LOCUS       NM_013185               2081 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus HCK proto-oncogene, Src family tyrosine kinase
            (Hck), mRNA.
ACCESSION   NM_013185
VERSION     NM_013185.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2081)
  AUTHORS   Wang,J., Chen,R., Liu,X., Shen,J., Yan,Y., Gao,Y., Tao,T. and
            Shi,J.
  TITLE     Hck Promotes Neuronal Apoptosis Following Intracerebral Hemorrhage
  JOURNAL   Cell Mol Neurobiol 37 (2), 251-261 (2017)
   PUBMED   27053350
  REMARK    GeneRIF: Hck was up-regulated in neurons adjacent to the hematoma
            after intracerebral hemorrhage.
REFERENCE   2  (bases 1 to 2081)
  AUTHORS   Mehlitz,A., Banhart,S., Maurer,A.P., Kaushansky,A., Gordus,A.G.,
            Zielecki,J., Macbeath,G. and Meyer,T.F.
  TITLE     Tarp regulates early Chlamydia-induced host cell survival through
            interactions with the human adaptor protein SHC1
  JOURNAL   J Cell Biol 190 (1), 143-157 (2010)
   PUBMED   20624904
REFERENCE   3  (bases 1 to 2081)
  AUTHORS   Paliwal,P., Radha,V. and Swarup,G.
  TITLE     Regulation of p73 by Hck through kinase-dependent and independent
            mechanisms
  JOURNAL   BMC Mol Biol 8, 45 (2007)
   PUBMED   17535448
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2081)
  AUTHORS   Huang,Z.Y., Barreda,D.R., Worth,R.G., Indik,Z.K., Kim,M.K.,
            Chien,P. and Schreiber,A.D.
  TITLE     Differential kinase requirements in human and mouse Fc-gamma
            receptor phagocytosis and endocytosis
  JOURNAL   J Leukoc Biol 80 (6), 1553-1562 (2006)
   PUBMED   16921024
REFERENCE   5  (bases 1 to 2081)
  AUTHORS   Cougoule,C., Carreno,S., Castandet,J., Labrousse,A.,
            Astarie-Dequeker,C., Poincloux,R., Le Cabec,V. and
            Maridonneau-Parini,I.
  TITLE     Activation of the lysosome-associated p61Hck isoform triggers the
            biogenesis of podosomes
  JOURNAL   Traffic 6 (8), 682-694 (2005)
   PUBMED   15998323
REFERENCE   6  (bases 1 to 2081)
  AUTHORS   Howlett,C.J., Bisson,S.A., Resek,M.E., Tigley,A.W. and Robbins,S.M.
  TITLE     The proto-oncogene p120(Cbl) is a downstream substrate of the Hck
            protein-tyrosine kinase
  JOURNAL   Biochem Biophys Res Commun 257 (1), 129-138 (1999)
   PUBMED   10092522
REFERENCE   7  (bases 1 to 2081)
  AUTHORS   Robbins,S.M., Quintrell,N.A. and Bishop,J.M.
  TITLE     Myristoylation and differential palmitoylation of the HCK
            protein-tyrosine kinases govern their attachment to membranes and
            association with caveolae
  JOURNAL   Mol Cell Biol 15 (7), 3507-3515 (1995)
   PUBMED   7791757
REFERENCE   8  (bases 1 to 2081)
  AUTHORS   Lowell,C.A., Soriano,P. and Varmus,H.E.
  TITLE     Functional overlap in the src gene family: inactivation of hck and
            fgr impairs natural immunity
  JOURNAL   Genes Dev 8 (4), 387-398 (1994)
   PUBMED   8125254
REFERENCE   9  (bases 1 to 2081)
  AUTHORS   Okano,Y., Sugimoto,Y., Fukuoka,M., Matsui,A., Nagata,K. and
            Nozawa,Y.
  TITLE     Identification of rat cDNA encoding hck tyrosine kinase from
            megakaryocytes
  JOURNAL   Biochem Biophys Res Commun 181 (3), 1137-1144 (1991)
   PUBMED   1764064
REFERENCE   10 (bases 1 to 2081)
  AUTHORS   Lock,P., Ralph,S., Stanley,E., Boulet,I., Ramsay,R. and Dunn,A.R.
  TITLE     Two isoforms of murine hck, generated by utilization of alternative
            translational initiation codons, exhibit different patterns of
            subcellular localization
  JOURNAL   Mol Cell Biol 11 (9), 4363-4370 (1991)
   PUBMED   1875927
  REMARK    GeneRIF: Alternate protein isoforms arise through the use of a
            non-AUG (CUG), and a downstream in-frame AUG translation initiation
            codons, in mouse and human. Same is likely true for rat as there is
            strong sequence conservation amongst different species.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC078890.1.
