LOCUS       NM_053449               4015 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus histone deacetylase 4 (Hdac4), mRNA.
ACCESSION   NM_053449 XM_001067733 XM_343629
VERSION     NM_053449.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4015)
  AUTHORS   Gu,X., Li,F., Che,X., Wei,X. and Li,P.
  TITLE     HDAC4 represses ER stress induced chondrocyte apoptosis by
            inhibiting ATF4 and attenuates cartilage degeneration in an
            osteoarthritis rat model
  JOURNAL   BMC Musculoskelet Disord 25 (1), 467 (2024)
   PUBMED   38879481
  REMARK    GeneRIF: HDAC4 represses ER stress induced chondrocyte apoptosis by
            inhibiting ATF4 and attenuates cartilage degeneration in an
            osteoarthritis rat model.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4015)
  AUTHORS   Zhang,D., Du,J., Yu,M. and Suo,L.
  TITLE     Urine-derived stem cells-extracellular vesicles ameliorate diabetic
            osteoporosis through HDAC4/HIF-1alpha/VEGFA axis by delivering
            microRNA-26a-5p
  JOURNAL   Cell Biol Toxicol 39 (5), 2243-2257 (2023)
   PUBMED   35554780
  REMARK    GeneRIF: Urine-derived stem cells-extracellular vesicles ameliorate
            diabetic osteoporosis through HDAC4/HIF-1alpha/VEGFA axis by
            delivering microRNA-26a-5p.
REFERENCE   3  (bases 1 to 4015)
  AUTHORS   Yang,Y., Wang,Z., Xu,Y., Liu,X., Sun,Y. and Li,W.
  TITLE     Knockdown of lncRNA H19 alleviates ox-LDL-induced HCAECs
            inflammation and injury by mediating miR-20a-5p/HDAC4 axis
  JOURNAL   Inflamm Res 71 (9), 1109-1121 (2022)
   PUBMED   35854140
  REMARK    Erratum:[Inflamm Res. 2023 Apr;72(4):893. doi:
            10.1007/s00011-023-01701-7.. PMID: 36806965]
REFERENCE   4  (bases 1 to 4015)
  AUTHORS   Moreno-Ruperez,A., Priego,T., Gonzalez-Nicolas,M.A.,
            Lopez-Calderon,A., Lazaro,A. and Martin,A.I.
  TITLE     Role of Glucocorticoid Signaling and HDAC4 Activation in Diaphragm
            and Gastrocnemius Proteolytic Activity in Septic Rats
  JOURNAL   Int J Mol Sci 23 (7), 3641 (2022)
   PUBMED   35408999
  REMARK    GeneRIF: Role of Glucocorticoid Signaling and HDAC4 Activation in
            Diaphragm and Gastrocnemius Proteolytic Activity in Septic Rats.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4015)
  AUTHORS   Wei,W., Chen,W. and He,N.
  TITLE     HDAC4 induces the development of asthma by increasing
            Slug-upregulated CXCL12 expression through KLF5 deacetylation
  JOURNAL   J Transl Med 19 (1), 258 (2021)
   PUBMED   34118928
  REMARK    GeneRIF: HDAC4 induces the development of asthma by increasing
            Slug-upregulated CXCL12 expression through KLF5 deacetylation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4015)
  AUTHORS   Fischle,W., Dequiedt,F., Hendzel,M.J., Guenther,M.G., Lazar,M.A.,
            Voelter,W. and Verdin,E.
  TITLE     Enzymatic activity associated with class II HDACs is dependent on a
            multiprotein complex containing HDAC3 and SMRT/N-CoR
  JOURNAL   Mol Cell 9 (1), 45-57 (2002)
   PUBMED   11804585
REFERENCE   7  (bases 1 to 4015)
  AUTHORS   Lu,J., McKinsey,T.A., Zhang,C.L. and Olson,E.N.
  TITLE     Regulation of skeletal myogenesis by association of the MEF2
            transcription factor with class II histone deacetylases
  JOURNAL   Mol Cell 6 (2), 233-244 (2000)
   PUBMED   10983972
REFERENCE   8  (bases 1 to 4015)
  AUTHORS   Grozinger,C.M. and Schreiber,S.L.
  TITLE     Regulation of histone deacetylase 4 and 5 and transcriptional
            activity by 14-3-3-dependent cellular localization
  JOURNAL   Proc Natl Acad Sci U S A 97 (14), 7835-7840 (2000)
   PUBMED   10869435
REFERENCE   9  (bases 1 to 4015)
  AUTHORS   Lemercier,C., Verdel,A., Galloo,B., Curtet,S., Brocard,M.P. and
            Khochbin,S.
