LOCUS       NM_001025409            2035 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus histone deacetylase 1 (Hdac1), mRNA.
ACCESSION   NM_001025409 XM_216349
VERSION     NM_001025409.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2035)
  AUTHORS   Dunaway,L.S., Cook,A.K., Kellum,C.E., Edell,C., Botta,D.,
            Molina,P.A., Sedaka,R.S., d'Uscio,L.V., Katusic,Z.S., Pollock,D.M.,
            Inscho,E.W. and Pollock,J.S.
  TITLE     Endothelial histone deacetylase 1 activity impairs kidney
            microvascular NO signaling in rats fed a high-salt diet
  JOURNAL   Acta Physiol (Oxf) 240 (9), e14201 (2024)
   PUBMED   39007513
  REMARK    GeneRIF: Endothelial histone deacetylase 1 activity impairs kidney
            microvascular NO signaling in rats fed a high-salt diet.
REFERENCE   2  (bases 1 to 2035)
  AUTHORS   Yang,H.T., Wang,G., Zhu,P.C. and Xiao,Z.Y.
  TITLE     Silencing EIF3A ameliorates pulmonary arterial hypertension through
            HDAC1 and PTEN/PI3K/AKT pathway in vitro and in vivo
  JOURNAL   Exp Cell Res 426 (1), 113555 (2023)
   PUBMED   36921705
  REMARK    GeneRIF: Silencing EIF3A ameliorates pulmonary arterial
            hypertension through HDAC1 and PTEN/PI3K/AKT pathway in vitro and
            in vivo.
REFERENCE   3  (bases 1 to 2035)
  AUTHORS   Chen,Y., Cai,K., Du,Y., Liu,Z. and Gong,Y.
  TITLE     HDAC1 overexpression promoted by METTL3-IGF2BP2 inhibits FGF21
            expression in metabolic syndrome-related liver injury
  JOURNAL   Biochem Cell Biol 101 (1), 52-63 (2023)
   PUBMED   36542845
  REMARK    GeneRIF: HDAC1 overexpression promoted by METTL3-IGF2BP2 inhibits
            FGF21 expression in metabolic syndrome-related liver injury.
REFERENCE   4  (bases 1 to 2035)
  AUTHORS   Pascoal,T.A., Chamoun,M., Lax,E., Wey,H.Y., Shin,M., Ng,K.P.,
            Kang,M.S., Mathotaarachchi,S., Benedet,A.L., Therriault,J.,
            Lussier,F.Z., Schroeder,F.A., DuBois,J.M., Hightower,B.G.,
            Gilbert,T.M., Zurcher,N.R., Wang,C., Hopewell,R., Chakravarty,M.,
            Savard,M., Thomas,E., Mohaddes,S., Farzin,S., Salaciak,A.,
            Tullo,S., Cuello,A.C., Soucy,J.P., Massarweh,G., Hwang,H.,
            Kobayashi,E., Hyman,B.T., Dickerson,B.C., Guiot,M.C., Szyf,M.,
            Gauthier,S., Hooker,J.M. and Rosa-Neto,P.
  TITLE     [11C]Martinostat PET analysis reveals reduced HDAC I availability
            in Alzheimer's disease
  JOURNAL   Nat Commun 13 (1), 4171 (2022)
   PUBMED   35853847
  REMARK    GeneRIF: [(11)C]Martinostat PET analysis reveals reduced HDAC I
            availability in Alzheimer's disease.
            Erratum:[Nat Commun. 2022 Oct 3;13(1):5833. doi:
            10.1038/s41467-022-33668-0.. PMID: 36192402]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2035)
  AUTHORS   Grabowska,A., Sas-Nowosielska,H., Wojtas,B., Holm-Kaczmarek,D.,
            Januszewicz,E., Yushkevich,Y., Czaban,I., Trzaskoma,P.,
            Krawczyk,K., Gielniewski,B., Martin-Gonzalez,A., Filipkowski,R.K.,
            Olszynski,K.H., Bernas,T., Szczepankiewicz,A.A., Sliwinska,M.A.,
            Kanhema,T., Bramham,C.R., Bokota,G., Plewczynski,D.,
            Wilczynski,G.M. and Magalska,A.
