LOCUS       NM_013074               3151 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus hypocretin receptor 2 (Hcrtr2), transcript
            variant 1, mRNA.
ACCESSION   NM_013074
VERSION     NM_013074.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3151)
  AUTHORS   Zamanirad,F., Eskandari,K., Mousavi,Z. and Haghparast,A.
  TITLE     Blockade of the orexin-2 receptors within the ventral tegmental
            area facilitates the extinction and prevents the reinstatement of
            methamphetamine-seeking behavior
  JOURNAL   Physiol Behav 273, 114382 (2024)
   PUBMED   37866644
  REMARK    GeneRIF: Blockade of the orexin-2 receptors within the ventral
            tegmental area facilitates the extinction and prevents the
            reinstatement of methamphetamine-seeking behavior.
REFERENCE   2  (bases 1 to 3151)
  AUTHORS   Nazari-Serenjeh,F., Azizbeigi,R., Rashvand,M., Mesgar,S.,
            Amirteymori,H. and Haghparast,A.
  TITLE     Distinct roles for orexin-1 and orexin-2 receptors in the dentate
            gyrus of the hippocampus in the methamphetamine-seeking behavior in
            the rats
  JOURNAL   Life Sci 312, 121262 (2023)
   PUBMED   36470538
  REMARK    GeneRIF: Distinct roles for orexin-1 and orexin-2 receptors in the
            dentate gyrus of the hippocampus in the methamphetamine-seeking
            behavior in the rats.
REFERENCE   3  (bases 1 to 3151)
  AUTHORS   Zareie,F., Ghalebandi,S., Askari,K., Mousavi,Z. and Haghparast,A.
  TITLE     Orexin receptors in the CA1 region of hippocampus modulate the
            stress-induced antinociceptive responses in an animal model of
            persistent inflammatory pain
  JOURNAL   Peptides 147, 170679 (2022)
   PUBMED   34718063
  REMARK    GeneRIF: Orexin receptors in the CA1 region of hippocampus modulate
            the stress-induced antinociceptive responses in an animal model of
            persistent inflammatory pain.
REFERENCE   4  (bases 1 to 3151)
  AUTHORS   Abounoori,M., Maddah,M.M., Akbari,E., Houshmand,G. and
            Ardeshiri,M.R.
  TITLE     The Effect of Orexin Receptor Antagonism on Quinpirole-Induced
            Compulsive-Like Checking Behavior in Rats
  JOURNAL   Neurotox Res 38 (1), 18-26 (2020)
   PUBMED   32207079
  REMARK    GeneRIF: The Effect of Orexin Receptor Antagonism on
            Quinpirole-Induced Compulsive-Like Checking Behavior in Rats.
REFERENCE   5  (bases 1 to 3151)
  AUTHORS   Dai,Y.E., Lee,Y.H., Li,T.L. and Hwang,L.L.
  TITLE     Mechanisms of orexin 2 receptor-mediated depolarization in the rat
            paraventricular nucleus of the hypothalamus
  JOURNAL   Eur J Pharmacol 869, 172802 (2020)
   PUBMED   31738930
  REMARK    GeneRIF: Mechanisms of orexin 2 receptor-mediated depolarization in
            the rat paraventricular nucleus of the hypothalamus.
REFERENCE   6  (bases 1 to 3151)
  AUTHORS   Johren,O., Neidert,S.J., Kummer,M., Dendorfer,A. and Dominiak,P.
  TITLE     Prepro-orexin and orexin receptor mRNAs are differentially
            expressed in peripheral tissues of male and female rats
  JOURNAL   Endocrinology 142 (8), 3324-3331 (2001)
   PUBMED   11459774
  REMARK    GeneRIF: Orexin receptor expression was studies in various tissues.
            OX2R is sexually dimorphic expressed in adrenal glands.
REFERENCE   7  (bases 1 to 3151)
  AUTHORS   Hungs,M. and Mignot,E.
  TITLE     Hypocretin/orexin, sleep and narcolepsy
  JOURNAL   Bioessays 23 (5), 397-408 (2001)
   PUBMED   11340621
  REMARK    Review article
REFERENCE   8  (bases 1 to 3151)
  AUTHORS   Hungs,M., Fan,J., Lin,L., Lin,X., Maki,R.A. and Mignot,E.
  TITLE     Identification and functional analysis of mutations in the
            hypocretin (orexin) genes of narcoleptic canines
  JOURNAL   Genome Res 11 (4), 531-539 (2001)
   PUBMED   11282968
REFERENCE   9  (bases 1 to 3151)
  AUTHORS   Willie,J.T., Chemelli,R.M., Sinton,C.M. and Yanagisawa,M.
