LOCUS       NM_001145334            3255 bp    mRNA    linear   ROD 10-APR-2024
DEFINITION  Rattus norvegicus hydroxycarboxylic acid receptor 1 (Hcar1), mRNA.
ACCESSION   NM_001145334 XM_001072594 XM_001079195
VERSION     NM_001145334.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3255)
  AUTHORS   Ni,Y., Lai,X., Li,L., Sun,J., Qu,Y., Chen,S. and Zhang,H.
  TITLE     Role of GPR81 in regulating intramuscular triglyceride storage
            during aerobic exercise in rats
  JOURNAL   Physiol Int 111 (1), 124-141 (2024)
   PUBMED   38294536
  REMARK    GeneRIF: Role of GPR81 in regulating intramuscular triglyceride
            storage during aerobic exercise in rats.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3255)
  AUTHORS   Wang,H., Xuan,P., Tian,H., Hao,X., Yang,J., Xu,X. and Qiao,L.
  TITLE     Adipose-derived mesenchymal stem cell-derived HCAR1 regulates
            immune response in the attenuation of sepsis
  JOURNAL   Mol Med Rep 26 (3) (2022)
   PUBMED   35856408
  REMARK    GeneRIF: Adiposederived mesenchymal stem cellderived HCAR1
            regulates immune response in the attenuation of sepsis.
REFERENCE   3  (bases 1 to 3255)
  AUTHORS   Briquet,M., Rocher,A.B., Alessandri,M., Rosenberg,N., de Castro
            Abrantes,H., Wellbourne-Wood,J., Schmuziger,C., Ginet,V., Puyal,J.,
            Pralong,E., Daniel,R.T., Offermanns,S. and Chatton,J.Y.
  TITLE     Activation of lactate receptor HCAR1 down-modulates neuronal
            activity in rodent and human brain tissue
  JOURNAL   J Cereb Blood Flow Metab 42 (9), 1650-1665 (2022)
   PUBMED   35240875
  REMARK    GeneRIF: Activation of lactate receptor HCAR1 down-modulates
            neuronal activity in rodent and human brain tissue.
REFERENCE   4  (bases 1 to 3255)
  AUTHORS   Scavuzzo,C.J., Rakotovao,I. and Dickson,C.T.
  TITLE     Differential effects of L- and D-lactate on memory encoding and
            consolidation: Potential role of HCAR1 signaling
  JOURNAL   Neurobiol Learn Mem 168, 107151 (2020)
   PUBMED   31881352
  REMARK    GeneRIF: Differential effects of L- and D-lactate on memory
            encoding and consolidation: Potential role of HCAR1 signaling.
REFERENCE   5  (bases 1 to 3255)
  AUTHORS   Shen,Z., Jiang,L., Yuan,Y., Deng,T., Zheng,Y.R., Zhao,Y.Y.,
            Li,W.L., Wu,J.Y., Gao,J.Q., Hu,W.W., Zhang,X.N. and Chen,Z.
  TITLE     Inhibition of G protein-coupled receptor 81 (GPR81) protects
            against ischemic brain injury
  JOURNAL   CNS Neurosci Ther 21 (3), 271-279 (2015)
   PUBMED   25495836
  REMARK    GeneRIF: Results indicate that lactate may aggravated ischemic
            brain injury by activating GPR81 and inhibition of GPR81 protects
            against ischemia-induced cell death via an antiapoptosis pathway
REFERENCE   6  (bases 1 to 3255)
  AUTHORS   Liu,C., Wu,J., Zhu,J., Kuei,C., Yu,J., Shelton,J., Sutton,S.W.,
            Li,X., Yun,S.J., Mirzadegan,T., Mazur,C., Kamme,F. and
            Lovenberg,T.W.
