LOCUS       NM_013179                577 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Rattus norvegicus hypocretin neuropeptide precursor (Hcrt), mRNA.
ACCESSION   NM_013179
VERSION     NM_013179.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 577)
  AUTHORS   Chen,B., Jin,K., Dong,J., Cheng,S., Kong,L., Hu,S., Chen,Z. and
            Lu,J.
  TITLE     Hypocretin-1/Hypocretin Receptor 1 Regulates Neuroplasticity and
            Cognitive Function through Hippocampal Lactate Homeostasis in
            Depressed Model
  JOURNAL   Adv Sci (Weinh) 11 (38), e2405354 (2024)
   PUBMED   39119889
  REMARK    GeneRIF: Hypocretin-1/Hypocretin Receptor 1 Regulates
            Neuroplasticity and Cognitive Function through Hippocampal Lactate
            Homeostasis in Depressed Model.
REFERENCE   2  (bases 1 to 577)
  AUTHORS   Dong,J., Zhang,J., Cheng,S., Qin,B., Jin,K., Chen,B., Zhang,Y. and
            Lu,J.
  TITLE     A high-fat diet induced depression-like phenotype via
            hypocretin-HCRTR1 mediated inflammation activation
  JOURNAL   Food Funct 15 (17), 8661-8673 (2024)
   PUBMED   39056112
  REMARK    GeneRIF: A high-fat diet induced depression-like phenotype via
            hypocretin-HCRTR1 mediated inflammation activation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 577)
  AUTHORS   Soejima,Y., Iwata,N., Yamamoto,K., Suyama,A., Nakano,Y. and
            Otsuka,F.
  TITLE     Mutual Effects of Orexin and Bone Morphogenetic Proteins on
            Catecholamine Regulation Using Adrenomedullary Cells
  JOURNAL   Int J Mol Sci 25 (3), 1585 (2024)
   PUBMED   38338864
  REMARK    GeneRIF: Mutual Effects of Orexin and Bone Morphogenetic Proteins
            on Catecholamine Regulation Using Adrenomedullary Cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 577)
  AUTHORS   Koumar,O.C., Martin,T., Bataille,A., Bulla,J., Crunel,V., Bouet,V.,
            Freret,T., Boumediene,K., Bauge,C., Moussay,S., Dauphin,F. and
            Bessot,N.
  TITLE     Core body temperature varies according to the time of exercise
            without affecting orexin-A production in the dorsal hypothalamus in
            male rats
  JOURNAL   J Therm Biol 114, 103522 (2023)
   PUBMED   37344019
  REMARK    GeneRIF: Core body temperature varies according to the time of
            exercise without affecting orexin-A production in the dorsal
            hypothalamus in male rats.
REFERENCE   5  (bases 1 to 577)
  AUTHORS   Ben Musa,R., Cornelius-Green,J., Hasser,E.M. and Cummings,K.J.
  TITLE     The effect of orexin on the hypoxic ventilatory response of female
            rats is greatest in the active phase during diestrus
  JOURNAL   J Appl Physiol (1985) 134 (3), 638-648 (2023)
   PUBMED   36656978
  REMARK    GeneRIF: The effect of orexin on the hypoxic ventilatory response
            of female rats is greatest in the active phase during diestrus.
REFERENCE   6  (bases 1 to 577)
  AUTHORS   de Miguel,M.J. and Burrell,M.A.
  TITLE     Immunocytochemical detection of orexin A in endocrine cells of the
            developing mouse gut
  JOURNAL   J Histochem Cytochem 50 (1), 63-69 (2002)
   PUBMED   11748295
REFERENCE   7  (bases 1 to 577)
  AUTHORS   Hungs,M. and Mignot,E.
  TITLE     Hypocretin/orexin, sleep and narcolepsy
  JOURNAL   Bioessays 23 (5), 397-408 (2001)
   PUBMED   11340621
  REMARK    Review article
REFERENCE   8  (bases 1 to 577)
  AUTHORS   Willie,J.T., Chemelli,R.M., Sinton,C.M. and Yanagisawa,M.