  TITLE     To eat or to sleep? Orexin in the regulation of feeding and
            wakefulness
  JOURNAL   Annu Rev Neurosci 24, 429-458 (2001)
   PUBMED   11283317
  REMARK    Review article
REFERENCE   10 (bases 1 to 3151)
  AUTHORS   Sakurai,T., Amemiya,A., Ishii,M., Matsuzaki,I., Chemelli,R.M.,
            Tanaka,H., Williams,S.C., Richardson,J.A., Kozlowski,G.P.,
            Wilson,S., Arch,J.R., Buckingham,R.E., Haynes,A.C., Carr,S.A.,
            Annan,R.S., McNulty,D.E., Liu,W.S., Terrett,J.A., Elshourbagy,N.A.,
            Bergsma,D.J. and Yanagisawa,M.
  TITLE     Orexins and orexin receptors: a family of hypothalamic
            neuropeptides and G protein-coupled receptors that regulate feeding
            behavior
  JOURNAL   Cell 92 (4), 573-585 (1998)
   PUBMED   9491897
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 18, 2021 this sequence version replaced NM_013074.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF041246.1, SRR26360176.2460921.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840105, SAMN12840109
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-342               JAXUCZ010000008.1  85986064-85986405   c
            343-521             JAXUCZ010000008.1  85911095-85911273   c
            522-765             JAXUCZ010000008.1  85906853-85907096   c
            766-881             JAXUCZ010000008.1  85899282-85899397   c
            882-1102            JAXUCZ010000008.1  85879639-85879859   c
            1103-1224           JAXUCZ010000008.1  85876493-85876614   c
            1225-1447           JAXUCZ010000008.1  85874391-85874613   c
            1448-3151           JAXUCZ010000008.1  85870279-85871982   c
FEATURES             Location/Qualifiers
     source          1..3151
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..3151
                     /gene="Hcrtr2"
                     /gene_synonym="ox-2-R; ox2-R; ox2r"
                     /note="hypocretin receptor 2"
                     /db_xref="GeneID:25605"
                     /db_xref="RGD:2788"
     exon            1..342
                     /gene="Hcrtr2"
                     /gene_synonym="ox-2-R; ox2-R; ox2r"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..1502
                     /gene="Hcrtr2"
                     /gene_synonym="ox-2-R; ox2-R; ox2r"
                     /note="isoform 1 is encoded by transcript variant 1;
                     orexin receptor type 2; hypocretin receptor type 2;
                     hypocretin (orexin) receptor 2"
                     /codon_start=1
                     /product="orexin receptor type 2 isoform 1"
                     /protein_id="NP_037206.1"
                     /db_xref="GeneID:25605"
                     /db_xref="RGD:2788"
                     /translation="MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLW
                     REYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVL
                     VTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPL
                     MFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEV
                     YPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPR
                     GSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFT
                     HTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDR
                     LARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVP
                     SSLLSTWLEV"
     exon            343..521
                     /gene="Hcrtr2"
                     /gene_synonym="ox-2-R; ox2-R; ox2r"
                     /inference="alignment:Splign:2.1.0"
     exon            522..765
                     /gene="Hcrtr2"
                     /gene_synonym="ox-2-R; ox2-R; ox2r"
                     /inference="alignment:Splign:2.1.0"
     exon            766..881
                     /gene="Hcrtr2"
                     /gene_synonym="ox-2-R; ox2-R; ox2r"
                     /inference="alignment:Splign:2.1.0"
     exon            882..1102
                     /gene="Hcrtr2"
                     /gene_synonym="ox-2-R; ox2-R; ox2r"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1224
                     /gene="Hcrtr2"
                     /gene_synonym="ox-2-R; ox2-R; ox2r"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1447
