LOCUS       NP_445899                488 aa            linear   ROD 14-OCT-2024
DEFINITION  histone deacetylase 2 [Rattus norvegicus].
ACCESSION   NP_445899 XP_001061582 XP_342150
VERSION     NP_445899.1
DBSOURCE    REFSEQ: accession NM_053447.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 488)
  AUTHORS   Zhang,Z.X., Tian,Y., Li,S., Jing,H.B., Cai,J., Li,M. and Xing,G.G.
  TITLE     Involvement of HDAC2-mediated kcnq2/kcnq3 genes transcription
            repression activated by EREG/EGFR-ERK-Runx1 signaling in bone
            cancer pain
  JOURNAL   Cell Commun Signal 22 (1), 416 (2024)
   PUBMED   39192337
  REMARK    GeneRIF: Involvement of HDAC2-mediated kcnq2/kcnq3 genes
            transcription repression activated by EREG/EGFR-ERK-Runx1 signaling
            in bone cancer pain.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 488)
  AUTHORS   Mao,D., Jiang,H., Zhang,F., Yang,H., Fang,X., Zhang,Q. and Zhao,G.
  TITLE     HDAC2 exacerbates rheumatoid arthritis progression via the
            IL-17-CCL7 signaling pathway
  JOURNAL   Environ Toxicol 38 (7), 1743-1755 (2023)
   PUBMED   37021908
  REMARK    GeneRIF: HDAC2 exacerbates rheumatoid arthritis progression via the
            IL-17-CCL7 signaling pathway.
REFERENCE   3  (residues 1 to 488)
  AUTHORS   Zhao,Y., Guo,Y., Sun,M., Hussion,S., Zheng,Y., Huang,H., Huo,X.,
            Zhao,Y., Zhang,F., Han,Y., Ning,Q., Xu,P., Sun,J. and Lu,S.
  TITLE     Selenium-sensitive histone deacetylase 2 is required for forkhead
            box O3A and regulates extracellular matrix metabolism in cartilage
  JOURNAL   J Bone Miner Metab 40 (6), 914-926 (2022)
   PUBMED   36156740
  REMARK    GeneRIF: Selenium-sensitive histone deacetylase 2 is required for
            forkhead box O3A and regulates extracellular matrix metabolism in
            cartilage.
            Erratum:[J Bone Miner Metab. 2023 Jan;41(1):143. doi:
            10.1007/s00774-022-01395-7. PMID: 36592235]
REFERENCE   4  (residues 1 to 488)
  AUTHORS   Li,Z., Sun,T., He,Z., Li,Z., Zhang,W., Wang,J. and Xiang,H.
  TITLE     SCFAs Ameliorate Chronic Postsurgical Pain-Related Cognition
            Dysfunction via the ACSS2-HDAC2 Axis in Rats
  JOURNAL   Mol Neurobiol 59 (10), 6211-6227 (2022)
   PUBMED   35902549
  REMARK    GeneRIF: SCFAs Ameliorate Chronic Postsurgical Pain-Related
            Cognition Dysfunction via the ACSS2-HDAC2 Axis in Rats.
REFERENCE   5  (residues 1 to 488)
  AUTHORS   Chmielewska,N., Wawer,A., Osuch,B., Maciejak,P. and Szyndler,J.
  TITLE     mTOR and HDAC2 are simultaneously activated during electrically
            induced kindling of seizures
  JOURNAL   Epilepsy Res 185, 106991 (2022)
   PUBMED   35926274
  REMARK    GeneRIF: mTOR and HDAC2 are simultaneously activated during
            electrically induced kindling of seizures.
REFERENCE   6  (residues 1 to 488)
  AUTHORS   Mahon,P.C., Hirota,K. and Semenza,G.L.
  TITLE     FIH-1: a novel protein that interacts with HIF-1alpha and VHL to
            mediate repression of HIF-1 transcriptional activity
  JOURNAL   Genes Dev 15 (20), 2675-2686 (2001)
   PUBMED   11641274
REFERENCE   7  (residues 1 to 488)
  AUTHORS   Ballas,N., Battaglioli,E., Atouf,F., Andres,M.E., Chenoweth,J.,
            Anderson,M.E., Burger,C., Moniwa,M., Davie,J.R., Bowers,W.J.,
            Federoff,H.J., Rose,D.W., Rosenfeld,M.G., Brehm,P. and Mandel,G.
  TITLE     Regulation of neuronal traits by a novel transcriptional complex
  JOURNAL   Neuron 31 (3), 353-365 (2001)
   PUBMED   11516394
REFERENCE   8  (residues 1 to 488)
  AUTHORS   Tsai,S.C., Valkov,N., Yang,W.M., Gump,J., Sullivan,D. and Seto,E.
  TITLE     Histone deacetylase interacts directly with DNA topoisomerase II
  JOURNAL   Nat Genet 26 (3), 349-353 (2000)
   PUBMED   11062478
REFERENCE   9  (residues 1 to 488)
  AUTHORS   Rountree,M.R., Bachman,K.E. and Baylin,S.B.
  TITLE     DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex
            at replication foci
  JOURNAL   Nat Genet 25 (3), 269-277 (2000)
   PUBMED   10888872
REFERENCE   10 (residues 1 to 488)
  AUTHORS   Bach,I., Rodriguez-Esteban,C., Carriere,C., Bhushan,A., Krones,A.,
            Rose,D.W., Glass,C.K., Andersen,B., Izpisua Belmonte,J.C. and
            Rosenfeld,M.G.
  TITLE     RLIM inhibits functional activity of LIM homeodomain transcription
            factors via recruitment of the histone deacetylase complex
  JOURNAL   Nat Genet 22 (4), 394-399 (1999)
   PUBMED   10431247
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000020.1.
            
            On or before Oct 3, 2008 this sequence version replaced
            XP_001061582.1, XP_342150.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC161939.1, SRR26643429.58128.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..488
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20q12"
     Protein         1..488
                     /product="histone deacetylase 2"
                     /EC_number="3.5.1.98"
                     /calculated_mol_wt=55214
     Region          9..374
                     /region_name="HDAC2"
                     /note="Histone deacetylase 2 (HDAC2); cd10011"
                     /db_xref="CDD:212535"
     Site            order(141..142,150..151,177,179,265,272,302,304)
                     /site_type="active"
                     /db_xref="CDD:212535"
     CDS             1..488
                     /gene="Hdac2"
                     /coded_by="NM_053447.2:207..1673"
                     /db_xref="GeneID:84577"
                     /db_xref="RGD:619976"
ORIGIN      
        1 maysqgggkk kvcyyydgdi gnyyygqghp mkphrirmth nlllnyglyr kmeiyrphka
       61 taeemtkyhs deyikflrsi rpdnmseysk qmqrfnvged cpvfdglfef cqlstggsva
      121 gavklnrqqt dmavnwaggl hhakkseasg fcyvndivla vlellkyhqr vlyididihh
      181 gdgveeafyt tdrvmtvsfh kygeyfpgtg dlrdigagkg kyyavnfpmr dgiddesygq
      241 ifkpiiskvm emyqpsavvl qcgadslsgd rlgcfnltvk ghakcvevvk tfnlpllmlg
      301 gggytirnva rcwtyetava ldceipnelp yndyfeyfgp dfklhispsn mtnqntpeym
      361 ekikqrlfen lrmlphapgv qmqaipedav hedsgdedge dpdkrisira sdkriacdee
      421 fsdsedegeg grrnvadhkk gakkarieed kkeaedkrtd vkeedkskdn sgektdtkga
      481 kseqlnnp
//
