LOCUS       NM_001414972            2353 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus histone deacetylase 10 (Hdac10), transcript
            variant 1, mRNA.
ACCESSION   NM_001414972 XM_006242218
VERSION     NM_001414972.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2353)
  AUTHORS   Wang,L., Zheng,S., Zhang,L., Xiao,H., Gan,H., Chen,H., Zhai,X.,
            Liang,P., Zhao,J. and Li,Y.
  TITLE     Histone Deacetylation 10 Alleviates Inflammation After
            Intracerebral Hemorrhage via the PTPN22/NLRP3 Pathway in Rats
  JOURNAL   Neuroscience 432, 247-259 (2020)
   PUBMED   32112918
  REMARK    GeneRIF: Histone Deacetylation 10 Alleviates Inflammation After
            Intracerebral Hemorrhage via the PTPN22/NLRP3 Pathway in Rats.
REFERENCE   2  (bases 1 to 2353)
  AUTHORS   Hai,Y., Shinsky,S.A., Porter,N.J. and Christianson,D.W.
  TITLE     Histone deacetylase 10 structure and molecular function as a
            polyamine deacetylase
  JOURNAL   Nat Commun 8, 15368 (2017)
   PUBMED   28516954
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2353)
  AUTHORS   Radhakrishnan,R., Li,Y., Xiang,S., Yuan,F., Yuan,Z., Telles,E.,
            Fang,J., Coppola,D., Shibata,D., Lane,W.S., Zhang,Y., Zhang,X. and
            Seto,E.
  TITLE     Histone deacetylase 10 regulates DNA mismatch repair and may
            involve the deacetylation of MutS homolog 2
  JOURNAL   J Biol Chem 290 (37), 22795-22804 (2015)
   PUBMED   26221039
REFERENCE   4  (bases 1 to 2353)
  AUTHORS   Oehme,I., Linke,J.P., Bock,B.C., Milde,T., Lodrini,M.,
            Hartenstein,B., Wiegand,I., Eckert,C., Roth,W., Kool,M., Kaden,S.,
            Grone,H.J., Schulte,J.H., Lindner,S., Hamacher-Brady,A.,
            Brady,N.R., Deubzer,H.E. and Witt,O.
  TITLE     Histone deacetylase 10 promotes autophagy-mediated cell survival
  JOURNAL   Proc Natl Acad Sci U S A 110 (28), E2592-E2601 (2013)
   PUBMED   23801752
REFERENCE   5  (bases 1 to 2353)
  AUTHORS   Kotian,S., Liyanarachchi,S., Zelent,A. and Parvin,J.D.
  TITLE     Histone deacetylases 9 and 10 are required for homologous
            recombination
  JOURNAL   J Biol Chem 286 (10), 7722-7726 (2011)
   PUBMED   21247901
REFERENCE   6  (bases 1 to 2353)
  AUTHORS   Liu,H., Hu,Q., D'ercole,A.J. and Ye,P.
  TITLE     Histone deacetylase 11 regulates oligodendrocyte-specific gene
            expression and cell development in OL-1 oligodendroglia cells
  JOURNAL   Glia 57 (1), 1-12 (2009)
   PUBMED   18627006
REFERENCE   7  (bases 1 to 2353)
  AUTHORS   Shimazu,T., Horinouchi,S. and Yoshida,M.
  TITLE     Multiple histone deacetylases and the CREB-binding protein regulate
            pre-mRNA 3'-end processing
  JOURNAL   J Biol Chem 282 (7), 4470-4478 (2007)
   PUBMED   17172643
REFERENCE   8  (bases 1 to 2353)
  AUTHORS   Tong,J.J., Liu,J., Bertos,N.R. and Yang,X.J.
  TITLE     Identification of HDAC10, a novel class II human histone
            deacetylase containing a leucine-rich domain
  JOURNAL   Nucleic Acids Res 30 (5), 1114-1123 (2002)
   PUBMED   11861901
REFERENCE   9  (bases 1 to 2353)
  AUTHORS   Fischer,D.D., Cai,R., Bhatia,U., Asselbergs,F.A., Song,C.,
            Terry,R., Trogani,N., Widmer,R., Atadja,P. and Cohen,D.
  TITLE     Isolation and characterization of a novel class II histone
            deacetylase, HDAC10
  JOURNAL   J Biol Chem 277 (8), 6656-6666 (2002)
   PUBMED   11739383
REFERENCE   10 (bases 1 to 2353)
  AUTHORS   Guardiola,A.R. and Yao,T.P.
