LOCUS       NM_053447               2184 bp    mRNA    linear   ROD 14-OCT-2024
DEFINITION  Rattus norvegicus histone deacetylase 2 (Hdac2), mRNA.
ACCESSION   NM_053447 XM_001061582 XM_342149
VERSION     NM_053447.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2184)
  AUTHORS   Zhang,Z.X., Tian,Y., Li,S., Jing,H.B., Cai,J., Li,M. and Xing,G.G.
  TITLE     Involvement of HDAC2-mediated kcnq2/kcnq3 genes transcription
            repression activated by EREG/EGFR-ERK-Runx1 signaling in bone
            cancer pain
  JOURNAL   Cell Commun Signal 22 (1), 416 (2024)
   PUBMED   39192337
  REMARK    GeneRIF: Involvement of HDAC2-mediated kcnq2/kcnq3 genes
            transcription repression activated by EREG/EGFR-ERK-Runx1 signaling
            in bone cancer pain.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2184)
  AUTHORS   Mao,D., Jiang,H., Zhang,F., Yang,H., Fang,X., Zhang,Q. and Zhao,G.
  TITLE     HDAC2 exacerbates rheumatoid arthritis progression via the
            IL-17-CCL7 signaling pathway
  JOURNAL   Environ Toxicol 38 (7), 1743-1755 (2023)
   PUBMED   37021908
  REMARK    GeneRIF: HDAC2 exacerbates rheumatoid arthritis progression via the
            IL-17-CCL7 signaling pathway.
REFERENCE   3  (bases 1 to 2184)
  AUTHORS   Zhao,Y., Guo,Y., Sun,M., Hussion,S., Zheng,Y., Huang,H., Huo,X.,
            Zhao,Y., Zhang,F., Han,Y., Ning,Q., Xu,P., Sun,J. and Lu,S.
  TITLE     Selenium-sensitive histone deacetylase 2 is required for forkhead
            box O3A and regulates extracellular matrix metabolism in cartilage
  JOURNAL   J Bone Miner Metab 40 (6), 914-926 (2022)
   PUBMED   36156740
  REMARK    GeneRIF: Selenium-sensitive histone deacetylase 2 is required for
            forkhead box O3A and regulates extracellular matrix metabolism in
            cartilage.
            Erratum:[J Bone Miner Metab. 2023 Jan;41(1):143. doi:
            10.1007/s00774-022-01395-7. PMID: 36592235]
REFERENCE   4  (bases 1 to 2184)
  AUTHORS   Li,Z., Sun,T., He,Z., Li,Z., Zhang,W., Wang,J. and Xiang,H.
  TITLE     SCFAs Ameliorate Chronic Postsurgical Pain-Related Cognition
            Dysfunction via the ACSS2-HDAC2 Axis in Rats
  JOURNAL   Mol Neurobiol 59 (10), 6211-6227 (2022)
   PUBMED   35902549
  REMARK    GeneRIF: SCFAs Ameliorate Chronic Postsurgical Pain-Related
            Cognition Dysfunction via the ACSS2-HDAC2 Axis in Rats.
REFERENCE   5  (bases 1 to 2184)
  AUTHORS   Chmielewska,N., Wawer,A., Osuch,B., Maciejak,P. and Szyndler,J.
  TITLE     mTOR and HDAC2 are simultaneously activated during electrically
            induced kindling of seizures
  JOURNAL   Epilepsy Res 185, 106991 (2022)
   PUBMED   35926274
  REMARK    GeneRIF: mTOR and HDAC2 are simultaneously activated during
            electrically induced kindling of seizures.
REFERENCE   6  (bases 1 to 2184)
  AUTHORS   Mahon,P.C., Hirota,K. and Semenza,G.L.
  TITLE     FIH-1: a novel protein that interacts with HIF-1alpha and VHL to
            mediate repression of HIF-1 transcriptional activity
  JOURNAL   Genes Dev 15 (20), 2675-2686 (2001)
   PUBMED   11641274
REFERENCE   7  (bases 1 to 2184)
  AUTHORS   Ballas,N., Battaglioli,E., Atouf,F., Andres,M.E., Chenoweth,J.,
            Anderson,M.E., Burger,C., Moniwa,M., Davie,J.R., Bowers,W.J.,
            Federoff,H.J., Rose,D.W., Rosenfeld,M.G., Brehm,P. and Mandel,G.