            
            On Jan 22, 2011 this sequence version replaced NM_013185.2.
            
            Summary: The protein encoded by this gene is a protein-tyrosine
            kinase that is predominantly expressed in hemopoietic cell
            types.The encoded protein may help couple the Fc receptor to the
            activation of the respiratory burst. In addition, it may play a
            role in neutrophil migration and in the degranulation of
            neutrophils. Alternate translation initiation site usage, including
            a non-AUG (CUG) codon, results in the production of two different
            isoforms in human and mouse. Based on strong sequence conservation
            amongst these species, this may also be true for rat. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078890.1, M83666.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            non-AUG initiation codon :: PMID: 10967098, 1875927
            RefSeq Select criteria   :: based on single protein-coding
                                        transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2081              BC078890.1         1-2081
FEATURES             Location/Qualifiers
     source          1..2081
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q41"
     gene            1..2081
                     /gene="Hck"
                     /gene_synonym="Hctk; p56Hck; p59Hck"
                     /note="HCK proto-oncogene, Src family tyrosine kinase"
                     /db_xref="GeneID:25734"
                     /db_xref="RGD:2785"
     exon            1..260
                     /gene="Hck"
                     /gene_synonym="Hctk; p56Hck; p59Hck"
                     /inference="alignment:Splign:2.1.0"
     CDS             199..1773
                     /gene="Hck"
                     /gene_synonym="Hctk; p56Hck; p59Hck"
                     /EC_number="2.7.10.2"
                     /note="non-AUG (CUG) translation initiation codon;
                     p56-HCK; hemopoietic cell tyrosine kinase; hematopoietic
                     cell kinase; hemopoietic cell kinase"
                     /codon_start=1
                     /product="tyrosine-protein kinase HCK"
                     /protein_id="NP_037317.2"
                     /db_xref="GeneID:25734"
                     /db_xref="RGD:2785"
                     /translation="MGGRSSCEDPGCPRGEGRVPRMGCVKSRFLREGSKASKIEPNAN
                     QKGPVYVPDPTSPKKLGPNSINSLPPGVVEGSEDTIVVALYDYEAIHREDLSFQKGDQ
                     MVVLEESGEWWKARSLATKKEGYIPSNYVARVNSLETEEWFFKGISRKDAERHLLAPG
                     NMLGSFMIRDSETTKGSYSLSVRDFDPQHGDTVKHYKIRTLDSGGFYISPRSTFSSLQ
                     ELVVHYKKGKDGLCQKLSVPCVSPKPQKPWEKDAWEIPRESLQMEKKLGAGQFGEVWM
                     ATYNKHTKVAVKTMKPGSMSVEAFLAEANLMKTLQHDKLVKLHAVVSQEPIFIVTEFM
                     AKGSLLDFLKSEEGSKQPLPKLIDFSAQISEGMAFIEQRNYIHRDLRAANILVSASLV
                     CKIADFGLARIIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVT
                     YGRIPYPGMSNPEVIRALEHGYRMPRPDNCPEELYSIMIRCWKNRPEERPTFEYIQSV
                     LDDFYTATESQYQQQP"
     exon            261..378
                     /gene="Hck"
                     /gene_synonym="Hctk; p56Hck; p59Hck"
                     /inference="alignment:Splign:2.1.0"
     exon            379..421
                     /gene="Hck"
                     /gene_synonym="Hctk; p56Hck; p59Hck"
                     /inference="alignment:Splign:2.1.0"
     exon            422..521
                     /gene="Hck"
                     /gene_synonym="Hctk; p56Hck; p59Hck"
                     /inference="alignment:Splign:2.1.0"
     exon            522..620
                     /gene="Hck"
                     /gene_synonym="Hctk; p56Hck; p59Hck"
                     /inference="alignment:Splign:2.1.0"
     exon            621..724
                     /gene="Hck"
                     /gene_synonym="Hctk; p56Hck; p59Hck"
                     /inference="alignment:Splign:2.1.0"
     exon            725..874
