LOCUS       NM_033234                620 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus hemoglobin subunit beta (Hbb), mRNA.
ACCESSION   NM_033234 XM_215033
VERSION     NM_033234.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 620)
  AUTHORS   Hung,H.Y., Chow,L.H., Kotlinska,J.H., Drabik,A., Silberring,J.,
            Chen,Y.H. and Huang,E.Y.
  TITLE     LVV-hemorphin-7 (LVV-H7) plays a role in antinociception in a rat
            model of alcohol-induced pain disorders
  JOURNAL   Peptides 136, 170455 (2021)
   PUBMED   33253777
  REMARK    GeneRIF: LVV-hemorphin-7 (LVV-H7) plays a role in antinociception
            in a rat model of alcohol-induced pain disorders.
REFERENCE   2  (bases 1 to 620)
  AUTHORS   Manu Pereira,M.D., Ropero,P., Loureiro,C. and Vives Corrons,J.L.
  TITLE     Low affinity hemoglobinopathy (Hb Vigo) due to a new mutation of
            beta globin gene (c200 A>T; Lys>Ile). A cause of rare anemia
            misdiagnosis
  JOURNAL   Am J Hematol 92 (4), E38-E40 (2017)
   PUBMED   28066926
REFERENCE   3  (bases 1 to 620)
  AUTHORS   Yu,L.H., Liu,D., Cai,R., Shang,X., Zhang,X.H., Ma,X.X., Yan,S.H.,
            Fang,P., Zheng,C.G., Wei,X.F., Liu,Y.H., Zhou,T.B. and Xu,X.M.
  TITLE     Changes in hematological parameters in alpha-thalassemia
            individuals co-inherited with erythroid Kruppel-like factor
            mutations
  JOURNAL   Clin Genet 88 (1), 56-61 (2015)
   PUBMED   24930900
REFERENCE   4  (bases 1 to 620)
  AUTHORS   Shephard,F., Greville-Heygate,O., Marsh,O., Anderson,S. and
            Chakrabarti,L.
  TITLE     A mitochondrial location for haemoglobins--dynamic distribution in
            ageing and Parkinson's disease
  JOURNAL   Mitochondrion 14 (1), 64-72 (2014)
   PUBMED   24333691
REFERENCE   5  (bases 1 to 620)
  AUTHORS   Bean,C.J., Boulet,S.L., Yang,G., Payne,A.B., Ghaji,N., Pyle,M.E.,
            Hooper,W.C., Bhatnagar,P., Keefer,J., Barron-Casella,E.A.,
            Casella,J.F. and Debaun,M.R.
  TITLE     Acute chest syndrome is associated with single nucleotide
            polymorphism-defined beta globin cluster haplotype in children with
            sickle cell anaemia
  JOURNAL   Br J Haematol 163 (2), 268-276 (2013)
   PUBMED   23952145
REFERENCE   6  (bases 1 to 620)
  AUTHORS   Silva,M.M., Rogers,P.H. and Arnone,A.
  TITLE     A third quaternary structure of human hemoglobin A at 1.7-A
            resolution
  JOURNAL   J Biol Chem 267 (24), 17248-17256 (1992)
   PUBMED   1512262
REFERENCE   7  (bases 1 to 620)
  AUTHORS   Brennan,S.O., Shaw,J., Allen,J. and George,P.M.
  TITLE     Beta 141 Leu is not deleted in the unstable haemoglobin
            Atlanta-Coventry but is replaced by a novel amino acid of mass 129
            daltons
  JOURNAL   Br J Haematol 81 (1), 99-103 (1992)
   PUBMED   1520632
REFERENCE   8  (bases 1 to 620)
  AUTHORS   Fischel-Ghodsian,N., Hirsch,P.C. and Bohlman,M.C.
  TITLE     Rapid detection of the hemoglobin C mutation by allele-specific
            polymerase chain reaction
  JOURNAL   Am J Hum Genet 47 (6), 1023-1024 (1990)
   PUBMED   2239966
REFERENCE   9  (bases 1 to 620)
  AUTHORS   Nagel,R.L., Lynfield,J., Johnson,J., Landau,L., Bookchin,R.M. and
            Harris,M.B.
  TITLE     Hemoglobin Beth Israel. A mutant causing clinically apparent
            cyanosis
  JOURNAL   N Engl J Med 295 (3), 125-130 (1976)
   PUBMED   1272328
REFERENCE   10 (bases 1 to 620)
  AUTHORS   Garrick,L.M., Sharma,V.S., McDonald,M.J. and Ranney,H.M.
  TITLE     Rat haemoglobin heterogeneity. Two structurally distinct alpha
            chains and functional behaviour of selected components
  JOURNAL   Biochem J 149 (1), 245-258 (1975)
   PUBMED   242324
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from X16417.1.
            
            On Jan 12, 2005 this sequence version replaced XM_215033.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X16417.1, FQ209544.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..620
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..620
                     /gene="Hbb"
                     /note="hemoglobin subunit beta"
                     /db_xref="GeneID:24440"
                     /db_xref="RGD:2783"
     exon            1..139
                     /gene="Hbb"
                     /inference="alignment:Splign:2.1.0"
     CDS             48..491
                     /gene="Hbb"
                     /note="III beta-1 globin; III beta-2 globin;
                     beta-1-globin; hemoglobin beta-1 chain; hemoglobin beta
                     chain, major-form; hemoglobin beta chain complex;
                     hemoglobin, beta"
                     /codon_start=1
                     /product="hemoglobin subunit beta-1"
                     /protein_id="NP_150237.1"
                     /db_xref="GeneID:24440"
                     /db_xref="RGD:2783"
                     /translation="MVHLTDAEKAAVNGLWGKVNPDDVGGEALGRLLVVYPWTQRYFD
                     SFGDLSSASAIMGNPKVKAHGKKVINAFNDGLKHLDNLKGTFAHLSELHCDKLHVDPE
                     NFRLLGNMIVIVLGHHLGKEFTPCAQAAFQKVVAGVASALAHKYH"
     exon            140..362
                     /gene="Hbb"
                     /inference="alignment:Splign:2.1.0"
     exon            363..620
                     /gene="Hbb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgcttctgac atagttgtgt tgactcacaa actcagaaac agacaccatg gtgcacctga
       61 ctgatgctga gaaggctgct gttaatggcc tgtggggaaa ggtgaaccct gatgatgttg
      121 gtggcgaggc cctgggcagg ctgctggttg tctacccttg gacccagagg tactttgata
      181 gctttgggga cctgtcctct gcctctgcta tcatgggtaa ccctaaggtg aaggcccatg
      241 gcaagaaggt gataaacgcc ttcaatgatg gcctgaaaca cttggacaac ctcaagggca
      301 cctttgctca tctgagtgaa ctccactgtg acaagctgca tgtggatcct gagaacttca
      361 ggctcctggg caatatgatt gtgattgtgt tgggccacca cctgggcaag gaattcaccc
      421 cctgtgcaca ggctgccttc cagaaggtgg tggctggagt ggccagtgcc ctggctcaca
      481 agtaccacta aacctctttt cctgctcttg tctttgtgca atggtcaatt gttcccaaga
      541 gagcatctgt cagttgttgt caaaatgaca aagacctttg aaaatctgtc ctactaataa
      601 aaggcattta ctttcactgc
//
