LOCUS       NM_001111269             632 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus hemoglobin, beta adult s chain (Hbb-bs), mRNA.
ACCESSION   NM_001111269 XM_001069372
VERSION     NM_001111269.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 632)
  AUTHORS   Bastos-Amador,P., Royo,F., Gonzalez,E., Conde-Vancells,J.,
            Palomo-Diez,L., Borras,F.E. and Falcon-Perez,J.M.
  TITLE     Proteomic analysis of microvesicles from plasma of healthy donors
            reveals high individual variability
  JOURNAL   J Proteomics 75 (12), 3574-3584 (2012)
   PUBMED   22516433
REFERENCE   2  (bases 1 to 632)
  AUTHORS   Chu,Q., Zhang,J., Wu,Y., Zhang,Y., Xu,G., Li,W. and Xu,G.T.
  TITLE     Differential gene expression pattern of diabetic rat retinas after
            intravitreal injection of erythropoietin
  JOURNAL   Clin Exp Ophthalmol 39 (2), 142-151 (2011)
   PUBMED   20973890
REFERENCE   3  (bases 1 to 632)
  AUTHORS   Sanna,M.T., Giardina,B., Scatena,R., Pellegrini,M., Olianas,A.,
            Manca,L., Masala,B., Castagnola,M. and Corda,M.
  TITLE     Functional alterations in adult and fetal hemoglobin Sassari
            Asp-alpha 126(H9)-->His. The role of alpha 1 alpha 2 contact
  JOURNAL   J Biol Chem 269 (28), 18338-18342 (1994)
   PUBMED   7518430
REFERENCE   4  (bases 1 to 632)
  AUTHORS   Paunesku,T., Stevanovic,M., Radosavljevic,D., Drmanac,R. and
            Crkvenjakov,R.
  TITLE     Origin of rat beta-globin haplotypes containing three and five
            genes
  JOURNAL   Mol Biol Evol 7 (5), 407-422 (1990)
   PUBMED   2263193
REFERENCE   5  (bases 1 to 632)
  AUTHORS   Woo,C., Lam,V.M. and Tam,J.W.
  TITLE     cDNA sequences of two beta-globin genes in a Sprague-Dawley rat
  JOURNAL   Nucleic Acids Res 17 (21), 8870 (1989)
   PUBMED   2587229
REFERENCE   6  (bases 1 to 632)
  AUTHORS   Stevanovic,M., Paunesku,T., Radosavljevic,D., Drmanac,R. and
            Crkvenjakov,R.
  TITLE     Variant chromosomal arrangement of adult beta-globin genes in rat
  JOURNAL   Gene 79 (1), 139-150 (1989)
   PUBMED   2777087
REFERENCE   7  (bases 1 to 632)
  AUTHORS   Stevanovic,M. and Crkvenjakov,R.
  TITLE     Genomic sequence of rat beta-globin minor gene
  JOURNAL   Nucleic Acids Res 17 (12), 4878 (1989)
   PUBMED   2748344
REFERENCE   8  (bases 1 to 632)
  AUTHORS   Wong,W.M., Lam,V.M., Cheng,L.Y. and Tam,J.W.
  TITLE     Genomic sequence of a Sprague-Dawley rat beta-globin gene
  JOURNAL   Nucleic Acids Res 16 (5), 2342 (1988)
   PUBMED   3357786
REFERENCE   9  (bases 1 to 632)
  AUTHORS   Ohshita,Y. and Hozumi,T.
  TITLE     Sequence of the rat beta-globin mRNA
  JOURNAL   Nucleic Acids Res 15 (3), 1336 (1987)
   PUBMED   3453111
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Mar 9, 2021 this sequence version replaced NM_001111269.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ210379.1, FQ209902.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680444, SAMN09767679
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-145               JAXUCZ010000001.1  167631486-167631630 c
            146-368             JAXUCZ010000001.1  167631148-167631370 c
            369-632             JAXUCZ010000001.1  167630245-167630508 c
FEATURES             Location/Qualifiers
     source          1..632
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..632
                     /gene="Hbb-bs"
                     /note="hemoglobin, beta adult s chain"
                     /db_xref="GeneID:689064"
                     /db_xref="RGD:1597422"
     exon            1..145
                     /gene="Hbb-bs"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..497
                     /gene="Hbb-bs"
                     /note="III beta-3 globin; beta-hemoglobin; beta-2-globin;
                     hemoglobin beta-2 chain; hemoglobin beta chain,
                     minor-form; beta-globin"
                     /codon_start=1
                     /product="hemoglobin subunit beta-2"
                     /protein_id="NP_001104739.1"
                     /db_xref="GeneID:689064"
                     /db_xref="RGD:1597422"
                     /translation="MVHLTDAEKATVSGLWGKVNADNVGAEALGRLLVVYPWTQRYFS
                     KFGDLSSASAIMGNPQVKAHGKKVINAFNDGLKHLDNLKGTFAHLSELHCDKLHVDPE
                     NFRLLGNMIVIVLGHHLGKEFTPCAQAAFQKVVAGVASALAHKYH"
     exon            146..368
                     /gene="Hbb-bs"
                     /inference="alignment:Splign:2.1.0"
     exon            369..632
                     /gene="Hbb-bs"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tatatttgct tctgatactg ttgtgttgac tcgcaacctc aggaacagac accatggtgc
       61 acctaactga tgctgagaag gctactgtta gtggcctgtg gggaaaggtg aatgctgata
      121 atgttggcgc tgaggccctg ggcaggctgc tggttgtcta cccttggacc cagaggtact
      181 tttctaaatt tggggacctg tcctctgcct ctgctatcat gggtaacccc caggtgaagg
      241 cccatggcaa gaaggtgata aatgccttca atgatggcct gaaacacttg gacaacctca
      301 agggcacctt tgctcatctg agtgaactcc actgtgacaa gctgcatgtg gatcctgaga
      361 acttcaggct cctgggcaat atgattgtga ttgtgttggg ccaccacctg ggcaaggaat
      421 tcaccccgtg tgcacaggct gccttccaga aggtggtggc tggagtggcc agtgccctgg
      481 ctcacaagta ccactaagcc ccctttcctg ctgttgtcta tgcacaaagg ttatgtgtcc
      541 cctagagaac aactgtcaac tgtgggggga aatgatgaag gcctttgggc agctagcttc
      601 tatctaataa atgatattta ctttcatcgc aa
//
