LOCUS       NM_053450               3754 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus histone deacetylase 5 (Hdac5), mRNA.
ACCESSION   NM_053450 XM_001081495
VERSION     NM_053450.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3754)
  AUTHORS   Fan T, Yu Y, Chen YL, Gu P, Wong S, Xia ZY, Liu JA and Cheung CW.
  TITLE     Histone deacetylase 5-induced deficiency of signal transducer and
            activator of transcription-3 acetylation contributes to spinal
            astrocytes degeneration in painful diabetic neuropathy
  JOURNAL   Glia 71 (4), 1099-1119 (2023)
   PUBMED   36579750
  REMARK    GeneRIF: Histone deacetylase 5-induced deficiency of signal
            transducer and activator of transcription-3 acetylation contributes
            to spinal astrocytes degeneration in painful diabetic neuropathy.
REFERENCE   2  (bases 1 to 3754)
  AUTHORS   Wang N, Prabhakar NR and Nanduri J.
  TITLE     Protein phosphatase 1 regulates reactive oxygen species-dependent
            degradation of histone deacetylase 5 by intermittent hypoxia
  JOURNAL   Am J Physiol Cell Physiol 323 (2), C423-C431 (2022)
   PUBMED   35704695
  REMARK    GeneRIF: Protein phosphatase 1 regulates reactive oxygen
            species-dependent degradation of histone deacetylase 5 by
            intermittent hypoxia.
REFERENCE   3  (bases 1 to 3754)
  AUTHORS   Pribut HJ, Vazquez D, Wei AD, Tennyson SS, Davis IR, Roesch MR and
            Li X.
  TITLE     Overexpressing Histone Deacetylase 5 in Rat Dorsal Striatum Alters
            Reward-Guided Decision-Making and Associated Neural Encoding
  JOURNAL   J Neurosci 41 (49), 10080-10090 (2021)
   PUBMED   34716230
  REMARK    GeneRIF: Overexpressing Histone Deacetylase 5 in Rat Dorsal
            Striatum Alters Reward-Guided Decision-Making and Associated Neural
            Encoding.
REFERENCE   4  (bases 1 to 3754)
  AUTHORS   He T, Huang J, Chen L, Han G, Stanmore D, Krebs-Haupenthal J,
            Avkiran M, Hagenmuller M and Backs J.
  TITLE     Cyclic AMP represses pathological MEF2 activation by
            myocyte-specific hypo-phosphorylation of HDAC5
  JOURNAL   J Mol Cell Cardiol 145, 88-98 (2020)
   PUBMED   32485181
  REMARK    GeneRIF: Cyclic AMP represses pathological MEF2 activation by
            myocyte-specific hypo-phosphorylation of HDAC5.
REFERENCE   5  (bases 1 to 3754)
  AUTHORS   Mochalova EP, Belova SP, Kostrominova TY, Shenkman BS and
            Nemirovskaya TL.
  TITLE     Differences in the Role of HDACs 4 and 5 in the Modulation of
            Processes Regulating MAFbx and MuRF1 Expression during Muscle
            Unloading
  JOURNAL   Int J Mol Sci 21 (13), 4815 (2020)
   PUBMED   32646070
  REMARK    GeneRIF: Differences in the Role of HDACs 4 and 5 in the Modulation
            of Processes Regulating MAFbx and MuRF1 Expression during Muscle
            Unloading.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3754)
  AUTHORS   McKinsey TA, Zhang CL, Lu J and Olson EN.
  TITLE     Signal-dependent nuclear export of a histone deacetylase regulates
            muscle differentiation
  JOURNAL   Nature 408 (6808), 106-111 (2000)
   PUBMED   11081517
REFERENCE   7  (bases 1 to 3754)
  AUTHORS   Lu J, McKinsey TA, Zhang CL and Olson EN.
  TITLE     Regulation of skeletal myogenesis by association of the MEF2
            transcription factor with class II histone deacetylases
  JOURNAL   Mol Cell 6 (2), 233-244 (2000)
   PUBMED   10983972
REFERENCE   8  (bases 1 to 3754)
  AUTHORS   Grozinger CM and Schreiber SL.
  TITLE     Regulation of histone deacetylase 4 and 5 and transcriptional
            activity by 14-3-3-dependent cellular localization
  JOURNAL   Proc Natl Acad Sci U S A 97 (14), 7835-7840 (2000)
   PUBMED   10869435
REFERENCE   9  (bases 1 to 3754)
  AUTHORS   Lemercier C, Verdel A, Galloo B, Curtet S, Brocard MP and Khochbin
            S.
