LOCUS       NP_001020580             482 aa            linear   ROD 10-FEB-2025
DEFINITION  histone deacetylase 1 [Rattus norvegicus].
ACCESSION   NP_001020580 XP_216349
VERSION     NP_001020580.1
DBSOURCE    REFSEQ: accession NM_001025409.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 482)
  AUTHORS   Dunaway,L.S., Cook,A.K., Kellum,C.E., Edell,C., Botta,D.,
            Molina,P.A., Sedaka,R.S., d'Uscio,L.V., Katusic,Z.S., Pollock,D.M.,
            Inscho,E.W. and Pollock,J.S.
  TITLE     Endothelial histone deacetylase 1 activity impairs kidney
            microvascular NO signaling in rats fed a high-salt diet
  JOURNAL   Acta Physiol (Oxf) 240 (9), e14201 (2024)
   PUBMED   39007513
  REMARK    GeneRIF: Endothelial histone deacetylase 1 activity impairs kidney
            microvascular NO signaling in rats fed a high-salt diet.
REFERENCE   2  (residues 1 to 482)
  AUTHORS   Yang,H.T., Wang,G., Zhu,P.C. and Xiao,Z.Y.
  TITLE     Silencing EIF3A ameliorates pulmonary arterial hypertension through
            HDAC1 and PTEN/PI3K/AKT pathway in vitro and in vivo
  JOURNAL   Exp Cell Res 426 (1), 113555 (2023)
   PUBMED   36921705
  REMARK    GeneRIF: Silencing EIF3A ameliorates pulmonary arterial
            hypertension through HDAC1 and PTEN/PI3K/AKT pathway in vitro and
            in vivo.
REFERENCE   3  (residues 1 to 482)
  AUTHORS   Chen,Y., Cai,K., Du,Y., Liu,Z. and Gong,Y.
  TITLE     HDAC1 overexpression promoted by METTL3-IGF2BP2 inhibits FGF21
            expression in metabolic syndrome-related liver injury
  JOURNAL   Biochem Cell Biol 101 (1), 52-63 (2023)
   PUBMED   36542845
  REMARK    GeneRIF: HDAC1 overexpression promoted by METTL3-IGF2BP2 inhibits
            FGF21 expression in metabolic syndrome-related liver injury.
REFERENCE   4  (residues 1 to 482)
  AUTHORS   Pascoal,T.A., Chamoun,M., Lax,E., Wey,H.Y., Shin,M., Ng,K.P.,
            Kang,M.S., Mathotaarachchi,S., Benedet,A.L., Therriault,J.,
            Lussier,F.Z., Schroeder,F.A., DuBois,J.M., Hightower,B.G.,
            Gilbert,T.M., Zurcher,N.R., Wang,C., Hopewell,R., Chakravarty,M.,
            Savard,M., Thomas,E., Mohaddes,S., Farzin,S., Salaciak,A.,
            Tullo,S., Cuello,A.C., Soucy,J.P., Massarweh,G., Hwang,H.,
            Kobayashi,E., Hyman,B.T., Dickerson,B.C., Guiot,M.C., Szyf,M.,
            Gauthier,S., Hooker,J.M. and Rosa-Neto,P.
  TITLE     [11C]Martinostat PET analysis reveals reduced HDAC I availability
            in Alzheimer's disease
  JOURNAL   Nat Commun 13 (1), 4171 (2022)
   PUBMED   35853847
  REMARK    GeneRIF: [(11)C]Martinostat PET analysis reveals reduced HDAC I
            availability in Alzheimer's disease.
            Erratum:[Nat Commun. 2022 Oct 3;13(1):5833. doi:
            10.1038/s41467-022-33668-0.. PMID: 36192402]
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 482)
  AUTHORS   Grabowska,A., Sas-Nowosielska,H., Wojtas,B., Holm-Kaczmarek,D.,
            Januszewicz,E., Yushkevich,Y., Czaban,I., Trzaskoma,P.,
            Krawczyk,K., Gielniewski,B., Martin-Gonzalez,A., Filipkowski,R.K.,
            Olszynski,K.H., Bernas,T., Szczepankiewicz,A.A., Sliwinska,M.A.,
            Kanhema,T., Bramham,C.R., Bokota,G., Plewczynski,D.,
            Wilczynski,G.M. and Magalska,A.
  TITLE     Activation-induced chromatin reorganization in neurons depends on
            HDAC1 activity
  JOURNAL   Cell Rep 38 (7), 110352 (2022)
   PUBMED   35172152
  REMARK    GeneRIF: Activation-induced chromatin reorganization in neurons
            depends on HDAC1 activity.
REFERENCE   6  (residues 1 to 482)
  AUTHORS   Cai,R.L., Yan-Neale,Y., Cueto,M.A., Xu,H. and Cohen,D.