  TITLE     Activation-induced chromatin reorganization in neurons depends on
            HDAC1 activity
  JOURNAL   Cell Rep 38 (7), 110352 (2022)
   PUBMED   35172152
  REMARK    GeneRIF: Activation-induced chromatin reorganization in neurons
            depends on HDAC1 activity.
REFERENCE   6  (bases 1 to 2035)
  AUTHORS   Cai,R.L., Yan-Neale,Y., Cueto,M.A., Xu,H. and Cohen,D.
  TITLE     HDAC1, a histone deacetylase, forms a complex with Hus1 and Rad9,
            two G2/M checkpoint Rad proteins
  JOURNAL   J Biol Chem 275 (36), 27909-27916 (2000)
   PUBMED   10846170
REFERENCE   7  (bases 1 to 2035)
  AUTHORS   Fuks,F., Burgers,W.A., Brehm,A., Hughes-Davies,L. and Kouzarides,T.
  TITLE     DNA methyltransferase Dnmt1 associates with histone deacetylase
            activity
  JOURNAL   Nat Genet 24 (1), 88-91 (2000)
   PUBMED   10615135
REFERENCE   8  (bases 1 to 2035)
  AUTHORS   Huang,Y., Myers,S.J. and Dingledine,R.
  TITLE     Transcriptional repression by REST: recruitment of Sin3A and
            histone deacetylase to neuronal genes
  JOURNAL   Nat Neurosci 2 (10), 867-872 (1999)
   PUBMED   10491605
REFERENCE   9  (bases 1 to 2035)
  AUTHORS   Bartl,S., Taplick,J., Lagger,G., Khier,H., Kuchler,K. and Seiser,C.
  TITLE     Identification of mouse histone deacetylase 1 as a growth
            factor-inducible gene
  JOURNAL   Mol Cell Biol 17 (9), 5033-5043 (1997)
   PUBMED   9271381
REFERENCE   10 (bases 1 to 2035)
  AUTHORS   Yang,W.M., Inouye,C., Zeng,Y., Bearss,D. and Seto,E.
  TITLE     Transcriptional repression by YY1 is mediated by interaction with a
            mammalian homolog of the yeast global regulator RPD3
  JOURNAL   Proc Natl Acad Sci U S A 93 (23), 12845-12850 (1996)
   PUBMED   8917507
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC097943.1.
            
            On Jul 15, 2005 this sequence version replaced XM_216349.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC097943.1, BC107476.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2035
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..2035
                     /gene="Hdac1"
                     /note="histone deacetylase 1"
                     /db_xref="GeneID:297893"
                     /db_xref="RGD:1309799"
     exon            1..67
                     /gene="Hdac1"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..1467
                     /gene="Hdac1"
                     /EC_number="3.5.1.98"
                     /note="HD1; protein deacetylase HDAC1; protein
                     decrotonylase HDAC1; protein deacylase HDAC1"
                     /codon_start=1
                     /product="histone deacetylase 1"
                     /protein_id="NP_001020580.1"
                     /db_xref="GeneID:297893"
                     /db_xref="RGD:1309799"
                     /translation="MAQTQGTKRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLN
                     YGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPV
                     FDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAI
                     LELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGK
                     GKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNL
                     TIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYF
                     EYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEE
                     SGDEDEEDPDKRISICSSDKRIACEEEFSDSDEEGEGGRKNSSNFKKAKRVKTEDEKE
                     KDPEEKKEVTEEEKTKEEKPEAKGVKEEVKMA"
     exon            68..180
                     /gene="Hdac1"
                     /inference="alignment:Splign:2.1.0"
     exon            181..298
                     /gene="Hdac1"
                     /inference="alignment:Splign:2.1.0"