  TITLE     Lactate inhibits lipolysis in fat cells through activation of an
            orphan G-protein-coupled receptor, GPR81
  JOURNAL   J Biol Chem 284 (5), 2811-2822 (2009)
   PUBMED   19047060
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Nov 4, 2022 this sequence version replaced NM_001145334.1.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR26643285.57239.1,
                                        SRR26643295.45393.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3255              JAXUCZ010000012.1  38371593-38374847
FEATURES             Location/Qualifiers
     source          1..3255
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q15"
     gene            1..3255
                     /gene="Hcar1"
                     /gene_synonym="Gpr81"
                     /note="hydroxycarboxylic acid receptor 1"
                     /db_xref="GeneID:689936"
                     /db_xref="RGD:1586364"
     exon            1..3255
                     /gene="Hcar1"
                     /gene_synonym="Gpr81"
                     /inference="alignment:Splign:2.1.0"
     CDS             348..1403
                     /gene="Hcar1"
                     /gene_synonym="Gpr81"
                     /note="G protein-coupled receptor 81"
                     /codon_start=1
                     /product="hydroxycarboxylic acid receptor 1"
                     /protein_id="NP_001138806.2"
                     /db_xref="GeneID:689936"
                     /db_xref="RGD:1586364"
                     /translation="MLFLSPSAMDNGSCCLIEGEPITQVMPPLLILAFLLGALGNGLA
                     LCGFCFHMKTWKSSTIYLFNLAVADFLLMICLPLRTDYYLRRRHWILGDIPCRLVLFM
                     LAMNRAGSIVFLTVVAVDRYFKVVHPHHMVNAISNRTAAAIVCVLWTLVILGTVYLLM
                     ESHLCVRGMVSSCESFIMESANGWHDIMFQLEFFLPLTIILFCSFRVVWSLRQRQQLT
                     RQARMRRATRFIMVVASVFITCYLPSVLARLYFLWTVPSSACDPSVHIALHVTLSLTY
                     LNSMLDPLVYYFSSPSFPKFYAKLKIRSLKPRRPGRSQARRSEEMPISNLCRKSSTDV
                     VNSSQRPSDGQWGLQVC"
ORIGIN      
        1 agagcattct gcagcccaga gtgcgaggga aaaggcaaaa ctagaaaagc aaaatcgtcc
       61 ccaggggtgg acccagcgac aagtctgctg cgtggctggc atcagacccc caagctgcag
      121 cctggcaatg tacgcttttg gaaaactgct ctcgcctcag agcctgaccc agctgcaggc
      181 ttcacctctg taggggacat gcagcttgtg atccaggctg aggagaaagg acctgctgtc
      241 ggctttcatt tcctgactga agttgggtga tgaggttagg ggcccagctg ccaaggggaa
      301 ccatagtgtt cagataggca gctgtgcctt tgtgtcagcc acctaggatg ctcttcctct
      361 ctccgagtgc tatggacaac gggtcgtgct gtctcatcga gggggaaccc atcacccagg
      421 taatgccacc tttactcatc ctggccttcc tgcttggagc cctgggcaac ggcctagccc
      481 tgtgtggttt ctgctttcac atgaagacct ggaagtcgag cactatttac cttttcaact
      541 tggctgtagc cgattttctc ctcatgatct gcctacccct tcggacagac tactacctca
      601 gacgtaggca ttggattttg ggggatattc cctgccgcct ggtcctcttc atgctggcca
      661 tgaatagggc cggaagcatt gtcttcctca ctgtggtggc cgtggacagg tatttcaaag
      721 tggtccaccc ccaccatatg gtgaacgcca tctccaatcg gactgcagct gccatcgtct
      781 gtgtcctctg gactttggtc atcttgggga ctgtgtatct tctgatggag agtcacctgt
