cyrus,Y., Damania,D., Kunte,D.P., Cruz,M.D.,
            Subramanian,H., Roy,H.K. and Backman,V.
  TITLE     HDAC up-regulation in early colon field carcinogenesis is involved
            in cell tumorigenicity through regulation of chromatin structure
  JOURNAL   PLoS One 8 (5), e64600 (2013)
   PUBMED   23724067
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4021)
  AUTHORS   Winnay,J.N. and Hammer,G.D.
  TITLE     Adrenocorticotropic hormone-mediated signaling cascades coordinate
            a cyclic pattern of steroidogenic factor 1-dependent
            transcriptional activation
  JOURNAL   Mol Endocrinol 20 (1), 147-166 (2006)
   PUBMED   16109736
REFERENCE   7  (bases 1 to 4021)
  AUTHORS   Dai,Y.S., Xu,J. and Molkentin,J.D.
  TITLE     The DnaJ-related factor Mrj interacts with nuclear factor of
            activated T cells c3 and mediates transcriptional repression
            through class II histone deacetylase recruitment
  JOURNAL   Mol Cell Biol 25 (22), 9936-9948 (2005)
   PUBMED   16260608
REFERENCE   8  (bases 1 to 4021)
  AUTHORS   Ajamian,F., Suuronen,T., Salminen,A. and Reeben,M.
  TITLE     Upregulation of class II histone deacetylases mRNA during neural
            differentiation of cultured rat hippocampal progenitor cells
  JOURNAL   Neurosci Lett 346 (1-2), 57-60 (2003)
   PUBMED   12850547
REFERENCE   9  (bases 1 to 4021)
  AUTHORS   Verdin,E., Dequiedt,F. and Kasler,H.G.
  TITLE     Class II histone deacetylases: versatile regulators
  JOURNAL   Trends Genet 19 (5), 286-293 (2003)
   PUBMED   12711221
  REMARK    Review article
REFERENCE   10 (bases 1 to 4021)
  AUTHORS   Kao,H.Y., Downes,M., Ordentlich,P. and Evans,R.M.
  TITLE     Isolation of a novel histone deacetylase reveals that class I and
            class II deacetylases promote SMRT-mediated repression
  JOURNAL   Genes Dev 14 (1), 55-66 (2000)
   PUBMED   10640276
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Apr 7, 2023 this sequence version replaced XM_008765843.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.33075.1,
                                           SRR26643296.20811.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760400,
                                           SAMN12840107 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-119               JAXUCZ010000007.1  130840899-130841017 c
            120-310             JAXUCZ010000007.1  130820725-130820915 c
            311-401             JAXUCZ010000007.1  130820539-130820629 c
            402-513             JAXUCZ010000007.1  130820131-130820242 c
            514-629             JAXUCZ010000007.1  130819377-130819492 c
            630-755             JAXUCZ010000007.1  130818800-130818925 c
            756-847             JAXUCZ010000007.1  130818350-130818441 c
            848-958             JAXUCZ010000007.1  130818025-130818135 c
            959-1139            JAXUCZ010000007.1  130817717-130817897 c
            1140-1336           JAXUCZ010000007.1  130817331-130817527 c
            1337-1531           JAXUCZ010000007.1  130816945-130817139 c
            1532-1733           JAXUCZ010000007.1  130815803-130816004 c
            1734-1867           JAXUCZ010000007.1  130812821-130812954 c
            1868-1988           JAXUCZ010000007.1  130812568-130812688 c
            1989-2038           JAXUCZ010000007.1  130812207-130812256 c
            2039-2146           JAXUCZ010000007.1  130810808-130810915 c
            2147-2202           JAXUCZ010000007.1  130810157-130810212 c
            2203-2290           JAXUCZ010000007.1  130809953-130810040 c
            2291-2410           JAXUCZ010000007.1  130808674-130808793 c
            2411-2508           JAXUCZ010000007.1  130808386-130808483 c
            2509-2627           JAXUCZ010000007.1  130807068-130807186 c
            2628-2761           JAXUCZ010000007.1  130806311-130806444 c
            2762-2846           JAXUCZ010000007.1  130805965-130806049 c