  TITLE     HDAC1, a histone deacetylase, forms a complex with Hus1 and Rad9,
            two G2/M checkpoint Rad proteins
  JOURNAL   J Biol Chem 275 (36), 27909-27916 (2000)
   PUBMED   10846170
REFERENCE   7  (residues 1 to 482)
  AUTHORS   Fuks,F., Burgers,W.A., Brehm,A., Hughes-Davies,L. and Kouzarides,T.
  TITLE     DNA methyltransferase Dnmt1 associates with histone deacetylase
            activity
  JOURNAL   Nat Genet 24 (1), 88-91 (2000)
   PUBMED   10615135
REFERENCE   8  (residues 1 to 482)
  AUTHORS   Huang,Y., Myers,S.J. and Dingledine,R.
  TITLE     Transcriptional repression by REST: recruitment of Sin3A and
            histone deacetylase to neuronal genes
  JOURNAL   Nat Neurosci 2 (10), 867-872 (1999)
   PUBMED   10491605
REFERENCE   9  (residues 1 to 482)
  AUTHORS   Bartl,S., Taplick,J., Lagger,G., Khier,H., Kuchler,K. and Seiser,C.
  TITLE     Identification of mouse histone deacetylase 1 as a growth
            factor-inducible gene
  JOURNAL   Mol Cell Biol 17 (9), 5033-5043 (1997)
   PUBMED   9271381
REFERENCE   10 (residues 1 to 482)
  AUTHORS   Yang,W.M., Inouye,C., Zeng,Y., Bearss,D. and Seto,E.
  TITLE     Transcriptional repression by YY1 is mediated by interaction with a
            mammalian homolog of the yeast global regulator RPD3
  JOURNAL   Proc Natl Acad Sci U S A 93 (23), 12845-12850 (1996)
   PUBMED   8917507
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC097943.1.
            
            On Jul 15, 2005 this sequence version replaced XP_216349.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC097943.1, BC107476.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..482
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     Protein         1..482
                     /product="histone deacetylase 1"
                     /EC_number="3.5.1.98"
                     /note="HD1; protein deacetylase HDAC1; protein
                     decrotonylase HDAC1; protein deacylase HDAC1"
                     /calculated_mol_wt=54962
     Region          4..374
                     /region_name="HDAC1"
                     /note="Histone deacetylase 1 (HDAC1); cd10010"
                     /db_xref="CDD:212534"
     Region          9..321
                     /region_name="Histone deacetylase"
                     /note="propagated from UniProtKB/Swiss-Prot (Q4QQW4.1)"
     Site            74
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:Q13547; propagated from
                     UniProtKB/Swiss-Prot (Q4QQW4.1)"
     Site            order(140..141,149..150,176,178,264,271,301,303)
                     /site_type="active"
                     /db_xref="CDD:212534"
     Site            220
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q13547; propagated from
                     UniProtKB/Swiss-Prot (Q4QQW4.1)"
     Region          390..482
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q4QQW4.1)"
     Site            393
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:16641100,
                     ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q4QQW4.1)"
     Site            406
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q92769; propagated from
                     UniProtKB/Swiss-Prot (Q4QQW4.1)"
     Site            409
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q13547; propagated from
                     UniProtKB/Swiss-Prot (Q4QQW4.1)"
     Site            421
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q4QQW4.1)"
     Site            423
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q4QQW4.1)"
     Site            432
                     /site_type="methylation"
                     /note="N6-methylated lysine, by EHMT2.
                     /evidence=ECO:0000250|UniProtKB:Q13547; propagated from
                     UniProtKB/Swiss-Prot (Q4QQW4.1)"
     CDS             1..482
                     /gene="Hdac1"
                     /coded_by="NM_001025409.1:19..1467"
                     /db_xref="GeneID:297893"
                     /db_xref="RGD:1309799"
ORIGIN      
        1 maqtqgtkrk vcyyydgdvg nyyygqghpm kphrirmthn lllnyglyrk meiyrphkan
       61 aeemtkyhsd dyikflrsir pdnmseyskq mqrfnvgedc pvfdglfefc qlstggsvas
      121 avklnkqqtd iavnwagglh hakkseasgf cyvndivlai lellkyhqrv lyididihhg
      181 dgveeafytt drvmtvsfhk ygeyfpgtgd lrdigagkgk yyavnyplrd giddesyeai
      241 fkpvmskvme mfqpsavvlq cgsdslsgdr lgcfnltikg hakcvefvks fnlpmlmlgg
      301 ggytirnvar cwtyetaval dteipnelpy ndyfeyfgpd fklhispsnm tnqntneyle
      361 kikqrlfenl rmlphapgvq mqaipedaip eesgdedeed pdkrisicss dkriaceeef
      421 sdsdeegegg rknssnfkka krvktedeke kdpeekkevt eeektkeekp eakgvkeevk
      481 ma
//