  TITLE     mHDA1/HDAC5 histone deacetylase interacts with and represses MEF2A
            transcriptional activity
  JOURNAL   J Biol Chem 275 (20), 15594-15599 (2000)
   PUBMED   10748098
REFERENCE   10 (bases 1 to 3754)
  AUTHORS   Kao HY, Downes M, Ordentlich P and Evans RM.
  TITLE     Isolation of a novel histone deacetylase reveals that class I and
            class II deacetylases promote SMRT-mediated repression
  JOURNAL   Genes Dev 14 (1), 55-66 (2000)
   PUBMED   10640276
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473948.1.
            
            On Dec 17, 2009 this sequence version replaced XM_001081495.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3754
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.1"
     gene            1..3754
                     /gene="Hdac5"
                     /note="histone deacetylase 5"
                     /db_xref="GeneID:84580"
                     /db_xref="RGD:619980"
     exon            1..136
                     /gene="Hdac5"
                     /inference="alignment:Splign:2.1.0"
     exon            137..347
                     /gene="Hdac5"
                     /inference="alignment:Splign:2.1.0"
     CDS             326..3667
                     /gene="Hdac5"
                     /EC_number="3.5.1.98"
                     /codon_start=1
                     /product="histone deacetylase 5"
                     /protein_id="NP_445902.1"
                     /db_xref="GeneID:84580"
                     /db_xref="RGD:619980"
                     /translation="MNSPNESDGMSGREPSLEILPRTPLHSIPVAVEVKPVLPAAMPS
                     SMGGGGGGSPSPVELRGALAGPMDPALREQQLQQELLVLKQQQQLQKQLLFAEFQKQH
                     DHLTRQHEVQLQKHLKQQQEMLAAKRQQELEQQRQREQQRQEELEKQRLEQQLLILRN
                     KEKSKESAIASTEVKLRLQEFLLSKSKEPTPGGLNHSLPQHPKCWGAHHASLDQSSPP
                     QSGPPGTPPSYKLPLLGPYDSRDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRRK
                     DGTVISTFKKRAVEITGTGPGVSSVCNSAPGSGPSSPNSSHSTIAENGFTGSVPNIPT
                     EMLPQHRALPLDSSPNQFSLYTSPSLPNISLGLQATVTVTNSHLTASPKLSTQQEAER
                     QALQSLRQGSTLTGKFMSTSSIPGCLLGVALEGDTSPHGHASLLQHVLLLEQARQQST
                     LIAVPLHGQSPLVTGERVATSMRTVGKLPRHRPLSRTQSSPLPQSPQALQQLVMQQQH
                     QQFLEKQKQQQMQLGKILTKTGELSRQPTTHPEETEEELTEQQEALLGEGALTMPREG
                     STESESTQEDLEEEEDEEEDEEDCIQVKDEDGESGPDEGADLEESSAGYKKLFADAQQ
                     LQPLQVYQAPLSLATVPHQALGRTQSSPAAPGSMKSPTDHPTVVKHLFTTGVVYDTFM
                     LKHQCMCGNTHVHPEHAGRIQSIWSRLQETGLLSKCERIRGRKATLDEIQTVHSEYHT
                     LLYGTSPLNRQKLDSKKLLGPISQKMYAMLPCGGIGVDSDTVWNEMHSSSAVRMAVGC
                     LVELAFKVAAGELKNGFAIIRPPGHHAEESTAMGFCFFNSVAITAKLLQQKLSVGKVL
                     IVDWDIHHGNGTQQAFYDDPSVLYISLHRYDNGNFFPGSGAPEEVGGGPGVGYNVNVA
                     WTGGVDPPIGDVEYLTAFRTVVMPIAHEFSPDVVLVSAGFDAVEGHLSPLGGYSVTAR
                     CFGHLTRQLMTLAGGRVVLALEGGHDLTAICDASEACVSALLSVELQPLDEAVLQQKP
                     SVNAVATLEKVIEIQSKHWSCVQRFATGLGCSLREAQTGEKEEAETVSAMALLSMGAE
                     QAQAAATQEHSPRPAEEPMEQEPAL"
     exon            348..419
                     /gene="Hdac5"
                     /inference="alignment:Splign:2.1.0"
     exon            420..679
                     /gene="Hdac5"
                     /inference="alignment:Splign:2.1.0"
     exon            680..824
                     /gene="Hdac5"
                     /inference="alignment:Splign:2.1.0"
     exon            825..939
                     /gene="Hdac5"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1070
