LOCUS       NM_053448               1956 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus histone deacetylase 3 (Hdac3), mRNA.
ACCESSION   NM_053448 XM_039097192
VERSION     NM_053448.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1956)
  AUTHORS   Han,X., Wang,S., Yong,Z., Zhang,X., Wang,X. and Sun,C.
  TITLE     HDAC3 Impairs Cardiac Function in Chronic Heart Failure Rats via
            Mediating MicroRNA-26b-3p to Target High Mobility Group AT-Hook 2
  JOURNAL   Curr Med Chem 30 (22), 2577-2589 (2023)
   PUBMED   36201274
  REMARK    GeneRIF: HDAC3 Impairs Cardiac Function in Chronic Heart Failure
            Rats via Mediating MicroRNA-26b-3p to Target High Mobility Group
            AT-Hook 2.
REFERENCE   2  (bases 1 to 1956)
  AUTHORS   Wang,Y.Y., Gao,B., Yang,Y., Jia,S.B., Ma,X.P., Zhang,M.H.,
            Wang,L.J., Ma,A.Q. and Zhang,Q.N.
  TITLE     Histone deacetylase 3 suppresses the expression of SHP-1 via
            deacetylation of DNMT1 to promote heart failure
  JOURNAL   Life Sci 292, 119552 (2022)
   PUBMED   33932446
  REMARK    GeneRIF: Histone deacetylase 3 suppresses the expression of SHP-1
            via deacetylation of DNMT1 to promote heart failure.
REFERENCE   3  (bases 1 to 1956)
  AUTHORS   Hu,L., Yang,K., Mai,X., Wei,J. and Ma,C.
  TITLE     Depleted HDAC3 attenuates hyperuricemia-induced renal interstitial
            fibrosis via miR-19b-3p/SF3B3 axis
  JOURNAL   Cell Cycle 21 (5), 450-461 (2022)
   PUBMED   35025700
  REMARK    GeneRIF: Depleted HDAC3 attenuates hyperuricemia-induced renal
            interstitial fibrosis via miR-19b-3p/SF3B3 axis.
REFERENCE   4  (bases 1 to 1956)
  AUTHORS   Niu,H., Song,W., Pei,D., Ma,C., Liu,F., Li,Y. and Han,S.
  TITLE     Depleted histone deacetylase 3 or restored microRNA-19b-1-5p
            facilitates recovery of spinal cord injury via inactivating
            JAK2/STAT3 signaling pathway
  JOURNAL   Genomics 114 (2), 110262 (2022)
   PUBMED   34971719
  REMARK    GeneRIF: Depleted histone deacetylase 3 or restored
            microRNA-19b-1-5p facilitates recovery of spinal cord injury via
            inactivating JAK2/STAT3 signaling pathway.
REFERENCE   5  (bases 1 to 1956)
  AUTHORS   Zheng,W., Xie,Q., Zhang,Z., Li,J., Fang,L. and Li,W.
  TITLE     Inhibited HDAC3 or Elevated MicroRNA-494-3p Plays a Protective Role
            in Myocardial Ischemia-Reperfusion Injury via Suppression of BRD4
  JOURNAL   Mol Neurobiol 58 (9), 4268-4279 (2021)
   PUBMED   33982231
REFERENCE   6  (bases 1 to 1956)
  AUTHORS   Fischle,W., Dequiedt,F., Hendzel,M.J., Guenther,M.G., Lazar,M.A.,
            Voelter,W. and Verdin,E.
  TITLE     Enzymatic activity associated with class II HDACs is dependent on a
            multiprotein complex containing HDAC3 and SMRT/N-CoR
  JOURNAL   Mol Cell 9 (1), 45-57 (2002)
   PUBMED   11804585
REFERENCE   7  (bases 1 to 1956)
  AUTHORS   Mahon,P.C., Hirota,K. and Semenza,G.L.
  TITLE     FIH-1: a novel protein that interacts with HIF-1alpha and VHL to
            mediate repression of HIF-1 transcriptional activity
  JOURNAL   Genes Dev 15 (20), 2675-2686 (2001)
   PUBMED   11641274
REFERENCE   8  (bases 1 to 1956)
  AUTHORS   Lu,J., McKinsey,T.A., Zhang,C.L. and Olson,E.N.