                     /gene="Hcrtr2"
                     /gene_synonym="ox-2-R; ox2-R; ox2r"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..3151
                     /gene="Hcrtr2"
                     /gene_synonym="ox-2-R; ox2-R; ox2r"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attcccggct ccagagcccc ttgtcgcggc ggcgcagcct ttcccaccgc gaatccccgg
       61 tgctcatggg gcaggcggag acaagcttgc agcactgagc cgaaccggac cagtccgtga
      121 tgtccagcac caaattggag gattccctcc ctcgtcgcaa ctggtcatct gcttcggagc
      181 tgaatgaaac tcaagagccg tttttaaacc ccacagacta tgacgacgag gaattcctgc
      241 ggtacctgtg gagggaatac ctacacccga aagaatatga gtgggtcctg atcgcagggt
      301 atatcatcgt gttcgtcgtg gctctcatcg ggaacgtcct ggtctgcgtg gcagtgtgga
      361 agaaccacca catgaggaca gtcaccaact acttcatagt caacctctcc ctggctgatg
      421 tgcttgtgac catcacctgc cttccagcca cccttgttgt tgacatcacc gagacttggt
      481 tctttggaca gtccctctgt aaggtcatcc cttatttaca gactgtgtca gtgtctgtgt
      541 ctgttcttac attgagctgc attgccttgg accgatggta cgccatttgt caccctttga
      601 tgttcaagag cacagccaaa cgggctcgaa acagcatcgt tgtcatctgg atcgtctcct
      661 gcatcataat gattcctcaa gccattgtca tggagcgcag cagcatgctc cctggcctag
      721 ccaataagac caccctcttt acagtctgcg atgaacgctg gggaggtgaa gtttacccaa
      781 agatgtacca catctgcttc tttctggtga cgtacatggc acccctgtgt cttatggtat
      841 tggcttatct ccaaatattc cgtaaactct ggtgcagaca gattcccgga acttcttctg
      901 tggttcagag aaaatggaag cagccgcagc cggtttctca gccccggggg tccggacagc
      961 agagcaaggc ccggattagc gctgtcgctg ctgagataaa gcagatccga gcacgaagga
     1021 aaacagcccg gatgctcatg gttgtacttc tggtctttgc aatttgctat ctaccaatca
     1081 gcatcctcaa tgtgctaaag agagtgttcg ggatgttcac acacaccgaa gacagagaga
     1141 ctgtctacgc ctggttcact ttttctcatt ggcttgtgta tgccaatagt gctgcaaacc
     1201 caattattta taattttctc agtggaaaat ttcgagagga atttaaagct gccttttctt
     1261 gctgtcttgg ggttcatcgt cgtcaaggag atcgcctcgc caggggacgc acaagtacag
     1321 agagcaggaa gtccctgact actcagatca gcaactttga taatgtatca aaactctcag
     1381 agcacgtggc gctcaccagc ataagcacac tcccagcagc caacggggca ggaccgcttc
     1441 aaaactggta tctacaacag ggagtgccat cttcactcct gtccacctgg ctggaggtct
     1501 gagggaagag acccgagcat ccttatggaa tctcacccat gtcttctcaa agagataatg
     1561 gtttacaaaa aaattgccac tgtgttctta gtgtgatgtt aaagaagatg gactttaagg
     1621 cacttatgcg ctttatgcgt aacccggatg acttgaggtt ttatttactg aagtttctgt
     1681 ttcgtggaag ccattcatgt tcaagaataa ttattgcctg gaagaaaact gataagtaaa
     1741 acacatacat aaatgatgaa ctggggatag aaccatgaac cctgtgtgta cttctcagca
     1801 ttagggccca tgaatctgga gagatttgga ttaatgtggt gaccttcata gtacaaatga
     1861 ttagaaaata aaacaggagg ccccaaatca tatcaatgtt gttggggtgc ttaactactt
     1921 cattatgtac taatgacaca aattagaaga cgtcatagga aggttttgct ttggaactga
     1981 gctatactga acattggaca ttgaccgacc tttatttcct ttgtatttca agccttcaat
     2041 gtgagatgtc aacgtcatta gttttgtcac taataagatg gtgtaataat tttaccaaat
     2101 atatttgaga tgaatgattt atggattttt ataatgtcat gaaaaccgta atattttgag
     2161 ttcattcctt tggggttaaa tattaaccca agtttatgag agggggaaaa aacatgattt
     2221 ctaaattttc cacaatgtgg aataataaag ctgttataaa ctattgataa gttcagtgta
     2281 aaaatgttag gcacagtact accccggttc accccagtgt acattaattc aggaagaata
     2341 attaactatg tttataagtg acaatctaaa tgtgtctaga gttgttacta atcataattg
     2401 aaatgagggc tattagcact ttgatacatt gtaacaatat caggcttgca ttagctgtga
     2461 attgtaacag gaattaactg catttcaaga aacatggcta gtccttacaa ttggaaacct
     2521 ttcagtggga cttaactttc aacagctctc actcttctac atcctgtcat aggcaaaagc
     2581 gtaaattcca ttagattatt ttcaaatagt ttccacattg cttgaggcaa actaatggga
     2641 attttaggat cattatataa gtaggagagt attcatttaa catcctctcc atcattttat
     2701 gcacagaaga aaacaacata aacctgaaaa tcactgttag ttctcgaagt tcaaagggaa
     2761 tgcttttcta cgctcttctg ctattgaaaa gggggacaga agactccccc aacttgccac
     2821 gtatttctat tcttttaaat tttctttata gactttggag ttagaaaaat ctgggttttt
     2881 catgaaatat gtttttatta ttgtatccat gtatgtatgt atcagcatgc cagttgttca
     2941 atagttattt acttaaaata attatatctt tatgcttgat tgtactgtgt cttcatgaag
     3001 atctttttca tataaaaatg tgattatatg tctcccaatg tgaaggttaa attatgtaat
     3061 ttttaggtaa aataatcgca tccatgttgt cttgttgtac catgtgaaaa attatgttgt
     3121 cgttcaatac ataaattgga tatttgctca t
//
