LOCUS       NM_001011898            1976 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus hematopoietic cell specific Lyn substrate 1
            (Hcls1), mRNA.
ACCESSION   NM_001011898 XM_221421
VERSION     NM_001011898.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1976)
  AUTHORS   Skokowa J, Klimiankou M, Klimenkova O, Lan D, Gupta K, Hussein K,
            Carrizosa E, Kusnetsova I, Li Z, Sustmann C, Ganser A, Zeidler C,
            Kreipe HH, Burkhardt J, Grosschedl R and Welte K.
  TITLE     Interactions among HCLS1, HAX1 and LEF-1 proteins are essential for
            G-CSF-triggered granulopoiesis
  JOURNAL   Nat Med 18 (10), 1550-1559 (2012)
   PUBMED   23001182
REFERENCE   2  (bases 1 to 1976)
  AUTHORS   Samuels AL, Klinken SP and Ingley E.
  TITLE     Liar, a novel Lyn-binding nuclear/cytoplasmic shuttling protein
            that influences erythropoietin-induced differentiation
  JOURNAL   Blood 113 (16), 3845-3856 (2009)
   PUBMED   19064729
REFERENCE   3  (bases 1 to 1976)
  AUTHORS   Ingley E, Sarna MK, Beaumont JG, Tilbrook PA, Tsai S, Takemoto Y,
            Williams JH and Klinken SP.
  TITLE     HS1 interacts with Lyn and is critical for erythropoietin-induced
            differentiation of erythroid cells
  JOURNAL   J Biol Chem 275 (11), 7887-7893 (2000)
   PUBMED   10713104
REFERENCE   4  (bases 1 to 1976)
  AUTHORS   Yamabhai M and Kay BK.
  TITLE     Examining the specificity of Src homology 3 domain--ligand
            interactions with alkaline phosphatase fusion proteins
  JOURNAL   Anal Biochem 247 (1), 143-151 (1997)
   PUBMED   9126384
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079081.1.
            
            On Feb 11, 2005 this sequence version replaced XM_221421.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079081.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5756307,
                                           SAMEA5760383 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1976
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q21"
     gene            1..1976
                     /gene="Hcls1"
                     /note="hematopoietic cell specific Lyn substrate 1"
                     /db_xref="GeneID:288077"
                     /db_xref="RGD:1304754"
     exon            1..31
                     /gene="Hcls1"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..1462
                     /gene="Hcls1"
                     /codon_start=1
                     /product="hematopoietic lineage cell-specific protein"
                     /protein_id="NP_001011898.1"
                     /db_xref="GeneID:288077"
                     /db_xref="RGD:1304754"
                     /translation="MWKSVVGHNVSVSVETQGDDWDTDPDFVNDISEKEQRWGAKTIE
                     GSGRTEHINIHQLRNKVSEEHDILKKRELESGPKASHGYGGRFGVERDRMDKSAVGHE
                     YVAEVEKHSSQTDAAKGFGGKYGVERDRADKSAVGFDYKGEVEKHASQKDYSHGFGGR
                     YGVEKDKRDKAALGYDYKGETEKHESQRDYAKGFGGQYGIQKDRVDKSAVGFNEMEAP
                     TTAYKKTTPIEAASSGARGLKAKFESMAEEKRKREEEEKAQQMARQQQERKAMVKMSR
                     EAQQPSVPVDEPAAPAPLPKKISSEVWPPAESHLPPQSEPVGGRREYPVPSLPTRQPP
                     PQNPLEDNEEPPALPPRTPEGLQVVEEPVYEAAPEPEPEPEPDYEDVGELDRPDEEAE
                     GDYEDVLEPEDTPSLSYQAGHSAGAGGAGISAVALYDYQGEGSDELSFDPDDVITDIE
                     MVDEGWWRGRCHGHFGLFPANYVKLL"
     exon            32..115
                     /gene="Hcls1"
                     /inference="alignment:Splign:2.1.0"
     exon            116..189
                     /gene="Hcls1"
                     /inference="alignment:Splign:2.1.0"
     exon            190..319
                     /gene="Hcls1"