  TITLE     Molecular cloning and characterization of a novel histone
            deacetylase HDAC10
  JOURNAL   J Biol Chem 277 (5), 3350-3356 (2002)
   PUBMED   11726666
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Dec 16, 2022 this sequence version replaced XM_006242218.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643285.29203.1,
                                           SRR26643294.30331.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-264               JAXUCZ010000007.1  122083583-122083846 c
            265-399             JAXUCZ010000007.1  122083378-122083512 c
            400-496             JAXUCZ010000007.1  122083132-122083228 c
            497-594             JAXUCZ010000007.1  122082803-122082900 c
            595-699             JAXUCZ010000007.1  122082610-122082714 c
            700-768             JAXUCZ010000007.1  122082374-122082442 c
            769-895             JAXUCZ010000007.1  122082085-122082211 c
            896-961             JAXUCZ010000007.1  122081833-122081898 c
            962-1021            JAXUCZ010000007.1  122081537-122081596 c
            1022-1111           JAXUCZ010000007.1  122081374-122081463 c
            1112-1218           JAXUCZ010000007.1  122081142-122081248 c
            1219-1283           JAXUCZ010000007.1  122081004-122081068 c
            1284-1536           JAXUCZ010000007.1  122080675-122080927 c
            1537-1621           JAXUCZ010000007.1  122080485-122080569 c
            1622-1713           JAXUCZ010000007.1  122080199-122080290 c
            1714-1770           JAXUCZ010000007.1  122080018-122080074 c
            1771-1849           JAXUCZ010000007.1  122079638-122079716 c
            1850-2032           JAXUCZ010000007.1  122079265-122079447 c
            2033-2192           JAXUCZ010000007.1  122079013-122079172 c
            2193-2353           JAXUCZ010000007.1  122078768-122078928 c
FEATURES             Location/Qualifiers
     source          1..2353
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..2353
                     /gene="Hdac10"
                     /note="histone deacetylase 10"
                     /db_xref="GeneID:362981"
                     /db_xref="RGD:1305874"
     exon            1..264
                     /gene="Hdac10"
                     /inference="alignment:Splign:2.1.0"
     CDS             206..2206
                     /gene="Hdac10"
                     /EC_number="3.5.1.48"
                     /EC_number="3.5.1.62"
                     /note="isoform 1 is encoded by transcript variant 1; HD10;
                     polyamine deacetylase HDAC10"
                     /codon_start=1
                     /product="polyamine deacetylase HDAC10 isoform 1"
                     /protein_id="NP_001401901.1"
                     /db_xref="GeneID:362981"
                     /db_xref="RGD:1305874"
                     /translation="MGTALVYHEDMTATRLLWDDPECEIECPERLTAALDGLRQRGLE
                     ERCQCLSVCEASEEELGLVHSPEYIALVQKTQTLDKEELHTLSKQYDAVYFHPDTFHC
                     ARLAAGAALRLVDAVLTGAVHNGVALVRPPGHHSQRAAANGFCVFNNVAIAARHAKQK
                     YGLQRILIVDWDVHHGQGIQYIFEDDPSVLYFSWHRYEHGNFWPFLPESDADTVGRGR
                     GQGFTVNLPWNQVGMGNADYLAAFLHVLLPLAFEFDPELVLVSAGFDSAIGDPEGQMQ
                     ATPECFAHLTQLLQVLAGGRICAVLEGGYHLESLAQSVCMMVQTLLGDPTPPLPGLMV
                     PCQSALESIQSVRTAQTPHWTSLQQNVAPVLSSSTHSPEGSSLPVLADSSTCTVAEDS
                     LSPCLDRPCHRPTPPICIAVALAVSGAALDLPPGVLHQEGSALREETEAWARLHKSQF
                     QDDDLAALGKSLCLLDGILDGQIRSAIATTTALATAATLGVLIQRCVAHRGQRLLCVA
                     LGQLDRPLDLAGNGRILWLSIRGKEADIWSMFHFSTPLPQTTGGFLSFILGLVLPLAY
                     GFQPDMVLMALGPAHGLQNAQAALLAAMLRSPVGGRILALVEEESILQLARTLAQVLH
                     GETPPSLGPFSMASPEEIQALMFLKAQLEPRWKLLQVAAPPP"
     exon            265..399
                     /gene="Hdac10"
                     /inference="alignment:Splign:2.1.0"
     exon            400..496
                     /gene="Hdac10"
                     /inference="alignment:Splign:2.1.0"
     exon            497..594
                     /gene="Hdac10"
                     /inference="alignment:Splign:2.1.0"
     exon            595..699
                     /gene="Hdac10"
                     /inference="alignment:Splign:2.1.0"
     exon            700..768
                     /gene="Hdac10"
                     /inference="alignment:Splign:2.1.0"
     exon            769..895
                     /gene="Hdac10"
