LOCUS       NM_053375               3064 bp    mRNA    linear   ROD 06-AUG-2024
DEFINITION  Rattus norvegicus hyperpolarization-activated cyclic
            nucleotide-gated potassium channel 1 (Hcn1), mRNA.
ACCESSION   NM_053375
VERSION     NM_053375.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3064)
  AUTHORS   Zhao,K., Li,Y., Lai,H., Niu,R., Li,H., He,S., Su,Z., Gui,Y.,
            Ren,L., Yang,X. and Zhou,L.
  TITLE     Alterations in HCN1 expression and distribution during
            epileptogenesis in rats
  JOURNAL   Epilepsy Res 202, 107355 (2024)
   PUBMED   38555654
  REMARK    GeneRIF: Alterations in HCN1 expression and distribution during
            epileptogenesis in rats.
REFERENCE   2  (bases 1 to 3064)
  AUTHORS   Lei,X., Yan,Y., Zeng,J., Wang,R., Li,S., Xiao,Z. and Liu,X.
  TITLE     Activation of HCN channels caused by elevated cAMP levels in
            periaqueductal gray promotes bone cancer pain
  JOURNAL   Neurochem Int 162, 105437 (2023)
   PUBMED   36336089
  REMARK    GeneRIF: Activation of HCN channels caused by elevated cAMP levels
            in periaqueductal gray promotes bone cancer pain.
REFERENCE   3  (bases 1 to 3064)
  AUTHORS   Singh,N., Zabbarova,I., Ikeda,Y., Kanai,A., Chermansky,C.,
            Yoshimura,N. and Tyagi,P.
  TITLE     Role of hyperpolarization-activated cyclic nucleotide-gated
            channels in aging bladder phenotype
  JOURNAL   Life Sci 289, 120203 (2022)
   PUBMED   34875252
  REMARK    GeneRIF: Role of hyperpolarization-activated cyclic
            nucleotide-gated channels in aging bladder phenotype.
REFERENCE   4  (bases 1 to 3064)
  AUTHORS   Xiao,H.L., Xiao,Y.J., Wang,Q., Chen,M.L. and Jiang,A.L.
  TITLE     Moxibustion Regulates Gastrointestinal Motility via HCN1 in
            Functional Dyspepsia Rats
  JOURNAL   Med Sci Monit 27, e932885 (2021)
   PUBMED   34845181
  REMARK    GeneRIF: Moxibustion Regulates Gastrointestinal Motility via HCN1
            in Functional Dyspepsia Rats.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3064)
  AUTHORS   Vay,S.U., Flitsch,L.J., Rabenstein,M., Moniere,H., Jakovcevski,I.,
            Andjus,P., Bijelic,D., Blaschke,S., Walter,H.L., Fink,G.R.,
            Schroeter,M. and Rueger,M.A.
  TITLE     The impact of hyperpolarization-activated cyclic nucleotide-gated
            (HCN) and voltage-gated potassium KCNQ/Kv7 channels on primary
            microglia function
  JOURNAL   J Neuroinflammation 17 (1), 100 (2020)
   PUBMED   32248813
  REMARK    GeneRIF: The impact of hyperpolarization-activated cyclic
            nucleotide-gated (HCN) and voltage-gated potassium KCNQ/Kv7
            channels on primary microglia function.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3064)
  AUTHORS   Lorincz,A., Notomi,T., Tamas,G., Shigemoto,R. and Nusser,Z.
  TITLE     Polarized and compartment-dependent distribution of HCN1 in
            pyramidal cell dendrites
  JOURNAL   Nat Neurosci 5 (11), 1185-1193 (2002)
   PUBMED   12389030
  REMARK    GeneRIF: in apical dendrites of hippocampal, subicular and
            neocortical layer-5 pyramidal cells
REFERENCE   7  (bases 1 to 3064)
  AUTHORS   Brauer,A.U., Savaskan,N.E., Kole,M.H., Plaschke,M., Monteggia,L.M.,
            Nestler,E.J., Simburger,E., Deisz,R.A., Ninnemann,O. and Nitsch,R.
  TITLE     Molecular and functional analysis of hyperpolarization-activated
            pacemaker channels in the hippocampus after entorhinal cortex
            lesion
  JOURNAL   FASEB J 15 (14), 2689-2701 (2001)
   PUBMED   11726545
REFERENCE   8  (bases 1 to 3064)
  AUTHORS   Stevens,D.R., Seifert,R., Bufe,B., Muller,F., Kremmer,E., Gauss,R.,
            Meyerhof,W., Kaupp,U.B. and Lindemann,B.
  TITLE     Hyperpolarization-activated channels HCN1 and HCN4 mediate
            responses to sour stimuli
  JOURNAL   Nature 413 (6856), 631-635 (2001)
   PUBMED   11675786
REFERENCE   9  (bases 1 to 3064)
  AUTHORS   Monteggia,L.M., Eisch,A.J., Tang,M.D., Kaczmarek,L.K. and
            Nestler,E.J.
