LOCUS       NP_445827                902 aa            linear   ROD 06-AUG-2024
DEFINITION  potassium/sodium hyperpolarization-activated cyclic
            nucleotide-gated channel 1 [Rattus norvegicus].
ACCESSION   NP_445827
VERSION     NP_445827.2
DBSOURCE    REFSEQ: accession NM_053375.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 902)
  AUTHORS   Zhao,K., Li,Y., Lai,H., Niu,R., Li,H., He,S., Su,Z., Gui,Y.,
            Ren,L., Yang,X. and Zhou,L.
  TITLE     Alterations in HCN1 expression and distribution during
            epileptogenesis in rats
  JOURNAL   Epilepsy Res 202, 107355 (2024)
   PUBMED   38555654
  REMARK    GeneRIF: Alterations in HCN1 expression and distribution during
            epileptogenesis in rats.
REFERENCE   2  (residues 1 to 902)
  AUTHORS   Lei,X., Yan,Y., Zeng,J., Wang,R., Li,S., Xiao,Z. and Liu,X.
  TITLE     Activation of HCN channels caused by elevated cAMP levels in
            periaqueductal gray promotes bone cancer pain
  JOURNAL   Neurochem Int 162, 105437 (2023)
   PUBMED   36336089
  REMARK    GeneRIF: Activation of HCN channels caused by elevated cAMP levels
            in periaqueductal gray promotes bone cancer pain.
REFERENCE   3  (residues 1 to 902)
  AUTHORS   Singh,N., Zabbarova,I., Ikeda,Y., Kanai,A., Chermansky,C.,
            Yoshimura,N. and Tyagi,P.
  TITLE     Role of hyperpolarization-activated cyclic nucleotide-gated
            channels in aging bladder phenotype
  JOURNAL   Life Sci 289, 120203 (2022)
   PUBMED   34875252
  REMARK    GeneRIF: Role of hyperpolarization-activated cyclic
            nucleotide-gated channels in aging bladder phenotype.
REFERENCE   4  (residues 1 to 902)
  AUTHORS   Xiao,H.L., Xiao,Y.J., Wang,Q., Chen,M.L. and Jiang,A.L.
  TITLE     Moxibustion Regulates Gastrointestinal Motility via HCN1 in
            Functional Dyspepsia Rats
  JOURNAL   Med Sci Monit 27, e932885 (2021)
   PUBMED   34845181
  REMARK    GeneRIF: Moxibustion Regulates Gastrointestinal Motility via HCN1
            in Functional Dyspepsia Rats.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 902)
  AUTHORS   Vay,S.U., Flitsch,L.J., Rabenstein,M., Moniere,H., Jakovcevski,I.,
            Andjus,P., Bijelic,D., Blaschke,S., Walter,H.L., Fink,G.R.,
            Schroeter,M. and Rueger,M.A.
  TITLE     The impact of hyperpolarization-activated cyclic nucleotide-gated
            (HCN) and voltage-gated potassium KCNQ/Kv7 channels on primary
            microglia function
  JOURNAL   J Neuroinflammation 17 (1), 100 (2020)
   PUBMED   32248813
  REMARK    GeneRIF: The impact of hyperpolarization-activated cyclic
            nucleotide-gated (HCN) and voltage-gated potassium KCNQ/Kv7
            channels on primary microglia function.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 902)
  AUTHORS   Lorincz,A., Notomi,T., Tamas,G., Shigemoto,R. and Nusser,Z.
  TITLE     Polarized and compartment-dependent distribution of HCN1 in
            pyramidal cell dendrites
  JOURNAL   Nat Neurosci 5 (11), 1185-1193 (2002)
   PUBMED   12389030
  REMARK    GeneRIF: in apical dendrites of hippocampal, subicular and
            neocortical layer-5 pyramidal cells
REFERENCE   7  (residues 1 to 902)
  AUTHORS   Brauer,A.U., Savaskan,N.E., Kole,M.H., Plaschke,M., Monteggia,L.M.,
            Nestler,E.J., Simburger,E., Deisz,R.A., Ninnemann,O. and Nitsch,R.
  TITLE     Molecular and functional analysis of hyperpolarization-activated
            pacemaker channels in the hippocampus after entorhinal cortex
            lesion
  JOURNAL   FASEB J 15 (14), 2689-2701 (2001)
   PUBMED   11726545
REFERENCE   8  (residues 1 to 902)
  AUTHORS   Stevens,D.R., Seifert,R., Bufe,B., Muller,F., Kremmer,E., Gauss,R.,
            Meyerhof,W., Kaupp,U.B. and Lindemann,B.
  TITLE     Hyperpolarization-activated channels HCN1 and HCN4 mediate
            responses to sour stimuli
  JOURNAL   Nature 413 (6856), 631-635 (2001)
   PUBMED   11675786
REFERENCE   9  (residues 1 to 902)
  AUTHORS   Monteggia,L.M., Eisch,A.J., Tang,M.D., Kaczmarek,L.K. and
            Nestler,E.J.