                     /inference="alignment:Splign:2.1.0"
     exon            320..430
                     /gene="Hcls1"
                     /inference="alignment:Splign:2.1.0"
     exon            431..485
                     /gene="Hcls1"
                     /inference="alignment:Splign:2.1.0"
     exon            486..596
                     /gene="Hcls1"
                     /inference="alignment:Splign:2.1.0"
     exon            597..652
                     /gene="Hcls1"
                     /inference="alignment:Splign:2.1.0"
     exon            653..722
                     /gene="Hcls1"
                     /inference="alignment:Splign:2.1.0"
     exon            723..934
                     /gene="Hcls1"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1051
                     /gene="Hcls1"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1265
                     /gene="Hcls1"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1328
                     /gene="Hcls1"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..1950
                     /gene="Hcls1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgaagagcca gagttttagc aacaaggaaa gatgtggaag tctgtagtgg ggcacaatgt
       61 atcggtttcc gtggagaccc agggtgatga ctgggacaca gaccctgact ttgtgaatga
      121 catctctgag aaggaacaac ggtggggagc caagaccatt gagggctctg gacgcacaga
      181 gcatatcaac atccaccagc tgaggaacaa agtgtccgag gagcatgaca ttctcaagaa
      241 gagagagctg gagtcggggc ctaaagcctc ccatggctat gggggtcggt ttggagtgga
      301 aagagaccgg atggacaaga gtgccgtggg ccacgagtat gttgctgaag tggagaaaca
      361 ctcgtctcag actgatgccg ccaaaggctt tgggggcaaa tatggagttg agagggaccg
      421 ggcagacaag tcagcggtgg gctttgacta caaaggagag gtggagaagc acgcatctca
      481 gaaagattac tctcatggct ttggtggccg ctacggggta gagaaggata aacgggacaa
      541 agcagctctg ggatatgact acaagggaga gacggagaag cacgagtctc agcgagatta
      601 tgccaagggc tttggtggtc aatatggaat ccagaaagac agagtggata agagtgctgt
      661 tggcttcaat gaaatggagg ccccaaccac ggcatataag aagacaacac ccatagaagc
      721 tgcttccagt ggtgcccgtg ggctgaaggc aaaattcgag tccatggctg aggagaagag
      781 gaagcgagaa gaagaagaga aggcacaaca gatggccagg cagcagcaag aacgaaaggc
      841 tatggtgaag atgagccgtg aagctcagca gccatccgtg cctgtggacg agcccgcagc
      901 accagccccg ttgcccaaga agatctcctc agaggtctgg cctccagcag agagtcacct
      961 accaccacag tccgagcccg tgggaggcag aagagaatac cctgtgccct ccctgcccac
     1021 gagacagcct ccacctcaga atcccctcga ggacaatgag gagcccccag ctctgccccc
     1081 taggactcca gaaggcctcc aggtggtaga agagccagtg tacgaagcag cacccgagcc
     1141 cgagcctgag cccgagcctg actatgagga tgttggagag ttagatcggc cggatgagga
     1201 agcagaggga gactatgagg atgtgctgga gcccgaggac accccttctc tatcctacca
     1261 ggctggacac tcagctgggg ctggcggtgc agggatctct gctgtagccc tttatgatta
     1321 ccaaggagag ggaagtgatg agctgtcctt tgacccagat gatgtcatca ctgacattga
     1381 gatggttgat gaaggctggt ggcggggccg atgtcatggc cactttggac tctttcctgc
     1441 aaactatgtc aagctcctct gatgagcttg tcttttaacc cctggtgttc gaagttgctc
     1501 tggccccctc ttcccactcc atggtactgc tgcaaggact tgactgaaca tcacgggatg
     1561 cctagagctc tagcagtctg tcttctgcct ctttaagagc cttaggtgga actgctcgag
     1621 gcaggggtgg ggctgagggg tggggttgag gggtggggtt gaggtttccc tctgtccctc
     1681 tgtttcctct cctccctgga gtaactcatg gaatcatctc gcagccctgc ctctttcaac
     1741 cacaccccag ctctgctgac ctctctctag agtgttggga ttccctcacc ccgaccctga
     1801 gtgccagcct agaggggagg ctctcactgg gctgcctgat tcgcccatgc tctgcttttg
     1861 ctcatttttc ttctcttaag atacaaattg gaactgccct tctgtttagt cctaaaactg
     1921 aaaataaagc aagactgtgg cttagctttc aaaaaaaaaa aaaaaaaaaa aaaaaa
//
