LOCUS       NM_013064               2569 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Rattus norvegicus hypocretin receptor 1 (Hcrtr1), mRNA.
ACCESSION   NM_013064
VERSION     NM_013064.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2569)
  AUTHORS   Chen,B., Jin,K., Dong,J., Cheng,S., Kong,L., Hu,S., Chen,Z. and
            Lu,J.
  TITLE     Hypocretin-1/Hypocretin Receptor 1 Regulates Neuroplasticity and
            Cognitive Function through Hippocampal Lactate Homeostasis in
            Depressed Model
  JOURNAL   Adv Sci (Weinh) 11 (38), e2405354 (2024)
   PUBMED   39119889
  REMARK    GeneRIF: Hypocretin-1/Hypocretin Receptor 1 Regulates
            Neuroplasticity and Cognitive Function through Hippocampal Lactate
            Homeostasis in Depressed Model.
REFERENCE   2  (bases 1 to 2569)
  AUTHORS   Dong,J., Zhang,J., Cheng,S., Qin,B., Jin,K., Chen,B., Zhang,Y. and
            Lu,J.
  TITLE     A high-fat diet induced depression-like phenotype via
            hypocretin-HCRTR1 mediated inflammation activation
  JOURNAL   Food Funct 15 (17), 8661-8673 (2024)
   PUBMED   39056112
  REMARK    GeneRIF: A high-fat diet induced depression-like phenotype via
            hypocretin-HCRTR1 mediated inflammation activation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2569)
  AUTHORS   Schuller,J. and Koch,M.
  TITLE     Blockade of the orexin 1-receptors and 'cocaine- and
            amphetamine-regulated transcript' in the nucleus accumbens shell
            alters impulse control in rats
  JOURNAL   Behav Brain Res 440, 114268 (2023)
   PUBMED   36539163
  REMARK    GeneRIF: Blockade of the orexin 1-receptors and 'cocaine- and
            amphetamine-regulated transcript' in the nucleus accumbens shell
            alters impulse control in rats.
REFERENCE   4  (bases 1 to 2569)
  AUTHORS   Veisi,A., Khaleghzadeh-Ahangar,H., Fattahi,M. and Haghparast,A.
  TITLE     The Role of Orexin-1 Receptors Within the Hippocampal CA1 Area in
            the Extinction and Reinstatement of Methamphetamine-Seeking
            Behaviors
  JOURNAL   Neurochem Res 48 (2), 671-680 (2023)
   PUBMED   36284025
  REMARK    GeneRIF: The Role of Orexin-1 Receptors Within the Hippocampal CA1
            Area in the Extinction and Reinstatement of Methamphetamine-Seeking
            Behaviors.
REFERENCE   5  (bases 1 to 2569)
  AUTHORS   Nazari-Serenjeh,F., Azizbeigi,R., Rashvand,M., Mesgar,S.,
            Amirteymori,H. and Haghparast,A.
  TITLE     Distinct roles for orexin-1 and orexin-2 receptors in the dentate
            gyrus of the hippocampus in the methamphetamine-seeking behavior in
            the rats
  JOURNAL   Life Sci 312, 121262 (2023)
   PUBMED   36470538
  REMARK    GeneRIF: Distinct roles for orexin-1 and orexin-2 receptors in the
            dentate gyrus of the hippocampus in the methamphetamine-seeking
            behavior in the rats.
REFERENCE   6  (bases 1 to 2569)
  AUTHORS   Wieland,H.A., Soll,R.M., Doods,H.N., Stenkamp,D., Hurnaus,R.,
            Lammle,B. and Beck-Sickinger,A.G.
  TITLE     The SK-N-MC cell line expresses an orexin binding site different
            from recombinant orexin 1-type receptor
  JOURNAL   Eur J Biochem 269 (4), 1128-1135 (2002)
   PUBMED   11856342
REFERENCE   7  (bases 1 to 2569)
  AUTHORS   Backberg,M., Hervieu,G., Wilson,S. and Meister,B.
  TITLE     Orexin receptor-1 (OX-R1) immunoreactivity in chemically identified
            neurons of the hypothalamus: focus on orexin targets involved in
            control of food and water intake
  JOURNAL   Eur J Neurosci 15 (2), 315-328 (2002)
   PUBMED   11849298
  REMARK    GeneRIF: Neurons containing Orexin 1 receptor immunoreactivity were
            widely distributed in the hypothalamus
REFERENCE   8  (bases 1 to 2569)
  AUTHORS   Hungs,M. and Mignot,E.
