LOCUS       NM_013221               2671 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus HMG-box transcription factor 1 (Hbp1), mRNA.
ACCESSION   NM_013221
VERSION     NM_013221.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2671)
  AUTHORS   Zhang,B.F., Song,W., Wang,J., Wen,P.F. and Zhang,Y.M.
  TITLE     Anti-high-mobility group box-1 (HMGB1) mediates the apoptosis of
            alveolar epithelial cells (AEC) by receptor of advanced glycation
            end-products (RAGE)/c-Jun N-terminal kinase (JNK) pathway in the
            rats of crush injuries
  JOURNAL   J Orthop Surg Res 17 (1), 20 (2022)
   PUBMED   35033142
  REMARK    GeneRIF: Anti-high-mobility group box-1 (HMGB1) mediates the
            apoptosis of alveolar epithelial cells (AEC) by receptor of
            advanced glycation end-products (RAGE)/c-Jun N-terminal kinase
            (JNK) pathway in the rats of crush injuries.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2671)
  AUTHORS   Zhao,T., Zhu,Y., Yao,L., Liu,L. and Li,N.
  TITLE     IGF-1 alleviates CCL4-induced hepatic cirrhosis and dysfunction of
            intestinal barrier through inhibition TLR4/NF-kappaB signaling
            mediated by down-regulation HMGB1
  JOURNAL   Ann Hepatol 26, 100560 (2021)
   PUBMED   34653689
  REMARK    GeneRIF: IGF-1 alleviates CCL4-induced hepatic cirrhosis and
            dysfunction of intestinal barrier through inhibition TLR4/NF-kappaB
            signaling mediated by down-regulation HMGB1.
REFERENCE   3  (bases 1 to 2671)
  AUTHORS   Huang,L., Zhang,D., Han,W. and Guo,C.
  TITLE     High-mobility group box-1 inhibition stabilizes intestinal
            permeability through tight junctions in experimental acute
            necrotizing pancreatitis
  JOURNAL   Inflamm Res 68 (8), 677-689 (2019)
   PUBMED   31139836
  REMARK    GeneRIF: These observations suggested, for the first time, that
            HMGB1 plays a critical role in the pathogenesis of acute
            necrotizing pancreatitis by affecting intestinal permeability and
            autophagy.
REFERENCE   4  (bases 1 to 2671)
  AUTHORS   Tian,F.J., An,L.N., Wang,G.K., Zhu,J.Q., Li,Q., Zhang,Y.Y.,
            Zeng,A., Zou,J., Zhu,R.F., Han,X.S., Shen,N., Yang,H.T., Zhao,X.X.,
            Huang,S., Qin,Y.W. and Jing,Q.
  TITLE     Elevated microRNA-155 promotes foam cell formation by targeting
            HBP1 in atherogenesis
  JOURNAL   Cardiovasc Res 103 (1), 100-110 (2014)
   PUBMED   24675724
REFERENCE   5  (bases 1 to 2671)
  AUTHORS   Raine,E.V., Wreglesworth,N., Dodd,A.W., Reynard,L.N. and
            Loughlin,J.
  TITLE     Gene expression analysis reveals HBP1 as a key target for the
            osteoarthritis susceptibility locus that maps to chromosome 7q22
  JOURNAL   Ann Rheum Dis 71 (12), 2020-2027 (2012)
   PUBMED   22586168
REFERENCE   6  (bases 1 to 2671)
  AUTHORS   Berasi,S.P., Xiu,M., Yee,A.S. and Paulson,K.E.
  TITLE     HBP1 repression of the p47phox gene: cell cycle regulation via the
            NADPH oxidase
  JOURNAL   Mol Cell Biol 24 (7), 3011-3024 (2004)
   PUBMED   15024088
REFERENCE   7  (bases 1 to 2671)
  AUTHORS   Kokkola,R., Sundberg,E., Ulfgren,A.K., Palmblad,K., Li,J., Wang,H.,
            Ulloa,L., Yang,H., Yan,X.J., Furie,R., Chiorazzi,N., Tracey,K.J.,
            Andersson,U. and Harris,H.E.
  TITLE     High mobility group box chromosomal protein 1: a novel
            proinflammatory mediator in synovitis
  JOURNAL   Arthritis Rheum 46 (10), 2598-2603 (2002)
   PUBMED   12384917
REFERENCE   8  (bases 1 to 2671)
  AUTHORS   Dintilhac,A. and Bernues,J.
  TITLE     HMGB1 interacts with many apparently unrelated proteins by
            recognizing short amino acid sequences
  JOURNAL   J Biol Chem 277 (9), 7021-7028 (2002)
   PUBMED   11748221
  REMARK    GeneRIF: Our results have led us to propose that HMGB1 may play a
            central role in the stabilization and/or assembly of several
            multifunctional complexes through protein-protein interactions
REFERENCE   9  (bases 1 to 2671)
  AUTHORS   Lavender,P., Vandel,L., Bannister,A.J. and Kouzarides,T.