      841 gtgtgcgggg gatggtgtca tcttgtgaga gcttcatcat ggagtcagcc aacgggtggc
      901 acgatatcat gttccagctg gagttcttcc tgcccctgac catcatcttg ttctgctcct
      961 tcagagttgt ttggagcctg agacagaggc aacagctgac cagacaggct cggatgagga
     1021 gggccacccg gttcatcatg gtggtggctt ccgtgttcat cacgtgttac ctgcccagcg
     1081 tgttggcgag gctctacttc ctctggacgg tgccctccag tgcctgtgac ccctctgtcc
     1141 acatagctct ccatgtcacc ctgagtctca cctacctgaa cagcatgctg gaccctcttg
     1201 tgtactactt ctcaagcccc tcgttcccca aattctatgc caagctcaaa atccgcagct
     1261 tgaaacccag acgcccagga cgctcgcagg cacggaggtc ggaagagatg ccaatttcga
     1321 atctctgtcg taagagttcc accgatgtgg taaatagttc ccagaggccg tctgacgggc
     1381 agtggggtct ccaagtgtgt tgaatgccat gaagacaaat ggcccagcag caaagcagag
     1441 acctgggcaa ctgtgagtta aatctgaagg gtgagggact tgaaaaatga cagccccccc
     1501 ccccgcccac ccgcccgccc gccccgctct ttctcagctg tgtctttctc actcaagtag
     1561 aagcaaaatc tacttccaaa tgactggttt gggtttaaat actctgatgg ccatggtaag
     1621 ggggcagccg catgtgagtg tgaaggaaac agtgggtgcc ggggttagga actactcaga
     1681 gcccgtgtcg ctttgcacgg ctgagaaaat cgctttgagc cttgccgggt cttgttctag
     1741 ctgggagaga gttaatgatc tcaataactc gtcggtattt cctggactga aaaaaaatag
     1801 aaactgcact gagtcaatac acttatttcc agctgagcga gaccctttac agcaggacac
     1861 ccagtcctag ccggtttttt atctttccct ggggagcctc ccaacatttc aatgtttgaa
     1921 catacaggtg gcccaggagg gcaaaagaaa gaagctattc caaccctcct aactttctgg
     1981 caatatgttt ctttgttttt tgttattttg ttttgttttt ttctgatttt aggtttgttt
     2041 ctttgtttct cttttgtttg catttcaaag aagatgtgta gggccttgtc tacacatagg
     2101 ctatcagata tttctccagt ggaaactgag agccttcgta ctaccaccag ggggtccttc
     2161 ctggtatttg ggacctgtta gttccaacac tgttgttttt cactgcttga ggcatgactg
     2221 tgagttgaaa tcatttcttc attctcaagt ctctgtcaag agcgcttgcc tagcaagcac
     2281 aaggccctgg gttcggtcct cagctccgga aaaaaaaaaa gtctctgtca aatccatagt
     2341 gtgttgtccc gctctatcca gcatcctcat gggttttgtc tctggtgctg ggcattgaac
     2401 ttgggacctt acctgaccta gacaagcact gaccactgaa ccccactccc aatcccgtcg
     2461 tgtccctttt agctgtagtg ttgttagcca actcttggga gaaaataaag cactagggga
     2521 ggcagcaaca gttcagctcc gctccctctc atcagtgtct agacttctag tcagccatgg
     2581 gggtttcttc ctactgtggg cctctctcac gcacgaatgt tccccaaata ctacctggtg
     2641 ttctcacagc caggggactc tgaaagcaca ggctgctctc gtcctggaga aggggaaata
     2701 gattccgtgt gttaacctta gctctacttt caagccacaa aagcggtgac tgacagtgat
     2761 tcactttcgc caattcccag ggcactctcc ccaagagaca ctttagccag agacactcct
     2821 caaggttgtc cccatggttt cccttgccag aggtgtcata cagcctagta gcaaaaacca
     2881 gtctgactgt aggagctgtc gagatggctc agaaggtgaa caggtctgcc accaagccac
     2941 caacctgagt atccctgaga cccacctgat agaaggcact aaatacattc atgcagtaac
     3001 aatgttactg gcgagtggat ctcagttttg actcttagtt taaatactta ttaggcttgt
     3061 gctcataggg aagattttat ttaactgcgc tcagtttcga attctccatt tgttcaacag
     3121 gggtggtact gatgccaaag ggtttggggg caaattcaat aacggtgccc tcattagcat
     3181 aaggaatttg tggttcctgg gtgcctagaa gaccatgtgt gtacagtaga cgagaaataa
     3241 agctgctgac cgact
//