  TITLE     Cloning and localization of the hyperpolarization-activated cyclic
            nucleotide-gated channel family in rat brain
  JOURNAL   Brain Res Mol Brain Res 81 (1-2), 129-139 (2000)
   PUBMED   11000485
REFERENCE   10 (residues 1 to 902)
  AUTHORS   Shi,W., Wymore,R., Yu,H., Wu,J., Wymore,R.T., Pan,Z.,
            Robinson,R.B., Dixon,J.E., McKinnon,D. and Cohen,I.S.
  TITLE     Distribution and prevalence of hyperpolarization-activated cation
            channel (HCN) mRNA expression in cardiac tissues
  JOURNAL   Circ Res 85 (1), e1-e6 (1999)
   PUBMED   10400919
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Mar 10, 2021 this sequence version replaced NP_445827.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.8758.1,
                                           SRR26360176.5947.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..902
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q14"
     Protein         1..902
                     /product="potassium/sodium hyperpolarization-activated
                     cyclic nucleotide-gated channel 1"
                     /calculated_mol_wt=101298
     Region          1..75
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKB0.2)"
     Region          87..129
                     /region_name="Ion_trans_N"
                     /note="Ion transport protein N-terminal; pfam08412"
                     /db_xref="CDD:400630"
     Region          122..>609
                     /region_name="PLN03192"
                     /note="Voltage-dependent potassium channel; Provisional"
                     /db_xref="CDD:215625"
     Site            132..153
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKB0.2)"
     Site            163..183
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKB0.2)"
     Site            205..225
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKB0.2)"
     Site            250..270
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKB0.2)"
     Site            285..307
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKB0.2)"
     Site            327
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9JKB0.2)"
     Region          347..351
                     /region_name="Selectivity filter.
                     /evidence=ECO:0000250|UniProtKB:O60741"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKB0.2)"
     Site            361..381
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKB0.2)"
     Region          464..572
                     /region_name="CAP_ED"
                     /note="effector domain of the CAP family of transcription
                     factors; members include CAP (or cAMP receptor protein
                     (CRP)), which binds cAMP, FNR (fumarate and nitrate
                     reduction), which uses an iron-sulfur cluster to sense
                     oxygen) and CooA, a heme containing CO...; cd00038"
                     /db_xref="CDD:237999"
     Site            order(528..529,538..540)
                     /site_type="other"
                     /note="ligand binding site [chemical binding]"
                     /db_xref="CDD:237999"
     Site            order(560..562,566..568)
                     /site_type="other"
                     /note="flexible hinge region"
                     /db_xref="CDD:237999"
     Region          634..681
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKB0.2)"
     Region          713..824
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKB0.2)"
     Region          858..902
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKB0.2)"
     CDS             1..902
                     /gene="Hcn1"
                     /coded_by="NM_053375.2:75..2783"
                     /db_xref="GeneID:84390"
                     /db_xref="RGD:620688"
ORIGIN      
        1 megggkpnsa snsrddgnsv ypskapatgp aaadkrlgtp pgggaagkeh gnsvcfkvdg
       61 gggeepagsf edaegprrqy gfmqrqftsm lqpgvnkfsl rmfgsqkave keqervktag
      121 fwiihpysdf rfywdlimli mmvgnlviip vgitffteqt ttpwiifnva sdtvflldli
      181 mnfrtgtvne dsseiildpk vikmnylksw fvvdfissip vdyiflivek gmdsevykta
      241 ralrivrftk ilsllrllrl srliryihqw eeifhmtydl asavvrifnl igmmlllchw
      301 dgclqflvpl lqdfppdcwv slnemvndsw gkqysyalfk amshmlcigy gaqapvsmsd
      361 lwitmlsmiv gatcyamfvg hataliqsld ssrrqyqeky kqveqymsfh klpadmrqki
      421 hdyyehryqg kifdeenils elndplreei vnfncrklva tmplfanadp nfvtamlskl
      481 rfevfqpgdy iiregavgkk myfiqhgvag vitksskemk ltdgsyfgei clltkgrrta
      541 svradtycrl yslsvdnfne vleeypmmrr afetvaidrl drigkknsil lqkfqkdlnt
      601 gvfnnqenei lkqivkhdre mvqaippiny pqmtalncts stttptsrmr tqsppvytat
      661 slshsnlhsp spstqtpqps ailspcsytt avcsppiqsp latrtfhyas ptasqlslmq
      721 qpqpqlqqsq vqqtqpqpqp qpqqpqqqqq qqqqqqqqqq qqqqqqqpqt pgsstpknev
      781 hkstqalhnt nltrevrpls asqpslphev stmisrphpt vgeslasipq pmatvhstgl
      841 qagsrstvpq rvtlfrqmss gaippnrgvp pappppaavq respsvlnkd pdaekprfas
      901 nl
//