  TITLE     Cloning and localization of the hyperpolarization-activated cyclic
            nucleotide-gated channel family in rat brain
  JOURNAL   Brain Res Mol Brain Res 81 (1-2), 129-139 (2000)
   PUBMED   11000485
REFERENCE   10 (bases 1 to 3064)
  AUTHORS   Shi,W., Wymore,R., Yu,H., Wu,J., Wymore,R.T., Pan,Z.,
            Robinson,R.B., Dixon,J.E., McKinnon,D. and Cohen,I.S.
  TITLE     Distribution and prevalence of hyperpolarization-activated cation
            channel (HCN) mRNA expression in cardiac tissues
  JOURNAL   Circ Res 85 (1), e1-e6 (1999)
   PUBMED   10400919
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Mar 10, 2021 this sequence version replaced NM_053375.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.8758.1,
                                           SRR26360176.5947.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-466               JAXUCZ010000002.1  51228710-51229175
            467-890             JAXUCZ010000002.1  51285771-51286194
            891-1052            JAXUCZ010000002.1  51470741-51470902
            1053-1271           JAXUCZ010000002.1  51531172-51531390
            1272-1418           JAXUCZ010000002.1  51562516-51562662
            1419-1659           JAXUCZ010000002.1  51580261-51580501
            1660-1824           JAXUCZ010000002.1  51627934-51628098
            1825-3064           JAXUCZ010000002.1  51631567-51632806
FEATURES             Location/Qualifiers
     source          1..3064
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q14"
     gene            1..3064
                     /gene="Hcn1"
                     /note="hyperpolarization-activated cyclic nucleotide-gated
                     potassium channel 1"
                     /db_xref="GeneID:84390"
                     /db_xref="RGD:620688"
     exon            1..466
                     /gene="Hcn1"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..2783
                     /gene="Hcn1"
                     /codon_start=1
                     /product="potassium/sodium hyperpolarization-activated
                     cyclic nucleotide-gated channel 1"
                     /protein_id="NP_445827.2"
                     /db_xref="GeneID:84390"
                     /db_xref="RGD:620688"
                     /translation="MEGGGKPNSASNSRDDGNSVYPSKAPATGPAAADKRLGTPPGGG
                     AAGKEHGNSVCFKVDGGGGEEPAGSFEDAEGPRRQYGFMQRQFTSMLQPGVNKFSLRM
                     FGSQKAVEKEQERVKTAGFWIIHPYSDFRFYWDLIMLIMMVGNLVIIPVGITFFTEQT
                     TTPWIIFNVASDTVFLLDLIMNFRTGTVNEDSSEIILDPKVIKMNYLKSWFVVDFISS
                     IPVDYIFLIVEKGMDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHM
                     TYDLASAVVRIFNLIGMMLLLCHWDGCLQFLVPLLQDFPPDCWVSLNEMVNDSWGKQY
                     SYALFKAMSHMLCIGYGAQAPVSMSDLWITMLSMIVGATCYAMFVGHATALIQSLDSS
                     RRQYQEKYKQVEQYMSFHKLPADMRQKIHDYYEHRYQGKIFDEENILSELNDPLREEI
                     VNFNCRKLVATMPLFANADPNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGV
                     AGVITKSSKEMKLTDGSYFGEICLLTKGRRTASVRADTYCRLYSLSVDNFNEVLEEYP
                     MMRRAFETVAIDRLDRIGKKNSILLQKFQKDLNTGVFNNQENEILKQIVKHDREMVQA
                     IPPINYPQMTALNCTSSTTTPTSRMRTQSPPVYTATSLSHSNLHSPSPSTQTPQPSAI
                     LSPCSYTTAVCSPPIQSPLATRTFHYASPTASQLSLMQQPQPQLQQSQVQQTQPQPQP
                     QPQQPQQQQQQQQQQQQQQQQQQQQQQPQTPGSSTPKNEVHKSTQALHNTNLTREVRP
                     LSASQPSLPHEVSTMISRPHPTVGESLASIPQPMATVHSTGLQAGSRSTVPQRVTLFR
                     QMSSGAIPPNRGVPPAPPPPAAVQRESPSVLNKDPDAEKPRFASNL"
     exon            467..890
                     /gene="Hcn1"
                     /inference="alignment:Splign:2.1.0"
     exon            891..1052
                     /gene="Hcn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1271
                     /gene="Hcn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1418
                     /gene="Hcn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..1659
                     /gene="Hcn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1660..1824