  TITLE     mHDA1/HDAC5 histone deacetylase interacts with and represses MEF2A
            transcriptional activity
  JOURNAL   J Biol Chem 275 (20), 15594-15599 (2000)
   PUBMED   10748098
REFERENCE   10 (bases 1 to 4015)
  AUTHORS   Grozinger,C.M., Hassig,C.A. and Schreiber,S.L.
  TITLE     Three proteins define a class of human histone deacetylases related
            to yeast Hda1p
  JOURNAL   Proc Natl Acad Sci U S A 96 (9), 4868-4873 (1999)
   PUBMED   10220385
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On or before Sep 1, 2012 this sequence version replaced
            XM_001067733.2, XM_343629.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643287.23282.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-78                JAXUCZ010000009.1  100197560-100197637 c
            79-317              JAXUCZ010000009.1  100164705-100164943 c
            318-389             JAXUCZ010000009.1  100076183-100076254 c
            390-631             JAXUCZ010000009.1  100050680-100050921 c
            632-782             JAXUCZ010000009.1  100034333-100034483 c
            783-903             JAXUCZ010000009.1  100024695-100024815 c
            904-1025            JAXUCZ010000009.1  100018481-100018602 c
            1026-1157           JAXUCZ010000009.1  100013993-100014124 c
            1158-1270           JAXUCZ010000009.1  100010352-100010464 c
            1271-1387           JAXUCZ010000009.1  100007494-100007610 c
            1388-1586           JAXUCZ010000009.1  100007207-100007405 c
            1587-1810           JAXUCZ010000009.1  100004898-100005121 c
            1811-2065           JAXUCZ010000009.1  99998890-99999144   c
            2066-2252           JAXUCZ010000009.1  99996052-99996238   c
            2253-2386           JAXUCZ010000009.1  99994292-99994425   c
            2387-2492           JAXUCZ010000009.1  99991738-99991843   c
            2493-2539           JAXUCZ010000009.1  99988140-99988186   c
            2540-2647           JAXUCZ010000009.1  99984745-99984852   c
            2648-2703           JAXUCZ010000009.1  99982715-99982770   c
            2704-2791           JAXUCZ010000009.1  99981864-99981951   c
            2792-2911           JAXUCZ010000009.1  99979516-99979635   c
            2912-3009           JAXUCZ010000009.1  99978680-99978777   c
            3010-3128           JAXUCZ010000009.1  99971610-99971728   c
            3129-3262           JAXUCZ010000009.1  99970072-99970205   c
            3263-3347           JAXUCZ010000009.1  99956805-99956889   c
            3348-3489           JAXUCZ010000009.1  99955846-99955987   c
            3490-4015           JAXUCZ010000009.1  99955098-99955623   c
FEATURES             Location/Qualifiers
     source          1..4015
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q36"
     gene            1..4015
                     /gene="Hdac4"
                     /note="histone deacetylase 4"
                     /db_xref="GeneID:363287"
                     /db_xref="RGD:619979"
     exon            1..78
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            79..317
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     CDS             296..3529
                     /gene="Hdac4"
                     /EC_number="3.5.1.98"
                     /note="HD4"
                     /codon_start=1
                     /product="histone deacetylase 4"
                     /protein_id="NP_445901.1"
                     /db_xref="GeneID:363287"
                     /db_xref="RGD:619979"
                     /translation="MSSQSHPDGLSGRDQPVELLNPARVNHMPSTVDVATALPLQVAP
                     AAVPMDLRLDHQFSLPLEPALREQQLQQELLALKQKQQIQRQILIAEFQRQHEQLSRQ
                     HEAQLHEHIKQQQEMLAMKHQQELLEHQRKLERHRQEQELEKQHREQKLQQLKNKEKG
                     KESAVASTEVKMKLQEFVLNKKKALAHRNLNHCMSSDPRYWYGKTQHSSLDQSSPPQS
                     GVSASYNHPVLGMYDAKDDFPLRKTASEPNLKLRSRLKQKVAERRSSPLLRRKDGPVA
                     TALKKRPLDVTDSACSSAPGSGPSSPNSSSGNVSTENGIAPTVPSTPAETSLAHRLVT