            2847-2982           JAXUCZ010000007.1  130804236-130804371 c
            2983-4021           JAXUCZ010000007.1  130803013-130804051 c
FEATURES             Location/Qualifiers
     source          1..4021
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..4021
                     /gene="Hdac7"
                     /gene_synonym="HD7; HD7a; Hdac7a"
                     /note="histone deacetylase 7"
                     /db_xref="GeneID:84582"
                     /db_xref="RGD:619982"
     exon            1..119
                     /gene="Hdac7"
                     /gene_synonym="HD7; HD7a; Hdac7a"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..3028
                     /gene="Hdac7"
                     /gene_synonym="HD7; HD7a; Hdac7a"
                     /EC_number="3.5.1.98"
                     /note="histone deacetylase 7A; protein deacetylase HDAC7"
                     /codon_start=1
                     /product="histone deacetylase 7"
                     /protein_id="NP_001406463.1"
                     /db_xref="GeneID:84582"
                     /db_xref="RGD:619982"
                     /translation="MHSPGAGCPALQPDTPGSQPQPMDLRVGQRPTVEPPPEPALLTL
                     QHPQRLHRHLFLAGLQQQQRSAEPMRLSMDPPLPELQGAQQEQELRQLLNKDKSKRSA
                     VASSVVKQKLAEVILKKQQAALERTVHPSSPSIPYRTLEPLDTEGAARSVLSSFLPPV
                     PSLPTEPPEHFPLRKTVSEPNLKLRYKPKKSLERRKNPLLRKESAPPSLRRRPAETLG
                     DSSPSSSSTPASGCSSPNDSEHGPNPALGSEALLGQRLRLQETSLAPFALPTVSLLPA
                     ITLGLPAPARADGDRRTHSTLGPRGPVLGNPHAPLFLHHGLEPEAGGTLPSRLQPILL
                     LDPSVSHAPLWTVPGLGPLPFHFAQPLLTTERLSGSGLHRPLNRTRSEPLPPSATASP
                     LLGPLQPRQDRLKPHVQLIKTAISPPQRPAKPSEKPRLRQIPSAEDLETDGGGVGPMA
                     NDGLEHRESGRGPPEGRGAVSLQQHQQVPLWEQQHLAGRLSQGGPGDSVLLPLAQIGH
                     RPLSRTQSSPAAPVSLLSPEPTCQTQVLNSSEAPATGLVYDSVMLKHQCSCGDNSKHP
                     EHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTNPLSRLKLD
                     NGKLTGLLAQRTFVMLPCGGVGVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELK
                     NGFAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQHGKASKILIVDWDVHHGNGTQQ
                     TFYQDPRVLYISLHRHDDGNFFPGSGAVDEVGTGSGEGFNVNVAWAGGLDPPMGDPEY
                     LAAFRIVVMPIAREFAPDLVLVSAGFDAAEGHPAPLGGYHVSAKCFGYMTQQLMSLAG
                     GAVVLALEGGHDLTAICDASEACVAALLGNKVDPLSQESWKQKPNLNAIRSLEAVVRV
                     HRKYWGCMQRLASCPDPWLPRVPGADAEVEAVTALASLSVGILAEDRPSKELMEEEEP
                     MNL"
     exon            120..310
                     /gene="Hdac7"
                     /gene_synonym="HD7; HD7a; Hdac7a"
                     /inference="alignment:Splign:2.1.0"
     exon            311..401
                     /gene="Hdac7"
                     /gene_synonym="HD7; HD7a; Hdac7a"
                     /inference="alignment:Splign:2.1.0"
     exon            402..513
                     /gene="Hdac7"
                     /gene_synonym="HD7; HD7a; Hdac7a"
                     /inference="alignment:Splign:2.1.0"
     exon            514..629
                     /gene="Hdac7"
                     /gene_synonym="HD7; HD7a; Hdac7a"
                     /inference="alignment:Splign:2.1.0"
     exon            630..755
                     /gene="Hdac7"
                     /gene_synonym="HD7; HD7a; Hdac7a"
                     /inference="alignment:Splign:2.1.0"
     exon            756..847
                     /gene="Hdac7"
                     /gene_synonym="HD7; HD7a; Hdac7a"
                     /inference="alignment:Splign:2.1.0"
     exon            848..958
                     /gene="Hdac7"
                     /gene_synonym="HD7; HD7a; Hdac7a"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1139
                     /gene="Hdac7"
                     /gene_synonym="HD7; HD7a; Hdac7a"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1336
