LOCUS       NM_012945               1549 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus heparin-binding EGF-like growth factor (Hbegf),
            mRNA.
ACCESSION   NM_012945
VERSION     NM_012945.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1549)
  AUTHORS   Zhang,C., Liu,Y., Yang,F., Liu,Y., Wang,N., Li,Y., Liu,Y., Qiu,Z.,
            Zhang,L., You,X. and Gan,L.
  TITLE     MicroRNA-194-5p/Heparin-binding EGF-like growth factor signaling
            mediates dexamethasone-induced activation of pseudorabies virus in
            rat pheochromocytoma cells
  JOURNAL   Vet Microbiol 290, 109974 (2024)
   PUBMED   38262115
  REMARK    GeneRIF: MicroRNA-194-5p/Heparin-binding EGF-like growth factor
            signaling mediates dexamethasone-induced activation of pseudorabies
            virus in rat pheochromocytoma cells.
REFERENCE   2  (bases 1 to 1549)
  AUTHORS   Yip,J.L.K., Xavier,S., Balasuriya,G.K., Hill-Yardin,E.L. and
            Spencer,S.J.
  TITLE     Macrophage regulation of the 'second brain': CD163 intestinal
            macrophages interact with inhibitory interneurons to regulate
            colonic motility - evidence from the Cx3cr1-Dtr rat model
  JOURNAL   Front Immunol 14, 1269890 (2023)
   PUBMED   37868978
  REMARK    GeneRIF: Macrophage regulation of the 'second brain': CD163
            intestinal macrophages interact with inhibitory interneurons to
            regulate colonic motility - evidence from the Cx3cr1-Dtr rat model.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1549)
  AUTHORS   Vishwakarma,J., Gupta,K., Mishra,J., Garg,A., Malik,R., Kashyap,A.,
            Shukla,M., Singh,D. and Bandyopadhyay,S.
  TITLE     Hypothyroidism induces motor deficit via altered cerebellar
            HB-EGF/EGFR and autophagy
  JOURNAL   J Endocrinol 257 (1), e220338 (2023)
   PUBMED   36655849
  REMARK    GeneRIF: Hypothyroidism induces motor deficit via altered
            cerebellar HB-EGF/EGFR and autophagy.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1549)
  AUTHORS   Sakamoto,T., Pak,K., Chavez,E., Ryan,A.F. and Kurabi,A.
  TITLE     HB-EGF Plays a Pivotal Role in Mucosal Hyperplasia During Otitis
            Media Induced by a Viral Analog
  JOURNAL   Front Cell Infect Microbiol 12, 823714 (2022)
   PUBMED   35281434
  REMARK    GeneRIF: HB-EGF Plays a Pivotal Role in Mucosal Hyperplasia During
            Otitis Media Induced by a Viral Analog.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1549)
  AUTHORS   Maachi,H., Fergusson,G., Ethier,M., Brill,G.N., Katz,L.S.,
            Honig,L.B., Metukuri,M.R., Scott,D.K., Ghislain,J. and Poitout,V.
  TITLE     HB-EGF Signaling Is Required for Glucose-Induced Pancreatic
            beta-Cell Proliferation in Rats
  JOURNAL   Diabetes 69 (3), 369-380 (2020)
   PUBMED   31882563
  REMARK    GeneRIF: Knockdown of HB-EGF in rat islets blocks beta-cell
            proliferation in response to glucose ex vivo and in vivo in
            transplanted glucose-infused rats. Findings identify a novel
            glucose/HB-EGF/EGFR axis implicated in beta-cell compensation to
            increased metabolic demand.
REFERENCE   6  (bases 1 to 1549)
  AUTHORS   Izumi,Y., Hirata,M., Hasuwa,H., Iwamoto,R., Umata,T., Miyado,K.,
            Tamai,Y., Kurisaki,T., Sehara-Fujisawa,A., Ohno,S. and Mekada,E.