                     REGSVAPLPLYTSPSLPNITLGLPATGPAAGAAGQQDAERLALPALQQRISLFPGTHL
                     TPYLSTSPLERDGGAAHNPLLQHMVLLEQPPTQTPLVTGLGALPLHTQSLVGADRVSP
                     SIHKLRQHRPLGRTQSAPLPQNAQALQHLVIQQQHQQFLEKHKQQFQQQQLHLSKMIS
                     KPSEPPRQPESHPEETEEELREHQALLDEPYLDRLPGQKEPSLAGVQVKQEPIESEEE
                     EVEATREAEPSQRPATEQELLFRQQALLLEQQRIHQLRNYQASMEAAGIPVSFGSHRP
                     LSRAQSSPASATFPMSVQEPPTKPRFTTGLVYDTLMLKHQCTCGNTNSHPEHAGRIQS
                     IWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHTLLYGTNPLNRQKLDSSLTSVFV
                     RLPCGGVGVDSDTIWNEVHSSGAARLAVGCVVELVFKVATGELKNGFAVVRPPGHHAE
                     ESTPMGFCYFNSVAIAAKLLQQRLNVSKILIVDWDVHHGNGTQQAFYNDPNVLYMSLH
                     RYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDPPMGDAEYLAAFRTVVMPIANE
                     FAPDVVLVSSGFDAVEGHPTPLGGYNLSAKCFGYLTKQLMGLAGGRIVLALEGGHDLT
                     AICDASEACVSALLGNELEPLPEKVLHQRPNANAVHSMEKVMGIHSEYWRCLQRLSPT
                     VGHSLIEAQKCENEEAETVTAMASLSVGVKPAEKRSEEEPMEEEPPL"
     exon            318..389
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            390..631
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            632..782
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            783..903
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1025
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1157
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..1270
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1387
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..1586
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            1587..1810
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            1811..2065
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            2066..2252
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            2253..2386
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            2387..2492
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            2493..2539
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            2540..2647
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            2648..2703
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            2704..2791
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            2792..2911
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            2912..3009
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            3010..3128
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            3129..3262
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            3263..3347
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            3348..3489
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            3490..4015
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagcgcctg acgggcgtag ggcgcggcct atccccgcgc ggctctgcgc tcgaggggga
       61 gcagcatcat ggttcaacgt tcatctctgc aaggccaggt gacaacttct gctcttcttg
      121 tggattactt ggtttacaag acgctgccag tgggacttcg agtttgcgca gctgggaccc
      181 gggcctcctc agttttgtac ctgcatgttc tcgtgggaat ttggagcgtg ttggagccac
      241 tgtttacctg gacatcttga gccatttcga acttaaggca ctgacgctgc tagcaatgag
      301 ctcccaaagc catccagatg gactttctgg ccgagaccag cctgtggagc tgctgaatcc
      361 tgcccgcgtg aaccacatgc ccagcacggt ggacgtggct acagcgctgc ctctgcaggt
      421 ggcccctgca gcagtaccca tggacctgcg cttggaccac cagttctcac tgcccttgga
      481 acctgcactg cgggagcagc aactgcagca ggaactccta gcactgaagc agaagcagca
      541 gatccagcgg cagatcctca ttgcagagtt ccagcgtcag catgagcagt tgtcccgaca
      601 gcatgaggca cagctgcatg aacatatcaa gcagcagcag gagatgctgg ccatgaagca
      661 ccagcaggag ctgctggagc accagcggaa actggagcgg caccggcaag agcaggagct
      721 ggagaagcag caccgtgagc agaagctgca gcagctcaag aacaaggaga agggcaaaga
      781 gagtgctgtg gcgagcacag aggtgaagat gaagctgcag gagtttgttc tcaacaagaa