                     /gene="Hdac7"
                     /gene_synonym="HD7; HD7a; Hdac7a"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..1531
                     /gene="Hdac7"
                     /gene_synonym="HD7; HD7a; Hdac7a"
                     /inference="alignment:Splign:2.1.0"
     exon            1532..1733
                     /gene="Hdac7"
                     /gene_synonym="HD7; HD7a; Hdac7a"
                     /inference="alignment:Splign:2.1.0"
     exon            1734..1867
                     /gene="Hdac7"
                     /gene_synonym="HD7; HD7a; Hdac7a"
                     /inference="alignment:Splign:2.1.0"
     exon            1868..1988
                     /gene="Hdac7"
                     /gene_synonym="HD7; HD7a; Hdac7a"
                     /inference="alignment:Splign:2.1.0"
     exon            1989..2038
                     /gene="Hdac7"
                     /gene_synonym="HD7; HD7a; Hdac7a"
                     /inference="alignment:Splign:2.1.0"
     exon            2039..2146
                     /gene="Hdac7"
                     /gene_synonym="HD7; HD7a; Hdac7a"
                     /inference="alignment:Splign:2.1.0"
     exon            2147..2202
                     /gene="Hdac7"
                     /gene_synonym="HD7; HD7a; Hdac7a"
                     /inference="alignment:Splign:2.1.0"
     exon            2203..2290
                     /gene="Hdac7"
                     /gene_synonym="HD7; HD7a; Hdac7a"
                     /inference="alignment:Splign:2.1.0"
     exon            2291..2410
                     /gene="Hdac7"
                     /gene_synonym="HD7; HD7a; Hdac7a"
                     /inference="alignment:Splign:2.1.0"
     exon            2411..2508
                     /gene="Hdac7"
                     /gene_synonym="HD7; HD7a; Hdac7a"
                     /inference="alignment:Splign:2.1.0"
     exon            2509..2627
                     /gene="Hdac7"
                     /gene_synonym="HD7; HD7a; Hdac7a"
                     /inference="alignment:Splign:2.1.0"
     exon            2628..2761
                     /gene="Hdac7"
                     /gene_synonym="HD7; HD7a; Hdac7a"
                     /inference="alignment:Splign:2.1.0"
     exon            2762..2846
                     /gene="Hdac7"
                     /gene_synonym="HD7; HD7a; Hdac7a"
                     /inference="alignment:Splign:2.1.0"
     exon            2847..2982
                     /gene="Hdac7"
                     /gene_synonym="HD7; HD7a; Hdac7a"
                     /inference="alignment:Splign:2.1.0"
     exon            2983..4021
                     /gene="Hdac7"
                     /gene_synonym="HD7; HD7a; Hdac7a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acagtcgctc tgcagcctcc ggcgaccggg gggatgtgag gccggcgccc cggccccccg
       61 cccgccatga gcccccggct ctgagggccc cggcccctgg atgcacagcc ccggcgcggg
      121 ctgccctgcc ctccagccag acacaccagg ctctcagccc cagcccatgg acctgcgagt
      181 gggccaaagg cccacagtgg agccgccacc agagcctgca ctgctgaccc tgcagcaccc
      241 tcagcgcctg caccgccatc tcttcctagc aggcttgcaa cagcaacagc gctcagctga
      301 gcccatgagg ctctccatgg acccaccgct gccggagctg cagggggcac agcaggagca
      361 agaacttcgg caacttctca ataaagacaa gagcaagcga agtgccgtag ccagcagtgt
      421 ggtcaagcag aaactggctg aagtgatcct gaagaaacag caggcagccc ttgagagaac
      481 agtccacccc agcagcccca gtatccccta cagaactctt gagcccttgg acacagaggg
      541 tgctgcccgc tccgtgctta gcagcttcct gcctcctgtt cccagcctgc ccactgaacc
      601 cccggaacat tttcccctgc gtaaaacagt gtctgagccg aacctgaagc tgcgctacaa
      661 acccaagaaa tccctggaga ggcgtaagaa tcccctgctc aggaaggaga gcgccccacc
      721 cagtcttcgg aggaggcctg ctgagactct tggagattcc tcccccagta gtagcagcac
      781 acctgcgtca gggtgcagct cccccaatga cagcgagcat ggccctaacc ctgccctggg
      841 ctcagaggcg ctcttgggcc agcggctgcg gctgcaggag acttctttgg ccccgttcgc