  TITLE     Regulation of neuronal traits by a novel transcriptional complex
  JOURNAL   Neuron 31 (3), 353-365 (2001)
   PUBMED   11516394
REFERENCE   8  (bases 1 to 2184)
  AUTHORS   Tsai,S.C., Valkov,N., Yang,W.M., Gump,J., Sullivan,D. and Seto,E.
  TITLE     Histone deacetylase interacts directly with DNA topoisomerase II
  JOURNAL   Nat Genet 26 (3), 349-353 (2000)
   PUBMED   11062478
REFERENCE   9  (bases 1 to 2184)
  AUTHORS   Rountree,M.R., Bachman,K.E. and Baylin,S.B.
  TITLE     DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex
            at replication foci
  JOURNAL   Nat Genet 25 (3), 269-277 (2000)
   PUBMED   10888872
REFERENCE   10 (bases 1 to 2184)
  AUTHORS   Bach,I., Rodriguez-Esteban,C., Carriere,C., Bhushan,A., Krones,A.,
            Rose,D.W., Glass,C.K., Andersen,B., Izpisua Belmonte,J.C. and
            Rosenfeld,M.G.
  TITLE     RLIM inhibits functional activity of LIM homeodomain transcription
            factors via recruitment of the histone deacetylase complex
  JOURNAL   Nat Genet 22 (4), 394-399 (1999)
   PUBMED   10431247
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000020.1.
            
            On Apr 27, 2023 this sequence version replaced NM_053447.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC161939.1, SRR26643429.58128.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-258               JAXUCZ010000020.1  42103127-42103384
            259-371             JAXUCZ010000020.1  42110786-42110898
            372-489             JAXUCZ010000020.1  42111998-42112115
            490-564             JAXUCZ010000020.1  42113754-42113828
            565-703             JAXUCZ010000020.1  42114829-42114967
            704-845             JAXUCZ010000020.1  42117392-42117533
            846-938             JAXUCZ010000020.1  42118652-42118744
            939-1047            JAXUCZ010000020.1  42118818-42118926
            1048-1188           JAXUCZ010000020.1  42121800-42121940
            1189-1297           JAXUCZ010000020.1  42122195-42122303
            1298-1428           JAXUCZ010000020.1  42122976-42123106
            1429-1584           JAXUCZ010000020.1  42123345-42123500
            1585-1642           JAXUCZ010000020.1  42125347-42125404
            1643-2184           JAXUCZ010000020.1  42125945-42126486
FEATURES             Location/Qualifiers
     source          1..2184
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20q12"
     gene            1..2184
                     /gene="Hdac2"
                     /note="histone deacetylase 2"
                     /db_xref="GeneID:84577"
                     /db_xref="RGD:619976"
     exon            1..258
                     /gene="Hdac2"
                     /inference="alignment:Splign:2.1.0"
     CDS             207..1673
                     /gene="Hdac2"
                     /EC_number="3.5.1.98"
                     /codon_start=1
                     /product="histone deacetylase 2"
                     /protein_id="NP_445899.1"
                     /db_xref="GeneID:84577"
                     /db_xref="RGD:619976"
                     /translation="MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLL
                     NYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCP
                     VFDGLFEFCQLSTGGSVAGAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLA
                     VLELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAG
                     KGKYYAVNFPMRDGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFN
                     LTVKGHAKCVEVVKTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNELPYNDY
                     FEYFGPDFKLHISPSNMTNQNTPEYMEKIKQRLFENLRMLPHAPGVQMQAIPEDAVHE
                     DSGDEDGEDPDKRISIRASDKRIACDEEFSDSEDEGEGGRRNVADHKKGAKKARIEED
                     KKEAEDKRTDVKEEDKSKDNSGEKTDTKGAKSEQLNNP"
     exon            259..371
                     /gene="Hdac2"
                     /inference="alignment:Splign:2.1.0"
     exon            372..489
                     /gene="Hdac2"