      841 gaaggctctg gcccaccgga acctgaacca ctgcatgtcc agcgaccccc gctactggta
      901 tgggaagaca cagcacagct cccttgacca gagctctcca ccccagagtg gggtgtcagc
      961 ctcctacaac caccctgtct tgggaatgta cgacgccaaa gatgacttcc ctcttaggaa
     1021 aacagcttct gaacctaacc tgaaattacg gtcaaggctt aagcagaaag tagctgagag
     1081 acggagcagc cccctgctgc gcaggaaaga tggccctgtg gccactgctc taaaaaagcg
     1141 acccctggat gttacagact ccgcatgtag cagcgcccct ggctccggtc ccagctcccc
     1201 caatagcagc tctggcaacg tcagcaccga gaatggcatt gcacccaccg tgcccagcac
     1261 tccagctgag acgagcttgg cacacagact tgtgactcga gaaggctctg ttgccccact
     1321 tcctctctat acatcaccat ccttgcccaa catcaccctg ggacttcctg ccactggccc
     1381 tgctgctggt gcagcaggcc agcaggatgc tgagaggctt gctctcccag ccctccagca
     1441 gcgaatctcc ttgttccctg ggacccacct caccccatac ctgagcacct cgcccctgga
     1501 gcgggacggt ggagcagctc acaaccccct cctgcagcac atggtcctgc tggagcagcc
     1561 acccacccag acgccccttg tcacaggcct gggggcactg cccctccaca cacagtccct
     1621 ggttggtgcg gacagggtgt ccccatccat tcacaagctg cggcagcacc gacctctggg
     1681 gcgcacgcag tcagcacccc tgccgcagaa cgcacaggcc ctgcagcacc tggtgatcca
     1741 gcagcagcac cagcagtttc tggagaagca caagcaacag ttccagcagc agcagctgca
     1801 cctcagcaag atgatttcta aacccagtga gccacctcgg cagcctgaga gccacccgga
     1861 ggagacagag gaggagctcc gtgaacacca ggccttgctg gatgagccct acctagatcg
     1921 gctccctggg cagaaggagc cctccttagc tggtgtgcag gtgaagcagg agcccatcga
     1981 gagtgaggag gaagaagtag aggccactcg agaggcggaa cccagccagc gcccagccac
     2041 tgaacaggag cttctcttta gacagcaagc tcttctgctg gagcagcaga ggatccacca
     2101 gttaaggaac taccaggcat ctatggaggc tgctggcatc cctgtgtcat ttggcagcca
     2161 cagacctctg tctcgcgcac agtcctcccc agcatctgcc accttcccca tgtcagtcca
     2221 ggagcccccc accaaaccaa ggttcaccac aggccttgtg tatgacacac tcatgttgaa
     2281 gcaccagtgc acctgtggga acaccaacag ccacccggag catgctggga ggatccagag
     2341 catctggtcc cgcctgcagg agactggcct ccgtggcaag tgtgagtgca tccgcggacg
     2401 caaggccaca ctggaagagc tgcagacagt gcactcggag gcccacacac tcctctatgg
     2461 cacaaaccct ctcaacagac agaaactgga cagctcgctg acctccgtgt ttgtcaggct
     2521 tccttgtggt ggtgttgggg tggatagtga taccatatgg aatgaggtgc actcgtctgg
     2581 ggcagcccgc ctggctgtag gctgtgtagt ggagctggtc ttcaaggtgg ccacgggaga
     2641 gctaaagaat ggctttgctg tggttcgtcc cccaggacac catgccgagg agagtacacc
     2701 catgggtttc tgctacttta attctgtggc aattgcagcc aaacttctcc agcagaggtt
     2761 gaatgtgagc aagatcctca ttgtagactg ggatgtgcac catgggaatg ggacccagca
     2821 ggccttctac aatgacccca atgttctcta catgtccctg caccgctatg acgatgggaa
     2881 cttcttccca ggaagtggag caccagatga ggtgggcaca gggccaggcg tgggtttcaa
     2941 tgtcaacatg gccttcacgg gtggcctcga tccccccatg ggagacgccg agtacctggc
     3001 agccttcaga acggtggtca tgccaatcgc aaatgagttt gccccagatg tggtactggt
     3061 gtcctcgggc ttcgatgctg tggagggcca ccccacacct cttggagggt acaatctctc
     3121 tgccaaatgt ttcgggtact tgacaaaaca gctgatgggc ttagctggtg gccggatcgt
     3181 gctggccctg gagggaggcc atgacctgac agccatctgt gatgcttctg aagcatgtgt
     3241 ttctgctctg ctgggaaatg agcttgagcc tctgccagaa aaggttctac atcagagacc
     3301 caatgccaat gccgtccact ccatggagaa agtgatgggc atccacagtg agtactggcg
     3361 ctgcctgcag cgtttgtccc ccactgtggg gcactctctg attgaggcgc agaagtgtga
     3421 gaatgaagaa gctgagacag tcaccgccat ggcctcgctg tctgtaggcg tcaaacctgc
     3481 tgagaagaga tctgaggagg agcccatgga ggaggagcca ccactgtagc cgaagctgct
     3541 gttctctcct ttgtctgtct gtcttaaggc tcagccaaga aactttcccg tgtcactcct
     3601 gcgtcctgcc ttggtgctct ctctgagtgc gaagggacag caggtgtgaa gcagcaacgg
     3661 gaggcctttc tgccgccctg gaccacaggt ctggagacgc acacgaacac caggtgtggc
     3721 agatcagatg gaacacagga cagtgcgcaa cacgtgggca cacagacatg ccgcagaagc
     3781 caagcacacg ctgctggggt cccccaggaa agccacgaag gaagaagctt gtggcaactt
     3841 gggcagagtt gctgaattga gttgacatga ggaaaatgaa aatcaaagat ctaataatac
     3901 agaacaaact tgattaaaac tggtgcttaa catttgattc ttacccacaa tcccacagtc
     3961 tccgtgtaaa ccactcaact catcttgtag cttttttaaa aaaaaaaaaa aacaa
//