                     /inference="alignment:Splign:2.1.0"
     exon            896..961
                     /gene="Hdac10"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1021
                     /gene="Hdac10"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1111
                     /gene="Hdac10"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1218
                     /gene="Hdac10"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1283
                     /gene="Hdac10"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1536
                     /gene="Hdac10"
                     /inference="alignment:Splign:2.1.0"
     exon            1537..1621
                     /gene="Hdac10"
                     /inference="alignment:Splign:2.1.0"
     exon            1622..1713
                     /gene="Hdac10"
                     /inference="alignment:Splign:2.1.0"
     exon            1714..1770
                     /gene="Hdac10"
                     /inference="alignment:Splign:2.1.0"
     exon            1771..1849
                     /gene="Hdac10"
                     /inference="alignment:Splign:2.1.0"
     exon            1850..2032
                     /gene="Hdac10"
                     /inference="alignment:Splign:2.1.0"
     exon            2033..2192
                     /gene="Hdac10"
                     /inference="alignment:Splign:2.1.0"
     exon            2193..2353
                     /gene="Hdac10"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtttccagc ggttagcttc tgactatcgg gcgggcttga gccgggacct ggtcttgggg
       61 tggttccctc ttgcccaggt ccagtgtcca ctacccggct ctgtcccaag cgagggctgt
      121 ttacgtgcat actgttaagt gagagtgggc agtgcaacca cctgccggca gagggcgtgt
      181 tgagttagag cggatcaaag tggccatggg cacagcactt gtgtaccacg aggacatgac
      241 agccacccga ctgctctggg atgaccctga gtgcgaaatt gagtgcccag agcgcctgac
      301 agctgccttg gatggcctgc ggcagcgtgg cctggaagaa aggtgccagt gtttgtcagt
      361 ttgtgaggca tcagaggaag agttgggact ggtgcacagc ccagaatata tagccctggt
      421 gcagaagacc cagaccctgg acaaagagga gctccacaca ctgtctaagc agtatgatgc
      481 tgtctacttc cacccggata cttttcactg tgcaaggctg gcagcggggg ctgcactgcg
      541 gctggtggat gctgtgctaa caggagctgt gcacaatggc gttgccctgg tgaggcctcc
      601 agggcaccat agtcagaggg cggctgccaa tggcttctgt gtgttcaaca acgtggctat
      661 agcagccaga catgccaagc agaaatacgg gctgcagagg attctcattg tcgactggga
      721 tgtccaccat ggccagggca tccagtatat ctttgaggat gaccccagtg tcctttattt
      781 ctcctggcac cgctatgagc atggaaactt ctggccgttc ctcccagagt ctgatgcaga
      841 cacagttggc cgagggcggg gccaaggttt cactgtcaat ttgccctgga accaggttgg
      901 gatgggaaat gctgactatt tggctgcctt cctgcatgtg ctgctcccgt tggcctttga
      961 gtttgaccct gagctggtgc tggtgtcagc tggattcgac tctgctattg gggaccctga
     1021 ggggcagatg caggccaccc ctgagtgctt tgcccatctt acacagctgc tacaggtgct
     1081 ggctggtggc cggatttgtg ctgtgttgga gggtggatac cacttagagt ccctagcaca
     1141 gtcagtgtgc atgatggtgc agacattgct tggtgacccc acacctcccc ttcctgggct
     1201 catggtgcca tgtcagagtg ccctggagtc tatccagagt gttcggacag cccagacccc
     1261 tcactggaca agcctccaac aaaacgtggc cccagttctg agttccagca cccactctcc
     1321 tgaagggagc tctctgcctg tgcttgctga cagttccaca tgtacagtag cagaggattc
     1381 actgagcccc tgcctggaca gaccgtgcca ccgccctacg cccccaatct gcatagctgt
     1441 tgccttggct gtgtcaggtg ctgccctgga cttacctcct ggagtgctcc atcaagaagg
     1501 gtcagccttg agggaggaga ccgaggcatg ggccaggctt cacaagtccc agtttcagga
     1561 cgacgatctt gccgcactgg ggaagagtct gtgcctctta gatggaatcc tggatgggca
     1621 gataagaagt gctatagcaa ccacaactgc ccttgccaca gcagcaactt tgggtgtgct
     1681 cattcagcga tgtgtagccc atagaggtca gaggcttctc tgtgtggccc tgggacaact
     1741 ggatcgaccc ctggaccttg caggcaatgg gagaattctg tggctcagca tccggggcaa
     1801 ggaggcagac atctggtcca tgttccactt ctccactcca ctgccacaga caactggagg
     1861 gtttctgagc ttcatcttgg gtctggtact gcccttagcc tatggcttcc agcctgacat
     1921 ggtgttgatg gccctggggc ccgcccatgg cctgcagaat gcccaagctg ctctcttggc
     1981 tgcaatgctt cggagcccag tagggggccg aattctagct ttagtggaag aggaatccat
     2041 actccagctt gcaagaaccc tggcacaggt attgcatgga gaaacacctc ccagtctggg
     2101 ccctttctcg atggcatctc cagaggagat ccaggccctt atgtttctaa aagctcagct
     2161 ggagcctcgg tggaagttgc tgcaggtggc tgctcctcca ccataaccgt gatcgccagt
     2221 cgcttgaaat cggccaaaga gggcgattcc tagttgaaga gcacactctg gcgcccatgg
     2281 cccgagacct acgtcccgtc tgtggcccag cttcctacct ccagaacaat aaacatcggc
     2341 taaacagaac aca
//