  TITLE     The HMG-box transcription factor HBP1 is targeted by the pocket
            proteins and E1A
  JOURNAL   Oncogene 14 (22), 2721-2728 (1997)
   PUBMED   9178770
REFERENCE   10 (bases 1 to 2671)
  AUTHORS   Lesage,F., Hugnot,J.P., Amri,E.Z., Grimaldi,P., Barhanin,J. and
            Lazdunski,M.
  TITLE     Expression cloning in K+ transport defective yeast and distribution
            of HBP1, a new putative HMG transcriptional regulator
  JOURNAL   Nucleic Acids Res 22 (18), 3685-3688 (1994)
   PUBMED   7937077
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB732549.1, BC091165.1 and BQ192519.1.
            
            On Dec 2, 2009 this sequence version replaced NM_013221.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ223257.1, FQ224288.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                CB732549.1         57-82
            27-2647             BC091165.1         1-2621
            2648-2671           BQ192519.1         1-24                c
FEATURES             Location/Qualifiers
     source          1..2671
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q16"
     gene            1..2671
                     /gene="Hbp1"
                     /gene_synonym="Hmgb1"
                     /note="HMG-box transcription factor 1"
                     /db_xref="GeneID:27080"
                     /db_xref="RGD:620444"
     exon            1..31
                     /gene="Hbp1"
                     /gene_synonym="Hmgb1"
                     /inference="alignment:Splign:2.1.0"
     CDS             17..1588
                     /gene="Hbp1"
                     /gene_synonym="Hmgb1"
                     /note="high mobility group protein 1; high mobility group
                     box transcription factor 1"
                     /codon_start=1
                     /product="HMG box-containing protein 1"
                     /protein_id="NP_037353.2"
                     /db_xref="GeneID:27080"
                     /db_xref="RGD:620444"
                     /translation="MATGLSEHHNMVWEVKTNQRPHAVQRLLLVMDERATGVSDSLEL
                     LQCNENVPSSPGYNSCDEHMELDDLPELQAVQSDPTQSAIYQLSSDVSHQEYPRPSWS
                     QNTSDIPENTHREDEVDWLTELANIATSPQSPLMQCSFYNRSSPVHIIATSKSLHSYA
                     RPPPVSSAKSGPAFPHDHWKEETPVRHERANSESESGIFCMSSLSDDDDLGWCNSWPS
                     TVWHCFLKGTRLCFHKESKKEWQDVEDFARAASCDEEEIQMGTHKGYGSDGLKLLSHE
                     ESVSFGESVLKLTFDPGTVEDGLLTVECKLDHPFYVKNKGWSSFYPSLTVVQHGIPCC
                     EIHIGDVCLPPGHPDAINFDDSGVFDTFKSYDFTPMDSSAVYVLSSMARQRRASLSCG
                     GPGTGQEFAGSEFSKSCGSPGSSQLSSSSLYTKAVKSHSSGTVSATSPNKCKRPMNAF
                     MLFAKKYRVEYTQMYPGKDNRAISVILGDRWKKMKNEERRMYTLEAKALAEEQKRLNP
                     DCWKRKRTNSGSQQH"
     exon            32..215
                     /gene="Hbp1"
                     /gene_synonym="Hmgb1"
                     /inference="alignment:Splign:2.1.0"
     exon            216..444
                     /gene="Hbp1"
                     /gene_synonym="Hmgb1"
                     /inference="alignment:Splign:2.1.0"
     exon            445..583
                     /gene="Hbp1"
                     /gene_synonym="Hmgb1"
                     /inference="alignment:Splign:2.1.0"
     exon            584..695
                     /gene="Hbp1"
                     /gene_synonym="Hmgb1"
                     /inference="alignment:Splign:2.1.0"
     exon            696..805
                     /gene="Hbp1"
                     /gene_synonym="Hmgb1"
                     /inference="alignment:Splign:2.1.0"
     exon            806..962
                     /gene="Hbp1"
                     /gene_synonym="Hmgb1"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1107
                     /gene="Hbp1"
                     /gene_synonym="Hmgb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1428
