LOCUS       NM_001005900             446 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus hematopoietic cell signal transducer (Hcst),
            mRNA.
ACCESSION   NM_001005900 XM_579155
VERSION     NM_001005900.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 446)
  AUTHORS   Saether,P.C., Hoelsbrekken,S.E., Fossum,S. and Dissen,E.
  TITLE     Rat and mouse CD94 associate directly with the activating
            transmembrane adaptor proteins DAP12 and DAP10 and activate NK cell
            cytotoxicity
  JOURNAL   J Immunol 187 (12), 6365-6373 (2011)
   PUBMED   22084441
  REMARK    GeneRIF: Both adaptor proteins DAP12 and DAP10 can associate with
            rat CD94/NKG2C; rat CD94 coimmunoprecipitates with both DAP12 and
            DAP10.
REFERENCE   2  (bases 1 to 446)
  AUTHORS   Rosen,D.B., Araki,M., Hamerman,J.A., Chen,T., Yamamura,T. and
            Lanier,L.L.
  TITLE     A Structural basis for the association of DAP12 with mouse, but not
            human, NKG2D
  JOURNAL   J Immunol 173 (4), 2470-2478 (2004)
   PUBMED   15294961
REFERENCE   3  (bases 1 to 446)
  AUTHORS   Chang,C., Dietrich,J., Harpur,A.G., Lindquist,J.A., Haude,A.,
            Loke,Y.W., King,A., Colonna,M., Trowsdale,J. and Wilson,M.J.
  TITLE     Cutting edge: KAP10, a novel transmembrane adapter protein
            genetically linked to DAP12 but with unique signaling properties
  JOURNAL   J Immunol 163 (9), 4651-4654 (1999)
   PUBMED   10528161
REFERENCE   4  (bases 1 to 446)
  AUTHORS   Wu,J., Song,Y., Bakker,A.B., Bauer,S., Spies,T., Lanier,L.L. and
            Phillips,J.H.
  TITLE     An activating immunoreceptor complex formed by NKG2D and DAP10
  JOURNAL   Science 285 (5428), 730-732 (1999)
   PUBMED   10426994
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY247020.1.
            
            On Apr 19, 2005 this sequence version replaced XM_579155.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY247020.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760393,
                                           SAMEA5760400 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..446
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="F344"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..446
                     /gene="Hcst"
                     /gene_synonym="Dap10"
                     /note="hematopoietic cell signal transducer"
                     /db_xref="GeneID:474146"
                     /db_xref="RGD:1359238"
     exon            1..114
                     /gene="Hcst"
                     /gene_synonym="Dap10"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..311
                     /gene="Hcst"
                     /gene_synonym="Dap10"
                     /note="membrane protein DAP10; DNAX-activation protein 10"
                     /codon_start=1
                     /product="hematopoietic cell signal transducer precursor"
                     /protein_id="NP_001005900.1"
                     /db_xref="GeneID:474146"
                     /db_xref="RGD:1359238"
                     /translation="MAPPGHLLFLFLLPVAASQTNEGSCSGCGPLSLPLLAGLVAADA
                     VMSLLIVGVVFVCMRLHSRPAQEDGRVYINMPGRG"
     exon            115..138
                     /gene="Hcst"
                     /gene_synonym="Dap10"
                     /inference="alignment:Splign:2.1.0"
     exon            139..270
                     /gene="Hcst"
                     /gene_synonym="Dap10"
                     /inference="alignment:Splign:2.1.0"
     exon            271..424
                     /gene="Hcst"
                     /gene_synonym="Dap10"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcctctctgc tgctcctcta ctgttctgaa gatcacaatt ttgaccagat cctttcaagt
       61 cccagcccag catggcccct ccaggtcacc tcctgttcct gttcctgctc ccagtggccg
      121 caagtcagac aaacgaaggt tcctgctccg gatgtgggcc tctgtccctg ccactcctgg
      181 caggcctggt ggctgcagat gcggtcatgt cacttctaat agtgggggtg gtgtttgtat
      241 gtatgcgcct acacagcagg cctgcccaag aagatggtcg agtctacatc aacatgcctg
      301 ggagaggctg acagctgcac cttccacttt tgtcttccaa ccatcctcga tcgcatgagg
      361 gtggggtagg gagcgtggga atgcattttc ttccggacta gaataaagca ttcaaatacc
      421 tctaaaaaaa aaaaaaaaaa aaaaaa
//