  TITLE     To eat or to sleep? Orexin in the regulation of feeding and
            wakefulness
  JOURNAL   Annu Rev Neurosci 24, 429-458 (2001)
   PUBMED   11283317
  REMARK    Review article
REFERENCE   9  (bases 1 to 577)
  AUTHORS   Sakurai,T., Amemiya,A., Ishii,M., Matsuzaki,I., Chemelli,R.M.,
            Tanaka,H., Williams,S.C., Richardson,J.A., Kozlowski,G.P.,
            Wilson,S., Arch,J.R., Buckingham,R.E., Haynes,A.C., Carr,S.A.,
            Annan,R.S., McNulty,D.E., Liu,W.S., Terrett,J.A., Elshourbagy,N.A.,
            Bergsma,D.J. and Yanagisawa,M.
  TITLE     Orexins and orexin receptors: a family of hypothalamic
            neuropeptides and G protein-coupled receptors that regulate feeding
            behavior
  JOURNAL   Cell 92 (4), 573-585 (1998)
   PUBMED   9491897
REFERENCE   10 (bases 1 to 577)
  AUTHORS   de Lecea,L., Kilduff,T.S., Peyron,C., Gao,X., Foye,P.E.,
            Danielson,P.E., Fukuhara,C., Battenberg,E.L., Gautvik,V.T.,
            Bartlett,F.S. 2nd, Frankel,W.N., van den Pol,A.N., Bloom,F.E.,
            Gautvik,K.M. and Sutcliffe,J.G.
  TITLE     The hypocretins: hypothalamus-specific peptides with
            neuroexcitatory activity
  JOURNAL   Proc Natl Acad Sci U S A 95 (1), 322-327 (1998)
   PUBMED   9419374
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Mar 19, 2021 this sequence version replaced NM_013179.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF019565.1, AF041241.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMN12840105
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-115               JAXUCZ010000010.1  86191410-86191524   c
            116-577             JAXUCZ010000010.1  86190289-86190750   c
FEATURES             Location/Qualifiers
     source          1..577
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q31"
     gene            1..577
                     /gene="Hcrt"
                     /gene_synonym="orexin-A"
                     /note="hypocretin neuropeptide precursor"
                     /db_xref="GeneID:25723"
                     /db_xref="RGD:2786"
     exon            1..115
                     /gene="Hcrt"
                     /gene_synonym="orexin-A"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..487
                     /gene="Hcrt"
                     /gene_synonym="orexin-A"
                     /note="orexin; Hypocretin (orexin) neuropeptide;
                     prepro-orexin; preprohypocretin"
                     /codon_start=1
                     /product="hypocretin neuropeptide precursor precursor"
                     /protein_id="NP_037311.1"
                     /db_xref="GeneID:25723"
                     /db_xref="RGD:2786"
                     /translation="MNLPSTKVPWAAVTLLLLLLLPPALLSLGVDAQPLPDCCRQKTC
                     SCRLYELLHGAGNHAAGILTLGKRRPGPPGLQGRLQRLLQANGNHAAGILTMGRRAGA
                     ELEPYPCPGRRCPTATATALAPRGGSRV"
     exon            116..577
                     /gene="Hcrt"
                     /gene_synonym="orexin-A"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acagaagacg acggcctcag actccttggg tatttggacc actgcaccga agataccatc
       61 tctccggatt gcctctccct gagctccaga caccatgaac cttccttcta caaaggttcc
      121 ctgggccgcc gtgacgctgc tgctgctgct actgctgccg ccggcgctgc tgtcgcttgg
      181 ggtggacgcg cagcctctgc ccgactgctg tcgccagaag acgtgttcct gccgtctcta
      241 cgaactgttg cacggagctg gcaaccacgc cgcgggcatc ctcactctgg gaaagcggcg
      301 acctggaccc ccaggcctcc aaggacggct gcagcgcctc cttcaggcca acggtaacca
      361 cgcagctggc atcctgacca tgggccgccg cgcaggcgca gagctagagc catatccctg
      421 ccctggtcgc cgctgtccga ctgcaaccgc caccgcttta gcgccccggg gcggatccag
      481 agtctgaacc cgtcttctat ccctgtccta gtcctaactt tcccctctcc tcgccagtcc
      541 ctaggcaata aagacgtttc tctgttggtg tgactaa
//