                     /inference="alignment:Splign:2.1.0"
     exon            490..564
                     /gene="Hdac2"
                     /inference="alignment:Splign:2.1.0"
     exon            565..703
                     /gene="Hdac2"
                     /inference="alignment:Splign:2.1.0"
     exon            704..845
                     /gene="Hdac2"
                     /inference="alignment:Splign:2.1.0"
     exon            846..938
                     /gene="Hdac2"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1047
                     /gene="Hdac2"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1188
                     /gene="Hdac2"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1297
                     /gene="Hdac2"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1428
                     /gene="Hdac2"
                     /inference="alignment:Splign:2.1.0"
     exon            1429..1584
                     /gene="Hdac2"
                     /inference="alignment:Splign:2.1.0"
     exon            1585..1642
                     /gene="Hdac2"
                     /inference="alignment:Splign:2.1.0"
     exon            1643..2184
                     /gene="Hdac2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagtgtcgcg cgtcggcgcc gctgccaacc ccgctctgcg atctcgggcc ctcccggcac
       61 ccgctcgccg tcccgctccg ggctgtcctt gctgcgaggg ccgccgcgcc cgccgtctcc
      121 ctcagccctc ttgtctggcc gccgggccgc ggcgggcgag agcagccgga ggaggagccg
      181 cagccaggag gcggcggccg gagcccatgg cgtacagtca aggaggcggc aagaagaaag
      241 tgtgctacta ttatgacggt gatatcggga attattatta cggccagggt catcccatga
      301 agccccatag gatccggatg actcataact tgcttctaaa ttatggttta taccgaaaaa
      361 tggaaatata taggcctcat aaggccactg ctgaagaaat gacaaaatac cacagtgatg
      421 agtatatcaa gtttctacga tcaataaggc cagataacat gtcagagtat agtaagcaga
      481 tgcagagatt taatgtcgga gaagactgtc cagtgttcga tggactcttt gagttttgtc
      541 agctctccac cggtggctca gttgctgggg ccgtgaagct gaaccgtcaa cagactgaca
      601 tggctgtcaa ctgggcggga ggactgcacc acgccaagaa gtcagaggcc tcaggattct
      661 gctacgttaa tgacattgtg cttgctgtcc tcgagctact gaaatatcat cagagagtct
      721 tatatattga catagacatc caccatggtg atggtgttga ggaagctttt tatacaacag
      781 atcgcgtgat gaccgtctca ttccataaat acggagaata ctttcctgga acaggagact
      841 tgagggatat tggtgctgga aaaggaaagt actacgctgt caactttccc atgagggacg
      901 gtatagatga cgagtcatat ggacagatat ttaagcctat aatctcaaaa gtgatggaga
      961 tgtaccagcc gagcgcggtg gtgctgcagt gtggcgctga ctccctctct ggtgacaggc
     1021 tgggctgctt caacctaact gtcaaaggtc acgctaaatg tgtagaagta gtgaaaactt
     1081 ttaacttgcc gttgctgatg cttggcggag gtggctacac aatccggaat gttgctcgat
     1141 gttggacgta tgagactgca gttgcccttg attgtgaaat tcccaatgag ttgccatata
     1201 atgattactt cgagtatttt ggaccagact tcaaactgca tattagtccc tcaaacatga
     1261 caaaccagaa cactccagaa tatatggaaa agataaaaca gcgtttattt gaaaatctgc
     1321 gaatgttacc acatgcgcct ggtgttcaaa tgcaagctat tccagaagat gctgttcatg
     1381 aagacagtgg tgatgaggat ggagaagacc ctgacaagag aatttctatt cgagcatcag
     1441 acaagcggat agcttgtgat gaagagttct cagattctga ggatgaaggt gaaggaggtc
     1501 gtaggaatgt cgctgatcat aagaagggag ccaaaaaagc caggattgag gaagacaaga
     1561 aggaggcgga ggacaagagg acagatgtta aggaagaaga caaatccaag gacaatagtg
     1621 gtgagaaaac agacaccaaa ggagccaaat cagaacaact caacaaccct tgaatttgac
     1681 tccccaacct taggaacctc gaaaagtgag acgattctgg gataagaaac cttcgctgtt
     1741 tgaggaagtt tggcttcatt ttatactgtt ttggcatgga ctgtatttat tttcaaaatg
     1801 gcttgttttt ggttttcctt ggcaagtttt attgtgagtt tttctaatta tgaagcaaat
     1861 ttttttccac catgctttat gtgattgtat ttaaattgat gtgttattat gtcaaaaaaa
     1921 aaaaaccgga tctattaaag aaacaattgg cctttctgag ctgatttttc catcttttgt
     1981 aattatcttt attaaaaaat tgtacttgga tggtcttctg tctgtttatt atgaaggctt
     2041 gtttccaagc ccgactgtga gactggagca tactcatggt gatttcagtg gcagagaccc
     2101 tctcactgag tctgtacgtg cttactggct ctaacaggta tttcctattt caataaaaat
     2161 gacaccatgt caccttgtat agtt
//