      901 tttgccgaca gtgtccttgc tgcccgcaat cacactgggg ctgcctgccc ctgccagggc
      961 tgatggtgac cgcaggaccc attcaacttt gggccctcgg ggtcctgtcc tagggaaccc
     1021 ccatgctccc ctcttcctgc accatggttt ggagccagag gctgggggca ccttaccctc
     1081 tcgcctgcag cccattctcc tgctggatcc ctcagtctct catgccccac tgtggactgt
     1141 gcccgggctc gggcccttgc ccttccactt tgcccagccc ttactgacca ccgagcggct
     1201 ctctgggtca ggcctccatc ggccacttaa ccggacccgc tcagagcccc tgccccccag
     1261 cgccactgcc tcccctctgc tgggccccct ccagccccgc caggatcggc tcaaacctca
     1321 tgtccagctg atcaagacag ccatctcccc tccccagagg cctgccaagc ccagtgagaa
     1381 gccccgactg cggcagatac cctcggctga ggacctagag acagatggtg ggggagtggg
     1441 acctatggcg aatgatggcc tggaacatag ggagtcaggc cgtgggccgc ctgagggcag
     1501 aggggccgtt tctctgcagc aacaccaaca ggtgccactc tgggagcagc agcatcttgc
     1561 tgggcggctc tcccagggag gccccgggga ctctgtgctg ctacctctgg cccagattgg
     1621 acaccggccc ctgtccagaa cccagtcttc cccagccgca cctgtctccc tgctgagccc
     1681 agagcccacc tgtcagaccc aagtcctcaa cagctcagag gcacctgcca cagggctggt
     1741 ctatgactcg gtgatgctga aacaccaatg ttcctgtgga gacaacagca agcatcccga
     1801 gcacgcaggc cgcatccaga gcatctggtc ccggctgcag gaacggggtc tccgcagcca
     1861 gtgtgagtgt ctccgaggcc gaaaggcttc cctagaagag ctgcagtcag tccactctga
     1921 aaggcacgtg ctcctctacg gcacaaaccc actcagccgc ctcaaactgg ataacgggaa
     1981 gcttacagga ctcctggccc agcggacgtt tgtgatgcta ccctgtggcg gggttggggt
     2041 agatactgac accatctgga atgagctgca ttcctccaat gcagcccgct gggctgcagg
     2101 cagcgtcacc gaccttgcct tcaaagtcgc ttcccgagag ctaaagaatg gctttgctgt
     2161 ggtgcggcct ccaggacacc atgcagatca ttctacagcc atgggctttt gcttcttcaa
     2221 ctctgtggcc atcgcctgcc gacagctgca gcaacacggc aaagccagca agatcctcat
     2281 tgtcgactgg gatgttcacc atggcaacgg cacacagcag actttctatc aggaccccag
     2341 ggtgctctac atatcccttc atcgccatga cgatggcaac ttcttcccgg gcagtggggc
     2401 cgtggatgag gtgggaaccg gcagtggcga gggcttcaac gtcaatgtgg cttgggctgg
     2461 gggcttggat ccacccatgg gggatcctga gtacctggct gctttcagga tagtggtgat
     2521 gcccattgcc cgcgagtttg ctccagacct ggtcctggtg tccgctgggt ttgacgctgc
     2581 agagggtcat ccagccccgc tgggcggcta ccatgtttct gccaaatgct ttgggtacat
     2641 gacacagcag ctgatgagct tggcaggagg tgcggtggtg ttggccttgg agggcggcca
     2701 tgacctcaca gccatctgtg atgcctctga ggcctgtgtg gcagctcttc tgggcaacaa
     2761 ggtggatccc ctttcacaag aaagctggaa acagaaaccc aacctcaatg ccatccgctc
     2821 tctggaagcc gtggtcaggg tgcacaggaa atactggggc tgcatgcagc gcttggcctc
     2881 ctgtccagac ccctggctgc ccagggtgcc gggagctgat gcagaagtgg aggccgtgac
     2941 tgcactggca tccctttccg ttggcatcct ggctgaagac aggccctcga aggagctgat
     3001 ggaagaggaa gaacccatga acctctaggg tctcagaaca gatcagcctg cagatgtggc
     3061 tctcctcatc actgttgtca accctgctcc tgggtcttca gagatcccct gggcaggtag
     3121 tcaggtccag agcacagcct accctgacgg ctatcccagg gaacttgaga agaccactgg
     3181 gtctgggatg ggggtgaggg aggactctgg gaggaggcag gctgggcacc agggtccagc
     3241 tgggctcttc cagaacagat taggccttct ggtgtccagg cccctagctg tggcctccat
     3301 ccctcaggac ggcacagagg gggactggct caagtgggcc catccataac cactattctt
     3361 aatgtggcct cagccggggt ggcctttccc aggttctgaa gggctggagg aataggagga
     3421 gccgagagtt tcctctcgcc tgcttcctca gatgcctttc gggtagcact gggctctgag
     3481 agccattctg agctgctctc tccctgtgag taatcacctg caagcctccc atacagtcac
     3541 tgtcccgcca gaagccaccc tctgtggacc atctcagtgc ccggtgcagc agacaggcgc
     3601 tctcttgagt cctgtgtctc ctacccaatg gtgccaaacc ttcatctccc ttcaaaagca
     3661 caacacaatc ccagggatgc ctggtcaccg cccccagtat gagccttctg tttctggggt
     3721 tcccccaccc ctcagctctg actgctgccc cacacaggac tagcttggct gagggatagg
     3781 aaggtgggag agtagacaga catgggggag gggaggccac cccagaagtc ttcaaggctt
     3841 ttgaggtcta ggcctgggac caagaaagag tatttttgtg tatgtgtgtg catgagtgcg
     3901 tgcgtgcgtg caagagtgtg tatgtgtgcg cgtcttcccc caaccccacc ataccttgtg
     3961 tatgtatgca tgtttttgta aaaaagaaaa aaaagtgaaa aaaaaaacct tccaaacaat
     4021 a
//