                     /gene="Hdac5"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1217
                     /gene="Hdac5"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..1330
                     /gene="Hdac5"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..1462
                     /gene="Hdac5"
                     /inference="alignment:Splign:2.1.0"
     exon            1463..1685
                     /gene="Hdac5"
                     /inference="alignment:Splign:2.1.0"
     exon            1686..1897
                     /gene="Hdac5"
                     /inference="alignment:Splign:2.1.0"
     exon            1898..2176
                     /gene="Hdac5"
                     /inference="alignment:Splign:2.1.0"
     exon            2177..2348
                     /gene="Hdac5"
                     /inference="alignment:Splign:2.1.0"
     exon            2349..2482
                     /gene="Hdac5"
                     /inference="alignment:Splign:2.1.0"
     exon            2483..2603
                     /gene="Hdac5"
                     /inference="alignment:Splign:2.1.0"
     exon            2604..2653
                     /gene="Hdac5"
                     /inference="alignment:Splign:2.1.0"
     exon            2654..2761
                     /gene="Hdac5"
                     /inference="alignment:Splign:2.1.0"
     exon            2762..2817
                     /gene="Hdac5"
                     /inference="alignment:Splign:2.1.0"
     exon            2818..2905
                     /gene="Hdac5"
                     /inference="alignment:Splign:2.1.0"
     exon            2906..3025
                     /gene="Hdac5"
                     /inference="alignment:Splign:2.1.0"
     exon            3026..3123
                     /gene="Hdac5"
                     /inference="alignment:Splign:2.1.0"
     exon            3124..3242
                     /gene="Hdac5"
                     /inference="alignment:Splign:2.1.0"
     exon            3243..3376
                     /gene="Hdac5"
                     /inference="alignment:Splign:2.1.0"
     exon            3377..3461
                     /gene="Hdac5"
                     /inference="alignment:Splign:2.1.0"
     exon            3462..3627
                     /gene="Hdac5"
                     /inference="alignment:Splign:2.1.0"
     exon            3628..3754
                     /gene="Hdac5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgttgttggt ggcggcggcg agcggagccg gaggagccgc cgcaaagatg gaggagccgt
       61 cgaggaggcg ctgccgctgc tgttgccgcc gctgctgccg ccgccgcccg cgaagccgga
      121 gctcgagcct cagcggggat gccgttttga gtgcctgact gcctcgcccc gaaggatggc
      181 cttggatggg cattagaggc cctgcggccc cgggctcctg tcccgtccgt ctgtctgtta
      241 tcgtctgtct ctcttgacat cacagcagct ccaccccctc ctgtcccagc ccccaacgtc
      301 agcttcctgc aggcccagag ccggcatgaa ctctcccaac gagtcggatg gcatgtcagg
      361 ccgggaacca tccttggaaa tcttgccacg gactcctctg cacagcatcc ctgtggcagt
      421 ggaggtgaag ccggtgctgc cagcagccat gcccagctcc atgggaggtg gaggtggagg
      481 tagccccagc cctgtggagc ttcggggggc tctggcaggc cccatggacc ccgcgcttcg
      541 ggagcagcaa ctgcagcaag agctcctggt gctcaagcag cagcagcagc tgcaaaagca
      601 gctcctgttt gccgagtttc agaagcagca cgaccacctg acgcggcagc atgaagtcca
      661 gctgcagaag cacctcaagc agcagcagga gatgctggcg gctaagaggc agcaggagct
      721 ggagcagcag cggcagcgcg agcagcagcg gcaagaggag ctagagaaac agcggctgga
      781 gcagcagctg cttattctac gaaacaagga gaagagcaaa gagagtgcca tcgccagcac
      841 cgaggtaaag ctgaggctcc aggaattcct gttgtccaag tcaaaggagc ccacaccagg