  TITLE     Hypocretin/orexin, sleep and narcolepsy
  JOURNAL   Bioessays 23 (5), 397-408 (2001)
   PUBMED   11340621
  REMARK    Review article
REFERENCE   9  (bases 1 to 2569)
  AUTHORS   Willie,J.T., Chemelli,R.M., Sinton,C.M. and Yanagisawa,M.
  TITLE     To eat or to sleep? Orexin in the regulation of feeding and
            wakefulness
  JOURNAL   Annu Rev Neurosci 24, 429-458 (2001)
   PUBMED   11283317
  REMARK    Review article
REFERENCE   10 (bases 1 to 2569)
  AUTHORS   Sakurai,T., Amemiya,A., Ishii,M., Matsuzaki,I., Chemelli,R.M.,
            Tanaka,H., Williams,S.C., Richardson,J.A., Kozlowski,G.P.,
            Wilson,S., Arch,J.R., Buckingham,R.E., Haynes,A.C., Carr,S.A.,
            Annan,R.S., McNulty,D.E., Liu,W.S., Terrett,J.A., Elshourbagy,N.A.,
            Bergsma,D.J. and Yanagisawa,M.
  TITLE     Orexins and orexin receptors: a family of hypothalamic
            neuropeptides and G protein-coupled receptors that regulate feeding
            behavior
  JOURNAL   Cell 92 (4), 573-585 (1998)
   PUBMED   9491897
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FN803424.1, JAXUCZ010000005.1 and AF041244.1.
            
            On Nov 20, 2020 this sequence version replaced NM_013064.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR26360194.44085.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN14984043, SAMN16418988 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-221               FN803424.1         1-221
            222-350             JAXUCZ010000005.1  147761668-147761796 c
            351-563             FN803424.1         223-435
            564-2292            AF041244.1         322-2050
            2293-2421           JAXUCZ010000005.1  147761668-147761796 c
            2422-2697           AF041244.1         2181-2456
FEATURES             Location/Qualifiers
     source          1..2569
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..2569
                     /gene="Hcrtr1"
                     /gene_synonym="Hctr1"
                     /note="hypocretin receptor 1"
                     /db_xref="GeneID:25593"
                     /db_xref="RGD:2787"
     exon            1..435
                     /gene="Hcrtr1"
                     /gene_synonym="Hctr1"
                     /inference="alignment:Splign:2.1.0"
     exon            436..553
                     /gene="Hcrtr1"
                     /gene_synonym="Hctr1"
                     /inference="alignment:Splign:2.1.0"
     exon            554..878
                     /gene="Hcrtr1"
                     /gene_synonym="Hctr1"
                     /inference="alignment:Splign:2.1.0"
     CDS             680..1930
                     /gene="Hcrtr1"
                     /gene_synonym="Hctr1"
                     /note="orexin receptor type 1; ox1r; hypocretin receptor
                     type 1; ox1-R; ox-1-R; hypocretin (orexin) receptor 1"
                     /codon_start=1
                     /product="orexin/Hypocretin receptor type 1"
                     /protein_id="NP_037196.1"
                     /db_xref="GeneID:25593"
                     /db_xref="RGD:2787"
                     /translation="MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQ
                     YEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPA
                     SLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARR
                     ARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSC
                     FFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEP
                     QPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDRE
                     AVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLS
                     LQSRCSVSKVSEHVVLTTVTTVLS"
     exon            879..1057
                     /gene="Hcrtr1"
                     /gene_synonym="Hctr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1301