  TITLE     A metalloprotease-disintegrin, MDC9/meltrin-gamma/ADAM9 and
            PKCdelta are involved in TPA-induced ectodomain shedding of
            membrane-anchored heparin-binding EGF-like growth factor
  JOURNAL   EMBO J 17 (24), 7260-7272 (1998)
   PUBMED   9857183
REFERENCE   7  (bases 1 to 1549)
  AUTHORS   Riese,D.J., Kim,E.D., Elenius,K., Buckley,S., Klagsbrun,M.,
            Plowman,G.D. and Stern,D.F.
  TITLE     The epidermal growth factor receptor couples transforming growth
            factor-alpha, heparin-binding epidermal growth factor-like factor,
            and amphiregulin to Neu, ErbB-3, and ErbB-4
  JOURNAL   J Biol Chem 271 (33), 20047-20052 (1996)
   PUBMED   8702723
REFERENCE   8  (bases 1 to 1549)
  AUTHORS   Thompson,S.A., Higashiyama,S., Wood,K., Pollitt,N.S., Damm,D.,
            McEnroe,G., Garrick,B., Ashton,N., Lau,K., Hancock,N. et al.
  TITLE     Characterization of sequences within heparin-binding EGF-like
            growth factor that mediate interaction with heparin
  JOURNAL   J Biol Chem 269 (4), 2541-2549 (1994)
   PUBMED   8300582
REFERENCE   9  (bases 1 to 1549)
  AUTHORS   Abraham,J.A., Damm,D., Bajardi,A., Miller,J., Klagsbrun,M. and
            Ezekowitz,R.A.
  TITLE     Heparin-binding EGF-like growth factor: characterization of rat and
            mouse cDNA clones, protein domain conservation across species, and
            transcript expression in tissues
  JOURNAL   Biochem Biophys Res Commun 190 (1), 125-133 (1993)
   PUBMED   7678488
REFERENCE   10 (bases 1 to 1549)
  AUTHORS   Higashiyama,S., Abraham,J.A., Miller,J., Fiddes,J.C. and
            Klagsbrun,M.
  TITLE     A heparin-binding growth factor secreted by macrophage-like cells
            that is related to EGF
  JOURNAL   Science 251 (4996), 936-939 (1991)
   PUBMED   1840698
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Nov 26, 2020 this sequence version replaced NM_012945.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L05489.1, SRR26643429.53860.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840105,
                                           SAMN12840106 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-75                JAXUCZ010000018.1  28390146-28390220   c
            76-249              JAXUCZ010000018.1  28389780-28389953   c
            250-427             JAXUCZ010000018.1  28387349-28387526   c
            428-583             JAXUCZ010000018.1  28382290-28382445   c
            584-674             JAXUCZ010000018.1  28381493-28381583   c
            675-1549            JAXUCZ010000018.1  28380337-28381211   c
FEATURES             Location/Qualifiers
     source          1..1549
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p11"
     gene            1..1549
                     /gene="Hbegf"
                     /gene_synonym="Dtr; GFHB; Hb-egf; Hegfl"
                     /note="heparin-binding EGF-like growth factor"
                     /db_xref="GeneID:25433"
                     /db_xref="RGD:2526"
     exon            1..75
                     /gene="Hbegf"
                     /gene_synonym="Dtr; GFHB; Hb-egf; Hegfl"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..656
                     /gene="Hbegf"
                     /gene_synonym="Dtr; GFHB; Hb-egf; Hegfl"
                     /note="proheparin-binding EGF-like growth factor;
                     Diphtheria toxin receptor (heparin binding epidermal
                     growth factor - like growth factor); heparin-binding
                     epidermal -growth - like growth factor; heparin binding