     exon            299..373
                     /gene="Hdac1"
                     /inference="alignment:Splign:2.1.0"
     exon            374..512
                     /gene="Hdac1"
                     /inference="alignment:Splign:2.1.0"
     exon            513..654
                     /gene="Hdac1"
                     /inference="alignment:Splign:2.1.0"
     exon            655..747
                     /gene="Hdac1"
                     /inference="alignment:Splign:2.1.0"
     exon            748..856
                     /gene="Hdac1"
                     /inference="alignment:Splign:2.1.0"
     exon            857..997
                     /gene="Hdac1"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1106
                     /gene="Hdac1"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1237
                     /gene="Hdac1"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1390
                     /gene="Hdac1"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1439
                     /gene="Hdac1"
                     /inference="alignment:Splign:2.1.0"
     exon            1440..2010
                     /gene="Hdac1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtccgggcgg cgagcaagat ggcgcagact cagggcacca agaggaaagt ctgttactac
       61 tacgacgggg atgttggaaa ctactattat ggacaagggc acccaatgaa gcctcaccga
      121 atccgaatga ctcataattt gctgctcaac tatggtctct accgaaaaat ggaaatctat
      181 cgtcctcaca aagccaacgc tgaggagatg accaagtacc acagcgacga ctacatcaag
      241 ttcttgcgtt ctattcgccc agacaatatg tctgaataca gcaagcagat gcagagattc
      301 aacgtgggtg aggactgtcc ggtatttgat ggcttgtttg agttctgtca gttgtccacg
      361 ggtggctctg tcgcgagtgc tgtgaaactc aataagcagc agacggacat cgctgtgaac
      421 tgggctgggg gcctgcacca tgcgaagaag tctgaagcat ccggcttctg ttacgtcaat
      481 gatattgtct tggccatcct ggaactgcta aagtatcacc agagggtgct gtatattgac
      541 attgacattc accatggcga tggcgtggaa gaggccttct ataccacaga ccgggtcatg
      601 actgtgtcct ttcataaata cggagagtac ttcccaggaa ctggggacct acgggatatt
      661 ggggctggca aaggcaagta ctacgccgtt aactacccac tgcgagatgg cattgatgat
      721 gagtcctatg aagccatctt taagccagtc atgtccaaag taatggagat gttccagcct
      781 agtgcagtgg tcctacagtg cggctcagac tccctgtctg gggatcggct aggttgcttc
      841 aatctgacca tcaaaggaca tgccaagtgt gtggagttcg tgaagagttt caacttgccg
      901 atgctaatgt tgggaggagg tggctatacc atccgtaatg tcgctcggtg ctggacttac
      961 gagacagctg tggccctgga cacagagatc cctaatgagc taccatacaa tgactacttt
     1021 gaatactttg gaccagattt caagcttcac atcagccctt ccaatatgac taaccagaac
     1081 actaatgaat acctggagaa gatcaagcag cggctctttg agaacttgag aatgctgccc
     1141 catgcccctg gggtccaaat gcaggccatc ccagaggatg ccatcccaga agagagcggt
     1201 gatgaggatg aggaagaccc tgacaaacga atttccatct gctcctctga caaacgcatt
     1261 gcctgtgagg aggaattctc tgattctgat gaggagggag aaggaggtcg caagaactct
     1321 tctaacttca aaaaagccaa aagagtcaaa acagaagatg aaaaagaaaa agatcccgag
     1381 gagaaaaaag aagtcacaga agaggagaaa accaaggagg agaagccaga agccaaaggg
     1441 gtcaaagaag aggtcaagat ggcctgagca aggtctgcag ctccatcttc tctccaagtc
     1501 ccttactttc cctcaatttc tcagatttta tattttctat tcctgtgtat ttatataaaa
     1561 tatattaaat ataacgtccc cagggactag atagggacca gcgcacaggg cagtggtact
     1621 gggagaactc ttcttcccag agctcccttg tccgtcctgc cctaggtctg agttttgaac
     1681 cacgtagggt ccaggtgaaa agaaaacaac cggaagacta aatcctgaac tgcaagtgcc
     1741 tgcttaggag ctctgctagg atggccttgt taagcttttc agcaggggcg actgtgtctt
     1801 ctggggcccc ttttcaggct tgggtaatat cagccatttt tagattggtt ctgtttctac
     1861 cttcccaccc accccgggca agcagaaaaa cttacactgc cccgtcttcc cccaattctg
     1921 caggtggagg ttgttagcct agcttccttt ttgagatatt ttcatttttg tgagactctt
     1981 tgtaataaaa cagcgcgttt ctataccttc aaaaaaaaaa aaaaaaaaaa aaaaa
//