                     /gene="Hcrtr1"
                     /gene_synonym="Hctr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1417
                     /gene="Hcrtr1"
                     /gene_synonym="Hctr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1418..1644
                     /gene="Hcrtr1"
                     /gene_synonym="Hctr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1645..1766
                     /gene="Hcrtr1"
                     /gene_synonym="Hctr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1767..2569
                     /gene="Hcrtr1"
                     /gene_synonym="Hctr1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caagtagaga tggggtccat ccctgctctg tgggcccccc acctcaggtg cgcgctgaat
       61 gcgaggtggc gggagcgtaa gtgtcgaaag gatgctcagg atatgaatga gccagcggac
      121 gcgtgaatgg aggtggatgg aagcgtgaag tacaaggcgg ggctccagct gggtgacctc
      181 gaggcagaca ggccggggct ccctcccctc tcctcccagc ctcccactcc gctcccctcc
      241 ccgcggcgcg cagaccttcc gagccctccc gagctaccgc gggcaacaga gacgggacca
      301 cgcagccacc gagcggacag cgcctcctca ggagggggct accccgccgc gtctccagct
      361 ctgccctaag gcgaagtccc gcgagcgagg tccagatacg agcaaccgag gatgccccgg
      421 gcccggagcc aacagggctc actagtaatg acacgggaca ctgactggag ggccggcatc
      481 tgggtgtacc aggctctggg tgaagtagtt cccaaatctt agagctcaat actcctcatc
      541 gtgacactga aaggaagttt gttctgggac cataaagacc tgagtgcaag accagggcct
      601 ttgaaaggag tgggctgagg gcttgtggga gtttctcttc ctccacagag cccaggatgc
      661 tcctcagctg aagtggctca tggaaccctc agccacgcct ggggcccagc ccggagtccc
      721 cactagcagt ggggaaccct tccacctgcc tccagactat gaggacgagt tcctccgcta
      781 cctgtggcgc gattatctct atccgaagca gtacgagtgg gttctcatcg cggcctacgt
      841 ggccgtgttt ctcatagcct tggtgggcaa cactctggtc tgcctggctg tgtggcggaa
      901 ccaccacatg aggacagtca ccaactactt cattgtcaac ctgtccctgg cagatgtgct
      961 ggtgactgcc atctgcctgc ctgccagcct gttagtggac atcaccgaat catggctctt
     1021 cggccatgcc ttgtgcaagg tcatccccta tctccaggcc gtgtcggtgt cagtggcagt
     1081 gctgactctc agcttcatcg ccctggaccg ctggtatgcc atctgccacc ctctgctgtt
     1141 caagagcaca gctcgccgtg cccgtggctc catcctgggc atctgggctg tgtcgctggc
     1201 tgtcatggtg ccccaggccg ctgtcatgga atgcagcagt gttctgcccg agctagccaa
     1261 tcgcacacgg ctcttctctg tctgtgatga gcgctgggca gatgaactct accctaagat
     1321 ctaccacagc tgcttcttct ttgtcaccta cctggccccg ctgggcctca tgggcatggc
     1381 ctatttccag atcttccgca agctctgggg cccccagatc ccgggtacca catcggcctt
     1441 ggtgcggaac tggaagcgac cctcagagca actggaagct cagcaccagg gcctgtgtac
     1501 agagccccaa ccccgggccc gagccttcct ggccgaggtg aagcagatgc gagctcggag
     1561 gaagactgcc aagatgctga tggtggttct gctggttttt gcactctgtt atctgcccat
     1621 cagtgtcctc aatgtcctta aaagagtgtt tgggatgttt cgccaagcca gcgaccggga
     1681 agctgtctac gcctgcttca ccttctccca ctggctggtg tacgccaaca gtgcggccaa
     1741 ccctatcatc tacaacttcc tcagtggcaa atttcgggag cagttcaagg ctgcattctc
     1801 ctgctgcctg cctggtctgg gtcccagctc ctctgccaga cacaagtcct tgtccttgca
     1861 gagccggtgt tctgtctcca aagtctctga gcatgttgtg ctgaccacag tcactacagt
     1921 gctgtcctga gtggggctgg ccaggctctg ggaggcttga tcctttgcct ggggctcacc
     1981 ccacccccac actcatggaa agactgctgc tgctcagtcc gatccctcaa ctccagtcct
     2041 agctttctgc ctgagtgact ccgccagagt cattccctct cttgaggttg catcccctaa
     2101 gctgagttga taggggctta agcatgctca agagagcaga gagcgttgta aaccgtctag
     2161 tgctgtggac gtggttactg tccctgtctc gtatggccct accctacagt gtcacttcac
     2221 cctatcagag cttggctttc tccccaaaga cctgtctcct actcaattat aggccctccc
     2281 tggctggagt ccgctccaag ggtccccaca ggcatatcca cctggcctga aggccaccag
     2341 aagtccggac tgcacatggc cagctgcacc aatgtgtccc tgtgaactaa tttgcgttca
     2401 gcccttctca gtgagctctg aagctaggtc caccctctcc aggtgtggac tgcacacagc
     2461 acaggctgga tctcgttggc attgtggagt gcttaaacac tctccatgcg gccgttcggc
     2521 atggaggcca acagcccgtg gcaactgtaa ttaaaagcct ggtaccgaa
//