                     epidermal growth factor-like growth factor;
                     heparin-binding epidermal -growth factor"
                     /codon_start=1
                     /product="proheparin-binding EGF-like growth factor
                     precursor"
                     /protein_id="NP_037077.1"
                     /db_xref="GeneID:25433"
                     /db_xref="RGD:2526"
                     /translation="MKLLPSVVLKLFLAAVLSALVTGESLERLRRGLAAATSNPDPPT
                     GTTNQLLPTGADRAQEVQDLEGTDLDLFKVAFSSKPQALATPGKEKNGKKKRKGKGLG
                     KKRDPCLKKYKDYCIHGECRYLKELRIPSCHCLPGYHGQRCHGLTLPVENPLYTYDHT
                     TVLAVVAVVLSSVCLLVIVGLLMFRYHRRGGYDLESEEKVKLGMASSH"
     exon            76..249
                     /gene="Hbegf"
                     /gene_synonym="Dtr; GFHB; Hb-egf; Hegfl"
                     /inference="alignment:Splign:2.1.0"
     exon            250..427
                     /gene="Hbegf"
                     /gene_synonym="Dtr; GFHB; Hb-egf; Hegfl"
                     /inference="alignment:Splign:2.1.0"
     exon            428..583
                     /gene="Hbegf"
                     /gene_synonym="Dtr; GFHB; Hb-egf; Hegfl"
                     /inference="alignment:Splign:2.1.0"
     exon            584..674
                     /gene="Hbegf"
                     /gene_synonym="Dtr; GFHB; Hb-egf; Hegfl"
                     /inference="alignment:Splign:2.1.0"
     exon            675..1549
                     /gene="Hbegf"
                     /gene_synonym="Dtr; GFHB; Hb-egf; Hegfl"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcccccccgt ctccgccagg ctcgggacca tgaagctgct gccgtcggtg gtgctgaagc
       61 tctttctggc cgcagtgttg tccgcgttgg tgaccggtga gagtctggag cggcttcgga
      121 gaggtctggc ggcagcaacc agcaaccctg accctcccac tggaaccaca aaccagctgc
      181 tacccacggg agctgatcgc gctcaggagg tccaggactt ggaagggacc gatctggacc
      241 ttttcaaagt tgctttctcc tccaagccac aagccctggc caccccagga aaagaaaaga
      301 acgggaaaaa gaagaggaaa ggcaaggggt taggaaagaa gagagatcca tgccttaaga
      361 aatacaagga ctactgcatc cacggagagt gcagatacct gaaggagctc cgtattccct
      421 cgtgccactg cctccctggt taccatggac agaggtgtca tgggctgacc ctaccggtag
      481 agaaccccct gtacacatat gaccacacta ccgtcttggc tgtggtggct gtagtactgt
      541 catctgtctg tcttcttgtc atcgtgggac ttctcatgtt caggtaccat aggcgaggag
      601 gttatgactt ggaaagtgag gagaaagtga agttgggcat ggctagctcc cactgaggag
      661 gatctgagct caaggagcct tcagaggatg gctacttctg agatggcggt tccttacaag
      721 ttctacagag ggaaaatact tcaccagcag ccatgaagac ttcttcattc attcccagtt
      781 gctaccctga ctgggcctcc tgtaattgct ctgcaaaaat atcagagcct ctaagtgcca
      841 aacagactat gccccgctgg gatctggatc agaagaaagc aggagcaagt gagcccttca
      901 ggccttcctg atcctccacc actgaaccca ctggtttgtt taaacactta gcttctggat
      961 taaagtgtca gctagtttcc atatgctcca ggatttttgg ctgaaaaaaa aaaaagaaga
     1021 gaggacggat gagtggttta tggactggaa gagatcaaca gagttgagaa gctaagtgtt
     1081 caagtagcca caggggatct gctgtttgga ccctccagca cgctggattt gatgagctaa
     1141 ctgtgaaata tctcaagccc gagaactctt gagttttggg acttctaccc agaggggaaa
     1201 aataacaagt attttgttgt tgttgttgtt tgtttgtttt taaaatgcct cttaaattat
     1261 atatttattt tattctatgt atgttaatat atttagtttt taacaatcta acaataatat
     1321 ttcaagtgcc tagactgtta ctttgccaat gtcctggccc gcctctcttg cagctcttcc
     1381 acctggctca atgccacact cccatctgct ctgtaaccca tctgtagtaa tttattgtct
     1441 gtctacattt cagaagatgc ccctgtagca gagtatccca gggtgggttg tgtatggtcg
     1501 gagtgcaagg atggatttgg gcagagccac tctgtgagtt ggactgcag
//