                     /gene="Hcn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1825..3064
                     /gene="Hcn1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccggcccctg ccccttggcc tcaagccccc ggcgagtctg gagccctcgc cgtcgccggt
       61 cgcgtccttc gggcatggaa ggcggcggca agcccaactc cgcttccaac agccgcgacg
      121 atggcaacag cgtttacccc tccaaggcgc ccgcgacggg gccggcggcg gccgacaagc
      181 gcctggggac cccgccgggg ggcggcgcgg ccgggaagga acacggcaac tccgtgtgct
      241 tcaaggtgga cggcggcgga ggagaggagc cggcgggcag cttcgaggat gccgaggggc
      301 cccggcgaca gtacggtttc atgcagaggc agttcacctc catgctgcag cctggggtca
      361 acaaattctc cctccgcatg ttcgggagcc agaaggcggt ggagaaggag caggaaaggg
      421 ttaaaactgc aggcttctgg attatccatc cgtacagtga cttcaggttt tattgggatt
      481 taataatgct tataatgatg gttggaaatt tggtcatcat accagttgga atcacattct
      541 tcacagagca aacaacaaca ccgtggatta ttttcaatgt ggcatcagat acagttttcc
      601 tgttggacct aatcatgaat tttaggactg ggactgtcaa cgaagacagc tctgaaatca
      661 tcctggaccc taaagtaatc aagatgaatt atttaaaaag ctggttcgtg gtggacttca
      721 tctcctcgat cccggtggat tatatctttc ttattgtaga gaaaggaatg gattcggaag
      781 tttacaagac cgccagagca cttcggatcg tgaggtttac aaaaattctc agtctcttgc
      841 gtttattacg cctttcaagg ttaattagat acatacacca gtgggaagag atattccaca
      901 tgacatatga tctcgccagt gcagtggtga gaatcttcaa cctcattggc atgatgctgc
      961 tcctgtgtca ctgggatggc tgtcttcagt ttctggtccc cctgctgcag gacttcccac
     1021 cggattgctg ggtttctcta aatgaaatgg ttaatgattc atgggggaaa cagtattcct
     1081 acgcactctt caaagctatg agtcacatgc tgtgcattgg ttatggcgcc caggcccccg
     1141 tcagcatgtc tgacctctgg attaccatgc tgagcatgat tgttggggcc acctgctatg
     1201 ccatgtttgt cggccatgcc acagctttga tccagtctct ggattcttca aggaggcagt
     1261 atcaagagaa gtacaagcaa gtagagcaat acatgtcatt ccacaagtta ccagctgaca
     1321 tgcgccagaa gatacatgat tactatgagc accgatacca aggcaagatc ttcgatgagg
     1381 aaaatattct cagtgaactt aatgatcctc tgagagagga aatagtcaac ttcaactgcc
     1441 ggaaactggt ggccaccatg cctctctttg ctaacgcgga tcccaatttc gtgacggcca
     1501 tgctgagcaa gctgagattt gaggtgttcc agcccggaga ctatatcatt cgagaaggag
     1561 ctgtggggaa gaaaatgtat ttcatccagc atggtgtggc tggtgtcatc accaagtcca
     1621 gtaaagaaat gaagttgaca gacggctctt actttggaga aatatgcctg ctgaccaagg
     1681 gccggcgcac tgccagtgtt cgagctgata catactgtcg cctttactcc ctttcggtgg
     1741 acaatttcaa cgaggtcttg gaggaatatc caatgatgag aagagccttt gagacagttg
     1801 ctattgaccg actagatcgg ataggcaaga aaaactctat tctcctgcag aagttccaga
     1861 aggatctgaa cactggtgtt ttcaacaacc aggagaatga gatcctgaag cagattgtga
     1921 agcatgacag agagatggta caagcgatcc ctccaatcaa ctatcctcaa atgacagccc
     1981 tgaattgcac atcttcaacc accaccccaa cgtcgcgcat gaggacccaa tctccaccag
     2041 tctacacagc gaccagcctc tctcacagca acctgcactc acccagcccc agcacacaga
     2101 cgcctcaacc ctcagccatc ctttcaccct gctcctacac cacagcagtc tgcagtcctc
     2161 ctatacagag ccccctggcc acgcgaactt tccattatgc ctctcccact gcatcccaat
     2221 tgtcactcat gcagcagcct cagccgcagc tacagcaatc ccaggtacag cagactcagc
     2281 cgcagccgca gccgcagccg cagcagccgc aacagcaaca acagcagcaa cagcagcagc
     2341 agcagcagca gcaacaacaa cagcagcagc aacagccaca gacacctggt agttccacac
     2401 cgaaaaatga agtgcacaag agcactcaag ctcttcataa caccaacctg accagagaag
     2461 tcaggcccct ctctgcctcg cagccttcgc tgccccatga ggtctccact atgatctcca
     2521 gaccgcatcc cactgtgggc gagtccctgg cctccatccc tcaacccatg gcaacagtcc
     2581 acagcactgg ccttcaggca gggagcagga gcaccgtgcc acagcgtgtc accttgttca
     2641 gacagatgtc ctcgggagcc attcccccca accgaggagt gcctccagca cccccaccac
     2701 cagcagctgt gcagagagag tctccctcag tcttaaataa agacccagat gcagaaaaac
     2761 cacgttttgc ttcgaattta tgattcttgc tgattgtcaa agcagaaaag aaatactcta
     2821 ataaacagaa tattctcaga tattatttta ttctatctca tgatagagcc ctatagccta
     2881 ctctaaaaag atattttaga agctctggcg tacatgcaaa tgtaaaaaca tatatacata
     2941 tattattaaa tatatatata tatctaaatg cccaagagaa gttcaaaaga cttgtataac
     3001 tttcagtgtt atgtcttcct ttctttaaaa ccattaaagg atttaacaca ttgttgtaag
     3061 atca
//