  TITLE     Regulation of skeletal myogenesis by association of the MEF2
            transcription factor with class II histone deacetylases
  JOURNAL   Mol Cell 6 (2), 233-244 (2000)
   PUBMED   10983972
REFERENCE   9  (bases 1 to 1956)
  AUTHORS   Grozinger,C.M. and Schreiber,S.L.
  TITLE     Regulation of histone deacetylase 4 and 5 and transcriptional
            activity by 14-3-3-dependent cellular localization
  JOURNAL   Proc Natl Acad Sci U S A 97 (14), 7835-7840 (2000)
   PUBMED   10869435
REFERENCE   10 (bases 1 to 1956)
  AUTHORS   Dangond,F., Foerznler,D., Weremowicz,S., Morton,C.C., Beier,D.R.
            and Gullans,S.R.
  TITLE     Cloning and expression of a murine histone deacetylase 3 (mHdac3)
            cDNA and mapping to a region of conserved synteny between murine
            chromosome 18 and human chromosome 5
  JOURNAL   Mol Cell Biol Res Commun 2 (2), 91-96 (1999)
   PUBMED   10542131
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On or before Mar 9, 2021 this sequence version replaced
            XM_039097192.1, NM_053448.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061988.1, SRR26643292.59578.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760433 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-119               JAXUCZ010000018.1  30040907-30041025   c
            120-202             JAXUCZ010000018.1  30040730-30040812   c
            203-345             JAXUCZ010000018.1  30038682-30038824   c
            346-427             JAXUCZ010000018.1  30030917-30030998   c
            428-484             JAXUCZ010000018.1  30030736-30030792   c
            485-540             JAXUCZ010000018.1  30030567-30030622   c
            541-674             JAXUCZ010000018.1  30030102-30030235   c
            675-755             JAXUCZ010000018.1  30029461-30029541   c
            756-829             JAXUCZ010000018.1  30029006-30029079   c
            830-894             JAXUCZ010000018.1  30028784-30028848   c
            895-984             JAXUCZ010000018.1  30026787-30026876   c
            985-1043            JAXUCZ010000018.1  30026631-30026689   c
            1044-1123           JAXUCZ010000018.1  30026302-30026381   c
            1124-1281           JAXUCZ010000018.1  30025849-30026006   c
            1282-1956           JAXUCZ010000018.1  30021847-30022521   c
FEATURES             Location/Qualifiers
     source          1..1956
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p11"
     gene            1..1956
                     /gene="Hdac3"
                     /note="histone deacetylase 3"
                     /db_xref="GeneID:84578"
                     /db_xref="RGD:619977"
     exon            1..119
                     /gene="Hdac3"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..1351
                     /gene="Hdac3"
                     /EC_number="3.5.1.98"
                     /function="deacetylation of lysine residues on N-terminal
                     part of core histones H2A, H2B, H3 and H4"
                     /note="histone deacetylase subfamily 1; HD3; protein
                     deacylase HDAC3; protein deacetylase HDAC3"
                     /codon_start=1
                     /product="histone deacetylase 3"
                     /protein_id="NP_445900.2"
                     /db_xref="GeneID:84578"
                     /db_xref="RGD:619977"
                     /translation="MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKK
                     MIVFKPYQASQHDMCRFHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFE
                     FCSRYTGASLQGATQLNNKICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKY
                     HPRVLYIDIDIHHGDGVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYC
                     LNVPLRDGIDDQSYKHLFQPVISQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGH
                     GECVEYVKSFNIPLLVLGGGGYTVRNVARCWTYETSLLVEEAISEELPYSEYFEYFAP
                     DFTLHPDVSTRIENQNSRQYLDQIRQTIFENLKMLNHAPSVQIHDVPADLLTYDRTDE
                     ADAEERGPEENYSRPEAPNEFYDGDHDNDKESDVEI"