                     /gene="Hbp1"
                     /gene_synonym="Hmgb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1429..1570
                     /gene="Hbp1"
                     /gene_synonym="Hmgb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1571..2654
                     /gene="Hbp1"
                     /gene_synonym="Hmgb1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttgaaagac ttggtaatgg cgacgggttt gtcggagcac cataatatgg tgtgggaagt
       61 gaagacgaac cagaggcctc atgcagtaca gagactcctg ctggtgatgg acgagagagc
      121 tacaggagtg agtgactcat tggagttgct gcagtgtaat gagaatgtgc cgtcctctcc
      181 aggatacaac tcctgtgatg agcacatgga gcttgatgac cttcctgaac ttcaggctgt
      241 tcaaagtgac cctacccaat ctgccatata ccagctcagt tcagatgtat ctcatcaaga
      301 atatccaaga ccatcttgga gccagaatac ctcagacata ccggaaaata ctcaccgtga
      361 agatgaggtg gactggctaa cagagttagc aaatattgcc actagtccac aaagtccact
      421 aatgcagtgc tcattttata acagatcatc tcctgtacac atcatagcta ctagcaaaag
      481 tttacattcc tatgcacgcc caccaccagt gtcctctgca aagagcggac cagccttccc
      541 tcatgaccac tggaaggaag aaacaccagt aagacatgaa agggcaaaca gtgagtcaga
      601 gtcaggaatt ttctgcatgt cctccctgtc agatgatgat gatctgggct ggtgcaattc
      661 ctggccatca accgtttggc attgctttct caaaggcaca cgactgtgct tccataagga
      721 aagcaaaaag gagtggcaag atgttgaaga ctttgctaga gccgccagct gtgatgagga
      781 ggagatccaa atgggcactc acaagggcta tgggtctgat ggtctaaagt tgttatccca
      841 tgaagagagt gtgtcattcg gtgagtctgt actgaagttg acatttgatc ctggtacagt
      901 agaagatggc ttgcttactg tggagtgcaa gctggaccac cctttctatg ttaaaaataa
      961 aggctggtca tcattttatc caagcttgac tgtggtacag cacggcattc catgctgtga
     1021 gattcatatt ggtgacgtat gtctacctcc tggacaccct gatgccatta atttcgatga
     1081 ttcaggtgtt tttgatacat ttaaaagcta tgacttcaca cctatggact cttccgcagt
     1141 ctacgttttg agtagtatgg ctcgccagcg ccgcgcatct ttgtcttgtg gaggacctgg
     1201 tactggtcaa gagtttgcag gatctgaatt cagtaaaagc tgtggttcac caggatcatc
     1261 acagctctcc tctagttctt tatacactaa agctgtcaaa agccacagct cagggactgt
     1321 gagtgccact tctcctaata agtgcaaaag accaatgaat gccttcatgc tttttgccaa
     1381 aaaatacaga gttgaatata ctcagatgta tccagggaaa gataacagag ccataagtgt
     1441 gatccttggt gacaggtgga aaaaaatgaa gaacgaggaa aggaggatgt atacattaga
     1501 agcaaaggct ttggctgaag aacaaaagcg tttaaatccc gactgctgga aaaggaaaag
     1561 aaccaattca ggctctcaac agcactaaac ctgatgcttc tgtctgtaag tctgtacctg
     1621 catcagtact gactctgtac ctgcataagg actgactctg gacggaaaag cttggaagac
     1681 cttggtctca ccatttgtcc tacatttgtg tgaccataaa atgctgggag cattgagttt
     1741 tgtaatgatt taatgggtga ggaggatctg ctttctccat tagagcatta agtaagctaa
     1801 aactatcaac attgtaaacc aaattgcctt attttccttc caaacttcat atatgtctat
     1861 caggtaatat aggcttgaaa attgatatcc tgtggtgcta aagtacagta gaaagagaga
     1921 tgtgtataca tgtcttattt taaattgtac gaaggggaat ttaaaaatat gtaactgctg
     1981 tttatacatc agctccttac tgcttattaa tctgtattgt acccacgata tcaggaatga
     2041 agcagaagct ggcctttcca tgaatagcca ccacatggcc cagtgtctct gccaaacaca
     2101 gttgcttcta gtctggccag tgccaagaga caacctaaca tggcaggtgg atggtgtcat
     2161 tgtctcagct gagagccacc tgcttcagat accatgggcg tgtgctgagt ggatgcacca
     2221 gggggcagca cagctccatg attcccagtg gggcccaagc caggctaagg tgcagtcagt
     2281 tagcattggg acagtcattg taatggtgct gttatcagtt gaaaccatgc tccctgtctc
     2341 ctcagccaca tcccctccgt ctctgctgtc atcttctctg tggtggggca gactttgcac
     2401 ttactgcagt gcaacacttg cactttaccc ctccggcttc tacagtagag caagtccttc
     2461 ggcagccctg ctgctttcgc tctgcgctac aatcatggct tctcatgtta cttaccaagt
     2521 ggtatttttg gttaggaatc acagctgtaa agttgatttc agttcattac acttcttaaa
     2581 catattgccc ctcaattttg cacactatat tcttgtatat tatttcaaat aaaatgaaaa
     2641 aagtctattt ctgaaaaaaa aaaaaaaaaa a
//