                     /gene="Hck"
                     /gene_synonym="Hctk; p56Hck; p59Hck"
                     /inference="alignment:Splign:2.1.0"
     exon            875..1027
                     /gene="Hck"
                     /gene_synonym="Hctk; p56Hck; p59Hck"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1207
                     /gene="Hck"
                     /gene_synonym="Hctk; p56Hck; p59Hck"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1284
                     /gene="Hck"
                     /gene_synonym="Hctk; p56Hck; p59Hck"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1438
                     /gene="Hck"
                     /gene_synonym="Hctk; p56Hck; p59Hck"
                     /inference="alignment:Splign:2.1.0"
     exon            1439..1570
                     /gene="Hck"
                     /gene_synonym="Hctk; p56Hck; p59Hck"
                     /inference="alignment:Splign:2.1.0"
     exon            1571..2057
                     /gene="Hck"
                     /gene_synonym="Hctk; p56Hck; p59Hck"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2036..2041
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hck"
                     /gene_synonym="Hctk; p56Hck; p59Hck"
     polyA_site      2057
                     /gene="Hck"
                     /gene_synonym="Hctk; p56Hck; p59Hck"
ORIGIN      
        1 gatggccagt gagcaccacc gggttgccgc tccccgcttg cactttacgg ttgcggctct
       61 cagacgggtg ggagggaacc aaagtcgccg gtaaaggcgg ctctgacccg ctcggagcgc
      121 caacgcagcc tccgtagccc gcaagtcttc gtcgcttgct ccgggctctc gagtccgggg
      181 ccaccagggg ccgcggcgct ggggggtcgt tcgagctgcg aggatccggg ctgcccgcga
      241 ggcgaagggc gggtgcccag gatgggatgt gtgaagtcca ggttcctccg agaaggaagc
      301 aaggcctcaa aaatagagcc aaatgccaac cagaaaggcc ctgtgtatgt gccggatccc
      361 acgtccccta agaagctggg accgaacagc atcaacagcc tgcccccggg ggtcgtggag
      421 ggctctgagg acaccattgt ggtcgcactg tacgactatg aggccattca ccgtgaagac
      481 ctcagcttcc agaagggaga ccagatggtg gttctggagg agtctgggga gtggtggaag
      541 gcccgttccc tggctaccaa gaaagaaggc tatatcccaa gcaattatgt agctcgagtt
      601 aactctttgg agactgagga gtggttcttc aagggtatca gccggaagga tgcagagcgc
      661 cacctgctgg ctcccgggaa catgctgggc tccttcatga tccgggacag tgagaccacc
      721 aaagggagct actcactttc tgttcgagac tttgaccccc agcacggaga cacggtgaag
      781 cattataaaa tccggacact ggacagtgga ggcttctaca tctctccgag gagcaccttc
      841 agcagcctgc aggaacttgt cgtccactac aagaagggga aggatgggct ctgccagaag
      901 ctgtcagtgc cctgtgtgtc tcccaaaccc cagaagccat gggagaaaga tgcctgggag
      961 attcctcgag aatccctcca gatggagaag aaactgggag ccgggcagtt tggagaagtg
     1021 tggatggcca cctacaacaa gcacaccaaa gtggcggtga agacaatgaa gccagggagc
     1081 atgtctgtgg aggccttcct ggcagaggcc aacctgatga agacgttaca gcatgataaa
     1141 ctggtgaagc tgcacgccgt ggtctctcag gagcccatct ttattgtcac cgagttcatg
     1201 gccaaaggaa gcctgctgga ctttctcaag agtgaagaag gcagcaagca gccactgcca
     1261 aaactcattg acttctcagc ccagatttca gagggcatgg ctttcattga gcagaggaac
     1321 tacatccacc gagacctccg ggctgccaac atcttggttt ctgcatcact ggtgtgtaag
     1381 atcgctgact ttggactggc acggatcatc gaggacaatg agtacacagc tcgggaagga
     1441 gccaagttcc ccatcaagtg gacagctcct gaagccatca actttggctc cttcaccatc
     1501 aagtcagatg tctggtcctt tggtatcctg ctgatggaaa tcgtcaccta cggccggatc
     1561 ccttacccag gtatgtcaaa cccagaggtg attcgagcac tagagcatgg gtaccgtatg
     1621 cctcgaccag ataactgccc agaggagctc tacagtatca tgatccgctg ctggaagaac
     1681 cgtccagagg aacggcccac tttcgaatac atccagagcg tgctggatga cttctacacg
     1741 gccactgaga gccagtatca gcagcaacct tgatgggccg gaagaacatg agcacagcca
     1801 gaagccccat cagggccttg acatgctcga cctgctgggc ccactctcag acgccccctc
     1861 ccccacattc cagctgtcga gtggagggag aggacttcac aatctctttt tgactctagt
     1921 catctgcaat ctgccattct cagggcctcc aagttagtgt ttctcatttg cctggaatga
     1981 actgaattca atctatagct gtgatttaag tgggaagctg ttaaaatagt atttaaataa
     2041 aagatgtgag tgtcaaaaaa aaaaaaaaaa aaaaaaaaaa a
//