     exon            120..202
                     /gene="Hdac3"
                     /inference="alignment:Splign:2.1.0"
     exon            203..345
                     /gene="Hdac3"
                     /inference="alignment:Splign:2.1.0"
     exon            346..427
                     /gene="Hdac3"
                     /inference="alignment:Splign:2.1.0"
     exon            428..484
                     /gene="Hdac3"
                     /inference="alignment:Splign:2.1.0"
     exon            485..540
                     /gene="Hdac3"
                     /inference="alignment:Splign:2.1.0"
     exon            541..674
                     /gene="Hdac3"
                     /inference="alignment:Splign:2.1.0"
     exon            675..755
                     /gene="Hdac3"
                     /inference="alignment:Splign:2.1.0"
     exon            756..829
                     /gene="Hdac3"
                     /inference="alignment:Splign:2.1.0"
     exon            830..894
                     /gene="Hdac3"
                     /inference="alignment:Splign:2.1.0"
     exon            895..984
                     /gene="Hdac3"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1043
                     /gene="Hdac3"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1123
                     /gene="Hdac3"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1281
                     /gene="Hdac3"
                     /inference="alignment:Splign:2.1.0"
     exon            1282..1956
                     /gene="Hdac3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgggggtggg gctggcgtcc ggcggcgggc gggcggctga gtcggggcct ggtcccccag
       61 caccatggcc aagaccgtgg cgtatttcta cgaccccgat gtgggcaact tccactacgg
      121 agctggacac ccgatgaaac cccatcgcct ggcattgact catagcctag tcctgcatta
      181 tggtctctat aagaagatga tcgtcttcaa gccttaccag gcctcccagc atgacatgtg
      241 ccgcttccat tctgaggact acattgactt cctgcagaga gtcagcccca ccaatatgca
      301 gggtttcacc aagagcctta atgccttcaa cgtgggtgac gactgccctg tgtttcccgg
      361 gctcttcgag ttctgctccc gctatacagg cgcatctctg caaggggcaa cacagctaaa
      421 caacaagatc tgtgatattg ccatcaactg ggctggtggt ctacatcatg ccaagaagtt
      481 tgaggcctct ggcttctgct atgtcaatga catagtaatt ggtatcctgg agctgctcaa
      541 gtaccaccct cgggtgctgt acattgatat tgacatccac catggtgacg gggttcagga
      601 agccttctac ctcactgacc gggtcatgac tgtgtccttc cacaaatatg gaaattactt
      661 ctttcctgga acaggtgata tgtatgaagt tggagcagag agtggccgct actattgtct
      721 caatgtgccc ttacgggatg gcattgatga ccagagttac aagcaccttt tccagccggt
      781 catcagccag gtggtggact tctatcagcc gacgtgcatc gtgctgcagt gtggcgctga
      841 ctccctgggc tgtgatcgat taggctgctt caatctcagc attcgaggac atggggaatg
      901 tgttgaatat gtcaagagtt tcaatatccc tctcctggtg ctgggaggtg gtggttacac
      961 cgttcgaaat gttgcccggt gctggacata tgaaacatct ctgctggtag aagaggccat
     1021 tagtgaggaa cttccctata gtgaatactt cgagtacttt gccccagatt tcacgctcca
     1081 tccagatgtc agcacccgca tcgagaatca gaactcacgc cagtatctag accagatccg
     1141 ccagaccatc tttgaaaact tgaagatgct gaaccatgca cccagtgtcc agattcatga
     1201 tgttccagca gatctcctga cctatgacag gactgacgag gccgatgctg aagagagagg
     1261 tcctgaggag aactacagca ggccagaagc acccaatgaa ttctatgatg gagaccatga
     1321 caatgacaag gaaagtgatg tggagattta agagcagcat ggatgccgtg tccccaagag
     1381 ttccttgtca cctctgtggt gggaaggaaa gtattgctct cccaggtctg aactgggtat
     1441 ccccagggtg tttactaact ctggtaacgg gtttggaaac cacatctggt tctagagtca
     1501 actaccccct ttcctcaaac tctcatatac ccgatggaca ggtctctgga acattatggg
     1561 taatgagccc tagcagctga ccccagcccc tcttcccctt atttgttcct ctgtccttcc
     1621 agcacagaga ctgttagaga tgaaagtctg gacggtacta aggtcccctc tgacttcctt
     1681 ctgggttctc tactgcagtt cttgcttcca tgcaaggtga acctgagggg aggaaggcat
     1741 ggctctctga aaccttaact gctgaggagg tacaggtgca aggaggagag ggtgtaaagc
     1801 tccaaccggc tttatgtcca ttttactgtt tttgatctaa taaaccaatt ggtatttttt
     1861 gtacctttct gggattttaa ttcttgctag ttaccaatgt atgatgggaa aaggaaatcg
     1921 agatgacgat gtgtataata aacttgttaa catcca
//