      901 cggcctcaac cattccctcc cacagcaccc caaatgctgg ggagcccatc atgcttcttt
      961 ggaccagagt tcccctcccc agagcggccc tcctgggacg cctccctcct acaaattgcc
     1021 tttgcttggg ccctatgaca gccgtgatga ctttcccctc cgtaaaacgg cctcggaacc
     1081 caacttaaaa gtacgttcaa ggctaaaaca gaaggtagct gagagaagaa gcagtcccct
     1141 cctgcgtcga aaggatggca ctgttattag tacttttaag aagagagcag tcgagatcac
     1201 aggcacaggg cctggggtgt cgtccgtgtg taacagtgcg cctggctctg gccccagctc
     1261 tcccaacagt tcccacagca ccatcgctga gaacggcttt actggctcag tccccaacat
     1321 ccccactgag atgctccccc agcaccgggc cctccctctg gacagttccc caaaccagtt
     1381 cagcctctac acgtctcctt ctctgcctaa catctcccta gggctgcagg ccactgtcac
     1441 tgttaccaac tcgcacctca ccgcctcccc gaagctgtcg acacagcagg aggctgagag
     1501 gcaggccctt cagtccctgc ggcagggcag cacactgacc ggcaagttca tgagcacatc
     1561 ctccatccct ggctgcctgc tgggagtggc cctggagggc gacacgagcc cccatgggca
     1621 cgcttccctg ctgcagcacg ttttgctgct ggagcaggcc cggcaacaga gcacgctcat
     1681 agcggtgcca ctccatgggc agtccccact ggtgacgggt gaacgtgtgg ccaccagcat
     1741 gaggacagtg ggcaagctcc caaggcaccg acctctgagc cgtactcagt cctcgcccct
     1801 gccgcagagt ccccaggccc tgcagcagct ggttatgcag cagcagcacc agcagttcct
     1861 agagaaacag aagcagcagc agatgcagct gggcaagatc cttaccaaaa ctggggagct
     1921 gtcaaggcag cccaccaccc accctgaaga gacagaggag gagctgacgg aacagcagga
     1981 ggccttgctg ggggaggggg ccctgaccat gccccgggaa ggttctacag agagcgagag
     2041 cacccaggaa gatctagaag aggaagagga tgaggaggag gacgaggagg actgcattca
     2101 ggtcaaggat gaggatggcg agagtggtcc tgatgagggc gcagacttgg aggagtccag
     2161 tgctggttac aaaaagttgt tcgcagatgc ccagcagtta cagcccctcc aggtatacca
     2221 ggcacccctc agcctggcca ctgtgcctca tcaggccctg ggccgcaccc agtcctcacc
     2281 tgctgctcct gggagcatga agagccccac agaccacccc actgtggtga agcacctctt
     2341 caccacaggt gtggtctatg acacgttcat gctgaagcat cagtgtatgt gcggaaacac
     2401 acatgtgcac ccagagcacg ccggccgcat ccagagcatc tggtcccggc tgcaggaaac
     2461 tggtctgctc agcaagtgtg agcggatccg gggtcgtaaa gccacactgg atgaaatcca
     2521 gaccgtgcac tctgagtacc acaccctgct ctatgggacc agtcccctta accggcagaa
     2581 gctggacagt aagaagctgc ttggccccat cagccagaag atgtacgcca tgctgccttg
     2641 tgggggcatt ggggtggaca gtgacactgt gtggaatgag atgcactcct ctagtgccgt
     2701 gcgaatggca gtgggctgcc tggtggagct ggccttcaag gtggctgcag gagagctcaa
     2761 gaatggattt gccatcatcc gacccccagg acatcatgct gaggagtcca cagccatggg
     2821 attctgcttc ttcaactccg tagccatcac agctaaactc ctgcagcaga agctgagcgt
     2881 gggcaaggtc ctcatcgtgg actgggacat tcaccacggc aatggcaccc agcaagcatt
     2941 ttacgatgac ccctccgtgc tctacatctc tttgcatcgc tacgacaatg ggaacttctt
     3001 tccaggctcc ggggctcctg aagaggttgg tggagggcca ggtgtggggt acaacgtaaa
     3061 tgtggcgtgg acaggaggtg tggatccccc cattggagat gtggaatacc tgacagcctt
     3121 caggacagta gtgatgccca ttgcccacga gttctcaccc gacgtcgttc tagtctccgc
     3181 tgggtttgat gctgttgaag gacatctgtc tccactgggt ggctattctg tcaccgccag
     3241 atgttttggc cacttgacca ggcagctcat gacactggca gggggccggg tggtgctggc
     3301 cctggaggga ggtcatgact tgaccgccat ctgtgatgct tctgaggcct gtgtctcggc
     3361 tctgctcagc gtggagctgc agcccttgga tgaagcagtc ttgcagcaaa agcccagcgt
     3421 caatgcagtt gccacactag agaaagtcat cgagatccag agcaaacact ggagctgtgt
     3481 acagaggttt gccactggtc tgggctgctc gctgcgggag gctcagacgg gtgagaaaga
     3541 ggaggccgag actgtgagcg ccatggccct gctttccatg ggggctgagc aggcccaggc
     3601 tgctgccact caagagcaca gcccccggcc agccgaggag cccatggagc aggagcctgc
     3661 cctgtgacac ccaggccccc ctccctctgg gcttcatcat tgtgattttg tttatttttt
     3721 ctattaaaaa cgaaaagtca cacattcaac agcg
//
