LOCUS       NM_001008890             624 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus hemoglobin subunit epsilon 1 (Hbe1), mRNA.
ACCESSION   NM_001008890 XM_215029
VERSION     NM_001008890.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 624)
  AUTHORS   Green,N.S., Ender,K.L., Pashankar,F., Driscoll,C., Giardina,P.J.,
            Mullen,C.A., Clark,L.N., Manwani,D., Crotty,J., Kisselev,S.,
            Neville,K.A., Hoppe,C. and Barral,S.
  TITLE     Candidate sequence variants and fetal hemoglobin in children with
            sickle cell disease treated with hydroxyurea
  JOURNAL   PLoS One 8 (2), e55709 (2013)
   PUBMED   23409025
REFERENCE   2  (bases 1 to 624)
  AUTHORS   Bastos-Amador,P., Royo,F., Gonzalez,E., Conde-Vancells,J.,
            Palomo-Diez,L., Borras,F.E. and Falcon-Perez,J.M.
  TITLE     Proteomic analysis of microvesicles from plasma of healthy donors
            reveals high individual variability
  JOURNAL   J Proteomics 75 (12), 3574-3584 (2012)
   PUBMED   22516433
REFERENCE   3  (bases 1 to 624)
  AUTHORS   Hu,X., Eszterhas,S., Pallazzi,N., Bouhassira,E.E., Fields,J.,
            Tanabe,O., Gerber,S.A., Bulger,M., Engel,J.D., Groudine,M. and
            Fiering,S.
  TITLE     Transcriptional interference among the murine beta-like globin
            genes
  JOURNAL   Blood 109 (5), 2210-2216 (2007)
   PUBMED   17077320
REFERENCE   4  (bases 1 to 624)
  AUTHORS   Mu,X., Liu,K., Kleymenova,E., Sar,M., Young,S.S. and Gaido,K.W.
  TITLE     Gene expression profiling of androgen receptor antagonists in the
            rat fetal testis reveals few common gene targets
  JOURNAL   J Biochem Mol Toxicol 20 (1), 7-17 (2006)
   PUBMED   16498641
REFERENCE   5  (bases 1 to 624)
  AUTHORS   He,Z. and Russell,J.E.
  TITLE     A human embryonic hemoglobin inhibits Hb S polymerization in vitro
            and restores a normal phenotype to mouse models of sickle cell
            disease
  JOURNAL   Proc Natl Acad Sci U S A 99 (16), 10635-10640 (2002)
   PUBMED   12124399
REFERENCE   6  (bases 1 to 624)
  AUTHORS   Satoh,H., Inokuchi,N., Nagae,Y. and Okazaki,T.
  TITLE     Molecular cloning and characterization of two sets of alpha-theta
            genes in the rat alpha-like globin gene cluster
  JOURNAL   Gene 230 (1), 91-99 (1999)
   PUBMED   10196478
REFERENCE   7  (bases 1 to 624)
  AUTHORS   Iwahara,S.I., Abe,Y. and Okazaki,T.
  TITLE     Identification of five embryonic hemoglobins of rat and ontogeny of
            their constituent globins during fetal development
  JOURNAL   J Biochem 119 (2), 360-366 (1996)
   PUBMED   8882731
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Oct 5, 2022 this sequence version replaced NM_001008890.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ144929.1, FQ222123.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680421, SAMN06680423
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-147               JAXUCZ010000001.1  167696134-167696280 c
            148-370             JAXUCZ010000001.1  167695793-167696015 c
            371-624             JAXUCZ010000001.1  167694820-167695073 c
FEATURES             Location/Qualifiers
     source          1..624
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..624
                     /gene="Hbe1"
                     /gene_synonym="Glnb1; Hbb-y"
                     /note="hemoglobin subunit epsilon 1"
                     /db_xref="GeneID:293267"
                     /db_xref="RGD:1305115"
     exon            1..147
                     /gene="Hbe1"
                     /gene_synonym="Glnb1; Hbb-y"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..499
                     /gene="Hbe1"
                     /gene_synonym="Glnb1; Hbb-y"
                     /note="epsilon 1 globin; hemoglobin, epsilon 1; hemoglobin
                     Y, beta-like embryonic chain; globin b1"
                     /codon_start=1
                     /product="hemoglobin subunit epsilon 1"
                     /protein_id="NP_001008890.1"
                     /db_xref="GeneID:293267"
                     /db_xref="RGD:1305115"
                     /translation="MVNFTAEEKSLINGLWSKVNVEEVGGEALGRLLVVYPWTQRFFD
                     SFGNLSSASAIMGNPRVKAHGKKVLTAFGETIKNLDNLKSALAKLSELHCDKLHVDPE
                     NFKLLGNVLVIVLASHFGNEFTAEVQAAWQKLVAGVATALSHKYH"
     exon            148..370
                     /gene="Hbe1"
                     /gene_synonym="Glnb1; Hbb-y"
                     /inference="alignment:Splign:2.1.0"
     exon            371..624
                     /gene="Hbe1"
                     /gene_synonym="Glnb1; Hbb-y"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgcacttgc ttctgacact tctgtggtca ccagcaacct cccagacttg acatcatggt
       61 gaactttact gctgaggaaa agagcctcat caatggccta tggagtaaag tgaatgttga
      121 ggaggttggt ggtgaagcct tgggaagact tctcgttgtg tacccatgga cccagagatt
      181 ctttgacagc tttgggaact tgtcctctgc ctctgccata atgggtaacc caagagtcaa
      241 agcccatggc aagaaggtgc tgactgcttt tggagaaacc attaagaacc tagacaacct
      301 caagtctgcc ttggccaagc tcagtgaact gcactgtgac aagctacatg ttgatcctga
      361 gaacttcaaa ctcttgggta atgtgctggt gattgttctg gctagtcact tcggcaatga
      421 attcacggct gaggtacagg ctgcctggca gaagttggtg gctggggtgg ccactgctct
      481 gtcccataag taccactgag ccctttctct agctgtccag caatcctgtg tgtcccctct
      541 gccctctttc ttcacatgag tactggactg gtccttgaaa ggacagcatg tttaataaag
      601 atcattcttc ctggtaatca aaaa
//
